New insights into corticosteroid-binding globulin and glucocorticoid delivery

Henley, D.E.; Lightman, S.L.

doi:10.1016/j.neuroscience.2011.02.053

Cited by 115Stress Responses and CortisolAdrenal Hormones and DisordersEstrogen and related hormone effects

New insights into corticosteroid-binding globulin and glucocorticoid delivery

Henley, D.E., Lightman, S.L.·2011·Neuroscience

DOI 10.1016/j.neuroscience.2011.02.053

Open this paper in CoChat — free account

Abstract

Corticosteroid-binding globulin (CBG) binds cortisol with high affinity and facilitates its transport in the blood. A recent discovery suggests that CBG may have a role beyond that of a simple transport carrier protein. CBG functions as a protein thermocouple that is exquisitely sensitive to temperature change, releasing cortisol in response to increasing temperatures within the human physiological range. It is also expressed in the human hypothalamus and cerebrospinal fluid, while in the rodent it is also found in other intracellular neuronal locations, suggesting a role in regulating access of glucocorticoids to their receptors in the CNS. Genetic variants of CBG have been detected in man and have been associated with fatigue-pain syndromes and hypotension, again suggesting a potential effect of CBG on the access of cortisol to brain glucocorticoid receptors. These new findings provide the basis for a novel concept of the mechanisms through which the body regulates access of glucocorticoids to the brain and other tissues of the body.

Integrity signals

Registry

Crossref · 10.1016/j.neuroscience.2011.02.053

Cites

92 of 92 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Corticosteroid-binding globulin binds up to 90% of circulating glucocorticoids, and free circulating glucocorticoids are usually about 5%.
“CBG is a thermosensitive glycoprotein that binds up to 90% of circulating GCs in the bloodstream. The remaining 10% may also be associated to serum albumin. In consequence, the levels of free circulating GCs are usually about 5% (66, 67).”
From The HPA â€“ Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain (2014) · cites this paper as [67]

Williams Textbook of Endocrinology
Melmed, S., & Polonsky, K. С. (2016) · Elsevier eBooks · doi:10.1016/c2013-0-15980-6 · Cited by 3,716 · see citing works
The Neuroendocrinology of Stress: A Never Ending Story
Lightman, S. L. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01711.x · Cited by 3,570 · see citing works
Self-citation
The Free Hormone Hypothesis: A Physiologically Based Mathematical Model*
MENDEL, C. M. (1989) · Endocrine Reviews · doi:10.1210/edrv-10-3-232 · Cited by 961 · see citing works
The serum transport of steroid hormones
SIITERI, P. K., MURAI, J. T., RAYMOURE, W. J., KUHN, R. W., HAMMOND, G. L., & NISKER, J. A. (1982) · Proceedings of the 1981 Laurentian Hormone Conference · doi:10.1016/b978-0-12-571138-8.50016-0 · Cited by 770 · see citing works
Williams Textbook of Endocrinology
Reutrakul, S. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000323673.44568.e8 · Cited by 710 · see citing works
STEROID-PROTEIN INTERACTIONS
Westphal, U. (1963) · doi:10.21236/ad0423987 · Cited by 675 · see citing works
The Functions of Corticosteroid-Binding Globulin and Sex Hormone-Binding Globulin: Recent Advances*
Rosner, W. (1990) · Endocrine Reviews · doi:10.1210/edrv-11-1-80 · Cited by 560 · see citing works
Ultradian hormone stimulation induces glucocorticoid receptor-mediated pulses of gene transcription
Stavreva, D. A., Wiench, M., John, S., Conway-Campbell, B. L., McKenna, M. A., Pooley, J. R., Johnson, T. A., Voss, T. C., Lightman, S. L., & Hager, G. L. (2009) · Nature Cell Biology · doi:10.1038/ncb1922 · Cited by 375 · see citing works
Self-citation
Early-life exposure to endotoxin alters hypothalamic-pituitary-adrenal function and predisposition to inflammation
Shanks, N., Windle, R. J., Perks, P. A., Harbuz, M. S., Jessop, D. S., Ingram, C. D., & Lightman, S. L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.090571897 · Cited by 374 · see citing works
Self-citation
Molecular Properties of Corticosteroid Binding Globulin and the Sex-Steroid Binding Proteins*
Hammond, G. L. (1990) · Endocrine Reviews · doi:10.1210/edrv-11-1-65 · Cited by 318 · see citing works
Septic Shock and Sepsis: A Comparison of Total and Free Plasma Cortisol Levels
Ho, J. T., Al-Musalhi, H., Chapman, M. J., Quach, T., Thomas, P. D., Bagley, C. J., Lewis, J. G., & Torpy, D. J. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0265 · Cited by 312 · see citing works
Glucocorticoid action networks and complex psychiatric and/or somatic disorders
Chrousos, G. P., & Kino, T. (2007) · Stress · doi:10.1080/10253890701292119 · Cited by 292 · see citing works
Corticosterone levels in the brain show a distinct ultradian rhythm but a delayed response to forced swim stress
Droste, S. K., de Groote, L., Atkinson, H. C., Lightman, S. L., Reul, J. M. H. M., & Linthorst, A. C. E. (2008) · Endocrinology · doi:10.1210/en.2008-0103 · Cited by 280 · see citing works
Self-citation
Primary structure of human corticosteroid binding globulin, deduced from hepatic and pulmonary cDNAs, exhibits homology with serine protease inhibitors.
Hammond, G. L., Smith, C. S., Goping, I. S., Underhill, D. A., Harley, M. J., Reventós, J., Musto, N. A., Gunsalus, G. L., & Bardin, C. W. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.15.5153 · Cited by 266 · see citing works
A Role for Corticosteroid-Binding Globulin in Delivery of Cortisol to Activated Neutrophils*
Hammond, G. L., Smith, C. S., Paterson, N. A. M., & Sibbald, W. J. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-71-1-34 · Cited by 265 · see citing works
The significance of glucocorticoid pulsatility
Lightman, S. L., Wiles, C. C., Atkinson, H. C., Henley, D. E., Russell, G. M., Leendertz, J. A., McKenna, M. A., Spiga, F., Wood, S. A., & Conway-Campbell, B. L. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.11.073 · Cited by 241 · see citing works
Self-citation
Origin of ultradian pulsatility in the hypothalamic–pituitary–adrenal axis
Walker, J. J., Terry, J. R., & Lightman, S. L. (2010) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2009.2148 · Cited by 239 · see citing works
Self-citation
The MAPK pathway and Egr-1 mediate stress-related behavioral effects of glucocorticoids
Revest, J., Blasi, F. D., Kitchener, P., Rougé‐Pont, F., Desmedt, A., Turiault, M., Tronche, F., & Piazza, P. V. (2005) · Nature Neuroscience · doi:10.1038/nn1441 · Cited by 236 · see citing works
A long-term increase in basal levels of corticosterone and a decrease in corticosteroid-binding globulin after acute stressor exposure
Fleshner, M., Terrence Deak, B., Spencer, R. L., Laudenslager, M. L., Watkins, L. R., & Maier, S. F. (1995) · Endocrinology · doi:10.1210/endo.136.12.7588279 · Cited by 235 · see citing works
Plasma free cortisol fraction reflects levels of functioning corticosteroid-binding globulin
Lewis, J. G., Bagley, C. J., Elder, P. A., Bachmann, A. W., & Torpy, D. J. (2005) · Clinica Chimica Acta · doi:10.1016/j.cccn.2005.03.044 · Cited by 214 · see citing works
Role of Neuraxial Steroids in Interventional Pain Management
Manchikanti, L. (2002) · Pain Physician · doi:10.36076/ppj.2002/5/182 · Cited by 204 · see citing works
Chronic social stress produces reductions in available splenic type II corticosteroid receptor binding and plasma corticosteroid binding globulin levels
Spencer, R. L., Miller, A. H., Moday, H., McEwen, B. S., Blanchard, R. J., Blanchard, D. C., & Sakai, R. R. (1996) · Psychoneuroendocrinology · doi:10.1016/0306-4530(95)00020-8 · Cited by 158 · see citing works
PROTEIN BINDING OF CORTICOIDS STUDIED BY GEL FILTRATION*
Heirwegh, P. D. M. K., Heremans, J. F., & Declerck-Raskin, M. (1962) · Journal of Clinical Investigation · doi:10.1172/jci104539 · Cited by 154 · see citing works
Delivery and Transport of Glucocorticoids to Target Cells
Ballard, P. L. (1979) · Monographs on endocrinology · doi:10.1007/978-3-642-81265-1_2 · Cited by 143 · see citing works
Corticosteroid-binding globulin influences kinetic parameters of plasma cortisol transport and clearance.
Bright, G. M. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.3.7883829 · Cited by 137 · see citing works
The influence of the route of oestrogen administration on serum levels of cortisol-binding globulin and total cortisol
Qureshi, A. C., Bahri, A., Breen, L. A., Barnes, S. C., Powrie, J. K., Thomas, S. M., & Carroll, P. V. (2007) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.02784.x · Cited by 133 · see citing works
Hypothalamic-Pituitary-Adrenal Axis Activation in Obstructive Sleep Apnea: The Effect of Continuous Positive Airway Pressure Therapy
Henley, D., Russell, G. M., Douthwaite, J. A., Wood, S. A., Buchanan, F., Gibson, R. H., Woltersdorf, W. W. W., Catterall, J. R., & Lightman, S. L. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1174 · Cited by 129 · see citing works
Self-citation
Corticosteroid-binding Globulin, a Structural Basis for Steroid Transport and Proteinase-triggered Release
Klieber, M. A., Underhill, C., Hammond, G. L., & Muller, Y. A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705014200 · Cited by 128 · see citing works
Temperature-Responsive Release of Cortisol from Its Binding Globulin: A Protein Thermocouple
Cameron, A., Henley, D., Carrell, R. W., Zhou, A., Clarke, A. R., & Lightman, S. L. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0942 · Cited by 127 · see citing works
Self-citation
Hyporesponsiveness to Glucocorticoids in Mice Genetically Deficient for the Corticosteroid Binding Globulin
Petersen, H. H., Andreassen, T. K., Breiderhoff, T., Bräsen, J. H., Schulz, H., Groß, V., Gröne, H., Nykjær, A., & Willnow, T. E. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00400-06 · Cited by 119 · see citing works
Assessment of adrenal function in cirrhotic patients: Salivary cortisol should be preferred
Galbois, A., Rudler, M., Massard, J., Fulla, Y., Bennani, A., Bonnefont‐Rousselot, D., Thibault, V., Reignier, S., Bourrier, A., Poynard, T., et al. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.01.026 · Cited by 117 · see citing works
Molecular studies of corticosteroid binding globulin structure, biosynthesis and function
Hammond, G. L., Smith, C. S., & Underhill, D. A. (1991) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(91)90300-t · Cited by 115 · see citing works
Serum Corticosteroid-Binding Globulin Concentration and Insulin Resistance Syndrome: A Population Study
Fernández‐Real, J. M., PUGEAT, M. M., Grasa, M., Broch, M., Vendrell, J. J., Brun, J., & Ricart, W. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2001-011843 · Cited by 114 · see citing works
Antithrombins Wibble and Wobble (T85M/K): Archetypal Conformational Diseases With In Vivo Latent-Transition, Thrombosis, and Heparin Activation
Beauchamp, N. J., Pike, R. N., Daly, M., et al. (1998) · Blood · doi:10.1182/blood.v92.8.2696 · Cited by 111 · see citing works
Increased Corticosterone Pulse Frequency During Adjuvant‐Induced Arthritis and its Relationship to Alterations in Stress Responsiveness
Windle, R., Wood, S. A., Kershaw, Y. M., Lightman, S. L., Ingram, C. D., & Harbuz, M. S. (2001) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2001.00715.x · Cited by 110 · see citing works
Self-citation
Familial Corticosteroid-Binding Globulin Deficiency Due to a Novel Null Mutation: Association with Fatigue and Relative Hypotension
Torpy, D. J., Bachmann, A. W., Grice, J. E., Fitzgerald, S. P., Phillips, P. J. J., Whitworth, J. A., & Jackson, R. V. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.8.7724 · Cited by 106 · see citing works
Cortisol and ACTH responses to psychosocial stress are modulated by corticosteroid binding globulin levels
Kumsta, R., Entringer, S., Hellhammer, D. H., & Wüst, S. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.08.007 · Cited by 104 · see citing works
Plasma Transcortin Influences Endocrine and Behavioral Stress Responses in Mice
Richard, É. M., Helbling, J., Tridon, C., Desmedt, A., Minni, A., Cador, M., Pourtau, L., Konsman, J. P., Mormède, P., & Moisan, M. (2009) · Endocrinology · doi:10.1210/en.2009-0862 · Cited by 100 · see citing works
Steroid Hormone Receptors in Astrocytic Neoplasms
Carroll, R. S., Zhang, J., Dashner, K., Sar, M., & Black, P. M. (1995) · Neurosurgery · doi:10.1227/00006123-199509000-00019 · Cited by 100 · see citing works
Corticosteroid Binding Globulin: A New Target for Cortisol-Driven Obesity
Ousova, O., Guyonnet‐Dupérat, V., Iannuccelli, N., Bidanel, J. P., Denis Milan, A., Genêt, C., Llamas, B., Martine Yerle, B., Gellin, J., Chardon, P., et al. (2004) · Molecular Endocrinology · doi:10.1210/me.2004-0005 · Cited by 100 · see citing works
Specific binding of human corticosteroid-binding globulin to cell membranes.
Hryb, D. J., Khan, M., Romas, N. A., & Rosner, W. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.10.3253 · Cited by 97 · see citing works
Steroid-protein interactions. Human corticosteroid binding globulin: some physicochemical properties and binding specificity
Mickelson, K. E., Forsthoefel, J., & Westphal, U. (1981) · Biochemistry · doi:10.1021/bi00524a047 · Cited by 95 · see citing works
Cortisol-binding globulin is important in the interpretation of dynamic tests of the hypothalamic--pituitary--adrenal axis.
Dhillo, W., Kong, W. M., le Roux, C. L., Alaghband-Zadeh, J., Jones, J., Carter, G. D., Mendoza, N., Meeran, K., & O'Shea, D. (2002) · European Journal of Endocrinology · doi:10.1530/eje.0.1460231 · Cited by 95 · see citing works
Serum Protein Alterations Produced in Women by Synthetic Estrogens
MUSA, B. U., DOE, R. P., & Seal, U. S. (1967) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-27-10-1463 · Cited by 93 · see citing works
That warm fuzzy feeling: brain serotonergic neurons and the regulation of emotion
Lowry, C. A., Lightman, S. L., & Nutt, D. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881108099956 · Cited by 92 · see citing works
Self-citation
Corticosteroid-binding globulin: The clinical significance of altered levels and heritable mutations
Gagliardi, L., Ho, J. T., & Torpy, D. J. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.07.015 · Cited by 88 · see citing works
Interaction of human CBG with cell membranes
Strel'chyonok, O. A., & Avvakumov, G. V. (1991) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(91)90305-o · Cited by 85 · see citing works
Novel Human Corticosteroid-Binding Globulin Variant with Low Cortisol-Binding Affinity1
Emptoz-Bonneton, A., Cousin, P., Seguchi, K., et al. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.1.6315 · Cited by 84 · see citing works
Mitotane increases the blood levels of hormone-binding proteins
van Seters, A. P., & Moolenaar, A. J. (1991) · European Journal of Endocrinology · doi:10.1530/acta.0.1240526 · Cited by 82 · see citing works
Approach to the Patient with Adrenocortical Carcinoma
Lacroix, A. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0990 · Cited by 81 · see citing works
Molecular and structural basis of steroid hormone binding and release from corticosteroid-binding globulin
Lin, H., Muller, Y. A., & Hammond, G. L. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.06.015 · Cited by 79 · see citing works
The S-to-R Transition of Corticosteroid-Binding Globulin and the Mechanism of Hormone Release
Zhou, A., Wei, Z., Stanley, P. L. D., Read, R. J., Stein, P. E., & Carrell, R. W. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.05.012 · Cited by 77 · see citing works
Cellular uptake of steroid carrier proteins—Mechanisms and implications
Willnow, T. E., & Nykjær, A. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.07.021 · Cited by 75 · see citing works
Novel Human Corticosteroid-Binding Globulin Variant with Low Cortisol-Binding Affinity
Emptoz-Bonneton, A. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.1.361 · Cited by 73 · see citing works
Significance of Pulsatility in the HPA Axis
Lightman, S. L., Windle, R., Julian, M. D., Harbuz, M. S., Shanks, N. M., Wood, S. A., Kershaw, Y. M., & Ingram, C. D. (2000) · Novartis Foundation symposium · doi:10.1002/0470870796.ch14 · Cited by 72 · see citing works
Self-citation
Induction of adenylate cyclase in a mammary carcinoma cell line by human corticosteroid-binding globulin
Nakhla, A. M., Khan, M., & Rosner, W. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(88)81329-9 · Cited by 68 · see citing works
Steroid-Protein Interactions Revisited
Westphal, U. (1986) · Monographs on endocrinology · doi:10.1007/978-3-642-82486-9_1 · Cited by 62 · see citing works
Steroid Hormones and Steroid Hormone Binding Globulins in Cerebrospinal Fluid Studied in Individuals with Intact and with Disturbed Blood-Cerebrospinal Fluid Barrier
Schwarz, S., & Pohl, P. (2008) · Neuroendocrinology · doi:10.1159/000126112 · Cited by 61 · see citing works
The Ultradian and Circadian Rhythms of Free Corticosterone in the Brain are Not Affected by Gender: An <i>In Vivo</i> Microdialysis Study in Wistar Rats
Droste, S. K., De Groote, L., Lightman, S. L., Reul, J. M. H. M., & Linthorst, A. C. E. (2009) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01811.x · Cited by 61 · see citing works
Self-citation
Spatial and temporal distribution of corticosteroid-binding globulin and its messenger ribonucleic acid in embryonic and fetal mice
Scrocchi, L. A., Orava, M., Smith, C. S., Han, V. K. M., & Hammond, G. L. (1993) · Endocrinology · doi:10.1210/endo.132.2.7916682 · Cited by 59 · see citing works
Steroid-protein interactions. Human corticosteroid-binding globulin: characterization of dimer and electrophoretic variants
Mickelson, K. E., Harding, G. B., Forsthoefel, M. W., & Westphal, U. (1982) · Biochemistry · doi:10.1021/bi00533a010 · Cited by 59 · see citing works
Characteristics of the Binding of Corticosteroid-Binding Globulin to Rat Cell Membranes*
Singer, C. J., Khan, M., & Rosner, W. (1988) · Endocrinology · doi:10.1210/endo-122-1-89 · Cited by 59 · see citing works
Transcortin Leuven: a variant of human corticosteroid-binding globulin with decreased cortisol-binding affinity.
BAELEN, H. V., Brepoels, R., & MOOR, P. D. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34790-2 · Cited by 57 · see citing works
Corticosteroid-binding globulin modulates cortisol concentration responses to a given production rate.
Bright, G. M., & Darmaun, D. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.3.7883828 · Cited by 57 · see citing works
Distinct, Time-Dependent Effects of Voluntary Exercise on Circadian and Ultradian Rhythms and Stress Responses of Free Corticosterone in the Rat Hippocampus
Droste, S. K., Collins, A., Lightman, S. L., Linthorst, A. C. E., & Reul, J. M. H. M. (2009) · Endocrinology · doi:10.1210/en.2009-0402 · Cited by 56 · see citing works
Self-citation
Human corticosteroid binding globulin is secreted by a hepatoma-derived cell line
Khan, M., Aden, D. P., & Rosner, W. (1984) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(84)90142-0 · Cited by 55 · see citing works
Corticosteroid-binding globulin biosynthesis in the mouse liver and kidney during postnatal development
Scrocchi, L. A., Hearn, S., Han, V. K. M., & Hammond, G. L. (1993) · Endocrinology · doi:10.1210/endo.132.2.8425503 · Cited by 55 · see citing works
Characteristics and biological role of steroid hormone receptors in neuroepithelial tumors
Paoletti, P., Butti, G., Zibera, C., et al. (1990) · Journal of neurosurgery · doi:10.3171/jns.1990.73.5.0736 · Cited by 53 · see citing works
Plasma Total and Glycosylated Corticosteroid-Binding Globulin Levels Are Associated with Insulin Secretion
Fernández‐Real, J. M., Grasa, M., Casamitjana, R., PUGEAT, M. M., Barret, C., & Ricart, W. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.9.5946 · Cited by 52 · see citing works
Novel Corticosteroid-Binding Globulin Variant That Lacks Steroid Binding Activity
Perogamvros, I., Underhill, C., Henley, D., Hadfield, K. D., Newman, W. G., Ray, D. W., Lightman, S. L., Hammond, G. L., & Trainer, P. J. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0746 · Cited by 50 · see citing works
Self-citation
The prednisolone suppression test in depression: Dose–response and changes with antidepressant treatment
Juruena, M. F., Cleare, A. J., Papadopoulos, A. S., Poon, L., Lightman, S. L., & Pariante, C. M. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.04.016 · Cited by 49 · see citing works
Self-citation
Expression of Corticosterone-binding Globulin in the Rat Hypothalamus
Möpert, B., Herbert, Z., Caldwell, J., et al. (2006) · Hormone and Metabolic Research · doi:10.1055/s-2006-925344 · Cited by 45 · see citing works
The Role of the Adrenal in Generating the Diurnal Variation in Circulating Levels of Corticosteroid-Binding Globulin in the Rat
Hsu, B. R., & Kuhn, R. W. (1988) · Endocrinology · doi:10.1210/endo-122-2-421 · Cited by 43 · see citing works
Corticosteroid‐binding globulin gene polymorphisms: clinical implications and links to idiopathic chronic fatigue disorders
Torpy, D. J., & Ho, J. T. (2007) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.02890.x · Cited by 38 · see citing works
Genotype–phenotype associations in understanding the role of corticosteroid-binding globulin in health and disease animal models
Moisan, M. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.07.017 · Cited by 37 · see citing works
Expression of Corticosteroid-binding Protein in the Human Hypothalamus, Co-localization with Oxytocin and Vasopressin
Sivukhina, E. V., Jirikowski, G. F., Bernstein, H., Lewis, J. G., & Herbert, Z. (2006) · Hormone and Metabolic Research · doi:10.1055/s-2006-925346 · Cited by 37 · see citing works
Expression of corticosteroid binding globulin in the rat central nervous system
Jirikowski, G. F., Pusch, L., Möpert, B., Herbert, Z., & Caldwell, J. D. (2007) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2007.03.007 · Cited by 37 · see citing works
Corticosteroid-binding globulin receptor of the rat hepatic membrane: solubilization, partial characterization, and the effect of steroids on binding.
Maitra, U. S., Khan, M., & Rosner, W. (1993) · Endocrinology · doi:10.1210/endo.133.4.8404624 · Cited by 36 · see citing works
An amino acid substitution in biobreeding rat corticosteroid binding globulin results in reduced steroid binding affinity.
Smith, C. S., & Hammond, G. L. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)55098-5 · Cited by 35 · see citing works
Intracellular CBG-like molecules in the rat pituitary
de Kloet, E. R., Voorhuis, T. A. M., Leunissen, J. L. M., & Koch, B. (1984) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(84)90235-8 · Cited by 35 · see citing works
Plasma Variation of Corticosteroid-binding Globulin and Sex Hormone-binding Globulin
Lewis, J. G., Möpert, B., Shand, B. I., Doogue, M. P., Soule, S. G., Frampton, C. M., & Elder, P. A. (2006) · Hormone and Metabolic Research · doi:10.1055/s-2006-925338 · Cited by 33 · see citing works
Study of the effect of changing glucose, insulin, and insulin-like growth factor-I levels on serum corticosteroid binding globulin in lean, obese, and obese subjects with glucose intolerance
Fernández‐Real, J. M., PUGEAT, M. M., Emptoz-Bonneton, A., & Ricart, W. (2001) · Metabolism · doi:10.1053/meta.2001.25647 · Cited by 32 · see citing works
Corticosteroid-binding globulin affects the relationship between circulating adiponectin and cortisol in men and women
Fernández‐Real, J. M., PUGEAT, M. M., López‐Bermejo, A., Bornet, H., & Ricart, W. (2005) · Metabolism · doi:10.1016/j.metabol.2004.11.015 · Cited by 32 · see citing works
Are Corticosteroid‐Binding Globulin and Sex Hormone‐Binding Globulin Hormones?a
Rosner, W., Hryb, D. J., Khan, M., et al. (1988) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1988.tb48859.x · Cited by 31 · see citing works
Protein Binding of Cortisol in Human Cerebrospinal Fluid
Prédine, J., Brailly, S., DELAPORTE, P., & Milgröm, E. (1984) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-58-1-6 · Cited by 27 · see citing works
Cosyntropin-stimulated salivary cortisol in hospitalized patients with hypoproteinemia
Raff, H., Brock, S., & Findling, J. W. (2008) · Endocrine · doi:10.1007/s12020-008-9101-y · Cited by 25 · see citing works
Extreme posture elevates corticosterone in a forced ambulation model of chronic stress in rats
Neufeld, J. H., Breen, L., & Hauger, R. L. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90005-1 · Cited by 21 · see citing works
The insulin resistance syndrome and the binding capacity of cortisol binding globulin (CBG) in men and women
Fernández‐Real, J. M., Grasa, Casamitjana, & Ricart, W. (2000) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2000.00864.x · Cited by 20 · see citing works
Corticosteroid-binding globulin modulates cortisol concentration responses to a given production rate
Bright, G. M. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.80.3.764 · Cited by 20 · see citing works
Structure and chromosomal location of the gene encoding mouse corticosteroid-binding globulin: strain differences in coding sequence and steroid-binding activity
Orava, M., Zhao, X. F., Leiter, E. H., et al. (1994) · Gene · doi:10.1016/0378-1119(94)90387-5 · Cited by 15 · see citing works
Expression of Corticosteroid-Binding Globulin in Human Astrocytoma Cell Line
Pusch, L., Wegmann, S. M., Caldwell, J. D., et al. (2009) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-009-9350-1 · Cited by 15 · see citing works
Corticosteroid-binding globulin receptor of the rat hepatic membrane: solubilization, partial characterization, and the effect of steroids on binding
Maitra, U. S. (1993) · Endocrinology · doi:10.1210/en.133.4.1817 · Cited by 13 · see citing works

Flagged first, then by citations

Sorted by citations

The HPA â€“ Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain
Bellavance, M.-A., & Rivest, S. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00136 · Cited by 419 · see citing works
Glucocorticoids mediate stress-induced priming of microglial pro-inflammatory responses
Frank, M. G., Thompson, B. M., Watkins, L. R., & Maier, S. F. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.10.005 · Cited by 310 · see citing works
“Of note, CD163 can be upregulated on activated microglia under pathological conditions (Borda et al., 2008; Holfelder et al., 2011) and thus CD163 may not be a suitable marker to differentiate microglia from other CNS macrophages given that the stressor used here activates microglia (Frank et al.,…”
Hypothalamic-pituitary – adrenal axis-feedback control
Keller‐Wood, M. (2015) · Comprehensive Physiology · doi:10.1002/cphy.c140065 · Cited by 131 · see citing works
Dynamic Pituitary-Adrenal Interactions in Response to Cardiac Surgery*
Gibbison, B., Spiga, F., Walker, J. J., Russell, G. M., Stevenson, K., Kershaw, Y., Zhao, Z., Henley, D., Angelini, G. D., & Lightman, S. L. (2015) · Critical Care Medicine · doi:10.1097/ccm.0000000000000773 · Cited by 87 · see citing works
Self-citation
Dynamic output and control of the hypothalamic-pituitary-adrenal axis in critical illness and major surgery
Gibbison, B., Angelini, G. D., & Lightman, S. L. (2013) · British Journal of Anaesthesia · doi:10.1093/bja/aet077 · Cited by 87 · see citing works
Self-citation
Rapid glucocorticoid feedback inhibition of ACTH secretion involves ligand-dependent membrane association of glucocorticoid receptors
Deng, Q., Riquelme, D., Trinh, L., Low, M. J., Tomić, M., Stojilkovic, S., & Aguilera, G. (2015) · Endocrinology · doi:10.1210/en.2015-1265 · Cited by 77 · see citing works
Dynamically changing effects of corticosteroids on human hippocampal and prefrontal processing
Henckens, M. J. A. G., Pu, Z., Hermans, E. J., van Wingen, G. A., Joëls, M., & Fernández, G. (2012) · Human Brain Mapping · doi:10.1002/hbm.21409 · Cited by 80 · see citing works
Greater glucocorticoid receptor activation in hippocampus of aged rats sensitizes microglia
Barrientos, R. M., Thompson, V. M., Kitt, M. M., Amat, J., Hale, M. W., Frank, M. G., Crysdale, N. Y., Stamper, C. E., Hennessey, P. A., Watkins, L. R., et al. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.12.003 · Cited by 70 · see citing works
Impact of Cortisol on Reduction in Muscle Strength and Mass: A Mendelian Randomization Study
Katsuhara, S., Yokomoto-Umakoshi, M., Umakoshi, H., Matsuda, Y., Iwahashi, N., Kaneko, H., Ogata, M., Fukumoto, T., Terada, E., Sakamoto, R., et al. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab862 · Cited by 55 · see citing works
The role of corticosteroid-binding globulin in the evaluation of adrenal insufficiency
Verbeeten, K. C., & Ahmet, A. H. (2018) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem-2017-0270 · Cited by 51 · see citing works

Giucocorticoid-Insensitive Bronchial Asthma
Lee, T. H., & Leung, D. Y. M. (2008) · Blackwell Science Ltd eBooks · doi:10.1002/9780470694923.ch33
[Medicinal activation and inhibition of function of glucocorticoid receptors as the basis for regulation of the glucocorticoid effect].
Pp, G. (1994) · PubMed · Cited by 1 · see citing works
Study on the Relationship Between Sensitivity to Glucocorticoid and Glucocorticoid Receptor Isoform in Patients with Idiopathic Thrombocytopenia Purpura
Zhu, Q. H. (2007) · Chinese Journal of Thrombosis and Hemostasis
Heterogeneity of Binding Sites for Glucocorticoid and the Glucocorticoid-Receptor Complex in Rat Livers
Muramatsu, M., Tanaka, M., Fujita, A., et al. (1984) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.36.87 · Cited by 1 · see citing works
The role of the glucocorticoid receptor and its impact on steroid response in moderate-severe COVID-19 patients
Aliska, G., Nafrialdi, N., Lie, K. C., Setiabudy, R., Putra, A. E., Widyahening, I. S., & Harahap, A. R. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175555 · Cited by 7 · see citing works

Authors: Henley, D. E., & Lightman, S. L.
Affiliations: The University of Western Australia (AU)
University of Bristol (GB)
Corresponding author: Lightman, S.L.
ORCID: Henley, D.E.
Lightman, S.L.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 2011-04
Volume: 180
Pages: 1-8
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/j.neuroscience.2011.02.053
OpenAlex: W1967090449
Cited by: 115
References: 92
Citations by year: 2026: 4 · 2025: 5 · 2024: 4 · 2023: 4 · 2022: 2 · 2021: 7 · 2020: 3 · 2019: 7 · 2018: 8 · 2017: 5 · 2016: 14 · 2015: 9 · 2014: 13 · 2013: 10 · 2012: 15
FWCI: 1.19
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
Explore Bristol Research (publishedVersion)
UWA Profiles and Research Repository (UWA) (submittedVersion)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords: corticosteroid-binding globulin, cortisol, glucocorticoid delivery, hypothalamus, cerebrospinal fluid, glucocorticoid receptor, genetic variants, hypotension
MeSH terms: Animals, Glucocorticoids, Humans, Transcortin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

New insights into corticosteroid-binding globulin and glucocorticoid delivery

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks