Dynamics and Mechanisms of CNS Myelination
Open accessAbstract
Vertebrate myelination is an evolutionary advancement essential for motor, sensory, and higher-order cognitive function. CNS myelin, a multilamellar differentiation of the oligodendrocyte plasma membrane, ensheaths axons to facilitate electrical conduction. Myelination is one of the most pivotal cell-cell interactions for normal brain development, involving extensive information exchange between differentiating oligodendrocytes and axons. The molecular mechanisms of myelination are discussed, along with new perspectives on oligodendrocyte plasticity and myelin remodeling of the developing and adult CNS.
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Oligodendrocytes modulate and consolidate neural circuit refinement.
“Oligodendrocytes modulate and consolidate neural circuit refinement, and abnormal maturation of oligodendrocytes may be linked to long-lasting changes in neural wiring and brain function (38).”
From In vivo Perturb-Seq reveals neuronal and glial abnormalities associated with autism risk genes (2020) · cites this paper as [38]
Abnormal maturation of oligodendrocytes may be linked to long-lasting changes in neural wiring and brain function.
“Oligodendrocytes modulate and consolidate neural circuit refinement, and abnormal maturation of oligodendrocytes may be linked to long-lasting changes in neural wiring and brain function (38).”
From In vivo Perturb-Seq reveals neuronal and glial abnormalities associated with autism risk genes (2020) · cites this paper as [38]
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Oligodendrocytes in development, myelin generation and beyond
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- Authors
- Bercury, K. K., & Macklin, W. B.
- Affiliations
- University of Colorado Anschutz (US)
- Corresponding author
- Macklin, Wendy B.
- ORCID
- Macklin, Wendy B.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 32
- Issue
- 4
- Pages
- 447-458
- ISSN
- 1534-5807 (ISSN-L)
- PMC
- PMC6715306
- OpenAlex
- W1992657248
- Cited by
- 320
- References
- 121
- Citations by year
- 2026: 26 · 2025: 26 · 2024: 23 · 2023: 18 · 2022: 37 · 2021: 28 · 2020: 30 · 2019: 34 · 2018: 31 · 2017: 29 · 2016: 26 · 2015: 11
- FWCI
- 4.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Developmental Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS056417, R01NS082203, NS 082203)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Keywords
- CNS myelination, oligodendrocytes, myelin, myelin remodeling, brain development, vertebrate evolution
- MeSH terms
- Animals, Axons, Brain, Cell Differentiation, Humans, Myelin Sheath, Neurons, Oligodendroglia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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