Cited by 109Neurotransmitter Receptor Influence on BehaviorRegulation of Appetite and ObesityNeuropeptides and Animal Physiology

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Reversible suppression of food reward behavior by chronic mu-opioid receptor antagonism in the nucleus accumbens

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Shin, A.C., Pistell, P.J., Phifer, C.B., Berthoud, H.R.·2010·Neuroscience

DOI 10.1016/j.neuroscience.2010.07.017PMC PMC2933316

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Abstract

Overindulgence in easily available energy-dense palatable foods is thought to be an important factor in the current obesity epidemic but the underlying neural mechanisms are not well understood. Here we demonstrate that mu-opioid receptor signaling in the nucleus accumbens may be important. Protracted suppression of endogenous mu-opioid receptor signaling focused on the nucleus accumbens shell for several days by means of microinjected beta-funaltrexamine (BFNA) diminished both "liking" of sucrose, as indicated by fewer positive hedonic orofacial responses, and the incentive reinforcement value ("wanting") of a food reward, as indicated by lower completion speed and increased time being distracted in the incentive runway. BFNA-treatment also decreased responding to sucrose and corn oil in the brief access lick paradigm, a test measuring a combination of mainly taste-guided "liking" and low-effort "wanting", as well as 4 h intake of sucrose solution. These effects were not due to nonspecific permanent neuronal changes, as they were fully reversible. We conclude that endogenous mu-opioid signaling in the nucleus accumbens is necessary for the full display of palatable food-induced hyperphagia through mechanisms including hedonic, motivational, and reinforcement processes. Development of obesity could be the result of predisposing innate differences in these mechanisms or overstimulation of these mechanisms by external factors.

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Authors: Shin, A. C., Pistell, P. J., Phifer, C. B., & Berthoud, H. R.
Affiliations: Pennington Biomedical Research Center (US)
Northwestern State University (US)
ORCID: Shin, A.C.
Berthoud, H.R.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 2010-10
Volume: 170
Issue: 2
Pages: 580-588
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/j.neuroscience.2010.07.017
PMC: PMC2933316
OpenAlex: W2104979095
Cited by: 109
References: 65
Citations by year: 2026: 4 · 2025: 6 · 2024: 1 · 2021: 2 · 2020: 47 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 6 · 2014: 6 · 2013: 9 · 2012: 6
FWCI: 3.11
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (DK071082, DK047348)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: mu-opioid receptor, nucleus accumbens shell, food reward, incentive motivation, beta-funaltrexamine, hyperphagia, obesity
MeSH terms: Animals, Appetitive Behavior, Male, Microinjections, Motivation, Naltrexone, Nucleus Accumbens, Reinforcement, Psychology, Reward, Sucrose, Rats, Sprague-Dawley, Receptors, Opioid, mu, Rats

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Reversible suppression of food reward behavior by chronic mu-opioid receptor antagonism in the nucleus accumbens

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