A local signature of LTP‐ and LTD‐like plasticity in human NREM sleep
Abstract
Paired associative stimulation (PAS) repeatedly pairs electrical nerve stimulation with transcranial magnetic stimulation of the contralateral motor hand area (M1 HAND). Depending on the interstimulus interval, PAS can induce a long‐term potentiation (LTP)‐like facilitation or long‐term depression (LTD)‐like suppression of cortical excitability. In three experimental sessions, 12 awake men received PAS of the right median nerve and left M1 HAND in the evening before sleep. To optimize the timing of paired stimulation in M1 HAND, the interstimulus interval of PAS was adjusted to the individual N20‐latency of the somatosensory evoked potential to induce LTP‐like effects (PAS N20+2ms), LTD‐like effects (PAS N20−5ms), or no timing‐dependent after‐effects (PAS control). Motor‐evoked potentials (MEPs) showed high interindividual variations in the conditioning effects of PAS N20+2ms and PAS N20−5ms on cortical excitability. However, PAS control allowed us to adjust for any unspecific stimulation effects and the MEP increase after PAS N20+2ms differed significantly from the MEP decrease after PAS N20−5ms. PAS N20+2ms and PAS N20−5ms also had a differential effect on regional expression of slow waves and slow spindle activity during the first hour of subsequent non‐rapid eye movement (NREM) sleep. At the electrode sites overlying the conditioned M1 HAND and the adjacent premotor cortex, local expression of slow spindle activity was significantly correlated with interindividual differences in the efficacy of PAS N20+2ms and PAS N20−5ms to potentiate or suppress cortical excitability. This correlation indicates that PAS shapes the local regulation of slow sleep spindles during subsequent NREM sleep.
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Similar effects of PAS stimulation on SWA were associated with local changes in slow spindle activity.
“In another study, similar effects of PAS stimulation on SWA were associated with local changes in slow spindle activity (85).”
From About Sleep's Role in Memory (2013) · cites this paper as [85]
In humans, the local expression of spindle activity during non-REM sleep increased or decreased depending on whether LTP-like or LTD-like plasticity had been induced through TMS before sleep.
“Correspondingly in humans, the local expression of spindle activity during non-REM sleep increased or decreased depending on whether LTP-like or LTD-like plasticity had been induced through transcranial magnetic stimulation (TMS) before sleep (85).”
From About Sleep's Role in Memory (2013) · cites this paper as [85]
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- Authors
- Bergmann, T. O., Mölle, M., Marshall, L., Kaya‐Yildiz, L., Born, J., & Roman Siebner, H.
- Affiliations
- Christian-Albrechts-Universität zu Kiel (DE)
- University of Lübeck (DE)
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2008-04-25
- Volume
- 27
- Issue
- 9
- Pages
- 2241-2249
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W2063608151
- Cited by
- 67
- References
- 50
- Citations by year
- 2025: 2 · 2024: 5 · 2021: 1 · 2020: 6 · 2019: 2 · 2018: 5 · 2017: 1 · 2016: 6 · 2015: 2 · 2014: 4 · 2013: 6 · 2012: 4
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- paired associative stimulation, long-term potentiation, long-term depression, NREM sleep, sleep spindles, slow waves, motor cortex excitability, individual differences, somatosensory evoked potentials, motor evoked potentials, premotor cortex, cortical plasticity
- MeSH terms
- Adult, Brain, Electric Stimulation, Electroencephalography, Hand, Humans, Male, Median Nerve, Memory, Sleep, Polysomnography, Long-Term Potentiation, Evoked Potentials, Motor, Long-Term Synaptic Depression, Transcranial Magnetic Stimulation
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