Reelin, Disabled 1, and β 1 integrins are required for the formation of the radial glial scaffold in the hippocampus
Open accessAbstract
The extracellular matrix molecule Reelin is required for the correct positioning of neurons during the development of the forebrain. However, the mechanism of Reelin action on neuronal migration is poorly understood. Reelin is assumed to act on neurons directly, but it may also affect the differentiation of glial cells necessary for neuronal migration. Here we show that a regular glial scaffold fails to form in vivo in the dentate gyrus of mice deficient of Reelin or Disabled 1, a neuronal adaptor protein in the Reelin signaling pathway. A subset of these defects is observed in mice that lack β 1 -class integrins, known to bind Reelin. Moreover, recombinant Reelin induced branching of glial processes in vitro . Our data suggest that Reelin affects glial differentiation via Disabled 1 and β 1 -class integrin-dependent signaling pathways.
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Reelin regulates neuronal lamination during embryonic development and supports neuronal migration and synaptic plasticity throughout life.
“As a serine protease of the extracellular matrix, Reelin regulates proper lamination of neurons during embryonic development and helps in migration of neurons and maintenance of synaptic plasticity throughout life [135–137].”
From Consensus Paper: Pathological Role of the Cerebellum in Autism (2012) · cites this paper as [137]
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- Authors
- Förster, E., Tielsch, A., Saum, B., Weiss, K. H., Johanssen, C., Graus-Porta, D., Müller, U., & Frotscher, M.
- Affiliations
- University of Freiburg (DE)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2002-09-20
- Volume
- 99
- Issue
- 20
- Pages
- 13178-13183
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC130606
- OpenAlex
- W1978473562
- Cited by
- 254
- References
- 49
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 5 · 2020: 8 · 2019: 5 · 2018: 11 · 2017: 12 · 2016: 8 · 2015: 5 · 2014: 11 · 2013: 17 · 2012: 14
- FWCI
- 4.27
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Funders
- European Commission
- Deutsche Forschungsgemeinschaft (SFB 505)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- reelin, Disabled-1, beta1 integrin, hippocampus, dentate gyrus, neuronal migration, glial differentiation, extracellular matrix, Reelin signaling, forebrain development
- MeSH terms
- Reelin Protein, Animals, Animals, Newborn, Cell Line, Glial Fibrillary Acidic Protein, Golgi Apparatus, Hippocampus, Humans, Mutation, Nerve Tissue Proteins, Neuroglia, RNA, Messenger, Serine Endopeptidases, Signal Transduction, Cell Adhesion Molecules, Neuronal, Extracellular Matrix Proteins, Prosencephalon, In Situ Hybridization, DNA, Complementary, Integrin beta1, Mice
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