Cited by 236Child Abuse and TraumaEpigenetics and DNA MethylationChild Welfare and Adoption

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DNA methylation and childhood maltreatment: From animal models to human studies

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Lutz, P.-E., Turecki, G.·2014·Neuroscience

DOI 10.1016/j.neuroscience.2013.07.069PMC PMC5293537

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Abstract

Childhood maltreatment (CM) has estimated prevalence among Western societies between 10% and 15%. As CM associates with increased risk of several psychiatric disorders, early age of illness onset, increased comorbidity and negative clinical outcome, it imposes a major public health, social and economic impact. Although the clinical consequences of CM are well characterized, a major challenge remains to understand how negative early-life events can affect brain function over extended periods of time. We review here both animal and human studies indicating that the epigenetic mechanism of DNA methylation is a crucial mediator of early-life experiences, thereby maintaining life-long neurobiological sequelae of CM, and strongly determining psychopathological risk.

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See all 236

Authors: Lutz, P.-E., & Turecki, G.
Affiliations: Douglas Mental Health University Institute (CA)
Corresponding author: Turecki, G.
ORCID: Turecki, G.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 2014-04
Volume: 264
Pages: 142-156
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/j.neuroscience.2013.07.069
PMC: PMC5293537
OpenAlex: W2014566312
Cited by: 236
References: 155
Citations by year: 2026: 2 · 2025: 5 · 2024: 3 · 2023: 27 · 2022: 10 · 2021: 34 · 2020: 28 · 2019: 12 · 2018: 31 · 2017: 24 · 2016: 24 · 2015: 17 · 2014: 19
FWCI: 2.92
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
HAL (submittedVersion, other-oa)
eScholarship@McGill (McGill) (submittedVersion)
Funders: Canadian Institutes of Health Research (119429_1)
Topics: Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Social Sciences › Sociology and Political Science › Child Welfare and Adoption
Keywords: DNA methylation, child abuse, epigenetics, childhood adversity, mental illness, animal models, psychopathological risk, comorbidities, age of onset
MeSH terms: Animals, Mental Disorders, Brain, Child, Child Abuse, Female, Humans, Male, Stress, Psychological, Age of Onset, DNA Methylation, Models, Animal, Epigenesis, Genetic, Mice, Rats

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DNA methylation and childhood maltreatment: From animal models to human studies

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