Cited by 102Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyPrimate Behavior and Ecology

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Distribution of oxytocin in the brain of a eusocial rodent

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Rosen, G.J., de Vries, G.J., Goldman, S.L., Goldman, B.D., Forger, N.G.·2008·Neuroscience

DOI 10.1016/j.neuroscience.2008.05.039PMC PMC2614305

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Abstract

Naked mole-rats are highly social rodents that live in large colonies characterized by a rigid social and reproductive hierarchy. Only one female, the queen, breeds. Most colony members are non-reproductive subordinates that work cooperatively to rear the young and maintain an underground burrow system. Little is known about the neurobiological basis of the complex sociality exhibited by this species. The neuropeptide oxytocin (Oxt) modulates social bonding and other social behaviors in many vertebrates. Here we examined the distribution of Oxt immunoreactivity in the brains of male and female naked mole-rats. As in other species, the majority of Oxt-immunoreactive (Oxt-ir) cells were found in the paraventricular and supraoptic nuclei, with additional labeled cells scattered throughout the preoptic and anterior hypothalamic areas. Oxt-ir fibers were found traveling toward and through the median eminence, as well as in the tenia tecta, septum, and nucleus of the diagonal band of Broca. A moderate network of fibers covered the bed nucleus of the stria terminalis and preoptic area, and a particularly dense fiber innervation of the nucleus accumbens and substantia innominata was observed. In the brainstem, Oxt-ir fibers were found in the periaqueductal gray, locus coeruleus, parabrachial nucleus, nucleus of the solitary tract, and nucleus ambiguus. The high levels of Oxt immunoreactivity in the nucleus accumbens and preoptic area are intriguing, given the link in other rodents between Oxt signaling in these regions and maternal behavior. Although only the queen gives birth or nurses pups in a naked mole-rat colony, most individuals actively participate in pup care.

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Brain Maps: Structure of the Rat Brain
Swanson, L. W. (1992) · Medical Entomology and Zoology · Cited by 1,878
Brain maps: structure of the rat brain
Guillery, R. W. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90187-q · Cited by 1,669
The neurobiology of pair bonding.
Young, L. J., & Wang, Z. (2004) · Nature Neuroscience · doi:10.1038/nn1327 · Cited by 1,523 · cited 1×
“Some social behaviors exhibited by naked mole-rats are modulated by VP in other species, such as vocal communication, pair-bonding, parental behavior, dominance-subordinance, and social memory (reviewed in de Wied et al., 1993; Goodson and Bass, 2001; Young and Wang, 2004).”
Immunohistochemical identification of neurons in the paraventricular nucleus of the hypothalamus that project to the medulla or to the spinal cord in the rat
Sawchenko, P. E., & Swanson, L. W. (1982) · Journal of Comparative Neurology · doi:10.1002/cne.902050306 · Cited by 1,150
Intra- and extrahypothalamic vasopressin and oxytocin pathways in the rat
Buijs, R. M., Swaab, D. F., Dogterom, J., & van Leeuwen, F. W. (1978) · Cell and Tissue Research · doi:10.1007/bf00224932 · Cited by 1,029
Cooperative Breeding in Mammals
(1996) · Cambridge University Press eBooks · doi:10.1017/cbo9780511574634 · Cited by 970
Oxytocin receptor distribution reflects social organization in monogamous and polygamous voles
Insel, T. R., & Shapiro, L. E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.5981 · Cited by 833
Intra- and extrahypothalamic vasopressin and oxytocin pathways in the rat
Buijs, R. M. (1978) · Cell and Tissue Research · doi:10.1007/bf00212323 · Cited by 830
Eusociality in a Mammal: Cooperative Breeding in Naked Mole-Rat Colonies
Jarvis, J. U. M. (1981) · Science · doi:10.1126/science.7209555 · Cited by 698
Social behavior functions and related anatomical characteristics of vasotocin/vasopressin systems in vertebrates
Goodson, J. L., & Bass, A. H. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00043-1 · Cited by 646
Neuropeptidergic regulation of affiliative behavior and social bonding in animals
Lim, M. M., & Young, L. J. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.06.028 · Cited by 624
Nucleus accumbens oxytocin and dopamine interact to regulate pair bond formation in female prairie voles
Liu, Y., & Wang, Z. X. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00555-4 · Cited by 580
Immunohistochemical analysis of magnocellular elements in rat hypothalamus: Distribution and numbers of cells containing neurophysin, oxytocin, and vasopressin
Rhodes, C. H., Morriell, J. I., & Pfaff, D. W. (1981) · The Journal of Comparative Neurology · doi:10.1002/cne.901980106 · Cited by 536
The Biology of the Naked Mole-Rat
(2017) · Princeton University Press eBooks · doi:10.1515/9781400887132 · Cited by 524
Identification of the vasopressin producing and of the oxytocin producing neurons in the hypothalamic magnocellular neurosecretory system of the rat
Vandesande, F., & Dierickx, K. (1975) · Cell and Tissue Research · doi:10.1007/bf00218970 · Cited by 496
Variations in maternal behaviour are associated with differences in oxytocin receptor levels in the rat
Francis, D. D., Champagne, F. C., & Meaney, M. J. (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00599.x · Cited by 496
Oxytocin activates the postpartum onset of rat maternal behavior in the ventral tegmental and medial preoptic areas.
Pedersen, C. A., Caldwell, J. D., Walker, C., Ayers, G., & Mason, G. A. (1994) · Behavioral Neuroscience · doi:10.1037/0735-7044.108.6.1163 · Cited by 475
The Naked Mole-Rat: A New Long-Living Model for Human Aging Research
Buffenstein, R. (2005) · The Journals of Gerontology Series A · doi:10.1093/gerona/60.11.1369 · Cited by 474
Chapter 12 Involvement of the brain oxytocin system in stress coping: interactions with the hypothalamo-pituitary-adrenal axis
Neumann, I. D. (2002) · Progress in brain research · doi:10.1016/s0079-6123(02)39014-9 · Cited by 387
Central Nervous System Effects of the Neurohypophyseal Hormones and Related Peptides
de Wied, D., Diamant, M., & Fodor, M. (1993) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1993.1009 · Cited by 327
Cooperative breeding in mammals
Jennions, M. D. (1994) · Trends in Ecology & Evolution · doi:10.1016/0169-5347(94)90202-x · Cited by 300
Oxytocin receptors in the nucleus accumbens facilitate “spontaneous” maternal behavior in adult female prairie voles
Olazábal, D. E., & Young, L. J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.04.017 · Cited by 289
Species and individual differences in juvenile female alloparental care are associated with oxytocin receptor density in the striatum and the lateral septum
Olazábal, D. E., & Young, L. J. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2005.12.010 · Cited by 230
Both oxytocin and vasopressin may influence alloparental behavior in male prairie voles
Bales, K. L., Kim, A. J., Lewis-Reese, A. D., & Sue Carter, C. (2004) · Hormones and Behavior · doi:10.1016/j.yhbeh.2004.01.004 · Cited by 217
Social suppression of ovarian cyclicity in captive and wild colonies of naked mole-rats, Heterocephalus glaber
Faulkes, C. G., Abbott, D. H., & Jarvis, J. U. M. (1990) · Reproduction · doi:10.1530/jrf.0.0880559 · Cited by 211
Neuroanatomical Circuitry for Mammalian Maternal Behaviora
Numan, M., & Sheehan, T. P. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb51915.x · Cited by 194
Neuroendocrine basis of social recognition
Winslow, J. T., & Insel, T. R. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.03.009 · Cited by 180
Social suppression of reproduction in male naked mole-rats, Heterocephalus glaber
Faulkes, C. G., Abbott, D. H., & Jarvis, J. U. M. (1991) · Reproduction · doi:10.1530/jrf.0.0910593 · Cited by 167
Ventral striatopallidal oxytocin and vasopressin V1a receptors in the monogamous prairie vole (Microtus ochrogaster)
Lim, M. M., Murphy, A. Z., & Young, L. J. (2004) · Journal of Comparative Neurology · doi:10.1002/cne.10973 · Cited by 163
Effects of androgens and estrogens on the vasopressin and oxytocin innervation of the adult rat brain
De Vries, G. J., Duetz, W., Buijs, R. M., van Heerikhuize, J., & Vreeburg, J. T. M. (1986) · Brain Research · doi:10.1016/0006-8993(86)91519-2 · Cited by 153
The distribution of vasopressin-, oxytocin-, and neurophysin-producing neurons in the guinea pig brain
Sofroniew, M. V., Weindl, A., Schinko, I., & Wetzstein, R. (1979) · Cell and Tissue Research · doi:10.1007/bf00234734 · Cited by 150
Immunocytochemical localization of the vasopressinergic and the oxytocinergic neurons in the human hypothalamus
Dierickx, K., & Vandesande, F. (1977) · Cell and Tissue Research · doi:10.1007/bf00220524 · Cited by 150
Identification of the vasopressin-neurophysin II and the oxytocin-neurophysin I producing neurons in the bovine hypothalamus
Vandesande, F., Dierickx, K., & Mey, J. D. (1975) · Cell and Tissue Research · doi:10.1007/bf00221802 · Cited by 149
Neuropeptides and sexual behaviour
Argiolas, A. (1999) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00068-8 · Cited by 148
Chapter 22 Cardiovascular effects of oxytocin
Petersson, M. (2002) · Progress in brain research · doi:10.1016/s0079-6123(02)39024-1 · Cited by 147
Oxytocin and vasopressin receptor distributions in a solitary and a social species of tuco‐tuco ( Ctenomys haigi and Ctenomys sociabilis )
Beery, A. K., Lacey, E. A., & Francis, D. D. (2008) · Journal of Comparative Neurology · doi:10.1002/cne.21638 · Cited by 144
The neurophysin-containing innervation of the forebrain of the mouse
Castel, M., & Morris, J. F. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90078-4 · Cited by 143
The distribution of vasotocin and isotocin in the brain of the rainbow trout
van den Dungen, H. M., Buijs, R. M., Pool, C. W., & Terlou, M. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902120205 · Cited by 141
Oxytocin and Vasopressin Immunoreactivity in Hypothalamic and Extrahypothalamic Sites in Late Pregnant and Postpartum Rats
Caldwell, J. D., Greer, R., Johnson, M. F., Prange, A. J., & Pedersen, C. A. (2008) · Neuroendocrinology · doi:10.1159/000124794 · Cited by 139
Central oxytocin and reproductive behaviours
Insel, T. R. (1997) · Reviews of Reproduction · doi:10.1530/ror.0.0020028 · Cited by 129
Dorsal medullary oxytocin, vasopressin, oxytocin antagonist, and TRH effects on gastric acid secretion and heart rate
Rogers, R. C., & Hermann, G. E. (1985) · Peptides · doi:10.1016/0196-9781(85)90441-3 · Cited by 116
Identification of neurophysin producing cells
Vandesande, F., Mey, J. D., & Dierickx, K. (1974) · Cell and Tissue Research · doi:10.1007/bf00222222 · Cited by 115
Estradiol influences oxytocin-immunoreactive brain systems
Jirikowski, G. F., Caldwell, J. D., Pedersen, C. A., & Stumpf, W. E. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90022-x · Cited by 111
Medial preoptic area oxytocin and female sexual receptivity.
Caldwell, J. D., Jirikowski, G. F., Greer, E. R., & Pedersen, C. A. (1989) · Behavioral Neuroscience · doi:10.1037//0735-7044.103.3.655 · Cited by 110
Oxytocin Activation of Maternal Behavior in the Rata
Pedersen, C. A., Caldwell, J. D., Peterson, G. W., Walker, C. H., & Mason, G. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb34346.x · Cited by 106
Circadian rhythms of locomotor activity in naked mole-rats (Heterocephalus glaber)
Riccio, A. P., & Goldman, B. D. (2000) · Physiology & Behavior · doi:10.1016/s0031-9384(00)00281-x · Cited by 104
Social control of reproduction in breeding and non-breeding male naked mole-rats ( Heterocephalus glaber )
Faulkes, C. G., & Abbott, D. H. (1991) · Reproduction · doi:10.1530/jrf.0.0930427 · Cited by 98
Medial preoptic area oxytocin and female sexual receptivity.
Caldwell, J. D., Jirikowski, G. F., Greer, E. R., et al. (1989) · Behavioral Neuroscience · doi:10.1037/0735-7044.103.3.655 · Cited by 92
Social control of brain morphology in a eusocial mammal
Holmes, M. M., Rosen, G. J., Jordan, C. L., Vries, G. J. D., Goldman, B. D., & Forger, N. G. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610344104 · Cited by 91
Immunocytochemical investigation of the hypothalamo-neurohypophysial system in birds
Goossens, N., Bl�hser, S., Oksche, A., Vandesande, F., & Dierickx, K. (1977) · Cell and Tissue Research · doi:10.1007/bf00220523 · Cited by 90
Establishing behavioral and physiological functions of central oxytocin: insights from studies of oxytocin and ingestive behaviors.
Verbalis, J. G., Blackburn, R. E., Hoffman, G. E., & Stricker, E. M. (1995) · PubMed · Cited by 85
Features of visual function in the naked mole-rat Heterocephalus glaber
Hetling, J. R., Baig-Silva, M. S., Comer, C. M., Pardue, M. T., Samaan, D. Y., Qtaishat, N. M., Pepperberg, D. R., & Park, T. J. (2005) · Journal of Comparative Physiology A · doi:10.1007/s00359-004-0584-6 · Cited by 73
Changes in immunostaining for oxytocin in the forebrain of the female rat during late pregnancy, parturition and early lactation
Jirikowski, G. F., Caldwell, J. D., Pilgrim, C., Stumpf, W. E., & Pedersen, C. A. (1989) · Cell and Tissue Research · doi:10.1007/bf00218899 · Cited by 73
The Psychobiological Basis of Cooperative Breeding in Rodents
Carter, C. S., & Roberts, R. L. (1996) · Cambridge University Press eBooks · doi:10.1017/cbo9780511574634.010 · Cited by 68
Immunohistochemical identification of the oxytocin and vasopressin neurons in the hypothalamus of the monkey (Macaca fuscata)
Kawata, M., & Sano, Y. (1982) · Anatomy and Embryology · doi:10.1007/bf00305474 · Cited by 67
The Study of Mammalian Cooperative Breeding
Solomon, N. G., & French, J. A. (1996) · Cambridge University Press eBooks · doi:10.1017/cbo9780511574634.002 · Cited by 66
Sex differences among oxytocin-immunoreactive neuronal systems in the mouse hypothalamus.
Hu, H., Gf, J., & Jd, C. (1990) · PubMed · Cited by 63
Perineal muscles and motoneurons are sexually monomorphic in the naked mole‐rat (Heterocephalus glaber)
Peroulakis, M. E., Goldman, B. D., & Forger, N. G. (2002) · Journal of Neurobiology · doi:10.1002/neu.10039 · Cited by 56
Mesotocin and vasotocin in the brain of the lizard Gekko gecko
Thepen, T., Voorn, P., Stoll, C., Sluiter, A. A., Pool, C. W., & Lohman, A. H. M. (1987) · Cell and Tissue Research · doi:10.1007/bf00218959 · Cited by 54
Speculations Concerning the Physiological Significance of Central Oxytocin in Maternal Behavior
McCarthy, M. M., Kow, L., & Pfaff, D. W. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb34347.x · Cited by 50
Identification of neurophysin producing cells
Mey, J. D., Vandesande, F., & Dierickx, K. (1974) · Cell and Tissue Research · doi:10.1007/bf00231545 · Cited by 44
Distribution of neurohypophysial peptides in the guinea pig brain. II. An immunocytochemical study of oxytocin
Dubois‐Dauphin, M., Tribollet, E., & Dreifuss, J. J. (1989) · Brain Research · doi:10.1016/0006-8993(89)91052-4 · Cited by 42
Distribution of vasopressin in the brain of the eusocial naked mole‐rat
Rosen, G. J., Vries, G. J. D., Goldman, S. L., Goldman, B. D., & Forger, N. G. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.21215 · Cited by 42
Vasotocin and mesotocin in the brains of amphibians: State of the art
Smeets, W. J. A. J., & González, A. (2001) · Microscopy Research and Technique · doi:10.1002/jemt.1128 · Cited by 39
Breeding status affects motoneuron number and muscle size in naked mole‐rats: Recruitment of perineal motoneurons?
Seney, M. L., Goldman, B. D., & Forger, N. G. (2006) · Journal of Neurobiology · doi:10.1002/neu.20314 · Cited by 33
A stereotaxic atlas of the brain of the naked mole-rat (Heterocephalus glaber)
Xiao, J., Levitt, J. B., & Buffenstein, R. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.03.077 · Cited by 32
Oxytocinergic innervation of the brain of the garden dormouse (Eliomys quercinus L.)
Hermes, M. L. H. J., Buijs, R. M., Masson‐Pévet, M., & Pévet, P. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902730209 · Cited by 32
The distribution of vasotocin and mesotocin immunoreactivity in the brain of the snake, Bothrops jararaca
Silveira, P. F., Breno, M. C., del Rı́o, M. P. M., & Mancera, J. M. (2002) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(02)00016-9 · Cited by 25
Distribution of neurophysin II immunoreactive nerve fibers within the subnuclei of the nucleus of the tractus solitarius of the rat
Kalia, M., Fuxé, K., Hökfelt, T. G. M., Härfstrand, A., Lang, R. E., & Ganten, D. (1984) · Brain Research · doi:10.1016/0006-8993(84)90682-6 · Cited by 17
Untitled work
Wang (1996) · doi:10.1002/(sici)1096-9861(19960318)366:4

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Authors: Rosen, G. J., de Vries, G. J., Goldman, S. L., Goldman, B. D., & Forger, N. G.
Affiliations: University of Massachusetts Amherst (US)
University of Connecticut (US)
Corresponding author: Forger, N.G.
ORCID: Forger, N.G.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 2008-08
Volume: 155
Issue: 3
Pages: 809-817
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/j.neuroscience.2008.05.039
PMC: PMC2614305
OpenAlex: W2038970714
Cited by: 102
References: 71
Citations by year: 2026: 4 · 2025: 3 · 2024: 5 · 2023: 3 · 2022: 2 · 2021: 6 · 2020: 19 · 2019: 8 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 8 · 2014: 8 · 2013: 6 · 2012: 4
FWCI: 7.53
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (K02MH072825, K02MH001497)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Primate Behavior and Ecology
Keywords: oxytocin, naked mole-rat, eusociality, social behavior, paraventricular nucleus, supraoptic nucleus, preoptic area, nucleus accumbens, substantia innominata, bed nucleus of the stria terminalis, median eminence, maternal behavior, pup care, social hierarchy
MeSH terms: Animals, Brain, Brain Mapping, Oxytocin, Mole Rats

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Distribution of oxytocin in the brain of a eusocial rodent

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