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Cited by 147Epilepsy research and treatmentNeuroscience and Neuropharmacology ResearchPharmacological Effects and Toxicity Studies

The DOI matches its Crossref record; 75 of the 78 references it cites were found in a registry or an index.

Quantitative analysis of parvalbumin-immunoreactive cells in the human epileptic hippocampus.

Andrioli, A., Alonso-Nanclares, L., Arellano, J.I., DeFelipe, J.·2007·Neuroscience
DOI 10.1016/j.neuroscience.2007.07.029
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Abstract

Hippocampal sclerosis is the most frequent pathology encountered in mesial temporal structures resected from patients with intractable temporal lobe epilepsy and it mainly involves hippocampal neuronal loss and gliosis. These alterations are accompanied by changes in the expression of a variety of molecules in the surviving neurons, as well as axonal reorganization in both excitatory and inhibitory circuits. The alteration of a subpopulation of GABAergic interneurons that expresses the calcium binding protein parvalbumin (PV) is thought to be a key factor in the epileptogenic process. We investigated the distribution and density of parvalbumin-immunoreactive (PV-ir) neurons in surgically resected hippocampal tissue from epileptic patients with and without sclerosis. Using quantitative stereological methods, we show for the first time that there is no correlation between total neuronal loss and PV-ir neuronal loss in any of the hippocampal fields. We also observed higher values of the total neuronal density in the sclerotic subiculum, which is accompanied by a lower density of PV-ir when compared with non-sclerotic epileptic and autopsy hippocampi. These findings suggest that, the apparently normal subiculum from sclerotic patients also shows unexpected changes in the density and proportion of PV-ir neurons.

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Metadata

Authors
Andrioli, A., Alonso-Nanclares, L., Arellano, J. I., & DeFelipe, J.
Affiliations
  • University of Verona (IT)
  • Consejo Superior de Investigaciones Científicas (ES)
Corresponding author
DeFelipe, J.
ORCID
Venue
Neuroscience
Publisher
Elsevier BV
Published
2007-10
Volume
149
Issue
1
Pages
131-143
ISSN
0306-4522 (ISSN-L)
DOI
10.1016/j.neuroscience.2007.07.029
OpenAlex
W2081122323
Cited by
147
References
78
Citations by year
2026: 5 · 2025: 7 · 2024: 10 · 2023: 8 · 2022: 12 · 2021: 6 · 2020: 7 · 2019: 8 · 2018: 12 · 2017: 6 · 2016: 6 · 2015: 13 · 2014: 13 · 2013: 7 · 2012: 3
FWCI
3.02
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
Funders
  • Comunidad de Madrid (08.5/0027/2001.1, R-04-40)
  • Ministerio de Educación, Cultura y Deporte (BFI2003-01018, BFI2003-02745, BFU2006-13395)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
Keywords
parvalbumin, GABAergic interneurons, hippocampal sclerosis, temporal lobe epilepsy, subiculum, neuronal density, neuronal loss, stereology, drug-resistant epilepsy, gliosis
MeSH terms
Adult, Aged, Cell Count, Epilepsy, Female, Hippocampus, Humans, Male, Middle Aged, Parvalbumins, Stereotaxic Techniques

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