The DOI matches its Crossref record; 70 of the 71 references it cites were found in a registry or an index.
Distribution of oxytocin in the brain of a eusocial rodent
Open accessAbstract
Naked mole-rats are highly social rodents that live in large colonies characterized by a rigid social and reproductive hierarchy. Only one female, the queen, breeds. Most colony members are non-reproductive subordinates that work cooperatively to rear the young and maintain an underground burrow system. Little is known about the neurobiological basis of the complex sociality exhibited by this species. The neuropeptide oxytocin (Oxt) modulates social bonding and other social behaviors in many vertebrates. Here we examined the distribution of Oxt immunoreactivity in the brains of male and female naked mole-rats. As in other species, the majority of Oxt-immunoreactive (Oxt-ir) cells were found in the paraventricular and supraoptic nuclei, with additional labeled cells scattered throughout the preoptic and anterior hypothalamic areas. Oxt-ir fibers were found traveling toward and through the median eminence, as well as in the tenia tecta, septum, and nucleus of the diagonal band of Broca. A moderate network of fibers covered the bed nucleus of the stria terminalis and preoptic area, and a particularly dense fiber innervation of the nucleus accumbens and substantia innominata was observed. In the brainstem, Oxt-ir fibers were found in the periaqueductal gray, locus coeruleus, parabrachial nucleus, nucleus of the solitary tract, and nucleus ambiguus. The high levels of Oxt immunoreactivity in the nucleus accumbens and preoptic area are intriguing, given the link in other rodents between Oxt signaling in these regions and maternal behavior. Although only the queen gives birth or nurses pups in a naked mole-rat colony, most individuals actively participate in pup care.
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“In fact, a single study has shown that OT can increase autistic individuals' ability to recall emotion in a voice intonation task.”
From Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior (2009) · cites this paper as [110]
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“A more important finding of this study was that prior exposure to OT increased the learning ability to subsequent emotional tasks [110].”
From Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior (2009) · cites this paper as [110]
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Citations
Cites
Brain Maps: Structure of the Rat Brain
Swanson, L. W. (1992) · Medical Entomology and Zoology · Cited by 1,878
Brain maps: structure of the rat brain
Guillery, R. W. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90187-q · Cited by 1,669
The neurobiology of pair bonding.
Young, L. J., & Wang, Z. (2004) · Nature Neuroscience · doi:10.1038/nn1327 · Cited by 1,523 · cited 1×
“Some social behaviors exhibited by naked mole-rats are modulated by VP in other species, such as vocal communication, pair-bonding, parental behavior, dominance-subordinance, and social memory (reviewed in de Wied et al., 1993; Goodson and Bass, 2001; Young and Wang, 2004).”
Sawchenko, P. E., & Swanson, L. W. (1982) · Journal of Comparative Neurology · doi:10.1002/cne.902050306 · Cited by 1,150
Intra- and extrahypothalamic vasopressin and oxytocin pathways in the rat
Buijs, R. M., Swaab, D. F., Dogterom, J., & van Leeuwen, F. W. (1978) · Cell and Tissue Research · doi:10.1007/bf00224932 · Cited by 1,029
Cooperative Breeding in Mammals
(1996) · Cambridge University Press eBooks · doi:10.1017/cbo9780511574634 · Cited by 970
Oxytocin receptor distribution reflects social organization in monogamous and polygamous voles
Insel, T. R., & Shapiro, L. E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.5981 · Cited by 833
Intra- and extrahypothalamic vasopressin and oxytocin pathways in the rat
Buijs, R. M. (1978) · Cell and Tissue Research · doi:10.1007/bf00212323 · Cited by 830
Eusociality in a Mammal: Cooperative Breeding in Naked Mole-Rat Colonies
Jarvis, J. U. M. (1981) · Science · doi:10.1126/science.7209555 · Cited by 698
Goodson, J. L., & Bass, A. H. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00043-1 · Cited by 646
Cited by
Sorted by citations
Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin
Dölen, G., Darvishzadeh, A., Huang, K. W., & Malenka, R. C. (2013) · Nature · doi:10.1038/nature12518 · Cited by 1,161
Oxytocin: The Great Facilitator of Life
Lee, H.-J., Macbeth, A. H., Pagani, J., & Young, W. S. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.04.001 · Cited by 1,037
Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior
Ross, H. E., & Young, L. J. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.05.004 · Cited by 856
“A recent study in the naked mole rat has shown OT fibers are present in the NAcc of this eusocial species as well [136].”
BackgroundEvolution of a Vertebrate Social Decision-Making Network
O’Connell, L. A., & Hofmann, H. A. (2012) · Science · doi:10.1126/science.1218889 · Cited by 608
Dumais, K. M., & Veenema, A. H. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.04.003 · Cited by 520
“Studies in non-human primates have also reported an absence of sex differences in OT-immunoreactive neurons in macaques (PVN, SON: Caffé et al., 1989) and marmosets (PVN, SON, BNST, MeA: Wang et al., 1997).”
BackgroundInfluential
Metadata
- Authors
- Rosen, G. J., de Vries, G. J., Goldman, S. L., Goldman, B. D., & Forger, N. G.
- Affiliations
- University of Massachusetts Amherst (US)
- University of Connecticut (US)
- Corresponding author
- Forger, N.G.
- ORCID
- Forger, N.G.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 155
- Issue
- 3
- Pages
- 809-817
- ISSN
- 0306-4522 (ISSN-L)
- PMC
- PMC2614305
- OpenAlex
- W2038970714
- Cited by
- 102
- References
- 71
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 5 · 2023: 3 · 2022: 2 · 2021: 6 · 2020: 19 · 2019: 8 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 8 · 2014: 8 · 2013: 6 · 2012: 4
- FWCI
- 7.53
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (K02MH072825, K02MH001497)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Primate Behavior and Ecology
- Keywords
- oxytocin, naked mole-rat, eusociality, social behavior, paraventricular nucleus, supraoptic nucleus, preoptic area, nucleus accumbens, substantia innominata, bed nucleus of the stria terminalis, median eminence, maternal behavior, pup care, social hierarchy
- MeSH terms
- Animals, Brain, Brain Mapping, Oxytocin, Mole Rats
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