Cited by 291Nitric Oxide and Endothelin EffectsRedox biology and oxidative stressNeutrophil, Myeloperoxidase and Oxidative Mechanisms

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Neuronal expression of the NADPH oxidase NOX4, and its regulation in mouse experimental brain ischemia

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Vallet, P., Charnay, Y., Steger, K., Ogier-Denis, E., Kovari, E., Herrmann, F., Michel, J.-P., Szanto, I.·2005·Neuroscience

DOI 10.1016/j.neuroscience.2004.12.038

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Abstract

Ischemia-induced neuronal damage has been linked to elevated production of reactive oxygen species (ROS) both in animal models and in humans. NADPH oxidase enzymes (NOX-es) are a major enzymatic source of ROS, but their role in brain ischemia has not yet been investigated. The present study was carried out to examine the expression of NOX4, one of the new NADPH oxidase isoforms in a mouse model of focal permanent brain ischemia. We demonstrate that NOX4 is expressed in neurons using in situ hybridization and immunohistochemistry. Ischemia, induced by middle cerebral artery occlusion resulted in a dramatic increase in cortical NOX4 expression. Elevated NOX4 mRNA levels were detectable as early as 24 h after the onset of ischemia and persisted throughout the 30 days of follow-up period, reaching a maximum between days 7 and 15. The early onset suggests neuronal reaction, while the peak period corresponds to the time of neoangiogenesis occurring mainly in the peri-infarct region. The occurrence of NOX4 in the new capillaries was confirmed by immunohistochemical staining. In summary, our paper reports the presence of the ROS producing NADPH oxidase NOX4 in neurons and demonstrates an upregulation of its expression under ischemic conditions. Moreover, a role for NOX4 in ischemia/hypoxia-induced angiogenesis is suggested by its prominent expression in newly formed capillaries.

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NOX enzymes and the biology of reactive oxygen
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NAD(P)H Oxidase: Role in Cardiovascular Biology and Disease
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Biochemistry and pathology of radical-mediated protein oxidation
Dean, R. T., Fu, S., Stocker, R., & Davies, M. J. (1997) · Biochemical Journal · doi:10.1042/bj3240001 · Cited by 1,678
Cytokines and acute neurodegeneration
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Lassegue, B. P., & Clempus, R. E. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00758.2002 · Cited by 1,026
Superoxide Production and Expression of Nox Family Proteins in Human Atherosclerosis
Sorescu, D., Weiss, D., Lassègue, B., Clempus, R. E., Szöcs, K., Sorescu, G. P., Valppu, L., Quinn, M. T., Lambeth, J. D., Vega, J. D., et al. (2002) · Circulation · doi:10.1161/01.cir.0000012917.74432.66 · Cited by 847
Identification of Renox, an NAD(P)H oxidase in kidney
Geiszt, M., Kopp, J. B., Várnai, P., & Leto, T. L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.130135897 · Cited by 840
Novel gp91 phox Homologues in Vascular Smooth Muscle Cells: nox1 Mediates Angiotensin II–Induced Superoxide Formation and Redox-Sensitive Signaling Pathways
Lassègue, B., Sorescu, D., Szöcs, K., Yin, Q., Akers, M., Zhang, Y., Grant, S. L., Lambeth, J. D., & Griendling, K. K. (2001) · Circulation Research · doi:10.1161/hh0901.090299 · Cited by 839

Show all 50 references

Research works printed but not linked: 2

Saran, 2003, To what end does nature produce superoxide?, NADPH oxidase as an autocrine modifier of membrane phospholipids generating paracrine lipid messengers. Free Radic Res, 37, 1045
Soberman, 2003, The expanding network of redox signaling, J Clin Invest, 111, 571, 10.1172/JCI18099 · DOI

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Kelly, K. A. (2009) · The Research Repository @ WVU (West Virginia University) · doi:10.33915/etd.4482
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Milton, R. H., & Abramov, A. Y. (2009) · Contemporary clinical neuroscience · doi:10.1007/978-1-60327-342-8_6
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Aderinto, N., Babawale, E. A., Olatunji, G. D., Kokori, E., Babarinde, F. O., Donaldy, W., Oyesiji, O. W., Vande-Pallen, F. V., Andibanbang, F., Obaje, A. A., et al. (2026) · The Egyptian Journal of Neurology Psychiatry and Neurosurgery · doi:10.1186/s41983-026-01094-4
Activité NADPH oxydase des cellules de leucémie aiguë myéloïde
Leclerc, J. (2013) · theses.fr (ABES) · doi:10.70675/5743e778zd4fdz4faazbccfz81db73478c61
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Eid, S. (2017) · theses.fr (ABES) · doi:10.70675/d5be110dzf78bz46a3z96b1zcb23d1eae233
Caractérisation des NADPH oxydases et effet de leur inhibition dans les leucémies aigues myéloïdes
Dakik, H. (2017) · theses.fr (ABES) · doi:10.70675/c50123fez19eaz4414zaf63z4c616441a1d3
Schwannopathy in diabetes : an investigation of the role of the mTOR, AhR, Nox4 and SMN1 proteins in the pathology of the disease
Massry, M. E. (2020) · theses.fr (ABES) · doi:10.70675/e6f359f8zd5f0z4fcczb33dz09a51a4ee0a9
Identification d’une mutation de Noxo1 activatrice de NADPH oxydase1 : impact sur les cellules colorectales et la plasticité neuronale
Benssouina, F.-Z. (2022) · theses.fr (ABES) · doi:10.70675/276c5067zc483z4f95zb64bz7585a1ebc1e6
Endothelial cell–pericyte interactions in ischemic stroke: From microvascular pathology to repair
Feng, S., Zhang, C., Zhao, Y., Wang, Y., 张柏民, Zhang, Q., Zheng, Y., Cheng, F., Li, C., Wang, X., et al. (2026) · Pharmacological Research · doi:10.1016/j.phrs.2026.108351
BindingDB Entry 50020295: NADPH Oxidases: From Molecular Mechanisms to Current Inhibitors.
BindingDB (2024) · UC San Diego · doi:10.7270/q2jm2g3p
The interaction of UVA radiation with cultured human skin cells
Zhang, J. (2014) · The University of Bath Online Publications Store (The University of Bath)

Authors: Vallet, P., Charnay, Y., Steger, K., Ogier-Denis, E., Kovari, E., Herrmann, F., Michel, J.-P., & Szanto, I.
Affiliations: University of Geneva (CH)
ORCID: Steger, K.
Herrmann, F.
Michel, J.-P.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 2005-01
Volume: 132
Issue: 2
Pages: 233-238
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/j.neuroscience.2004.12.038
OpenAlex: W1971556924
Cited by: 291
References: 50
Citations by year: 2026: 4 · 2025: 5 · 2024: 7 · 2023: 11 · 2022: 8 · 2021: 10 · 2020: 10 · 2019: 10 · 2018: 13 · 2017: 19 · 2016: 14 · 2015: 11 · 2014: 21 · 2013: 14 · 2012: 26
FWCI: 9.79
Type: journal article
Language: en
Open access: green
archive-ouverte.unige.ch
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords: NOX4, NADPH oxidase, cerebral ischemia, focal cerebral ischemia, middle cerebral artery occlusion, reactive oxygen species, neuronal expression, ischemic neuronal injury, gene upregulation
MeSH terms: NADPH Oxidase 4, Animals, Brain Ischemia, Disease Models, Animal, Immunohistochemistry, Kidney, Functional Laterality, Mice, Inbred C57BL, Neurons, RNA, Messenger, Time Factors, Blotting, Northern, Blotting, Western, Gene Expression Regulation, Enzymologic, In Situ Hybridization, NADPH Oxidases, Reverse Transcriptase Polymerase Chain Reaction, Infarction, Middle Cerebral Artery, Mice

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Neuronal expression of the NADPH oxidase NOX4, and its regulation in mouse experimental brain ischemia

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