Cited by 147Epilepsy research and treatmentNeuroscience and Neuropharmacology ResearchPharmacological Effects and Toxicity Studies

The DOI matches its Crossref record; 75 of the 78 references it cites were found in a registry or an index.

Quantitative analysis of parvalbumin-immunoreactive cells in the human epileptic hippocampus.

Andrioli, A., Alonso-Nanclares, L., Arellano, J.I., DeFelipe, J.·2007·Neuroscience

DOI 10.1016/j.neuroscience.2007.07.029

Open this paper in CoChat — free account

Abstract

Hippocampal sclerosis is the most frequent pathology encountered in mesial temporal structures resected from patients with intractable temporal lobe epilepsy and it mainly involves hippocampal neuronal loss and gliosis. These alterations are accompanied by changes in the expression of a variety of molecules in the surviving neurons, as well as axonal reorganization in both excitatory and inhibitory circuits. The alteration of a subpopulation of GABAergic interneurons that expresses the calcium binding protein parvalbumin (PV) is thought to be a key factor in the epileptogenic process. We investigated the distribution and density of parvalbumin-immunoreactive (PV-ir) neurons in surgically resected hippocampal tissue from epileptic patients with and without sclerosis. Using quantitative stereological methods, we show for the first time that there is no correlation between total neuronal loss and PV-ir neuronal loss in any of the hippocampal fields. We also observed higher values of the total neuronal density in the sclerotic subiculum, which is accompanied by a lower density of PV-ir when compared with non-sclerotic epileptic and autopsy hippocampi. These findings suggest that, the apparently normal subiculum from sclerotic patients also shows unexpected changes in the density and proportion of PV-ir neurons.

Integrity signals

Registry

Crossref · 10.1016/j.neuroscience.2007.07.029

Cites

75 of 75 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Surgical Treatment of the Epilepsies
Kotagal, P. (1994) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-199407000-00009 · Cited by 2,759
Outcome with respect to epileptic seizures.
Engel, J. (1993) · Medical Entomology and Zoology · Cited by 2,044
The human nervous system
Paxinos, G., & Jürgen, K. (2004) · Cited by 1,478
Greenfield's Neuropathology
(1964) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1964.tb115841.x · Cited by 1,411
Active propagation of somatic action potentials into neocortical pyramidal cell dendrites
Stuart, G. J., & Sakmann, B. (1994) · Nature · doi:10.1038/367069a0 · Cited by 1,289
Surgical treatment of the epilepsies
Bloomfield, S. M., & Shetter, A. G. (1988) · Surgical Neurology · doi:10.1016/0090-3019(88)90022-5 · Cited by 1,206
Mossy fiber synaptic reorganization in the epileptic human temporal lobe
Sutula, T. P., Cascino, G. D., Cavazos, J. E., Parada, I., & Ramirez, L. F. (1989) · Annals of Neurology · doi:10.1002/ana.410260303 · Cited by 1,152
On the Origin of Interictal Activity in Human Temporal Lobe Epilepsy in Vitro
Cohen, I., Navarro, V., Clémenceau, S., Baulac, M., & Miles, R. (2002) · Science · doi:10.1126/science.1076510 · Cited by 1,001
Differences between somatic and dendritic inhibition in the hippocampus
Miles, R., Tóth, K., Gulyás, A. I., Hájos, N., & Freund, T. F. (1996) · Neuron · doi:10.1016/s0896-6273(00)80101-4 · Cited by 942
Hippocampal interneuron loss and plasticity in human temporal lobe epilepsy
de Lanerolle, N. C., Kim, J. H., Robbins, R. J., & Spencer, D. D. (1989) · Brain Research · doi:10.1016/0006-8993(89)90234-5 · Cited by 926

Show all 78 references

Sorted by citations

Pathophysiogenesis of Mesial Temporal Lobe Epilepsy: Is Prevention of Damage Antiepileptogenic?
Curia, G., Lucchi, C., Vinet, J., Gualtieri, F., Marinelli, C., Torsello, A., Costantino, L., & Biagini, G. (2014) · Current Medicinal Chemistry · doi:10.2174/0929867320666131119152201 · Cited by 216
Genetics and Function of Neocortical GABAergic Interneurons in Neurodevelopmental Disorders
Rossignol, E. (2011) · Neural Plasticity · doi:10.1155/2011/649325 · Cited by 192
GABAergic disinhibition and impaired KCC2 cotransporter activity underlie tumor-associated epilepsy: Reduced KCC2 Underlie Tumor-Related Epilepsy
Campbell, S. L., Robel, S., Cuddapah, V. A., Robert, S., Buckingham, S. C., Kahle, K. T., & Sontheimer, H. (2015) · Glia · doi:10.1002/glia.22730 · Cited by 185
The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders
Wen, T. H., Binder, D. K., Ethell, I. M., & Razak, K. A. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00270 · Cited by 170
Age-Dependent Specific Changes in Area CA2 of the Hippocampus and Social Memory Deficit in a Mouse Model of the 22q11.2 Deletion Syndrome
Piskorowski, R. A., Nasrallah, K., Diamantopoulou, A., Mukai, J., Hassan, S. I., Siegelbaum, S. A., Gogos, J. A., & Chevaleyre, V. (2016) · Neuron · doi:10.1016/j.neuron.2015.11.036 · Cited by 180
Loss of hippocampal interneurons and epileptogenesis: a comparison of two animal models of acquired epilepsy
Huusko, N., Römer, C., Ndode‐Ekane, X. E., Łukasiuk, K., & Pitkänen, A. (2013) · Brain Structure and Function · doi:10.1007/s00429-013-0644-1 · Cited by 140
Modulating neuroinflammation and oxidative stress to prevent epilepsy and improve outcomes after traumatic brain injury
Eastman, C. L., D’Ambrosio, R., & Ganesh, T. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107907 · Cited by 140
Selective Na V 1.1 activation rescues Dravet syndrome mice from seizures and premature death
Richards, K., Milligan, C. J., Richardson, R. J., Jancovski, N., Grunnet, M., Jacobson, L. H., Undheim, E. A. B., Mobli, M., Chow, C. Y., Herzig, V., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1804764115 · Cited by 132
The Role of Parvalbumin Interneurons in Neurotransmitter Balance and Neurological Disease
Nahar, L., Delacroix, B. M., & Nam, H. W. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.679960 · Cited by 126
Three‐dimensional relationships between perisynaptic astroglia and human hippocampal synapses
Witcher, M. R., Park, Y. D., Lee, M. R., Sharma, S., Harris, K. M., & Kirov, S. A. (2009) · Glia · doi:10.1002/glia.20946 · Cited by 121
Reprogramming reactive glia into interneurons reduces chronic seizure activity in a mouse model of mesial temporal lobe epilepsy
Lentini, C., d’Orange, M., Marichal, N., Trottmann, M.-M., Vignoles, R., Foucault, L., Verrier, C., Massera, C., Raineteau, O., Conzelmann, K.-K., et al. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.09.002 · Cited by 114
Initial loss but later excess of GABAergic synapses with dentate granule cells in a rat model of temporal lobe epilepsy
Thind, K. K., Yamawaki, R. M., Phanwar, I., Zhang, G., Wen, X., & Buckmaster, P. S. (2009) · The Journal of Comparative Neurology · doi:10.1002/cne.22235 · Cited by 111
Differential vulnerability of interneurons in the epileptic hippocampus
Marx, M., Haas, C. A., & Häussler, U. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00167 · Cited by 104
Primate-specific origins and migration of cortical GABAergic neurons
Petanjek, Z. (2009) · Frontiers in Neuroanatomy · doi:10.3389/neuro.05.026.2009 · Cited by 108
Involvement of cortical fast-spiking parvalbumin-positive basket cells in epilepsy
Jiang, X., Lachance, M., & Rossignol, E. (2016) · Progress in brain research · doi:10.1016/bs.pbr.2016.04.012 · Cited by 101
Hippocampus and epilepsy: Findings from human tissues
Huberfeld, G., Blauwblomme, T., & Miles, R. (2015) · Revue Neurologique · doi:10.1016/j.neurol.2015.01.563 · Cited by 104
The epileptic human hippocampal cornu ammonis 2 region generates spontaneous interictal-like activity in vitro
Wittner, L., Huberfeld, G., Clémenceau, S., Erőss, L., Dezamis, E., Entz, L., Ulbert, I., Baulac, M., Freund, T. F., Maglóczky, Z., et al. (2009) · Brain · doi:10.1093/brain/awp238 · Cited by 98
Delta-Opioid Receptors Mediate Unique Plasticity onto Parvalbumin-Expressing Interneurons in Area CA2 of the Hippocampus
Piskorowski, R. A., & Chevaleyre, V. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0649-13.2013 · Cited by 94
Seizure-Suppressant and Neuroprotective Effects of Encapsulated BDNF-Producing Cells in a Rat Model of Temporal Lobe Epilepsy
Falcicchia, C., Paolone, G., Emerich, D. F., Lovisari, F., Bell, W. J., Fradet, T., Wahlberg, L. U., & Simonato, M. (2018) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2018.03.001 · Cited by 94
Input-Timing-Dependent Plasticity in the Hippocampal CA2 Region and Its Potential Role in Social Memory
Leroy, F., Brann, D. H., Meira, T., & Siegelbaum, S. A. (2017) · Neuron · doi:10.1016/j.neuron.2017.07.036 · Cited by 91
Selective Silencing of Hippocampal Parvalbumin Interneurons Induces Development of Recurrent Spontaneous Limbic Seizures in Mice
Drexel, M., Romanov, R. A., Wood, J. C., Weger, S., Heilbronn, R., Wulff, P., Tasan, R. O., Harkany, T., & Sperk, G. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.3456-16.2017 · Cited by 92
Purkinje cell loss in essential tremor: Random sampling quantification and nearest neighbor analysis
Choe, M., Cortes, E. P., Vonsattel, J., Kuo, S., Faust, P. L., & Louis, E. D. (2016) · Movement Disorders · doi:10.1002/mds.26490 · Cited by 91
Quantification of subfield pathology in hippocampal sclerosis: A systematic review and meta-analysis
Steve, T. A., Jirsch, J. D., & Gross, D. W. (2014) · Epilepsy Research · doi:10.1016/j.eplepsyres.2014.07.003 · Cited by 88
Cannabidiol exerts antiepileptic effects by restoring hippocampal interneuron functions in a temporal lobe epilepsy model
Khan, A. A., Shekh‐Ahmad, T., Khalil, A., Walker, M. C., & Ali, A. B. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14202 · Cited by 86
Distribution of interneurons in the CA2 region of the rat hippocampus
Botcher, N. A., Falck, J. E., Thomson, A. M., & Mercer, A. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00104 · Cited by 91
Hippocampal Area CA2: An Overlooked but Promising Therapeutic Target
Chevaleyre, V., & Piskorowski, R. A. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.06.007 · Cited by 85
CA2: A Highly Connected Intrahippocampal Relay
Middleton, S. J., & McHugh, T. J. (2019) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-080719-100343 · Cited by 80
Enhanced excitability of the hippocampal CA2 region and its contribution to seizure activity in a mouse model of temporal lobe epilepsy
Whitebirch, A. C., LaFrancois, J. J., Jain, S. S., Leary, P., Santoro, B., Siegelbaum, S. A., & Scharfman, H. E. (2022) · Neuron · doi:10.1016/j.neuron.2022.07.020 · Cited by 81
Differential Susceptibility of Interneurons Expressing Neuropeptide Y or Parvalbumin in the Aged Hippocampus to Acute Seizure Activity
Kuruba, R., Hattiangady, B., Parihar, V. K., Shuai, B., & Shetty, A. K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024493 · Cited by 77
Human pallial MGE-type GABAergic interneuron cell therapy for chronic focal epilepsy
Bershteyn, M., Bröer, S., Parekh, M. B., Maury, Y., Havlicek, S., Kriks, S., Fuentealba, L. C., Lee, S., Zhou, R., Subramanyam, G., et al. (2023) · Cell stem cell · doi:10.1016/j.stem.2023.08.013 · Cited by 76
Gulf War Illness: Mechanisms Underlying Brain Dysfunction and Promising Therapeutic Strategies
Dickey, B. R., Madhu, L. N., & Shetty, A. K. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107716 · Cited by 74
Dysfunction of the Dentate Basket Cell Circuit in a Rat Model of Temporal Lobe Epilepsy
Zhang, W., & Buckmaster, P. S. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.6199-08.2009 · Cited by 75
Seizure frequency correlates with loss of dentate gyrus GABAergic neurons in a mouse model of temporal lobe epilepsy
Buckmaster, P. S., Abrams, E., & Wen, X. (2017) · The Journal of Comparative Neurology · doi:10.1002/cne.24226 · Cited by 73
A Study of Amyloid-β and Phosphotau in Plaques and Neurons in the Hippocampus of Alzheimer’s Disease Patients
Furcila, D., DeFelipe, J., & Alonso‐Nanclares, L. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180173 · Cited by 73
Self-citation
Parvalbumin interneurons and calretinin fibers arising from the thalamic nucleus reuniens degenerate in the subiculum after kainic acid-induced seizures
Drexel, M., Preidt, A. P., Kirchmair, E., & Sperk, G. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.05.021 · Cited by 66
Closed-loop optogenetic control of the dynamics of neural activity in non-human primates
Zaaimi, B., Turnbull, M., Hazra, A., Wang, Y., Gándara, C., McLeod, F., McDermott, E. E., Escobedo‐Cousin, E., Idil, A. S., Bailey, R. G., et al. (2022) · Nature Biomedical Engineering · doi:10.1038/s41551-022-00945-8 · Cited by 63
Synaptic integration by different dendritic compartments of hippocampal CA1 and CA2 pyramidal neurons
Piskorowski, R. A., & Chevaleyre, V. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0769-4 · Cited by 72
Dysfunction of hippocampal interneurons in epilepsy
Liu, Y., Yu, F., Liu, W., He, X., & Peng, B. (2014) · Neuroscience Bulletin · doi:10.1007/s12264-014-1478-4 · Cited by 67
Effects of thyroid hormone replacement on associative learning and hippocampal synaptic plasticity in adult hypothyroid rats
Fernández‐Lamo, I., Montero‐Pedrazuela, A., Delgado-Garcia, J. M., Guadaño‐Ferraz, A., & Gruart, A. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06862.x · Cited by 68
Do Structural Changes in GABA Neurons Give Rise to the Epileptic State?
Houser, C. R. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-94-017-8914-1_12 · Cited by 65
Prefrontal cognitive deficits in mice with altered cerebral cortical GABAergic interneurons
Bissonette, G. B., Bae, M. H., Suresh, T., Jaffe, D. E., & Powell, E. M. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.10.051 · Cited by 64
Differential distribution of neurons in the gyral white matter of the human cerebral cortex
García‐Marín, V., Blázquez‐Llorca, L., Rodríguez, J., González‐Soriano, J., & DeFelipe, J. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22485 · Cited by 63
Self-citation
Interneuron Transplantation as a Treatment for EpilepsyPreprint
Hunt, R. F., & Baraban, S. C. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a022376 · Cited by 68
Voltage-Dependent Calcium Channels, Calcium Binding Proteins, and Their Interaction in the Pathological Process of Epilepsy
Xu, J., & Tang, F.-R. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092735 · Cited by 60
Subregional Density of Neurons, Neurofibrillary Tangles and Amyloid Plaques in the Hippocampus of Patients With Alzheimer’s Disease
Furcila, D., Domínguez-Álvaro, M., DeFelipe, J., & Alonso‐Nanclares, L. (2019) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2019.00099 · Cited by 59
Self-citation
Parvalbumin Interneuron Dysfunction in Neurological Disorders: Focus on Epilepsy and Alzheimer’s Disease
Leitch, B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105549 · Cited by 59
Three-dimensional synaptic organization of the human hippocampal CA1 field
Montero-Crespo, M., Dominguez-Alvaro, M., Rondon-Carrillo, P., Alonso-Nanclares, L., DeFelipe, J., & Blazquez-Llorca, L. (2020) · eLife · doi:10.7554/elife.57013 · Cited by 60
Self-citation
Impairment of GABA release in the hippocampus at the time of the first spontaneous seizure in the pilocarpine model of temporal lobe epilepsy
Soukupovà, M., Binaschi, A., Falcicchia, C., Zucchini, S., Roncon, P., Palma, E., Magri, E., Grandi, E., & Simonato, M. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.04.014 · Cited by 55
Contusion brain damage in mice for modelling of post-traumatic epilepsy with contralateral hippocampus sclerosis: Comprehensive and longitudinal characterization of spontaneous seizures, neuropathology, and neuropsychiatric comorbidities
Golub, V. M., & Reddy, D. S. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113946 · Cited by 54
Large Intercalated Neurons of Amygdala Relay Noxious Sensory Information
Bienvenu, T., Busti, D., Micklem, B. R., Mansouri, M., Magill, P. J., Ferraguti, F., & Capogna, M. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1323-14.2015 · Cited by 55
Changes in the expression of GABAA receptor subunit mRNAs in parahippocampal areas after kainic acid induced seizures
Drexel, M., Kirchmair, E., & Sperk, G. (2013) · Frontiers in Neural Circuits · doi:10.3389/fncir.2013.00142 · Cited by 51
Inhibitory Plasticity Permits the Recruitment of CA2 Pyramidal Neurons by CA3
Nasrallah, K., Piskorowski, R. A., & Chevaleyre, V. (2015) · eNeuro · doi:10.1523/eneuro.0049-15.2015 · Cited by 49
Mechanisms of increased hippocampal excitability in the Mashl+/− mouse model of Na+/K+‐ ATP ase dysfunction
Hunanyan, A. S., Helseth, A. R., Abdelnour, E., Kherallah, B., Sachdev, M., Chung, L., Masoud, M., Richardson, J. P., Li, Q., Nadler, J. V., et al. (2018) · Epilepsia · doi:10.1111/epi.14441 · Cited by 49
Pathophysiological Characteristics Associated With Epileptogenesis in Human Hippocampal Sclerosis
Kitaura, H., Shirozu, H., Masuda, H., Fukuda, M., Fujii, Y., & Kakita, A. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.02.013 · Cited by 47
Therapeutic potential of NaV1.1 activators
Jensen, H. S., Grunnet, M., & Bastlund, J. F. (2014) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.12.007 · Cited by 47
Organization and control of epileptic circuits in temporal lobe epilepsy
Alexander, A., Maroso, M., & Soltész, I. (2016) · Progress in brain research · doi:10.1016/bs.pbr.2016.04.007 · Cited by 44
Parvalbumin Role in Epilepsy and Psychiatric Comorbidities: From Mechanism to Intervention
Godoy, L. D., Prizon, T., Rossignoli, M. T., Leite, J. P., & Liberato, J. L. (2022) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2022.765324 · Cited by 45
The frequency of spontaneous seizures in rats correlates with alterations in sensorimotor gating, spatial working memory, and parvalbumin expression throughout limbic regions
Wolf, D. C., Bueno-Júnior, L. S., Lopes‐Aguiar, C., Silva, R. A. D. V. D., Kandratavicius, L., & Leite, J. P. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.11.008 · Cited by 37
Parvalbumin and neuropeptide Y expressing hippocampal GABA-ergic inhibitory interneuron numbers decline in a model of Gulf War illness
Megahed, T., Hattiangady, B., Shuai, B., & Shetty, A. K. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00447 · Cited by 38
Different patterns of epileptiform-like activity are generated in the sclerotic hippocampus from patients with drug-resistant temporal lobe epilepsy
Reyes-García, S. Z., Scorza, C. A., Araújo, N. S., Ortiz‐Villatoro, N. N., Jardim, A. P., Centeno, R. S., Yacubian, E. M. T., Faber, J., & Cavalheiro, É. A. (2018) · Scientific Reports · doi:10.1038/s41598-018-25378-9 · Cited by 38
Alterations of the Microvascular Network in Sclerotic Hippocampi From Patients With Epilepsy
Kastanauskaite, A., Alonso‐Nanclares, L., Blázquez‐Llorca, L., Pastor, J., de Sola, R. G., & DeFelipe, J. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181b08622 · Cited by 36
Self-citation
Functional alterations in GABAergic fast-spiking interneurons in chronically injured epileptogenic neocortex
Ma, Y., & Prince, D. A. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.03.027 · Cited by 34
Estrogen administration modulates hippocampal GABAergic subpopulations in the hippocampus of trimethyltin-treated rats
Corvino, V., di Maria, V., Marchese, E., Lattanzi, W., Biamonte, F., Michetti, F., & Geloso, M. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00433 · Cited by 31
Regulation of the E/I-balance by the neural matrisome
Mueller-Buehl, C., Wegrzyn, D., Bauch, J., & Faissner, A. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1102334 · Cited by 35
A Stereological Study of Synapse Number in the Epileptic Human Hippocampus
Alonso‐Nanclares, L., Kastanauskaite, A., Rodríguez, J., González‐Soriano, J., & DeFelipe, J. (2011) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2011.00008 · Cited by 33
Self-citation
Synaptic Reorganization of the Perisomatic Inhibitory Network in Hippocampi of Temporal Lobe Epileptic Patients
Wittner, L., & Maglóczky, Z. (2017) · BioMed Research International · doi:10.1155/2017/7154295 · Cited by 32
Survival of mossy cells of the hippocampal dentate gyrus in humans with mesial temporal lobe epilepsy
Seress, L., Ábrahám, H., Horváth, Z., Doczi, T. P., Janszky, J., Klemm, J., Byrne, R. W., & Bakay, R. A. E. (2009) · Journal of neurosurgery · doi:10.3171/2008.11.jns08779 · Cited by 32
GABAergic complex basket formations in the human neocortex
Blázquez‐Llorca, L., García‐Marín, V., & DeFelipe, J. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22496 · Cited by 30
Self-citation
Silencing of Hippocampal Somatostatin Interneurons Induces Recurrent Spontaneous Limbic Seizures in Mice
Drexel, M., Rahimi, S., & Sperk, G. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.02.007 · Cited by 27
The functional microscopic neuroanatomy of the human subthalamic nucleus
Alkemade, A., de Hollander, G., Miletić, S., Keuken, M. C., Balesar, R. A., de Boer, O. J., Swaab, D. F., & Forstmann, B. U. (2019) · Brain Structure and Function · doi:10.1007/s00429-019-01960-3 · Cited by 26
Selective Loss and Axonal Sprouting of GABAergic Interneurons in the Sclerotic Hippocampus Induced by LiCl–Pilocarpine
Long, L., Xiao, B., Feng, L., Yi, F., Li, G., Li, S., Abuhamed, M. M., Chen, S., Bi, F., & Li, Y. (2010) · International Journal of Neuroscience · doi:10.3109/00207454.2010.530007 · Cited by 25
Alterations in hippocampal and cortical densities of functionally different interneurons in rat models of absence epilepsy
Papp, P., Kovács, Z., Szocsics, P., Juhász, G. D., & Maglóczky, Z. (2018) · Epilepsy Research · doi:10.1016/j.eplepsyres.2018.05.013 · Cited by 25
GABA bouton subpopulations in the human dentate gyrus are differentially altered in mesial temporal lobe epilepsy
Alhourani, A., Fish, K. N., Wozny, T. A., Sudhakar, V. R., Hamilton, R. L., & Richardson, R. M. (2019) · Journal of Neurophysiology · doi:10.1152/jn.00523.2018 · Cited by 26
SP–SR interneurones: A novel class of neurones of the CA2 region of the hippocampus
Mercer, A., Botcher, N. A., Eastlake, K., & Thomson, A. M. (2012) · Hippocampus · doi:10.1002/hipo.22010 · Cited by 24
CA2 orchestrates hippocampal network dynamics
Oliva, A., Fernández‐Ruiz, A., & Karaba, L. A. (2022) · Hippocampus · doi:10.1002/hipo.23495 · Cited by 28
Age‐dependent increase of perineuronal nets in the human hippocampus and precocious aging in epilepsy
Lehner, A., Hoffmann, L., Rampp, S., Coras, R., Paulsen, F. P., Frischknecht, R., Hamer, H. M., Walther, K., Brandner, S., Hofer, W., et al. (2024) · Epilepsia Open · doi:10.1002/epi4.12963 · Cited by 23
Calcium‐binding proteins in focal cortical dysplasia
Kuchukhidze, G., Wieselthaler, A., Drexel, M., Unterberger, I., Luef, G., Ortler, M., Becker, A. J., Trinka, E., & Sperk, G. (2015) · Epilepsia · doi:10.1111/epi.13053 · Cited by 22
Ictal onset sites and γ‐aminobutyric acidergic neuron loss in epileptic pilocarpine‐treated rats
Wyeth, M. S., Nagendran, M., & Buckmaster, P. S. (2020) · Epilepsia · doi:10.1111/epi.16490 · Cited by 21
What are the similarities and differences between schizophrenia and schizophrenia-like psychosis of epilepsy? A neuropathological approach to the understanding of schizophrenia spectrum and epilepsy
Kandratavicius, L., Hallak, J. E. C., & Leite, J. P. (2014) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2014.01.005 · Cited by 20
Selective plasticity of hippocampal GABAergic interneuron populations following kindling of different brain regions
Botterill, J. J., Nogovitsyn, N., Caruncho, H. J., & Kalynchuk, L. E. (2016) · The Journal of Comparative Neurology · doi:10.1002/cne.24071 · Cited by 20
Hippocampal area CA2: interneuron disfunction during pathological states
Piskorowski, R. A., & Chevaleyre, V. (2023) · Frontiers in Neural Circuits · doi:10.3389/fncir.2023.1181032 · Cited by 22
Two functional inhibitory circuits are comprised of a heterogeneous population of fast-spiking cortical interneurons
Li, P., & Huntsman, M. M. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.01.033 · Cited by 20
Alterations of the microvascular network in the sclerotic hippocampus of patients with temporal lobe epilepsy
Alonso‐Nanclares, L., & DeFelipe, J. (2014) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2013.12.009 · Cited by 19
Self-citation
Automated immunohistochemical method to quantify neuronal density in brain sections: Application to neuronal loss after status epilepticus
Maucler, C., Béghin, A., Ressnikoff, D., Bezin, L., & Marinesco, S. (2014) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2014.01.009 · Cited by 19
GABAAand GABABreceptor subunit localization on neurochemically identified neurons of the human subthalamic nucleus
Wu, X. H., Song, J. J., Faull, R. L. M., & Waldvogel, H. J. (2017) · The Journal of Comparative Neurology · doi:10.1002/cne.24368 · Cited by 18
Hypertrophy of hippocampal end folium neurons in patients with mesial temporal lobe epilepsy
Ryufuku, M., Toyoshima, Y., Kitaura, H., Zheng, Y., Fu, Y., Miyahara, H., Murakami, H., Masuda, H., Kameyama, S., Takahashi, H., et al. (2011) · Neuropathology · doi:10.1111/j.1440-1789.2010.01191.x · Cited by 17
Delineating selective vulnerability of inhibitory interneurons in Alpers' syndrome
Smith, L. A., Erskine, D., Blain, A. P., Taylor, R. W., McFarland, R., & Lax, N. Z. (2022) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12833 · Cited by 15
Proportional loss of parvalbumin‐immunoreactive synaptic boutons and granule cells from the hippocampus of sea lions with temporal lobe epilepsy
Cameron, S., Lopez, A., Glabman, R. A., Abrams, E., Johnson, S., Field, C. L., Gulland, F. M. D., & Buckmaster, P. S. (2019) · The Journal of Comparative Neurology · doi:10.1002/cne.24680 · Cited by 15
Reorganization of the Brain Extracellular Matrix in Hippocampal Sclerosis
Sitaš, B., Bobić‐Rasonja, M., Mrak, G., Trnski, S., Skorić, M. K., Orešković, D., Knezović, V., Gadže, Ž. P., Petanjek, Z., Šimić, G., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158197 · Cited by 16
Evolutionary conservation of hippocampal mossy fiber synapse properties
Pelkey, K. A., Vargish, G. A., Pellegrini, L. V., Calvigioni, D., Chapeton, J. I., Yuan, X. Q., Hunt, S., Cummins, A. C., Eldridge, M. A. G., Pickel, J. M., et al. (2023) · Neuron · doi:10.1016/j.neuron.2023.09.005 · Cited by 16
Reduced Cholecystokinin-Expressing Interneuron Input Contributes to Disinhibition of the Hippocampal CA2 Region in a Mouse Model of Temporal Lobe Epilepsy
Whitebirch, A. C., Santoro, B., Barnett, A., Lisgaras, C. P., Scharfman, H. E., & Siegelbaum, S. A. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.2091-22.2023 · Cited by 14
Subiculum–entorhinal cortex interactions during in vitro ictogenesis
Herrington, R., Lévesque, M., & Avoli, M. (2015) · Seizure · doi:10.1016/j.seizure.2015.07.002 · Cited by 13
Compensatory Regulation of Excitation/Inhibition Balance in the Ventral Hippocampus: Insights from Fragile X Syndrome
Papatheodoropoulos, C. (2025) · Biology · doi:10.3390/biology14040363 · Cited by 15
Etiology-related Degree of Sprouting of Parvalbumin-immunoreactive Axons in the Human Dentate Gyrus in Temporal Lobe Epilepsy
Ábrahám, H., Molnár, J. E., Sóki, N., Gyimesi, C., Horváth, Z., Janszky, J., Doczi, T. P., & Seress, L. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.09.018 · Cited by 12
Differential vulnerability of neuronal subpopulations of the subiculum in a mouse model for mesial temporal lobe epilepsy
Franz, J., Barheier, N., Wilms, H., Tulke, S., Haas, C. A., & Häussler, U. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1142507 · Cited by 12
Human stem cell-derived GABAergic interneuron development reveals early emergence of subtype diversity and gradual electrochemical maturation
Bershteyn, M., Zhou, H., Fuentealba, L. C., Chen, C., Subramanyam, G., Cherkowsky, D., Sevilla, E. S., Hampel, P., Salvatierra, J., Sezan, M., et al. (2025) · Neuron · doi:10.1016/j.neuron.2025.06.010 · Cited by 14
Effect of gestational ethanol exposure on parvalbumin and calretinin expressing hippocampal neurons in a chick model of fetal alcohol syndrome
Marshall, A. G., McCarthy, M., Brishnehan, K. M., Rao, V., Batia, L. M., Gupta, M., Das, S., Mitra, N. K., & Chaudhuri, J. D. (2009) · Alcohol · doi:10.1016/j.alcohol.2008.12.004 · Cited by 11
Regulation of Parvalbumin Interactome in the Perilesional Cortex after Experimental Traumatic Brain Injury
Hiltunen, J., Ndode‐Ekane, X. E., Lipponen, A., Drexel, M., Sperk, G., Puhakka, N., & Pitkänen, A. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.08.018 · Cited by 10
Development of parvalbumin-immunoreactive neurons in the postnatal human hippocampal formation
Ábrahám, H., Kojima, H., Götzer, K., Molnár, A., Tornóczky, T., & Seress, L. (2023) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2023.1058370 · Cited by 10
Alterations of Neuronal Dynamics as a Mechanism for Cognitive Impairment in Epilepsy
Lenck‐Santini, P., & Sakkaki, S. (2020) · Current topics in behavioral neurosciences · doi:10.1007/7854_2020_193 · Cited by 12

Authors: Andrioli, A., Alonso-Nanclares, L., Arellano, J. I., & DeFelipe, J.
Affiliations: University of Verona (IT)
Consejo Superior de Investigaciones Científicas (ES)
Corresponding author: DeFelipe, J.
ORCID: Andrioli, A.
Arellano, J.I.
DeFelipe, J.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 2007-10
Volume: 149
Issue: 1
Pages: 131-143
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/j.neuroscience.2007.07.029
OpenAlex: W2081122323
Cited by: 147
References: 78
Citations by year: 2026: 5 · 2025: 7 · 2024: 10 · 2023: 8 · 2022: 12 · 2021: 6 · 2020: 7 · 2019: 8 · 2018: 12 · 2017: 6 · 2016: 6 · 2015: 13 · 2014: 13 · 2013: 7 · 2012: 3
FWCI: 3.02
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
Funders: Comunidad de Madrid (08.5/0027/2001.1, R-04-40)
Ministerio de Educación, Cultura y Deporte (BFI2003-01018, BFI2003-02745, BFU2006-13395)
Topics: Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
Keywords: parvalbumin, GABAergic interneurons, hippocampal sclerosis, temporal lobe epilepsy, subiculum, neuronal density, neuronal loss, stereology, drug-resistant epilepsy, gliosis
MeSH terms: Adult, Aged, Cell Count, Epilepsy, Female, Hippocampus, Humans, Male, Middle Aged, Parvalbumins, Stereotaxic Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Quantitative analysis of parvalbumin-immunoreactive cells in the human epileptic hippocampus.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks