The DOI matches its Crossref record; 75 of the 78 references it cites were found in a registry or an index.
Quantitative analysis of parvalbumin-immunoreactive cells in the human epileptic hippocampus.
Abstract
Hippocampal sclerosis is the most frequent pathology encountered in mesial temporal structures resected from patients with intractable temporal lobe epilepsy and it mainly involves hippocampal neuronal loss and gliosis. These alterations are accompanied by changes in the expression of a variety of molecules in the surviving neurons, as well as axonal reorganization in both excitatory and inhibitory circuits. The alteration of a subpopulation of GABAergic interneurons that expresses the calcium binding protein parvalbumin (PV) is thought to be a key factor in the epileptogenic process. We investigated the distribution and density of parvalbumin-immunoreactive (PV-ir) neurons in surgically resected hippocampal tissue from epileptic patients with and without sclerosis. Using quantitative stereological methods, we show for the first time that there is no correlation between total neuronal loss and PV-ir neuronal loss in any of the hippocampal fields. We also observed higher values of the total neuronal density in the sclerotic subiculum, which is accompanied by a lower density of PV-ir when compared with non-sclerotic epileptic and autopsy hippocampi. These findings suggest that, the apparently normal subiculum from sclerotic patients also shows unexpected changes in the density and proportion of PV-ir neurons.
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“Analysis of post-mortem human brain tissues demonstrated reduced PV cell density and immunoreactivity at epileptic foci in the hippocampus and neocortex (Sloviter et al., 1991; Ferrer et al., 1994; Andrioli et al., 2007).”
From The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders (2018) · cites this paper as Andrioli et al., 2007
Citations
Cites
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Sorted by citations
Pathophysiogenesis of Mesial Temporal Lobe Epilepsy: Is Prevention of Damage Antiepileptogenic?
Curia, G., Lucchi, C., Vinet, J., Gualtieri, F., Marinelli, C., Torsello, A., Costantino, L., & Biagini, G. (2014) · Current Medicinal Chemistry · doi:10.2174/0929867320666131119152201 · Cited by 216
“Many hilar neurons are aminobutyric acid (GABA)ergic, and number of GABAergic interneurons are reduced in the dentate gyrus of patients with TLE [80-83] and rodent models [84-90].”
BackgroundGenetics and Function of Neocortical GABAergic Interneurons in Neurodevelopmental Disorders
Rossignol, E. (2011) · Neural Plasticity · doi:10.1155/2011/649325 · Cited by 192
Campbell, S. L., Robel, S., Cuddapah, V. A., Robert, S., Buckingham, S. C., Kahle, K. T., & Sontheimer, H. (2015) · Glia · doi:10.1002/glia.22730 · Cited by 185
“Depolarizing GABA responses were observed in slices of human cortical tissue from epilepsy patients (Deisz, 2002) and were also shown to contribute to interictal activity in human TLE (Cohen et al., 2002).”
BackgroundInfluentialThe Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders
Wen, T. H., Binder, D. K., Ethell, I. M., & Razak, K. A. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00270 · Cited by 170
“Analysis of post-mortem human brain tissues demonstrated reduced PV cell density and immunoreactivity at epileptic foci in the hippocampus and neocortex (Sloviter et al., 1991; Ferrer et al., 1994; Andrioli et al., 2007).”
BackgroundPiskorowski, R. A., Nasrallah, K., Diamantopoulou, A., Mukai, J., Hassan, S. I., Siegelbaum, S. A., Gogos, J. A., & Chevaleyre, V. (2016) · Neuron · doi:10.1016/j.neuron.2015.11.036 · Cited by 180
Metadata
- Authors
- Andrioli, A., Alonso-Nanclares, L., Arellano, J. I., & DeFelipe, J.
- Affiliations
- University of Verona (IT)
- Consejo Superior de Investigaciones Científicas (ES)
- Corresponding author
- DeFelipe, J.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2007-10
- Volume
- 149
- Issue
- 1
- Pages
- 131-143
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2081122323
- Cited by
- 147
- References
- 78
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 10 · 2023: 8 · 2022: 12 · 2021: 6 · 2020: 7 · 2019: 8 · 2018: 12 · 2017: 6 · 2016: 6 · 2015: 13 · 2014: 13 · 2013: 7 · 2012: 3
- FWCI
- 3.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Funders
- Comunidad de Madrid (08.5/0027/2001.1, R-04-40)
- Ministerio de Educación, Cultura y Deporte (BFI2003-01018, BFI2003-02745, BFU2006-13395)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Keywords
- parvalbumin, GABAergic interneurons, hippocampal sclerosis, temporal lobe epilepsy, subiculum, neuronal density, neuronal loss, stereology, drug-resistant epilepsy, gliosis
- MeSH terms
- Adult, Aged, Cell Count, Epilepsy, Female, Hippocampus, Humans, Male, Middle Aged, Parvalbumins, Stereotaxic Techniques
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