Early prenatal exposure to LPS results in anxiety- and depression-related behaviors in adulthood
Open accessAbstract
Maternal immune activation can result in different behavioral abnormalities and brain dysfunction, depending on the nature of the inflammogen and the timing of the challenge. Few studies report the possible link between prenatal exposure to inflammation and mood disorders. Here we aimed to evaluate the effects of a single low lipopolysaccharide (LPS) injection to the dam at gestational day 9 on the offspring behavior and hippocampal function. We found that mice exposed to LPS show anxiety- and depression-related behaviors. Specifically, we found that animals prenatally exposed to LPS avoided the open arms of an elevated plus maze, the center of an open field and the lit side of a light/dark box, and they spent more time immobile in both the forced swimming and tail suspension tests, when compared with offspring of saline-injected dams. In addition, LPS mice had reduced serotonin and noradrenaline levels in the hippocampus and diminished Reelin immunoreactivity in the dentate gyrus, while their adult hippocampal neurogenesis was not affected. Results presented here support specific long-term effects of the response to a bacterial immunogen early in pregnancy, as opposed to different effects previously reported of viral immunogens and/or responses in late pregnancy. Our work adds to recent reports and stresses the relevance of considering prenatal exposure to a maternal immune response as a risk factor for mood disorders.
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In murine models, LPS and poly(I:C) exposure decreased 5-HT levels in hippocampus.
“In murine models, exposure to LPS (Depino, 2015) and poly(I:C) (Winter et al., 2009) decreased 5-HT levels in the hippocampus.”
From Neuroinflammation as a risk factor for attention deficit hyperactivity disorder (2019) · cites this paper as Depino, 2015
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- Authors
- Depino, A. M.
- Affiliations
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Corresponding author
- Depino, A.M.
- ORCID
- Depino, A.M.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 299
- Pages
- 56-65
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2003085573
- Cited by
- 132
- References
- 53
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 15 · 2023: 10 · 2022: 21 · 2021: 11 · 2020: 12 · 2019: 11 · 2018: 14 · 2017: 13 · 2016: 9 · 2015: 6
- FWCI
- 4.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Conicet (submittedVersion, cc-by-nc-sa)
- Funders
- CONICET (PIP2010-2012)
- UBACyT (GEF2010-2012)
- ANPCyT (PICT2010-1334)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Keywords
- maternal immune activation, lipopolysaccharide, prenatal inflammation, anxiety, depression, mood disorders, hippocampus, serotonin, norepinephrine, reelin, dentate gyrus, hippocampal neurogenesis, offspring behavior, elevated plus maze, forced swim test, tail suspension test, light/dark test
- MeSH terms
- Reelin Protein, Animals, Anxiety, Depression, Female, Hippocampus, Inflammation, Lipopolysaccharides, Male, Mice, Inbred C57BL, Motor Activity, Nerve Tissue Proteins, Norepinephrine, Pregnancy, Prenatal Exposure Delayed Effects, Serine Endopeptidases, Serotonin, Cell Adhesion Molecules, Neuronal, Extracellular Matrix Proteins, Mice
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