Age-Dependent Specific Changes in Area CA2 of the Hippocampus and Social Memory Deficit in a Mouse Model of the 22q11.2 Deletion Syndrome
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Several neuropsychiatric disorders are associated with cognitive and social dysfunction. Postmortem studies of patients with schizophrenia have revealed specific changes in area CA2, a long-overlooked region of the hippocampus recently found to be critical for social memory formation. To examine how area CA2 is altered in psychiatric illness, we used the Df(16)A(+/-) mouse model of the 22q11.2 microdeletion, a genetic risk factor for developing several neuropsychiatric disorders, including schizophrenia. We report several age-dependent CA2 alterations: a decrease in the density of parvalbumin-expressing interneurons, a reduction in the amount of feedforward inhibition, and a change in CA2 pyramidal-neuron intrinsic properties. Furthermore, we found that area CA2 is less plastic in Df(16)A(+/-) mice, making it nearly impossible to evoke action potential firing in CA2 pyramidal neurons. Finally, we show that Df(16)A(+/-) mice display impaired social cognition, providing a potential mechanism and a neural substrate for this impairment in psychiatric disorders.
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Several mouse models for both autism spectrum disorder and schizophrenia have large effects on PV-IN function.
“The Df (16)A± transgenic mouse and the LgDel(±) mouse, both of which model the 22q11.2deletion in humans [5,[40][41][42][43], the contactin associated protein 2 mouse [44][45][46], the neurexin transgene model [47], Shank models [20,[48][49][50], and platelet-derived growth factor receptor-beta (Pdgfrb) knockout mouse [51,52] are examples of models for both ASD and schizophrenia, which have large”
From Parvalbumin interneuron vulnerability and brain disorders (2021) · cites this paper as [41]
Df(16)A+/- mice exhibited decreased firing of CA2 pyramidal neurons during the three-chamber sociability assay, perhaps due to increased current through a K+ channel (TREK-1).
“these mice exhibited decrease firing of CA2 pyramidal neurons during the three-chamber sociability assay, perhaps due to increased current through a K+ channel (TREK-1) [73].”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [73]
In the Df(16)A+/- mouse model of the human 22q11.2 microdeletion, impaired social memory has been suggested to be a consequence of reduced density of PV interneurons in area CA2 of the hippocampus and consequent impaired feedforward inhibition of CA2 pyramidal neurons.
“In the Df(16)A +/-mouse model of the human 22q11.2microdeletion, impaired social memory has been suggested to be a consequence of reduced density of PV interneurons in area CA2 of the hippocampus and the consequent impaired feedforward inhibition of CA2 pyramidal neurons [73].”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [73]
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- Authors
- Piskorowski, R. A., Nasrallah, K., Diamantopoulou, A., Mukai, J., Hassan, S. I., Siegelbaum, S. A., Gogos, J. A., & Chevaleyre, V.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Columbia University (US)
- Columbia University Irving Medical Center (US)
- Corresponding author
- Gogos, Joseph A.
- Chevaleyre, Vivien
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 89
- Issue
- 1
- Pages
- 163-176
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC4706988
- OpenAlex
- W2229474614
- Cited by
- 180
- References
- 56
- Citations by year
- 2026: 7 · 2025: 22 · 2024: 21 · 2023: 15 · 2022: 20 · 2021: 18 · 2020: 13 · 2019: 12 · 2018: 27 · 2017: 15 · 2016: 10
- FWCI
- 18.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- Funders
- Agence Nationale de la Recherche (ANR-13-JSV4-0002, ANR-12-BSV4-0021)
- Centre National de la Recherche Scientifique
- National Institutes of Health (5r01mh096274-06)
- National Institute of Mental Health (R01-MH096274, R01MH097879)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- hippocampal CA2, 22q11.2 deletion syndrome, social memory, social cognition, parvalbumin interneurons, feedforward inhibition, neuroplasticity, schizophrenia, age-related changes, neuropsychiatric disorders
- MeSH terms
- Action Potentials, Aging, Animals, Cognition Disorders, DiGeorge Syndrome, Disease Models, Animal, Hippocampus, Male, Memory, Mice, Transgenic, Neurons, Parvalbumins, Schizophrenia, Social Behavior
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