The DOI matches its Crossref record; 156 of the 156 references it cites were found in a registry or an index.
DNA methylation and childhood maltreatment: From animal models to human studies
Open accessAbstract
Childhood maltreatment (CM) has estimated prevalence among Western societies between 10% and 15%. As CM associates with increased risk of several psychiatric disorders, early age of illness onset, increased comorbidity and negative clinical outcome, it imposes a major public health, social and economic impact. Although the clinical consequences of CM are well characterized, a major challenge remains to understand how negative early-life events can affect brain function over extended periods of time. We review here both animal and human studies indicating that the epigenetic mechanism of DNA methylation is a crucial mediator of early-life experiences, thereby maintaining life-long neurobiological sequelae of CM, and strongly determining psychopathological risk.
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“Both DNA methylation and demethylation mechanisms are likely recruited during early life unfavorable experiences [136].”
From Food Addiction and Psychosocial Adversity: Biological Embedding, Contextual Factors, and Public Health Implications (2020) · cites this paper as [136]
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Metadata
- Authors
- Lutz, P.-E., & Turecki, G.
- Affiliations
- Douglas Mental Health University Institute (CA)
- Corresponding author
- Turecki, G.
- ORCID
- Turecki, G.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2014-04
- Volume
- 264
- Pages
- 142-156
- ISSN
- 0306-4522 (ISSN-L)
- PMC
- PMC5293537
- OpenAlex
- W2014566312
- Cited by
- 236
- References
- 155
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 3 · 2023: 27 · 2022: 10 · 2021: 34 · 2020: 28 · 2019: 12 · 2018: 31 · 2017: 24 · 2016: 24 · 2015: 17 · 2014: 19
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion, other-oa)
- eScholarship@McGill (McGill) (submittedVersion)
- Funders
- Canadian Institutes of Health Research (119429_1)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Social Sciences › Sociology and Political Science › Child Welfare and Adoption
- Keywords
- DNA methylation, child abuse, epigenetics, childhood adversity, mental illness, animal models, psychopathological risk, comorbidities, age of onset
- MeSH terms
- Animals, Mental Disorders, Brain, Child, Child Abuse, Female, Humans, Male, Stress, Psychological, Age of Onset, DNA Methylation, Models, Animal, Epigenesis, Genetic, Mice, Rats
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