D-serine treatment reduces cocaine-primed reinstatement in rats following extended access to cocaine self-administration
Open accessAbstract
The most intractable feature of drug addiction is the high rate of relapse, even following extended periods of abstinence from drug-taking. Evidence suggests that allowing rats extended access to cocaine self-administration leads to behavioral characteristics in these animals that are consistent with the development of addiction in humans. In the current study, rats were allowed to self-administer cocaine over a total of 22 daily sessions, the final seven of which were long-access (LgA) sessions of 6 h duration. Assessments of reinstatement of drug-seeking behavior were made following reintroduction to the drug-taking environment and noncontingent priming with either conditioned stimulus (CS) or cocaine in both extinguished and abstinent subject groups. Three separate groups of rats were treated with either saline or D-serine (100 mg/kg i.p.) administered 2 h prior to, or immediately following, each extinction training session. Saline-treated LgA rats were resistant to the effects of extinction training to reduce noncontingent priming of reinstatement of drug-seeking behavior with either CS or cocaine. In contrast, treatment with D-serine either before or immediately following the sessions resulted in a significant enhancement in the ability of extinction training to reduce cocaine-primed reinstatement of drug-seeking behavior. These results suggest that D-serine can act to enhance the consolidation of extinction learning in LgA rats, and is therefore a promising adjunctive agent along with behavioral therapy for the treatment of cocaine addiction.
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Exogenous D-serine treatment reverts impaired plasticity and reduces behavioral manifestations associated with cocaine addiction, including cocaine-induced place preference, reinstatement of cocaine self-administration, and locomotor sensitization to cocaine.
“In keeping, exogenous D-serine treatment reverts the impaired plasticity and reduces a number of behavioral manifestations associated to cocaine addiction, including cocaine-induced place preference 121, 122 , reinstatement of cocaine self-administration (relapse) 123 and locomotor sensitization to cocaine 120, 121 .”
From Astrocyte function from information processing to cognition and cognitive impairment (2019) · cites this paper as [123]
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- Authors
- Kelamangalath, L., & Wagner, J. J.
- Affiliations
- University of Georgia (US)
- ORCID
- Wagner, J.J.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 169
- Issue
- 3
- Pages
- 1127-1135
- ISSN
- 0306-4522 (ISSN-L)
- PMC
- PMC2914147
- OpenAlex
- W2025192741
- Cited by
- 25
- References
- 35
- Citations by year
- 2026: 1 · 2022: 1 · 2020: 1 · 2019: 1 · 2017: 3 · 2016: 2 · 2015: 6 · 2014: 3 · 2013: 3 · 2012: 1
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health National Institute on Drug Abuse (DA016302)
- University of Georgia Interdisciplinary Toxicology Program
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- D-serine, cocaine self-administration, extended access, reinstatement, extinction training, extinction consolidation, conditioned stimulus, relapse, drug addiction treatment, glutamate modulators
- MeSH terms
- Central Nervous System Stimulants, Animals, Cocaine, Extinction, Psychological, Male, Recurrence, Self Administration, Serine, Stereoisomerism, Time Factors, Rats, Sprague-Dawley, Cocaine-Related Disorders, Rats, Drug-Seeking Behavior
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