The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Mechanisms regulating the development of oligodendrocytes and central nervous system myelin
Open accessAbstract
Oligodendrocytes and the myelin they produce are a remarkable vertebrate specialization that enables rapid and efficient nerve conduction within the central nervous system. The generation of myelin during development involves a finely-tuned pathway of oligodendrocyte precursor specification, proliferation and migration followed by differentiation and the subsequent myelination of appropriate axons. In this review we summarize the molecular mechanisms known to regulate each of these processes, including the extracellular ligands that promote or inhibit development of the oligodendrocyte lineage, the intracellular pathways they signal through and the key transcription factors that mediate their effects. Many of these regulatory mechanisms have recurring roles in regulating several transitions during oligodendrocyte development, highlighting their importance. It is also highly likely that many of these developmental mechanisms will also be involved in myelin repair in human neurological disease.
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Self-citationGlycolytic oligodendrocytes maintain myelin and long-term axonal integrity
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Cell death and control of cell survival in the oligodendrocyte lineage
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The bHLH Transcription Factors OLIG2 and OLIG1 Couple Neuronal and Glial Subtype Specification
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“The importance of OLIG2 function in the specification of the oligodendrocyte lineage is well-established; Olig2 gene knockouts fail to produce OPCs within most regions of the CNS (Lu et al., 2002; Zhou and Anderson, 2002; Ligon et al., 2006), and inducible expression of Olig2 in Nestin-positive progenitor cells result…”
BackgroundInfluentialA critical period for social experience-dependent oligodendrocyte maturation and myelination
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Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling
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“In both humans and mice, however, there is increasing evidence that myelination occurs throughout life, either to replace lost oligodendrocytes and myelin or to myelinate previously unmyelinated axons (Bartzokis et al., 2012; Young et al., 2013).”
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Cited by
Myelination of the Nervous System: Mechanisms and Functions
Nave, K.-A., & Werner, H. B. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100913-013101 · Cited by 983
Altering the course of schizophrenia: progress and perspectives
Millan, M. J., Andrieux, A., Bartzokis, G., Cadenhead, K., Dazzan, P., Fusar-Poli, P., Gallinat, J., Giedd, J., Grayson, D. R., Heinrichs, M., et al. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.28 · Cited by 516
Oligodendrocyte, Astrocyte, and Microglia Crosstalk in Myelin Development, Damage, and Repair
Domingues, H. S., Portugal, C. C., Socodato, R., & Relvas, J. B. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00071 · Cited by 432
van der Knaap, M. S., & Bugiani, M. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1739-1 · Cited by 403
Dynamics and Mechanisms of CNS Myelination
Bercury, K. K., & Macklin, W. B. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.01.016 · Cited by 320
Metadata
- Authors
- Mitew, S., Hay, C. M., Peckham, H., Xiao, J., Koenning, M., & Emery, B.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 276
- Pages
- 29-47
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2008184458
- Cited by
- 251
- References
- 26
- FWCI
- 8.33
- Type
- journal article
- Language
- en
- Open access
- green
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- Mitew, S., Hay, C. M., Peckham, H., Xiao, J., Koenning, M., & Emery, B. (2014). Mechanisms regulating the development of oligodendrocytes and central nervous system myelin. Neuroscience. https://doi.org/10.1016/j.neuroscience.2013.11.029
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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