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Beyond neurovascular coupling, role of astrocytes in the regulation of vascular tone

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Filosa, J.A., Morrison, H.W., Iddings, J.A., Du, W., Kim, K.J.·2016·Neuroscience
DOI 10.1016/j.neuroscience.2015.03.064PMC PMC4592693
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Abstract

The brain possesses two intricate mechanisms that fulfill its continuous metabolic needs: cerebral autoregulation, which ensures constant cerebral blood flow over a wide range of arterial pressures and functional hyperemia, which ensures rapid delivery of oxygen and glucose to active neurons. Over the past decade, a number of important studies have identified astrocytes as key intermediaries in neurovascular coupling (NVC), the mechanism by which active neurons signal blood vessels to change their diameter. Activity-dependent increases in astrocytic Ca(2+) activity are thought to contribute to the release of vasoactive substances that facilitate arteriole vasodilation. A number of vasoactive signals have been identified and their role on vessel caliber assessed both in vitro and in vivo. In this review, we discuss mechanisms implicating astrocytes in NVC-mediated vascular responses, limitations encountered as a result of the challenges in maintaining all the constituents of the neurovascular unit intact and deliberate current controversial findings disputing a main role for astrocytes in NVC. Finally, we briefly discuss the potential role of pericytes and microglia in NVC-mediated processes.

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  • Under prolonged stress it can result in chronical inflammation.

    “under prolonged stress it can result in chronical inflammation [20, 36, 105, 109].”

    From Gliovascular alterations in sporadic and familial Alzheimer's disease: <scp><i>APOE3</i></scp> Christchurch homozygote glioprotection (2023) · cites this paper as [20]

    The Introduction section ‘Are microglia cells also components of the NVC response?’ discusses inflammatory responses to LPS and microglia–astrocyte signaling, but does not say that prolonged stress results in chronic inflammation. Searches for ‘prolonged stress chronic inflammation’ and ‘chronic inflammation stress’ found no passage making that connection; page numbers were unavailable in our copy. (LLM, conf=0.74)

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Cited by

Sorted by citations

Authors
Filosa, J. A., Morrison, H. W., Iddings, J. A., Du, W., & Kim, K. J.
Affiliations
  • Augusta University (US)
  • University of Arizona (US)
ORCID
Venue
Neuroscience
Publisher
Elsevier BV
Published
2016-05
Volume
323
Pages
96-109
ISSN
0306-4522 (ISSN-L)
DOI
10.1016/j.neuroscience.2015.03.064
PMC
PMC4592693
OpenAlex
W2063703188
Cited by
222
References
14
Citations by year
2026: 15 · 2025: 15 · 2024: 25 · 2023: 13 · 2022: 19 · 2021: 34 · 2020: 17 · 2019: 13 · 2018: 17 · 2017: 16 · 2016: 32 · 2015: 5 · 2014: 1
FWCI
1.86
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Heart, Lung, and Blood Institute (R01 HL089067-02)
  • American Heart Association (11PRE7400037)
  • NINR (F32 NR013611)
Topics
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords
astrocytes, neurovascular coupling, cerebrovascular tone, cerebral autoregulation, functional hyperemia, astrocyte calcium signaling, vasoactive substances, neurovascular unit, pericytes, microglia
MeSH terms
Neurovascular Coupling, Animals, Astrocytes, Vasoconstriction, Vasodilation, Microglia, Calcium Signaling, Pericytes

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