Cited by 102Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyPrimate Behavior and Ecology

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Distribution of oxytocin in the brain of a eusocial rodent

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Rosen, G.J., de Vries, G.J., Goldman, S.L., Goldman, B.D., Forger, N.G.·2008·Neuroscience

DOI 10.1016/j.neuroscience.2008.05.039PMC PMC2614305

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Abstract

Naked mole-rats are highly social rodents that live in large colonies characterized by a rigid social and reproductive hierarchy. Only one female, the queen, breeds. Most colony members are non-reproductive subordinates that work cooperatively to rear the young and maintain an underground burrow system. Little is known about the neurobiological basis of the complex sociality exhibited by this species. The neuropeptide oxytocin (Oxt) modulates social bonding and other social behaviors in many vertebrates. Here we examined the distribution of Oxt immunoreactivity in the brains of male and female naked mole-rats. As in other species, the majority of Oxt-immunoreactive (Oxt-ir) cells were found in the paraventricular and supraoptic nuclei, with additional labeled cells scattered throughout the preoptic and anterior hypothalamic areas. Oxt-ir fibers were found traveling toward and through the median eminence, as well as in the tenia tecta, septum, and nucleus of the diagonal band of Broca. A moderate network of fibers covered the bed nucleus of the stria terminalis and preoptic area, and a particularly dense fiber innervation of the nucleus accumbens and substantia innominata was observed. In the brainstem, Oxt-ir fibers were found in the periaqueductal gray, locus coeruleus, parabrachial nucleus, nucleus of the solitary tract, and nucleus ambiguus. The high levels of Oxt immunoreactivity in the nucleus accumbens and preoptic area are intriguing, given the link in other rodents between Oxt signaling in these regions and maternal behavior. Although only the queen gives birth or nurses pups in a naked mole-rat colony, most individuals actively participate in pup care.

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Preface
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.002.0006
Copyright Page
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.002.0003
Abbreviations Used for Major Brain Regions
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.002.0007
Dedication
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.002.0004
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Authors: Rosen, G. J., de Vries, G. J., Goldman, S. L., Goldman, B. D., & Forger, N. G.
Affiliations: University of Massachusetts Amherst (US)
University of Connecticut (US)
Corresponding author: Forger, N.G.
ORCID: Forger, N.G.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 2008-08
Volume: 155
Issue: 3
Pages: 809-817
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/j.neuroscience.2008.05.039
PMC: PMC2614305
OpenAlex: W2038970714
Cited by: 102
References: 71
Citations by year: 2026: 4 · 2025: 3 · 2024: 5 · 2023: 3 · 2022: 2 · 2021: 6 · 2020: 19 · 2019: 8 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 8 · 2014: 8 · 2013: 6 · 2012: 4
FWCI: 7.53
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (K02MH072825, K02MH001497)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Primate Behavior and Ecology
Keywords: oxytocin, naked mole-rat, eusociality, social behavior, paraventricular nucleus, supraoptic nucleus, preoptic area, nucleus accumbens, substantia innominata, bed nucleus of the stria terminalis, median eminence, maternal behavior, pup care, social hierarchy
MeSH terms: Animals, Brain, Brain Mapping, Oxytocin, Mole Rats

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Distribution of oxytocin in the brain of a eusocial rodent

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