TGF-β signaling is required for maintenance of retinal ganglion cell differentiation and survival
Open accessAbstract
Purpose To determine the role of TGF-β1 in the maintenance of retinal ganglion cell line (RGC-5) differentiation and integrity. Methods RGC-5 cells were differentiated in media conditioned by human non-pigmented ciliary epithelial cells (HNPE) for 4 days before treatment with TGF-β1 for 24 h. Cells were examined for morphological changes and harvested for western blot and real-time PCR analysis. For study of apoptosis, differentiated RGC-5 cells were grown in serum-free medium for 24 h in the presence or absence of TGF-β1 and collected for Annexin V/Propidium iodide FACs analysis. The role of MAPK pathways in TGF-β1-dependent signaling was determined by treatment with specific inhibitors of ERK, JNK and p38. Results Differentiation of RGC-5 cells in HNPE-conditioned media (CM) increased the neural cell markers, Brn-3c, NF-160, Thy1.2, Tau and PGP9.5. Treatment with TGF-β1 significantly increased the length of neurites extended by differentiated RGC-5s, concomitant with increased expression of NF-160 and PGP9.5, but not Brn-3c, Thy1.2 or Tau. TGF-β1 also decreased RGC-5 cell apoptosis in serum-free medium. p38 phosphorylation, but not smad2/3, JNK or ERK phosphorylation, was increased in TGF-β1 treated cells. Specific inhibition of p38 signaling reversed TGF-β1 induced neurite growth. Conclusions These findings demonstrate the induction of RGC-5 cell differentiation by HNPE-derived CM and illustrate a role for TGF-β1 in maintaining RGC-5 cell survival and promoting neurite outgrowth through p38 MAPK.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
These growth factors may produce non-canonical signaling outside of the Smad transcription factors, such as through the MAPK pathway.
“These growth factors may produce non-canonical signaling outside of the Smad transcription factors, such as through the MAPK pathway40,41.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [41]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
2 retracted
RETRACTED: Characterization of a transformed rat retinal ganglion cell line
Krishnamoorthy, R. R., Agarwal, P., Prasanna, G., Vopat, K., Lambert, W. S., Sheedlo, H. J., Pang, I., Shade, D. L., Wordinger, R. J., Yorio, T., et al. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00224-2 · Cited by 319 · see citing works
RetractedHong, S., Lee, J. E., Kim, C. Y., & Seong, G. J. (2007) · BMC Neuroscience · doi:10.1186/1471-2202-8-81 · Cited by 73 · see citing works
RetractedSPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS
Feng, X.-H., & Derynck, R. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.022404.142018 · Cited by 1,869 · see citing works
Hirschi, K. K., Rohovsky, S. A., & D'Amore, P. A. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.3.805 · Cited by 796 · see citing works
Self-citationTGF‐β receptor‐activated p38 MAP kinase mediates Smad‐independent TGF‐β responses
Yu, L., DeRouen, M. C., & Zhang, Y. E. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf366 · Cited by 721 · see citing works
Valcourt, U., Kowanetz, M., Niimi, H., Heldin, C., & Moustakas, A. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-08-0658 · Cited by 609 · see citing works
TRAF6 Mediates Smad-Independent Activation of JNK and p38 by TGF-β
Yamashita, M., Fátyol, K., Jin, C., Wang, X., Liu, Z.-G., & Zhang, Y. E. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.09.002 · Cited by 559 · see citing works
Genetic programs of epithelial cell plasticity directed by transforming growth factor-β
Zavadil, J., Bitzer, M., Liang, D., Yang, Y.-C., Massimi, A. B., Kneitz, S., Piek, E., & Böttinger, E. P. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111614398 · Cited by 534 · see citing works
Green, A. J., McQuaid, S., Hauser, S. L., Allen, I. V., & Lyness, R. W. (2010) · Brain · doi:10.1093/brain/awq080 · Cited by 489 · see citing works
Biphasic Effect of Transforming Growth Factor-β1 on in Vitro Angiogenesis
Pepper, M. S., Vassalli, J. D., Orci, L., & Montesano, R. (1993) · Experimental Cell Research · doi:10.1006/excr.1993.1043 · Cited by 329 · see citing works
Loss of TGF-β1 Leads to Increased Neuronal Cell Death and Microgliosis in Mouse Brain
Brionne, T. C., Tesseur, I., Masliah, E., & Wyss-Coray, T. (2003) · Neuron · doi:10.1016/s0896-6273(03)00766-9 · Cited by 325 · see citing works
TGF-β Signaling Specifies Axons during Brain Development
Yi, J. J., Barnes, A. P., Hand, R., Polleux, F., & Ehlers, M. D. (2010) · Cell · doi:10.1016/j.cell.2010.06.010 · Cited by 284 · see citing works
Watanabe, H., de Caestecker, M. P., & Yamada, Y. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m005724200 · Cited by 273 · see citing works
Mechanical Environment of the Optic Nerve Head in Glaucoma
Downs, J. C., Roberts, M. D., & Burgoyne, C. F. (2008) · Optometry and Vision Science · doi:10.1097/opx.0b013e31817841cb · Cited by 252 · see citing works
Horowitz, J. C., Rogers, D. S., Sharma, V., Vittal, R., White, E. S., Cui, Z., & Thannickal, V. J. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2006.10.001 · Cited by 241 · see citing works
Du, J., Bernasconi, P., Clauser, K. R., Mani, D. R., Finn, S. P., Beroukhim, R., Burns, M., Julian, B., Peng, X. P., Hieronymus, H., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt.1513 · Cited by 232 · see citing works
Walshe, T. E., Saint‐Geniez, M., Maharaj, A. S. R., Sekiyama, E., Maldonado, A. E., & D'Amore, P. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005149 · Cited by 207 · see citing works
Self-citationVEGF-dependent tumor angiogenesis requires inverse and reciprocal regulation of VEGFR1 and VEGFR2
Zhang, Z., Neiva, K. G., Lingen, M. W., Ellis, L. M., & Nor, J. E. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.152 · Cited by 197 · see citing works
Recharacterization of the RGC-5 Retinal Ganglion Cell Line
Bergen, N. J. V., Wood, J. P. M., Chidlow, G., Trounce, I. A., Casson, R. J., Ju, W., Weinreb, R. N., & Crowston, J. G. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-3484 · Cited by 187 · see citing works
Yang, W. Z., Chen, Y., Zhang, Y., Wang, X., Yang, N., & Zhu, D. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3060 · Cited by 144 · see citing works
Sigma-1 Receptor Regulation of Voltage-Gated Calcium Channels Involves a Direct Interaction
Tchedre, K. T., Huang, R., Dibas, A., Krishnamoorthy, R. R., Dillon, G. H., & Yorio, T. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-1867 · Cited by 139 · see citing works
Wang, S. W., Mu, X., Bowers, W. J., Kim, D.-S., Plas, D. T., Crair, M. C., Federoff, H. J., Gan, L., & Klein, W. H. (2002) · Development · doi:10.1242/dev.129.2.467 · Cited by 134 · see citing works
Gordon‐Thomson, C., de Iongh, R. U., Hales, A. M., Chamberlain, C. G., & McAvoy, J. W. (1998) · PubMed · Cited by 132 · see citing works
Astrocyte Protection of Neurons
Dhandapani, K. M., Hadman, M., Sevilla, L. M. D., Wade, M. F., Mahesh, V. B., & Brann, D. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305835200 · Cited by 129 · see citing works
Close, J., Gümüşçü, B., & Reh, T. A. (2005) · Development · doi:10.1242/dev.01882 · Cited by 127 · see citing works
Pattern Electroretinogram in Glaucoma Suspects: New Findings from a Longitudinal Study
Bode, S. F. N., Jehle, T., & Bach, M. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-6381 · Cited by 101 · see citing works
Endo, Y., Beauchamp, E. M., Woods, D. M., Taylor, W. G., Toretsky, J. A., Üren, A., & Rubin, J. S. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01780-07 · Cited by 97 · see citing works
Tchedre, K. T., & Yorio, T. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-1101 · Cited by 94 · see citing works
Kinase-Dependent Differentiation of a Retinal Ganglion Cell Precursor
Frassetto, L. J., Schlieve, C. R., Lieven, C. J., Utter, A. A., Jones, M. V., Agarwal, N. A., & Levin, L. A. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-0340 · Cited by 87 · see citing works
Ding, R., Darland, D. C., Parmacek, M. S., & D'Amore, P. A. (2004) · Stem Cells and Development · doi:10.1089/scd.2004.13.509 · Cited by 87 · see citing works
Self-citationp38 MAPK activation by TGF-β1 increases MLC phosphorylation and endothelial monolayer permeability
Goldberg, P. L., MacNaughton, D. E., Clements, R., Minnear, F. L., & Vincent, P. A. (2002) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2002.282.1.l146 · Cited by 80 · see citing works
Calpeptin provides functional neuroprotection to rat retinal ganglion cells following Ca2+ influx
Das, A., Garner, D. P., Re, A. M. D., Woodward, J. J., Kumar, D. M., Agarwal, N. A., Banik, N. L., & Ray, S. K. (2006) · Brain Research · doi:10.1016/j.brainres.2006.02.051 · Cited by 72 · see citing works
A Comparison of Differentiation Protocols for RGC-5 Cells
Wood, J. P. M., Chidlow, G., Tran, T. T. K., Crowston, J. G., & Casson, R. J. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-4305 · Cited by 64 · see citing works
Krishnamoorthy, R. R., Rao, V. R., Dauphin, R., Prasanna, G., Johnson, C. A., & Yorio, T. (2008) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y08-040 · Cited by 63 · see citing works
Endoglin Modulation of TGF-ß1-Induced Collagen Synthesis is Dependent on ERK1/2 MAPK Activation
Rodríguez‐Barbero, A., Obreo, J., Álvarez-Muñoz, P., Pandiella, A., Bernabéu, C., & López-Novoa, J. M. (2006) · Cellular Physiology and Biochemistry · doi:10.1159/000095181 · Cited by 54 · see citing works
Zac1 functions through TGFβIIto negatively regulate cell number in the developing retina
Ma, L., Cantrup, R., Varrault, A., Colak, D., Klenin, N., Götz, M., McFarlane, S., Journot, L., & Schuurmans, C. J. (2007) · Neural Development · doi:10.1186/1749-8104-2-11 · Cited by 47 · see citing works
Induction of axon and dendrite formation during early RGC-5 cell differentiation
Lieven, C. J., Millet, L. E., Hoegger, M. J., & Levin, L. A. (2007) · Experimental Eye Research · doi:10.1016/j.exer.2007.08.001 · Cited by 45 · see citing works
Jurašková, B., Andrýs, C., Holmerová, I., Solichová, D., Hrnčiariková, D., Vaňková, H., Vašátko, T., & Krejsek, J. (2010) · The journal of nutrition health & aging · doi:10.1007/s12603-010-0325-1 · Cited by 44 · see citing works
Undevia, N. S., Dorscheid, D. R., Marroquin, B. A., Gugliotta, W. L., Tse, R., & White, S. R. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00044.2004 · Cited by 44 · see citing works
Bone morphogenetic proteins promote neurite outgrowth in retinal ganglion cells.
Kerrison, J. B., Lewis, R. N., Otteson, D. C., & Zack, D. J. (2005) · PubMed · Cited by 40 · see citing works
High-Content Microscopy Identifies New Neurite Outgrowth Regulators
Laketa, V., Simpson, J. C., Bechtel, S., Wiemann, S., & Pepperkok, R. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-08-0666 · Cited by 39 · see citing works
Modulation of retinal capillary endothelial cells by Müller glial cell-derived factors.
Abukawa, H., Tomi, M., Kiyokawa, J., Hori, S., Kondo, T., Terasaki, T., & Hosoya, K. (2009) · PubMed Central · Cited by 38 · see citing works
Franke, A. G., Gubbe, C., Beier, M., & Dünker, N. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.20869 · Cited by 37 · see citing works
Transforming Growth Factor Beta in Experimentally Detached Retina and Periretinal Membranes
Guérin, C. J., Hu, L., Scicli, G. M., & Scicli, A. G. (2001) · Experimental Eye Research · doi:10.1006/exer.2001.1095 · Cited by 32 · see citing works
Harvey, R., & Chintala, S. K. (2007) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.06-0990 · Cited by 31 · see citing works
Yu, H., Liu, Q., & Gui-nan, L. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.04.115 · Cited by 27 · see citing works
Yamanaka, R. (2002) · Japanese Journal of Ophthalmology · doi:10.1016/s0021-5155(02)00536-1 · Cited by 13 · see citing works
Flagged first, then by citations
1 of the 48 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Tchedre KT Huang RQ Dibas A Krishnamoorthy RR Dillon GH Yorio T 2008b Sigma-1 receptor regulation of voltage-gated calcium channels involves a direct interaction between sigma-1 receptors and the voltage-gated L-type calcium channel Investigative Ophthalmology & Visual Science 18641291
Cited by
Sorted by citations
GDF10 is a signal for axonal sprouting and functional recovery after stroke
Li, S., Nie, E. H., Yin, Y., Benowitz, L. I., Tung, S., Vinters, H. V., Bahjat, F. R., Stenzel-Poore, M. P., Kawaguchi, R., Coppola, G., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4146 · Cited by 181 · see citing works
TGF-β Superfamily Signaling in the Eye: Implications for Ocular Pathologies
Hachana, S., & Larrivée, B. (2022) · Cells · doi:10.3390/cells11152336 · Cited by 104 · see citing works
The Regulatory Effects of Transforming Growth Factor-β on Nerve Regeneration
Li, S., Gu, X., & Yi, S. (2016) · Cell Transplantation · doi:10.3727/096368916x693824 · Cited by 99 · see citing works
Ma, W., Silverman, S. M., Zhao, L., Villasmil, R., Campos, M. M., Amaral, J., & Wong, W. T. (2019) · eLife · doi:10.7554/elife.42049 · Cited by 85 · see citing works
More than meets the eye: The role of microglia in healthy and diseased retina
Murenu, E., Gerhardt, M.-J., Biel, M., & Michalakis, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1006897 · Cited by 73 · see citing works
The Role of Shear-Induced Transforming Growth Factor-β Signaling in the Endothelium
Walshe, T. E., Paz, N. G. D., & D'Amore, P. A. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.302161 · Cited by 72 · see citing works
Self-citationPeriostin promotes the generation of fibrous membranes in proliferative vitreoretinopathy
Ishikawa, K., Yoshida, S., Nakao, S., Nakama, T., Kita, T., Asato, R., Sassa, Y., Arita, R., Miyazaki, M., Enaida, H., et al. (2013) · The FASEB Journal · doi:10.1096/fj.13-229740 · Cited by 67 · see citing works
Assunção-Silva, R. C., Mendes-Pinheiro, B., Patrício, P., Behie, L. A., Teixeira, F. G., Pinto, L., & Salgado, A. J. (2018) · Biochimie · doi:10.1016/j.biochi.2018.07.026 · Cited by 64 · see citing works
Human Organoids for the Study of Retinal Development and Disease
Bell, C. M., Zack, D. J., & Berlinicke, C. A. (2020) · Annual Review of Vision Science · doi:10.1146/annurev-vision-121219-081855 · Cited by 63 · see citing works
The Controversial Role of TGF-β in Neovascular Age-Related Macular Degeneration Pathogenesis
Tosi, G. M., Orlandini, M., & Galvagni, F. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113363 · Cited by 60 · see citing works
Wada, Y., Nakamachi, T., Endo, K., Seki, T., Ohtaki, H., Tsuchikawa, D., Hori, M., Tsuchida, M., Yoshikawa, A., Matkovits, A., et al. (2013) · Journal of Molecular Neuroscience · doi:10.1007/s12031-013-0017-5 · Cited by 57 · see citing works
Present and New Treatment Strategies in the Management of Glaucoma
Kolko, M. (2015) · The Open Ophthalmology Journal · doi:10.2174/1874364101509010089 · Cited by 54 · see citing works
Pleiotropic and retinoprotective functions of PACAP
Shioda, S., Takenoya, F., Wada, N., Hirabayashi, T., Seki, T., & Nakamachi, T. (2016) · Anatomical Science International · doi:10.1007/s12565-016-0351-0 · Cited by 50 · see citing works
The many faces of p38 mitogen-activated protein kinase in progenitor/stem cell differentiation
Oeztuerk-Winder, F., & Ventura, J. (2012) · Biochemical Journal · doi:10.1042/bj20120401 · Cited by 48 · see citing works
Vessoni, A. T., Herai, R. H., Karpiak, J. V., Leal, A. M. D. S., Trujillo, C. A., Quinet, A., Agnez‐Lima, L. F., Menck, C. F. M., & Muotri, A. R. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw008 · Cited by 47 · see citing works
Ye, Z., Wei, J., Zhan, C., & Hou, J. L. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.917587 · Cited by 42 · see citing works
Platania, C. B. M., Fisichella, V., Fidilio, A., Geraci, F., Lazzara, F., Leggio, G. M., Salomone, S., Drago, F., Pignatello, R., Caraci, F., et al. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102076 · Cited by 45 · see citing works
Sippl, C., Bosserhoff, A., Fischer, D., & Tamm, E. R. (2011) · Experimental Eye Research · doi:10.1016/j.exer.2011.08.011 · Cited by 44 · see citing works
Schira‐Heinen, J., Falkenberg, H., Hendricks, M., Waldera-Lupa, D. M., Kögler, G., Meyer, H. E., Müller, H. W., & Stühler, K. (2015) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m115.049312 · Cited by 35 · see citing works
TGF-β Controls miR-181/ERK Regulatory Network during Retinal Axon Specification and Growth
Carrella, S., Barbato, S., D’Agostino, Y., Salierno, F. G., Manfredi, A., Banfi, S., & Conte, I. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144129 · Cited by 35 · see citing works
Vessel Enlargement in Development and Pathophysiology
Gifre-Renom, L., & Jones, E. A. V. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.639645 · Cited by 34 · see citing works
Protective effects of TGF-β inhibitors in a rat model of NMDA-induced retinal degeneration
Ueda, K., Nakahara, T., Mori, A., Sakamoto, K., & Ishii, K. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.11.054 · Cited by 31 · see citing works
CNS repair and axon regeneration: Using genetic variation to determine mechanisms
Tedeschi, A., Omura, T., & Costigan, M. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.05.004 · Cited by 30 · see citing works
Decreased miR-187 induces retinal ganglion cell apoptosis through upregulating SMAD7 in glaucoma
Zhang, Q., Wang, W., Li, J., Shi-yuan, T., & Zhang, T. (2015) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2015.08.028 · Cited by 29 · see citing works
Yu, C., Gui, W., He, H., Wang, X., Zuo, J., Huang, L., Zhou, N., Wang, K., & Wang, Y. (2014) · NeuroMolecular Medicine · doi:10.1007/s12017-014-8293-y · Cited by 26 · see citing works
Carrella, S., D’Agostino, Y., Barbato, S., Huber‐Reggi, S. P., Salierno, F. G., Manfredi, A., Neuhauss, S. C. F., Banfi, S., & Conte, I. (2015) · Developmental Neurobiology · doi:10.1002/dneu.22282 · Cited by 22 · see citing works
Qian, C., Xin, Y., Qi, C., Wang, H. M., Dong, B. C., Zack, D. J., Blackshaw, S., Hattar, S. S., Zhou, F., & Qian, J. X. (2024) · Nature Communications · doi:10.1038/s41467-024-46428-z · Cited by 20 · see citing works
Smad3 deficiency increases cortical and hippocampal neuronal loss following traumatic brain injury
Villapol, S., Wang, Y., Adams, M., & Symes, A. J. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.10.008 · Cited by 22 · see citing works
Zhang, C., Qin, S., Xie, H., Qiu, Q., Wang, H., Zhang, J., Luo, D., & Zhang, J. (2022) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.63.10.14 · Cited by 21 · see citing works
TGFβ Signaling Induces Expression of Gadd45b in Retinal Ganglion Cells
Liu, B., Sun, X., Suyeoka, G. M., Garcia, J. G. N., & Leiderman, Y. I. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-10142 · Cited by 20 · see citing works
Kiwanuka, E., Hackl, F., Caterson, E. J., Nowinski, D. J., Junker, J. P. E., Gerdin, B., & Eriksson, E. K. (2013) · Journal of Surgical Research · doi:10.1016/j.jss.2013.05.065 · Cited by 18 · see citing works
TGF-β1 Regulation of P-JNK and L-Type Calcium Channel Cav1.2 in Cortical Neurons
Liu, Z., Sheng, J., Peng, G., Yang, J., Chen, W., & Li, K. (2018) · Journal of Molecular Neuroscience · doi:10.1007/s12031-018-1033-2 · Cited by 18 · see citing works
Delivering bioactive molecules as instructive cues to engineered tissues
Gabriel, D., Dvir, T., & Kohane, D. S. (2012) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2012.668521 · Cited by 17 · see citing works
Bielmeier, C. B., Schmitt, S. I., Kleefeldt, N., Boneva, S. K., Schlecht, A., Vallon, M., Tamm, E. R., Hillenkamp, J., Ergün, S., Neueder, A., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052626 · Cited by 15 · see citing works
Hagl, C. I., Schäfer, K. ‐., Hellwig, I., Barrenschee, M., Harde, J., Holtmann, M. H., Porschek, S., Egberts, J. D., Becker, T., Wedel, T., et al. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12119 · Cited by 15 · see citing works
Kaiser, J., Maibach, M. A., Piovesana, E., Salpeter, I., Escher, N. A., Ormen, Y., & Schwab, M. E. (2020) · eNeuro · doi:10.1523/eneuro.0104-20.2020 · Cited by 14 · see citing works
Neuron-specific RNA-sequencing reveals different responses in peripheral neurons after nerve injury
Bolívar, S., Sanz, E., Ovelleiro, D., Zochodne, D. W., & Udina, E. (2023) · eLife · doi:10.7554/elife.91316 · Cited by 13 · see citing works
Harel, T., Levy‐Lahad, E., Daana, M., Mechoulam, H., Cederboim, S. H., Gur, M., Meiner, V., & Elpeleg, O. N. (2019) · European Journal of Human Genetics · doi:10.1038/s41431-019-0380-y · Cited by 12 · see citing works
Sanie‐Jahromi, F., Mahmoudi, A., Khalili, M. R., & Nowroozzadeh, M. H. (2022) · Current Eye Research · doi:10.1080/02713683.2022.2103153 · Cited by 12 · see citing works
Cell-Based Therapies for Glaucoma
Luis, J., Eastlake, K., Lamb, W. D. B., Limb, G. A., Jayaram, H., & Khaw, P. T. (2023) · Translational Vision Science & Technology · doi:10.1167/tvst.12.7.23 · Cited by 11 · see citing works
IPP5 inhibits neurite growth in primary sensory neurons by maintaining TGF- /Smad signaling
Han, Q., Gao, N.-N., Guo-QiangMa, Zhang, Z., Yu, W.-H., Pan, J., Wang, Q., Zhang, X., & Bao, L. (2012) · Journal of Cell Science · doi:10.1242/jcs.114280 · Cited by 11 · see citing works
Cabrera‐Maqueda, J. M., Boia, R., Lucas‐Ruiz, F., González‐Riquelme, M. J., Ambrósio, A. F., Santiago, A. R., Vidal‐Sanz, M., Agudo‐Barriuso, M., & Galindo‐Romero, C. (2023) · Experimental Eye Research · doi:10.1016/j.exer.2023.109627 · Cited by 9 · see citing works
Li, Y., Chen, W., Deng, H., Li, T., Liu, Z., Liu, X., Zhang, Z., Chen, X., Sheng, J., & Li, K. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.04.010 · Cited by 9 · see citing works
Gao, N., & Yu, F. X. (2024) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.65.3.35 · Cited by 8 · see citing works
Otic Neurogenesis Is Regulated by TGFβ in a Senescence-Independent Manner
Magariños, M., Barajas-Azpeleta, R., Varela‐Nieto, I., & Aburto, M. R. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00217 · Cited by 7 · see citing works
How scars shape the neural landscape: Key molecular mediators of TGF-β1’s anti-neuritogenic effects
Jeon, K., & Huxlin, K. R. (2020) · PLoS ONE · doi:10.1371/journal.pone.0234950 · Cited by 6 · see citing works
Retinal Ganglion Cell Replacement in Glaucoma Therapy: A Narrative Review
Kosior‐Jarecka, E., & Grzybowski, A. E. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13237204 · Cited by 5 · see citing works
Qi, T., Feng, Y., Kononenko, N. L., Ising, C., van Beers, T., Sesia, T., Cursiefen, C., Prokosch, V., & Liu, H. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251379844 · Cited by 2 · see citing works
Braunger, B. M., Pielmeier, S. M., Demmer, C., Landstorfer, V., Kawall, D., Abramov, N., Leibinger, M., Kleiter, I., Fischer, D., Jägle, H., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0991-13.2013 · Cited by 58 · see citing works
Guo, Q., Yao, Y., Ding, Y., Chen, L., Zhang, Q., Zhang, H., & Xue, J. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1899684 · Cited by 1 · see citing works
Hosen, S., Ikeda-Yorifuji, I., & Yamashita, T. (2024) · Neuroscience Letters · doi:10.1016/j.neulet.2024.137832 · Cited by 1 · see citing works
Chloride channel protein 2 prevents glutamate-induced apoptosis in retinal ganglion cells.
Bi, M., Hong, S., Ma, L.-J., Zhou, H., Lu, J., Zhao, J., & Zheng, Y. (2016) · PubMed Central · Cited by 1 · see citing works
Modelling and treating dysregulated fibrosis in primary open angle glaucoma
Hill, L. J. (2015) · University of Birmingham Institutional Research Archive (University of Birmingham)
Neuron-specific RNA-sequencing reveals different responses in peripheral neurons after nerve injuryPreprint
Bolívar, S., Sanz, E., Ovelleiro, D., Zochodne, D. W., & Udina, E. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.21.549881
Bolívar, S., Sanz, E., Ovelleiro, D., Zochodne, D. W., & Udina, E. (2023) · eLife · doi:10.7554/elife.91316.1
Neuron-specific RNA-sequencing reveals different responses in peripheral neurons after nerve injuryPreprint
Bolívar, S., Sanz, E., Ovelleiro, D., Zochodne, D. W., & Udina, E. (2024) · eLife · doi:10.7554/elife.91316.2
Neuron-specific RNA-sequencing reveals different responses in peripheral neurons after nerve injury
Bolívar, S., Sanz, E., Ovelleiro, D., Zochodne, D. W., & Udina, E. (2024) · eLife · doi:10.7554/elife.91316.3
Shear Stress as a Driver of Retinal Müller Glia Survival and Fibrotic Reprogramming
Prieto-López, L., van Oterendorp, C., Vecino, E., & Pereiro, X. (2026) · Cell Biochemistry and Function · doi:10.1002/cbf.70224
Neuroprotective strategies for retinal disease
Wei, G., PHAM, H., RANDALL-JARRARD, E., Eade, K., & Friedlander, M. (2026) · Handbook of clinical neurology · doi:10.1016/b978-0-443-22212-2.00024-0
- Authors
- Walshe, T. E., Leach, L. L., & D'Amore, P. A.
- Affiliations
- Harvard University (US)
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2011-08
- Volume
- 189
- Pages
- 123-131
- ISSN
- 0306-4522 (ISSN-L)
- PMC
- PMC3150228
- OpenAlex
- W1982118682
- Cited by
- 59
- References
- 48
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 6 · 2023: 5 · 2022: 7 · 2021: 1 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 5 · 2015: 7 · 2014: 1 · 2013: 8 · 2012: 4
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- NIH (EY05318)
- Core grant for Vision Research (P30EY14104)
- Knights Templar Eye Foundation award
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
- Keywords
- TGF-β1 signaling, retinal ganglion cells, RGC-5 cells, neuronal differentiation, cell survival, neurite outgrowth, p38 MAPK, apoptosis, PGP 9.5, MAPK inhibition
- MeSH terms
- Animals, Cell Differentiation, Cell Line, Cell Survival, Cilia, Epithelial Cells, Humans, Retinal Ganglion Cells, Signal Transduction, Biomarkers, Neurites, Culture Media, Conditioned, Apoptosis, MAP Kinase Signaling System, Intracellular Space, Rats, Smad Proteins, Transforming Growth Factor beta1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
