The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Differential effects of acute and regular physical exercise on cognition and affect
Open accessAbstract
The effects of regular exercise versus a single bout of exercise on cognition, anxiety, and mood were systematically examined in healthy, sedentary young adults who were genotyped to determine brain-derived neurotrophic factor (BDNF) allelic status (i.e., Val-Val or Val66Met polymorphism). Participants were evaluated on novel object recognition (NOR) memory and a battery of mental health surveys before and after engaging in either a) a four-week exercise program, with exercise on the final test day, b) a four-week exercise program, without exercise on the final test day, c) a single bout of exercise on the final test day, or d) remaining sedentary between test days. Exercise enhanced object recognition memory and produced a beneficial decrease in perceived stress, but only in participants who exercised for four weeks including the final day of testing. In contrast, a single bout of exercise did not affect recognition memory and resulted in increased perceived stress levels. An additional novel finding was that the improvements on the NOR task were observed exclusively in participants who were homozygous for the BDNF Val allele, indicating that altered activity-dependent release of BDNF in Met allele carriers may attenuate the cognitive benefits of exercise. Importantly, exercise-induced changes in cognition were not correlated with changes in mood/anxiety, suggesting that separate neural systems mediate these effects. These data in humans mirror recent data from our group in rodents. Taken together, these current findings provide new insights into the behavioral and neural mechanisms that mediate the effects of physical exercise on memory and mental health in humans.
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Cites
A Global Measure of Perceived Stress
Cohen, S., Kamarck, T., & Mermelstein, R. (1983) · Journal of Health and Social Behavior · doi:10.2307/2136404 · Cited by 32,807
Egan, M. F., Kojima, M., Callicott, J. H., Goldberg, T. E., Kolachana, B. S., Bertolino, A., Zaitsev, E., Gold, B., Goldman, D., Dean, M., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00035-7 · Cited by 3,888
Running enhances neurogenesis, learning, and long-term potentiation in mice
van Praag, H., Christie, B. R., Sejnowski, T. J., & Gage, F. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13427 · Cited by 2,904
Smith, P. J., Blumenthal, J. A., Hoffman, B. M., Cooper, H., Strauman, T. A., Welsh-Bohmer, K., Browndyke, J. N., & Sherwood, A. (2010) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181d14633 · Cited by 1,714
An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus
Pereira, A. C., Huddleston, D. E., Brickman, A. M., Sosunov, A. A., Hen, R., McKhann, G. M., Sloan, R., Gage, F. H., Brown, T. R., & Small, S. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611721104 · Cited by 1,353
Effects of exercise training on older patients with major depression
Blumenthal, J. A., Babyak, M. A., Moore, K. A., Craighead, W. E., Herman, S., Khatri, P., Waugh, R., Napolitano, M. A., Forman, L. M., Appelbaum, M., et al. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.19.2349 · Cited by 1,277 · cited 3×
“While some studies have shown higher prevalence of depression (Blumenthal et al., 1999) and anxiety (Jiang et al., 2005; Montag et al., 2010) in Met carriers, others do not (Hashimoto et al., 2004; Lang et al., 2005; Frustaci et al., 2008; Duncan et al., 2009).”
Angevaren, M., Aufdemkampe, G., Verhaar, H., Aleman, A., & Vanhees, L. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005381.pub3 · Cited by 1,130
Exercise and Pharmacotherapy in the Treatment of Major Depressive Disorder
Blumenthal, J. A., Babyak, M. A., Doraiswamy, P. M., Watkins, L., Hoffman, B. M., Barbour, K. A., Herman, S., Craighead, W. E., Brosse, A. L., Waugh, R., et al. (2007) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318148c19a · Cited by 1,019
Lawlor, D. A., & Hopker, S. W. (2001) · BMJ · doi:10.1136/bmj.322.7289.763 · Cited by 995 · cited 1×
“Moreover, the literature is primarily comprised of retrospective rather than prospective studies (Lawlor and Hopker, 2001; Smith et al., 2010).”
BackgroundDavis, C. L., Tomporowski, P. D., McDowell, J. E., Austin, B. P., Miller, P. H., Yanasak, N. E., Allison, J. D., & Naglieri, J. A. (2011) · Health Psychology · doi:10.1037/a0021766 · Cited by 911
Cited by
The Effects of Stress on Physical Activity and Exercise
Stults-Kolehmainen, M. A., & Sinha, R. (2014) · Sports Medicine · doi:10.1007/s40279-013-0090-5 · Cited by 1,192
Basso, J. C., & Suzuki, W. A. (2016) · Brain Plasticity · doi:10.3233/bpl-160040 · Cited by 911
The effects of cardiovascular exercise on human memory: a review with meta-analysis
Roig, M., Nordbrandt, S., Geertsen, S. S., & Nielsen, J. B. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.06.012 · Cited by 460
Impact of Physical Exercise on Substance Use Disorders: A Meta-Analysis
Wang, D., Wang, Y., Wang, Y., Li, R., & Zhou, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110728 · Cited by 340
Acute exercise improves motor memory: exploring potential biomarkers.
Skriver, K., Roig, M., Lundbye-Jensen, J., Pingel, J., Helge, J. W., Kiens, B., & Nielsen, J. B. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.08.004 · Cited by 326
Metadata
- Authors
- Hopkins, M. E., Davis, F. C., VanTieghem, M. R., Whalen, P. J., & Bucci, D. J.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2012-07
- Volume
- 215
- Pages
- 59-68
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2015780512
- Cited by
- 218
- References
- 19
- FWCI
- 9.43
- Type
- journal article
- Language
- en
- Open access
- green
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