The DOI matches its Crossref record; 50 of the 51 references it cites were found in a registry or an index.
Neuron number decreases in the rat ventral, but not dorsal, medial prefrontal cortex between adolescence and adulthood
Abstract
Neuroimaging studies have established that there are losses in the volume of gray matter in certain cortical regions between adolescence and adulthood, with changes in the prefrontal cortex being particularly dramatic. Previous work from our laboratory has demonstrated that cell death can occur as late as the fourth postnatal week in the rat cerebral cortex. The present study examined the possibility that neuronal loss may occur between adolescence and adulthood in the rat prefrontal cortex. Rats of both sexes were examined during adolescence (at day 35) and young adulthood (at day 90). The volume, neuronal number, and glial number of the medial prefrontal cortex (mPFC) were quantified using unbiased stereological techniques. Neurons were lost from the ventral, but not dorsal, mPFC between adolescence and adulthood, suggesting a late wave of apoptosis that was region-specific. This was accompanied by a decrease in the volume of the female ventral mPFC. In contrast to neuron number, the number of glial cells was stable in the ventral mPFC and increased between adolescence and adulthood in the dorsal mPFC. Sex-specific developmental changes in neuron number, glial number, and volume resulted in sex differences in adults that were not seen during adolescence. The loss of neurons at this time may make the peri-adolescent prefrontal cortex particularly susceptible to the influence of environmental factors.
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“Stereological analyses have revealed declines in the number of neurons within both of these regions between adolescence and adulthood in rats, effects studied in the basolateral nucleus of the amygdala (Rubinow & Juraska, 2009) and seen in ventral (but not dorsal) mPFC (Markham et al, 2007)”
From Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data (2011) · cites this paper as Markham et al, 2007
In the citing paper
“In both humans and laboratory animals, the volume of frontal cortex decreases in adolescence whereas the volume of the amygdala increases (e.g., Giedd et al, 1996; Giedd, 2004; Markham et al, 2007).”
From Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data (2011) · cites this paper as Markham et al, 2007
In the citing paper
“In both humans and laboratory animals, the volume of frontal cortex decreases in adolescence whereas the volume of the amygdala increases (e.g., Giedd et al, 1996; Giedd, 2004; Markham et al, 2007).”
From Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data (2011) · cites this paper as Markham et al, 2007
In the citing paper
“In both humans and laboratory animals, the volume of frontal cortex decreases in adolescence whereas the volume of the amygdala increases (e.g., Giedd et al, 1996; Giedd, 2004; Markham et al, 2007).”
From Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data (2011) · cites this paper as Markham et al, 2007
In the citing paper
“Stereological analyses have revealed declines in the number of neurons within both of these regions between adolescence and adulthood in rats, effects studied in the basolateral nucleus of the amygdala (Rubinow & Juraska, 2009) and seen in ventral (but not dorsal) mPFC (Markham et al, 2007)”
From Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data (2011) · cites this paper as Markham et al, 2007
In the citing paper
“In rodents, frontal white matter is also affected by age and hormones in both sexes (Markham et al., 2007).”
From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Markham et al., 2007
Citations
Cites
Brain development during childhood and adolescence: a longitudinal MRI study
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Stress, sensitive periods and maturational events in adolescent depression
Andersen, S. L., & Teicher, M. H. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.01.004 · Cited by 1,005
Air pollution, cognitive deficits and brain abnormalities: A pilot study with children and dogs
Calderón‐Garcidueñas, L., Mora-Tiscareño, A., Ontiveros, E., Gómez-Garza, G., Mejía, G. B., Broadway, J. M., Chapman, S., Valencia‐Salazar, G., Jewells, V. L., Maronpot, R. R., et al. (2008) · Brain and Cognition · doi:10.1016/j.bandc.2008.04.008 · Cited by 580
Stress and the developing adolescent brain
Eiland, L. R., & Romeo, R. D. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.10.048 · Cited by 539
Sex Differences and the Impact of Steroid Hormones on the Developing Human Brain
Neufang, S., Specht, K., Hausmann, M., Güntürkün, O., Herpertz‐Dahlmann, B., Fink, G. R., & Konrad, K. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn100 · Cited by 436
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Metadata
- Authors
- Markham, J. A., Morris, J. R., & Juraska, J. M.
- Affiliations
- University of Illinois Urbana-Champaign (US)
- ORCID
- Juraska, J.M.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2007-02
- Volume
- 144
- Issue
- 3
- Pages
- 961-968
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2058932154
- Cited by
- 230
- References
- 51
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 12 · 2023: 11 · 2022: 9 · 2021: 12 · 2020: 12 · 2019: 9 · 2018: 19 · 2017: 14 · 2016: 20 · 2015: 9 · 2014: 5 · 2013: 25 · 2012: 13
- FWCI
- 1.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD07333, T32HD007333)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- neuronal loss, ventromedial prefrontal cortex, dorsomedial prefrontal cortex, adolescence, adulthood, apoptosis, gray matter volume, glial cells, sex differences, postnatal development, rat brain
- MeSH terms
- Aging, Animals, Cell Count, Environment, Female, Male, Nerve Fibers, Myelinated, Neuroglia, Neuronal Plasticity, Neurons, Sex Characteristics, Cell Death, Prefrontal Cortex, Rats, Long-Evans, Cell Proliferation, Rats
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