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Cited by 271

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Oxysterols and neurodegenerative diseases

Björkhem, Ingemar, Cedazo-Minguez, Angel, Leoni, Valerio, Meaney, Steve·2009·Molecular Aspects of Medicine
DOI 10.1016/j.mam.2009.02.001
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Abstract

In contrast to their parent molecule cholesterol, two of its side-chain oxidized metabolites are able to cross the blood-brain barrier. There is a concentration-driven flux of 24S-hydroxycholesterol (24S-OHC) from the brain into the circulation, which is of major importance for elimination of excess cholesterol from the brain. The opposite flux of 27-hydroxycholesterol (27-OHC) from the circulation into the brain may regulate a number of key enzymes within the brain. In vitro experiments suggest that the balance between the levels of these two molecules may be of importance for the generation of beta-amyloid peptides. In primary cultures of rat hippocampal cells 27-OHC is able to suppress expression of the activity regulated cytoskeleton-associated protein (Arc), a protein important in memory consolidation which is reduced in patients with Alzheimer's disease (AD). In the present work we explore the possibility that the flux of 27-OHC from the circulation into the brain represents the missing link between AD and hypercholesterolemia, and discuss the possibility that modification of this flux may be a therapeutic strategy. Lastly, we discuss the use of oxysterols as diagnostic markers in neurodegenerative disease.

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Crossref · 10.1016/j.mam.2009.02.001

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4 of 4 references verified0 citation errors · 0 not checkable

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  • Cholesterol oxidation products (oxysterols) that accumulate in the brain are key actors in Alzheimer's disease pathogenesis because they lead to neuron dysfunction and degeneration, mainly by enhancing oxidative stress and inflammation.

    “For instance, cholesterol oxidation products (i.e., oxysterols) that accumulate in the brain are key actors in AD pathogenesis because they lead to neuron dysfunction and degeneration, mainly by enhancing oxidative stress and inflammation [11,14].”

    From ApoE3 vs. ApoE4 Astrocytes: A Detailed Analysis Provides New Insights into Differences in Cholesterol Homeostasis (2022) · cites this paper as [14]

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Metadata

Authors
Björkhem, I., Cedazo-Minguez, A., Leoni, V., & Meaney, S.
Venue
Molecular Aspects of Medicine
Publisher
Elsevier BV
Published
2009-06
Volume
30
Issue
3
Pages
171-179
ISSN
0098-2997
DOI
10.1016/j.mam.2009.02.001
Cited by
271
References
4
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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