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Neural HO-1/sterol interactions in vivo: Implications for Alzheimer’s disease

Hascalovici, J.R., Song, W., Liberman, A., Vaya, J., Khatib, S., Holcroft, C., Laferla, F., Schipper, H.M.·2014·Neuroscience
DOI 10.1016/j.neuroscience.2014.09.001
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Abstract

Background Up-regulation of heme oxygenase-1 (HO-1) and altered cholesterol (CH) metabolism are characteristic of Alzheimer-diseased (AD) neural tissues. We previously provided evidence of significant HO-1/sterol interactions in vitro (cultured rat astroglia) and in post-mortem human AD brain (Religious Orders Study). Methods The current experiments were designed to further delineate these interactions in vivo by comparing the behavior of HO-1/sterol interactions in two mouse models; (1) a novel HO-1 transgenic mouse (GFAP.HMOX1) engineered to selectively express human HO-1 in the astrocytic compartment and (2) the previously described triple transgenic AD mouse (3xTg-AD). In samples of frontal cortex, total CH, CH precursors and relevant oxysterols were quantified by gas chromatography-mass spectrometry (GC-MS) and HO-1 protein expression was assessed by ELISA. The relationships of HO-1 expression to total CH, CH precursors and total oxysterols were determined for both mouse models using linear regression analysis. Results HO-1 expression is increased in GFAP.HMOX1 mice relative to wild type and in 11-12-month-old 3xTg-AD mice (with AD-like phenotype) relative to control mice and 5-6-month-old 3xTg-AD mice (no AD-like phenotype). Total oxysterols significantly decreased as HO-1 expression increased in GFAP.HMOX1 mice expressing high levels of HO-1, whereas total oxysterols increased as HO-1 expression increased in aged 3xTg-AD mice. Total CH and total CH precursors increased…

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Metadata

Authors
Hascalovici, J. R., Song, W., Liberman, A., Vaya, J., Khatib, S., Holcroft, C., Laferla, F., & Schipper, H. M.
Venue
Neuroscience
Publisher
Elsevier BV
Published
2014-11
Volume
280
Pages
40-49
ISSN
0306-4522
DOI
10.1016/j.neuroscience.2014.09.001
Cited by
16
References
2
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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