The DOI matches its Crossref record; 75 of the 78 references it cites were found in a registry or an index.
Quantitative analysis of parvalbumin-immunoreactive cells in the human epileptic hippocampus.
Abstract
Hippocampal sclerosis is the most frequent pathology encountered in mesial temporal structures resected from patients with intractable temporal lobe epilepsy and it mainly involves hippocampal neuronal loss and gliosis. These alterations are accompanied by changes in the expression of a variety of molecules in the surviving neurons, as well as axonal reorganization in both excitatory and inhibitory circuits. The alteration of a subpopulation of GABAergic interneurons that expresses the calcium binding protein parvalbumin (PV) is thought to be a key factor in the epileptogenic process. We investigated the distribution and density of parvalbumin-immunoreactive (PV-ir) neurons in surgically resected hippocampal tissue from epileptic patients with and without sclerosis. Using quantitative stereological methods, we show for the first time that there is no correlation between total neuronal loss and PV-ir neuronal loss in any of the hippocampal fields. We also observed higher values of the total neuronal density in the sclerotic subiculum, which is accompanied by a lower density of PV-ir when compared with non-sclerotic epileptic and autopsy hippocampi. These findings suggest that, the apparently normal subiculum from sclerotic patients also shows unexpected changes in the density and proportion of PV-ir neurons.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Analysis of post-mortem human brain tissues demonstrated reduced PV cell density and immunoreactivity at epileptic foci in the hippocampus and neocortex (Sloviter et al., 1991; Ferrer et al., 1994; Andrioli et al., 2007).”
From The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders (2018) · cites this paper as Andrioli et al., 2007
Citations
Cites
Surgical Treatment of the Epilepsies
Kotagal, P. (1994) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-199407000-00009 · Cited by 2,759
Outcome with respect to epileptic seizures.
Engel, J. (1993) · Medical Entomology and Zoology · Cited by 2,044
Paxinos, G., & Jürgen, K. (2004) · Cited by 1,478
(1964) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1964.tb115841.x · Cited by 1,411
Active propagation of somatic action potentials into neocortical pyramidal cell dendrites
Stuart, G. J., & Sakmann, B. (1994) · Nature · doi:10.1038/367069a0 · Cited by 1,289
Surgical treatment of the epilepsies
Bloomfield, S. M., & Shetter, A. G. (1988) · Surgical Neurology · doi:10.1016/0090-3019(88)90022-5 · Cited by 1,206
Mossy fiber synaptic reorganization in the epileptic human temporal lobe
Sutula, T. P., Cascino, G. D., Cavazos, J. E., Parada, I., & Ramirez, L. F. (1989) · Annals of Neurology · doi:10.1002/ana.410260303 · Cited by 1,152
On the Origin of Interictal Activity in Human Temporal Lobe Epilepsy in Vitro
Cohen, I., Navarro, V., Clémenceau, S., Baulac, M., & Miles, R. (2002) · Science · doi:10.1126/science.1076510 · Cited by 1,001
Differences between somatic and dendritic inhibition in the hippocampus
Miles, R., Tóth, K., Gulyás, A. I., Hájos, N., & Freund, T. F. (1996) · Neuron · doi:10.1016/s0896-6273(00)80101-4 · Cited by 942
Hippocampal interneuron loss and plasticity in human temporal lobe epilepsy
de Lanerolle, N. C., Kim, J. H., Robbins, R. J., & Spencer, D. D. (1989) · Brain Research · doi:10.1016/0006-8993(89)90234-5 · Cited by 926
Functional organization of the extrinsic and intrinsic circuitry of the parahippocampal region
Witter, M. P., Groenewegen, H. J., Lopes, F. H. D. S., & Lohman, A. H. M. (1989) · Progress in Neurobiology · doi:10.1016/0301-0082(89)90009-9 · Cited by 918
The Anatomical Connections of the Macaque Monkey Orbitofrontal Cortex. A Review
Cavada, C. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.220 · Cited by 917
Parvalbumin in Most γ-Aminobutyric Acid-Containing Neurons of the Rat Cerebral Cortex
Celio, M. R. (1986) · Science · doi:10.1126/science.3945815 · Cited by 740
Calcium-binding proteins: selective markers of nerve cells
Andressen, C., Bl�mcke, I., & Celio, M. R. (1993) · Cell and Tissue Research · doi:10.1007/bf00318606 · Cited by 701
Sloviter, R. S. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902800203 · Cited by 686
Synaptic reorganization by mossy fibers in human epileptic fascia dentata
Babb, T. L., Kupfer, W. R., Pretorius, J. K., Crandall, P. H., & Levesque, M. F. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90380-7 · Cited by 656
Interneuron Diversity series: Rhythm and mood in perisomatic inhibition
Freund, T. F. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00227-3 · Cited by 641
Granule cell dispersion in the dentate gyrus of humans with temporal lobe epilepsy
Houser, C. R. (1990) · Brain Research · doi:10.1016/0006-8993(90)91601-c · Cited by 604
Hendry, S. H. C., Jones, E. G., Emson, P. C., Lawson, D. E. M., Heizmann, C. W., & Streit, P. (1989) · Experimental Brain Research · doi:10.1007/bf00247904 · Cited by 512
Temporal Lobe Volumetric Cell Densities in Temporal Lobe Epilepsy
Babb, T. L., Brown, W. J., Pretorius, J. K., Davenport, C. J., Lieb, J. P., & Crandall, P. H. (1984) · Epilepsia · doi:10.1111/j.1528-1157.1984.tb03484.x · Cited by 488
Rosene, D. L., & Van Hoesen, G. W. (1987) · Cerebral Cortex · doi:10.1007/978-1-4615-6616-8_9 · Cited by 422
Role of the calcium-binding protein parvalbumin in short-term synaptic plasticity
Caillard, O., Moreno, H., Schwaller, B., Llano, I., Celio, M. R., & Marty, A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.230362997 · Cited by 406
Glutamate decarboxylase-immunoreactive neurons are preserved in human epileptic hippocampus
Tl, B., Pretorius, J., Kupfer, W. R., & Crandall, P. H. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-07-02562.1989 · Cited by 363
Sloviter, R. S., Sollas, A. L., Barbaro, N. M., & Laxer, K. D. (1991) · Journal of Comparative Neurology · doi:10.1002/cne.903080306 · Cited by 349
Visualization of chandelier cell axons by parvalbumin immunoreactivity in monkey cerebral cortex.
DeFelipe, J., Hendry, S. H. C., & Jones, E. G. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.6.2093 · Cited by 338
Self-citationColbert, C. M., & Johnston, D. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-21-06676.1996 · Cited by 315
The development, ultrastructure and synaptic connections of the mossy cells of the dentate gyrus
Ribak, C. E., Seress, L., & Amaral, D. G. (1985) · Journal of Neurocytology · doi:10.1007/bf01170832 · Cited by 311
Fritschy, J., Meskenaïte, V., Weinmann, O., Honer, M., Benke, D., & Möhler, H. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00481.x · Cited by 305
DeFelipe, J. (1999) · Brain · doi:10.1093/brain/122.10.1807 · Cited by 297
Self-citationGABAergic cells in the dentate gyrus appear to be local circuit and projection neurons
Seress, L., & Ribak, C. E. (1983) · Experimental Brain Research · doi:10.1007/bf00239181 · Cited by 266
Toledo-Rodriguez, M. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh092 · Cited by 241
Sloviter, R. S. (1991) · Hippocampus · doi:10.1002/hipo.450010105 · Cited by 228
Lewis, D. A., & Lund, J. S. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.902930406 · Cited by 220
Histopathology and reorganization of chandelier cells in the human epileptic sclerotic hippocampus
Arellano, J. I. (2003) · Brain · doi:10.1093/brain/awh004 · Cited by 210
Self-citationPreservation of perisomatic inhibitory input of granule cells in the epileptic human dentate gyrus
Wittner, L., Maglóczky, Z., Borhegyi, Z., Halász, P., Tóth, S., Erőss, L., Szabó, Z., & Freund, T. F. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00446-8 · Cited by 185
Changes in the distribution and connectivity of interneurons in the epileptic human dentate gyrus
Maglóczky, Z., Wittner, L., Borhegyi, Z., Halász, P., Vajda, J., Czirják, S., & Freund, T. F. (2000) · Neuroscience · doi:10.1016/s0306-4522(99)00474-1 · Cited by 174
Cation‐Chloride Cotransporters and GABA‐ergic Innervation in the Human Epileptic Hippocampus
Muñoz, A., Méndez, P., DeFelipe, J., & Alvarez-Leefmans, F. J. (2007) · Epilepsia · doi:10.1111/j.1528-1167.2007.00986.x · Cited by 170
Self-citationLaminar organization of the pyramidal cell layer of the subiculum in the rat
Ishizuka, N. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1195 · Cited by 144
Adams, J. H., & Duchen, L. W. (1998) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199801000-00010 · Cited by 143
Wittner, L. (2004) · Brain · doi:10.1093/brain/awh339 · Cited by 140
Surgical Treatment of Epilepsies
Zentner, J. (2002) · Springer eBooks · doi:10.1007/978-3-7091-6117-3_3 · Cited by 139
The synaptology of parvalbumin‐immunoreactive neurons in the primate prefrontal cortex
Williams, S. M., Goldman, P. S., & Leranth, C. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903200307 · Cited by 139
Mesial temporal sclerosis : historical background and an overview from a modern perspective
GLOOR, P. (1997) · Medical Entomology and Zoology · Cited by 136
Siegel, A. M., Wieser, H. G., Wichmann, W., & Yasargil, G. M. (1990) · Epilepsy Research · doi:10.1016/0920-1211(90)90009-k · Cited by 133
Mathern, G. W., Pretorius, J. K., & Babb, T. L. (1995) · Journal of neurosurgery · doi:10.3171/jns.1995.82.2.0211 · Cited by 122
Quantitative analysis of synaptic potentiation during kindling of the perforant path
Sutula, T. P., & Steward, O. (1986) · Journal of Neurophysiology · doi:10.1152/jn.1986.56.3.732 · Cited by 114
Isokawa, M., Levesque, M. F., Tl, B., & Engel, J. D. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-04-01511.1993 · Cited by 113
Hippocampal sclerosis revisited
Fisher, P. D., Sperber, E. F., & Moshé, S. L. (1998) · Brain and Development · doi:10.1016/s0387-7604(98)00069-2 · Cited by 110
The Role of the Subiculum in Epilepsy and Epileptogenesis
Stafstrom, C. E. (2005) · Epiliepsy currents/Epilepsy currents · doi:10.1111/j.1535-7511.2005.00049.x · Cited by 106
Wittner, L., Erőss, L., Szabó, Z., Tóth, S., Czirják, S., Halász, P., Freund, T. F., & Maglóczky, Z. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00264-6 · Cited by 104
Inhibitory function in two models of chronic epileptogenesis
Prince, D. A., & Jacobs, K. M. (1998) · Epilepsy Research · doi:10.1016/s0920-1211(98)00042-4 · Cited by 97
Parvalbumin-immunoreactive structures in the hippocampus of the human adult
Braak, E., Strotkamp, B., & Braak, H. (1991) · Cell and Tissue Research · doi:10.1007/bf00305720 · Cited by 94
Microanatomy of the dysplastic neocortex from epileptic patients
Alonso‐Nanclares, L. (2004) · Brain · doi:10.1093/brain/awh331 · Cited by 94
Self-citationOn the structure of the human archicortex
Braak, H. (1974) · Cell and Tissue Research · doi:10.1007/bf00223955 · Cited by 90
Inhibition in synchronously firing human hippocampal neurons
Isokawa-Akesson, M., Wilson, C. L., & Babb, T. L. (1989) · Epilepsy Research · doi:10.1016/0920-1211(89)90030-2 · Cited by 88
Correlation of transcriptome profile with electrical activity in temporal lobe epilepsy
Arion, D., Sabatini, M., Unger, T. L., Pastor, J., Alonso‐Nanclares, L., Ballesteros‐Yáñez, I., de Sola, R. G., Muñoz, A., Mirnics, K., & DeFelipe, J. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.12.012 · Cited by 86
Self-citationAltered synaptic circuitry in the human temporal neocortex removed from epileptic patients
Marco, P., & DeFelipe, J. (1997) · Experimental Brain Research · doi:10.1007/pl00005608 · Cited by 84
Self-citationFinch, D. M., & Babb, T. L. (1981) · Brain Research · doi:10.1016/0006-8993(81)91203-8 · Cited by 81
Electrophysiological and morphological diversity of neurons from the rat subicular complex in vitro
de la Prida, L. M., Suárez, F., & Pozo, M. A. (2003) · Hippocampus · doi:10.1002/hipo.10123 · Cited by 81
Tl, B., & Brown, W. J. (1986) · PubMed · Cited by 81
Chronic focal neocortical epileptogenesis: does disinhibition play a role?
Prince, D. A., Jacobs, K. M., Salin, P. A., Hoffman, S. N., & Parada, I. (1997) · PubMed · Cited by 78
Ribak, C. E., Seress, L., & Léránth, C. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903270211 · Cited by 68
Zhu, Z.-Q., Armstrong, D. L., Hamilton, W. J., & Grossman, R. G. (1997) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199709000-00004 · Cited by 67
Dawodu, S., & Thom, M. (2005) · Epilepsia · doi:10.1111/j.0013-9580.2005.21804.x · Cited by 63
Reelin expression during embryonic brain development in lacertilian lizards
Goffinet, A. M., Bar, I., Bernier, B., Trujillo, C. M., Raynaud, A., & Meyer, G. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19991129)414:4 · Cited by 62
Axonal sprouting of GABAergic interneurons in temporal lobe epilepsy
Bausch, S. B. (2005) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2005.07.019 · Cited by 56
Houser, C. R., Swartz, B. E., Walsh, G. O., & Delgado‐Escueta, A. V. (1992) · PubMed · Cited by 55
Chronic focal neocortical epileptogenesis: Does disinhibition play a role?
Prince, D. A., Jacobs, K. M., Salin, P. A., Hoffman, S. N., & Parada, I. (1997) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y97-036 · Cited by 54
Scotti, A. L., Kalt, G., Bollag, O., & Nitsch, C. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00309-0 · Cited by 40
Muñoz, A., Arellano, J. I., & DeFelipe, J. (2002) · The Journal of Comparative Neurology · doi:10.1002/cne.10287 · Cited by 39
Self-citationBabb, T. L., Ying, Z., Mikuni, N., Nishiyama, K., Drazba, J. A., Bingaman, W. E., Wyllie, E., Wylie, C. J., & Yacubova, K. (2000) · Epilepsia · doi:10.1111/j.1528-1157.2000.tb01561.x · Cited by 33
Zhong, Y.-M., Yukie, M., & Rockland, K. (2006) · Experimental Brain Research · doi:10.1007/s00221-005-0187-7 · Cited by 26
Cellular Mechanisms of Pharmacoresistance in Slices from Epilepsy Surgery
Deisz, R. A. (2002) · Novartis Foundation symposium · doi:10.1002/0470846356.ch14 · Cited by 21
Is epilepsy a disorder of inhibition or excitation?
Avoli, M. (1983) · PubMed · Cited by 14
Cited by
Sorted by citations
Pathophysiogenesis of Mesial Temporal Lobe Epilepsy: Is Prevention of Damage Antiepileptogenic?
Curia, G., Lucchi, C., Vinet, J., Gualtieri, F., Marinelli, C., Torsello, A., Costantino, L., & Biagini, G. (2014) · Current Medicinal Chemistry · doi:10.2174/0929867320666131119152201 · Cited by 216
“Many hilar neurons are aminobutyric acid (GABA)ergic, and number of GABAergic interneurons are reduced in the dentate gyrus of patients with TLE [80-83] and rodent models [84-90].”
BackgroundGenetics and Function of Neocortical GABAergic Interneurons in Neurodevelopmental Disorders
Rossignol, E. (2011) · Neural Plasticity · doi:10.1155/2011/649325 · Cited by 192
Campbell, S. L., Robel, S., Cuddapah, V. A., Robert, S., Buckingham, S. C., Kahle, K. T., & Sontheimer, H. (2015) · Glia · doi:10.1002/glia.22730 · Cited by 185
“Depolarizing GABA responses were observed in slices of human cortical tissue from epilepsy patients (Deisz, 2002) and were also shown to contribute to interictal activity in human TLE (Cohen et al., 2002).”
BackgroundInfluentialThe Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders
Wen, T. H., Binder, D. K., Ethell, I. M., & Razak, K. A. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00270 · Cited by 170
“Analysis of post-mortem human brain tissues demonstrated reduced PV cell density and immunoreactivity at epileptic foci in the hippocampus and neocortex (Sloviter et al., 1991; Ferrer et al., 1994; Andrioli et al., 2007).”
BackgroundPiskorowski, R. A., Nasrallah, K., Diamantopoulou, A., Mukai, J., Hassan, S. I., Siegelbaum, S. A., Gogos, J. A., & Chevaleyre, V. (2016) · Neuron · doi:10.1016/j.neuron.2015.11.036 · Cited by 180
Metadata
- Authors
- Andrioli, A., Alonso-Nanclares, L., Arellano, J. I., & DeFelipe, J.
- Affiliations
- University of Verona (IT)
- Consejo Superior de Investigaciones Científicas (ES)
- Corresponding author
- DeFelipe, J.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2007-10
- Volume
- 149
- Issue
- 1
- Pages
- 131-143
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2081122323
- Cited by
- 147
- References
- 78
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 10 · 2023: 8 · 2022: 12 · 2021: 6 · 2020: 7 · 2019: 8 · 2018: 12 · 2017: 6 · 2016: 6 · 2015: 13 · 2014: 13 · 2013: 7 · 2012: 3
- FWCI
- 3.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Funders
- Comunidad de Madrid (08.5/0027/2001.1, R-04-40)
- Ministerio de Educación, Cultura y Deporte (BFI2003-01018, BFI2003-02745, BFU2006-13395)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Keywords
- parvalbumin, GABAergic interneurons, hippocampal sclerosis, temporal lobe epilepsy, subiculum, neuronal density, neuronal loss, stereology, drug-resistant epilepsy, gliosis
- MeSH terms
- Adult, Aged, Cell Count, Epilepsy, Female, Hippocampus, Humans, Male, Middle Aged, Parvalbumins, Stereotaxic Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
