Cited by 320Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research StudiesNeonatal and fetal brain pathology

Dynamics and Mechanisms of CNS Myelination

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Bercury, Kathryn K., Macklin, Wendy B.·2015·Developmental Cell

Abstract

Vertebrate myelination is an evolutionary advancement essential for motor, sensory, and higher-order cognitive function. CNS myelin, a multilamellar differentiation of the oligodendrocyte plasma membrane, ensheaths axons to facilitate electrical conduction. Myelination is one of the most pivotal cell-cell interactions for normal brain development, involving extensive information exchange between differentiating oligodendrocytes and axons. The molecular mechanisms of myelination are discussed, along with new perspectives on oligodendrocyte plasticity and myelin remodeling of the developing and adult CNS.

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Crossref · 10.1016/j.devcel.2015.01.016

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Authors
Bercury, K. K., & Macklin, W. B.
Affiliations
University of Colorado Anschutz (US)
Corresponding author
Macklin, Wendy B.
Venue
Developmental Cell
Publisher
Elsevier BV
Published
2015-02
Volume
32
Issue
4
Pages
447-458
ISSN
1534-5807 (ISSN-L)
OpenAlex
W1992657248
Cited by
320
References
121
Citations by year
2026: 26 · 2025: 26 · 2024: 23 · 2023: 18 · 2022: 37 · 2021: 28 · 2020: 30 · 2019: 34 · 2018: 31 · 2017: 29 · 2016: 26 · 2015: 11
FWCI
4.03
Type
journal article
Language
en
Open access
Locations
  • Developmental Cell (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Neurological Disorders and Stroke (R01NS056417, R01NS082203, NS 082203)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
Keywords
CNS myelination, oligodendrocytes, myelin, myelin remodeling, brain development, vertebrate evolution
MeSH terms
Animals, Axons, Brain, Cell Differentiation, Humans, Myelin Sheath, Neurons, Oligodendroglia

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