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Differential effects of prenatal stress on the morphological maturation of hippocampal neurons
Abstract
The present study was designed to clarify an intensity-dependent effect of prenatal stress on the morphological development of hippocampal neurons in rats. In addition, the involvement of receptors for glucocorticoids, i.e. mineralocorticoid receptors and glucocorticoid receptors, in stress-induced changes in the morphology of hippocampal neurons was examined by an in vitro pharmacological approach. The effects of mild prenatal stress on neurogenesis and long-term potentiation in the hippocampus were also investigated in adult offspring. Prenatal stress affected the morphological development of the hippocampus in an intensity-dependent manner. Short-lasting, mild prenatal stress enhanced neonatal neurogenesis and differentiation of processes of hippocampal neurons, whereas long-lasting, severe stress impaired their morphology. Mineralocorticoid receptor was found to mediate enhancement of neurogenesis and differentiation of processes of cultured hippocampal neurons. In contrast, glucocorticoid receptor was involved in the suppression of their morphology. Short-lasting, mild prenatal stress, which has previously been shown to enhance learning performance in adult offspring, facilitated neurogenesis and long-term potentiation in the adult hippocampus. These findings suggest that prenatal stress has enhancing and suppressing effects on the development of hippocampal neurons depending on intensity, and that mineralocorticoid receptors and glucocorticoid receptors contribute to stress-induced morphological changes.
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“Impaired neurogenesis and associated cognitive impairment have been repeatedly reported in prenatally stressed animals (Lemaire et al., 2000; Fujioka et al., 2006; Lemaire et al., 2006).”
From High pregnancy anxiety during mid-gestation is associated with decreased gray matter density in 6-9-year-old children. (2010) · cites this paper as Fujioka et al., 2006
In the citing paper
“Our findings are consistent with accumulating evidence from animal studies that medial temporal and prefrontal cortical regions are shaped by early experience (e.g. Coe et al., 2003; Salm et al., 2004; Fujioka et al., 2006; Murmu et al., 2006).”
From High pregnancy anxiety during mid-gestation is associated with decreased gray matter density in 6-9-year-old children. (2010) · cites this paper as Fujioka et al., 2006
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Metadata
- Authors
- Fujioka, A., Fujioka, T., Ishida, Y., Maekawa, T., & Nakamura, S.
- Affiliations
- Yamaguchi University (JP)
- Corresponding author
- Fujioka, T.
- Nakamura, S.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2006
- Volume
- 141
- Issue
- 2
- Pages
- 907-915
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2051951421
- Cited by
- 165
- References
- 33
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 1 · 2022: 9 · 2021: 7 · 2020: 6 · 2019: 3 · 2018: 4 · 2017: 15 · 2016: 9 · 2015: 14 · 2014: 18 · 2013: 8 · 2012: 12
- FWCI
- 3.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- prenatal stress, hippocampal neurons, neuronal morphology, neurogenesis, mineralocorticoid receptor, glucocorticoid receptor, glucocorticoids, long-term potentiation, stress intensity, adult offspring, learning performance, hippocampal development
- MeSH terms
- Animals, Bromodeoxyuridine, Cell Differentiation, Cells, Cultured, Electric Stimulation, Embryo, Mammalian, Female, Glucocorticoids, Hippocampus, Immunohistochemistry, Microtubule-Associated Proteins, Neurons, Phosphopyruvate Hydratase, Pregnancy, Prenatal Exposure Delayed Effects, Stress, Physiological, Time Factors, Tubulin, Silver Staining, Rats, Sprague-Dawley, Long-Term Potentiation, Cell Size, Rats
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