Differential distribution and activation of microglia in the brain of male C57BL/6J mice

The Mouse Brain in Stereotaxic Coordinates

Paxinos, G. (2001) · Cited by 12,859 · see citing works

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827 · see citing works

Microglia: a sensor for pathological events in the CNS

Kreutzberg, G. W. (1996) · Trends in Neurosciences · doi:10.1016/0166-2236(96)10049-7 · Cited by 4,396 · see citing works

Microglia: Active sensor and versatile effector cells in the normal and pathologic brain

Hanisch, U.-K., & Kettenmann, H. (2007) · Nature Neuroscience · doi:10.1038/nn1997 · Cited by 3,676 · see citing works

Physiology of Microglia

Kettenmann, H., Hanisch, U.-K., Noda, M., & Verkhratsky, A. (2011) · Physiological Reviews · doi:10.1152/physrev.00011.2010 · Cited by 3,547 · see citing works

Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator

West, M. J., Slomianka, L., & Gundersen, H. J. G. (1991) · The Anatomical Record · doi:10.1002/ar.1092310411 · Cited by 2,994 · see citing works

Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration

Qin, L., Wu, X., Block, M. L., Liu, Y., Breese, G. R., Hong, J., Knapp, D. J., & Crews, F. T. (2007) · Glia · doi:10.1002/glia.20467 · Cited by 2,144 · see citing works

Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain

Lawson, L. J., Perry, V. H., Dri, P., & Gordon, S. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90229-w · Cited by 2,045 · see citing works

Microglial physiology: unique stimuli, specialized responses

Ransohoff, R. M., & Perry, V. H. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132528 · Cited by 1,858 · see citing works

Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism

Block, M. L., & Hong, J.-S. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.06.004 · Cited by 1,557 · see citing works

Debris clearance by microglia: an essential link between degeneration and regeneration

Neumann, H., Kotter, M. R., & Franklin, R. J. M. (2008) · Brain · doi:10.1093/brain/awn109 · Cited by 1,111 · see citing works

Microglia and neuroinflammation: a pathological perspective

Streit (2004) · Journal of Neuroinflammation · doi:10.1186/1742-2094-1-14 · Cited by 1,039 · see citing works

Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia

Asahi, M., Wang, X., Mori, T., Sumii, T., Jung, J.-C., Moskowitz, M. A., Fini, M. E., & Lo, E. H. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-19-07724.2001 · Cited by 1,004 · see citing works

Regional Difference in Susceptibility to Lipopolysaccharide-Induced Neurotoxicity in the Rat Brain: Role of Microglia

Kim, W., Mohney, R. P., Wilson, B. C., Jeohn, G., Liu, B., & Hong, J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-16-06309.2000 · Cited by 881 · see citing works

Microglial activation and dopamine terminal loss in early Parkinson's disease

Ouchi, Y., Yoshikawa, E., Sekine, Y., Futatsubashi, M., Kanno, T., Ogusu, T., & Torizuka, T. (2005) · Annals of Neurology · doi:10.1002/ana.20338 · Cited by 846 · see citing works

The role of microglia and macrophages in the pathophysiology of the CNS

Stollg, G., & Jander, S. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00083-5 · Cited by 683 · see citing works

Cerebral Microglia Recruit Monocytes into the Brain in Response to Tumor Necrosis Factorα Signaling during Peripheral Organ Inflammation

D'Mello, C., Le, T., & Swain, M. G. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3567-08.2009 · Cited by 675 · see citing works

Microglia in health and disease

Kim, S. U., & de Vellis, J. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20562 · Cited by 663 · see citing works

Dynamics of microglial activation: A confocal time-lapse analysis in hippocampal slices

Stence, N., Waite, M., & Dailey, M. E. (2001) · Glia · doi:10.1002/1098-1136(200103)33:3 · Cited by 617 · see citing works

Activated Macrophages and Microglia Induce Dopaminergic Sprouting in the Injured Striatum and Express Brain-Derived Neurotrophic Factor and Glial Cell Line-Derived Neurotrophic Factor

Batchelor, P., Liberatore, G. T., Wong, J. Y. F., Porritt, M. J., Frerichs, F., Donnan, G. A., & Howells, D. W. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-05-01708.1999 · Cited by 576 · see citing works

NADPH Oxidase Mediates Lipopolysaccharide-induced Neurotoxicity and Proinflammatory Gene Expression in Activated Microglia

Qin, L., Liu, Y., Wang, T., Wei, S.-J., Block, M. L., Wilson, B., Liu, B., & Hong, J.-S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m307657200 · Cited by 574 · see citing works

Microglial control of neuronal death and synaptic properties

Bessis, A., Béchade, C., Bernard, D., & Roumier, A. (2006) · Glia · doi:10.1002/glia.20459 · Cited by 454 · see citing works

Neuroinflammation and Oxidation/Nitration of α-Synuclein Linked to Dopaminergic Neurodegeneration

Gao, H., Kotzbauer, P. T., Uryu, K., Leight, S., Trojanowski, J. Q., & Lee, V. M. ‐. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0143-07.2008 · Cited by 435 · see citing works

Toll-Like Receptor 4 on Nonhematopoietic Cells Sustains CNS Inflammation during Endotoxemia, Independent of Systemic Cytokines

Chakravarty, S., & Herkenham, M. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4268-04.2005 · Cited by 396 · see citing works

Identification of microglia in light and electron microscopy

Mori, S., & Leblond, C. P. (1969) · Journal of Comparative Neurology · doi:10.1002/cne.901350104 · Cited by 330 · see citing works

Evidence for synaptic stripping by cortical microglia

Trapp, B. D., Wujek, J. R., Criste, G. A., Jalabi, W., Yin, X., Kidd, G. J., Stohlman, S. A., & Ransohoff, R. M. (2006) · Glia · doi:10.1002/glia.20462 · Cited by 318 · see citing works

An inflammatory review of Parkinson's disease

Orr, C. F., Rowe, D. B., & Halliday, G. M. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00127-2 · Cited by 309 · see citing works

Neuroglial cells in the cerebral cortex of rats from young adulthood to old age: an electron microscope study

Vaughan, D. W., & Peters, A. (1974) · Journal of Neurocytology · doi:10.1007/bf01098730 · Cited by 301 · see citing works

Specific Domains of β-Amyloid from Alzheimer Plaque Elicit Neuron Killing in Human Microglia

Giulian, D., Haverkamp, L. J., Yu, J., Karshin, W. L., Tom, D., Li, J., Kirkpatrick, J. B., Kuo, Y., & Roher, A. E. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-19-06021.1996 · Cited by 266 · see citing works

Regulating Factors for Microglial Activation.

Nakamura, Y. (2002) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.25.945 · Cited by 241 · see citing works

Investigation of glial cells in semithin sections. II. Variation with age in the numbers of the various glial cell types in rat cortex and corpus callosum

Ling, E., & Leblond, C. P. (1973) · The Journal of Comparative Neurology · doi:10.1002/cne.901490105 · Cited by 223 · see citing works

Running exercise protects the substantia nigra dopaminergic neurons against inflammation-induced degeneration via the activation of BDNF signaling pathway

Wu, S.-Y., Wang, T.-F., Yu, L., Jen, C. J., Chuang, J.-I., Wu, F.-S., Wu, C.-W., & Kuo, Y.-M. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.09.006 · Cited by 206 · see citing works

Dextromethorphan Protects Dopaminergic Neurons against Inflammation-Mediated Degeneration through Inhibition of Microglial Activation

Liu, Y., Qin, L., Li, G., Zhang, W., An, L., Liu, B., & Hong, J. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.043166 · Cited by 205 · see citing works

Lipopolysaccharide-activated microglia induce dysfunction of the blood-brain barrier in rat microvascular endothelial cells co-cultured with microglia

Sumi, N., Nishioku, T., Takata, F., Matsumoto, J., Watanabe, T., Shuto, H., Yamauchi, A., Dohgu, S., & Kataoka, Y. (2010) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-009-9446-7 · Cited by 179 · see citing works

Microglia release activators of neuronal proliferation mediated by activation of mitogen‐activated protein kinase, phosphatidylinositol‐3‐kinase/Akt and delta–Notch signalling cascades

Morgan, S. C., Taylor, D. L., & Pocock, J. M. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02461.x · Cited by 175 · see citing works

Microglia Activation and Anti-inflammatory Regulation in Alzheimer’s Disease

Lue, L., Kuo, Y., Beach, T. G., & Walker, D. G. (2010) · Molecular Neurobiology · doi:10.1007/s12035-010-8106-8 · Cited by 175 · see citing works

Cooperation between toll‐like receptor 2 and 4 in the brain of mice challenged with cell wall components derived from gram‐negative and gram‐positive bacteria

Laflamme, N., Echchannaoui, H., Landmann, R. M., & Rivest, S. (2003) · European Journal of Immunology · doi:10.1002/eji.200323821 · Cited by 160 · see citing works

Equilibrium and kinetic properties of the Evans blue-albumin system

Freedman, F., & Johnson, J. (1969) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1969.216.3.675 · Cited by 122 · see citing works

Differential expression of chemokines and chemokine receptors during microglial activation and inhibition

Kremlev, S. G., Roberts, R. L., & Palmer, C. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2003.11.012 · Cited by 117 · see citing works

Circulating monocytic cells infiltrate layers of anterograde axonal degeneration where they transform into microglia

Bechmann, I., Goldmann, J., Kovac, A. D., Kwidzinski, E., Simbürger, E., Naftolin, F. N., Dirnagl, U., Nitsch, R., & Priller, J. (2005) · The FASEB Journal · doi:10.1096/fj.04-2599fje · Cited by 117 · see citing works

Differential neutrophil infiltration contributes to regional differences in brain inflammation in the substantia nigra pars compacta and cortex

Ji, K., Eu, M. Y., Kang, S., Gwag, B. J., Jou, I., & Joe, E.-H. (2008) · Glia · doi:10.1002/glia.20677 · Cited by 69 · see citing works

Immune cells may fend off Alzheimer disease

Britschgi, M., & Wyss‐Coray, T. (2007) · Nature Medicine · doi:10.1038/nm0407-408 · Cited by 60 · see citing works

Cell counts in the substantia nigra: a comparison of single section counts and disector counts in patients with Parkinson's disease and in controls

Y., S., Collan, Y. U., Röyttä, M., Rinne, J. O., & Rinne, U. K. (1995) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1995.tb01023.x · Cited by 52 · see citing works

Detection of delta opioid receptor and N-methyl-D-aspartate receptor-like immunoreactivity in retinoic acid-differentiated neuroblastoma x glioma (NG108-15) cells

Beczkowska, I. W., Gracy, K. N., Pickel, V. M., & Inturrisi, C. E. (1997) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19970101)47:1 · Cited by 11 · see citing works

Local cues establish and maintain region-specific phenotypes of basal ganglia microglia

De Biase, L. M., Schuebel, K. E., Fusfeld, Z. H., Jair, K., Hawes, I. A., Cimbro, R., Zhang, H.-Y., Liu, Q.-R., Shen, H., Xi, Z.-X., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.06.020 · Cited by 432 · see citing works

Cell Densities in the Mouse Brain: A Systematic Review

Keller, D., Erö, C., & Markram, H. (2018) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2018.00083 · Cited by 380 · see citing works

Neuroinflammation in the normal aging hippocampus

Barrientos, R. M., Kitt, M. M., Watkins, L. R., & Maier, S. F. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.03.007 · Cited by 315 · see citing works

Where Is Dopamine and how do Immune Cells See it?: Dopamine-Mediated Immune Cell Function in Health and Disease

Matt, S. M., & Gaskill, P. J. (2019) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-019-09851-4 · Cited by 286 · see citing works

Microglia-neuron crosstalk: Signaling mechanism and control of synaptic transmission

Marinelli, S., Basilico, B., Marrone, M. C., & Ragozzino, D. (2019) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2019.05.017 · Cited by 233 · see citing works

Microglia Response During Parkinson’s Disease: Alpha-Synuclein Intervention

Ferreira, S. A., & Romero‐Ramos, M. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00247 · Cited by 220 · see citing works

Glucose metabolic crosstalk and regulation in brain function and diseases

Zhang, S., Lachance, B. B., Mattson, M. P., & Jia, X. (2021) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2021.102089 · Cited by 205 · see citing works

Macrophages and CNS remyelination

Miron, V. E., & Franklin, R. J. M. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12705 · Cited by 196 · see citing works

BDNF reverses aging-related microglial activation

Wu, S.-Y., Pan, B.-S., Tsai, S., Chiang, Y.-T., Huang, B., Mo, F., & Kuo, Y. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01887-1 · Cited by 174 · see citing works

Significant roles of neuroinflammation in Parkinson’s disease: therapeutic targets for PD prevention

Lee, Y., Lee, S., Chang, S., & Lee, J. (2019) · Archives of Pharmacal Research · doi:10.1007/s12272-019-01133-0 · Cited by 169 · see citing works

Transcriptional profiling of microglia; current state of the art and future perspectives

Gerrits, E., Heng, Y., Boddeke, E. W. G. M., & Eggen, B. J. L. (2020) · Glia · doi:10.1002/glia.23767 · Cited by 140 · see citing works

Microglia-driven regulation of oligodendrocyte lineage cells, myelination, and remyelination

Miron, V. E. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.3ri1116-494r · Cited by 134 · see citing works

Infection and Risk of Parkinson’s Disease

Smeyne, R. J., Noyce, A. J., Byrne, M., Savica, R., & Marras, C. (2021) · Journal of Parkinson's Disease · doi:10.3233/jpd-202279 · Cited by 125 · see citing works

Microglia at the blood brain barrier in health and disease

Mayer, M. G., & Fischer, T. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1360195 · Cited by 128 · see citing works

Detecting Microglial Density With Quantitative Multi-Compartment Diffusion MRI

Yi, S. Y., Barnett, B. R., Torres-Velázquez, M., Zhang, Y., Hurley, S. A., Rowley, P. A., Hernando, D., & Yu, J.-P. J. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00081 · Cited by 104 · see citing works

Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease

Gordon, R., Singh, N., Lawana, V., Ghosh, A., Harischandra, D. S., Jin, H., Hogan, C., Sarkar, S., Rokad, D., Panicker, N., et al. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.04.008 · Cited by 105 · see citing works

Neuroinflammation in heart failure: new insights for an old disease

Díaz, H. S., Toledo, C., Andrade, D. C., Marcus, N. J., & Río, R. D. (2019) · The Journal of Physiology · doi:10.1113/jp278864 · Cited by 102 · see citing works

Extracellular Vesicles as Nanotherapeutics for Parkinson’s Disease

Leggio, L., Paternò, G., Vivarelli, S., L’Episcopo, F., Tirolo, C., Raciti, G., Pappalardo, F., Giachino, C., Caniglia, S., Serapide, M. F., et al. (2020) · Biomolecules · doi:10.3390/biom10091327 · Cited by 100 · see citing works

Glymphatic System Dysfunction and Sleep Disturbance May Contribute to the Pathogenesis and Progression of Parkinson’s Disease

Massey, A., Boag, M. K., Magnier, A., Bispo, D. P. C. F., Khoo, T. K., & Pountney, D. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232112928 · Cited by 101 · see citing works

From development to dysfunction: Microglia and the complement cascade in CNS homeostasis

Zabel, M. K., & Kirsch, W. M. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.02.001 · Cited by 95 · see citing works

Ion Channels and Receptors as Determinants of Microglial Function

Izquierdo, P., Attwell, D., & Madry, C. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2018.12.007 · Cited by 102 · see citing works

Controversies and prospects about microglia in maternal immune activation models for neurodevelopmental disorders

Smolders, S., Notter, T., Smolders, S., Rigo, J., & Brône, B. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.06.001 · Cited by 93 · see citing works

Microglia mediate diesel exhaust particle-induced cerebellar neuronal toxicity through neuroinflammatory mechanisms

Roqué, P. J., Dao, K., & Costa, L. G. (2016) · NeuroToxicology · doi:10.1016/j.neuro.2016.08.006 · Cited by 93 · see citing works

Microglia energy metabolism in metabolic disorder

Kalsbeek, M. J. T., Mulder, L., & Yi, C. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.09.028 · Cited by 93 · see citing works

In Vivo TSPO Signal and Neuroinflammation in Alzheimer’s Disease

Tournier, B. B., Tsartsalis, S., Ceyzériat, K., Garibotto, V., & Millet, P. (2020) · Cells · doi:10.3390/cells9091941 · Cited by 79 · see citing works

Neuroinflammatory challenges compromise neuronal function in the aging brain: Postoperative cognitive delirium and Alzheimer’s disease

Cortese, G. P., & Bürger, C. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.08.027 · Cited by 74 · see citing works

Loss of Brain Norepinephrine Elicits Neuroinflammation-Mediated Oxidative Injury and Selective Caudo-Rostral Neurodegeneration

Song, S., Jiang, L., Oyarzabal, E. A., Wilson, B. C., Li, Z., Shih, Y. I., Wang, Q., & Hong, J. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1235-1 · Cited by 73 · see citing works

Neuroinflammation and Glial Phenotypic Changes in Alpha-Synucleinopathies

Refolo, V., & Stefanova, N. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00263 · Cited by 71 · see citing works

The NRF2-Dependent Transcriptional Regulation of Antioxidant Defense Pathways: Relevance for Cell Type-Specific Vulnerability to Neurodegeneration and Therapeutic Intervention

Boas, S. M., Joyce, K. L., & Cowell, R. M. (2021) · Antioxidants · doi:10.3390/antiox11010008 · Cited by 69 · see citing works

Multiple-Hit Hypothesis in Parkinson’s Disease: LRRK2 and Inflammation

Cabezudo, D., Baekelandt, V., & Lobbestael, E. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00376 · Cited by 74 · see citing works

Estrogen ameliorates microglial activation by inhibiting the Kir2.1 inward-rectifier K+ channel

Wu, S.-Y., Chen, Y., Tsai, S., Wu, S., Shih, Y., Jiang‐Shieh, Y., Yang, T.-T., & Kuo, Y. (2016) · Scientific Reports · doi:10.1038/srep22864 · Cited by 67 · see citing works

Microglia and BDNF at the crossroads of stressor related disorders: Towards a unique trophic phenotype

Prowse, N. A., & Hayley, S. P. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.09.018 · Cited by 67 · see citing works

Role of Microglial Activation and Neuroinflammation in Neurotoxicity of Acrylamide in Vivo and in Vitro

Zong, C., Hasegawa, R., Urushitani, M., Zhang, L., Nagashima, D., Sakurai, T., Ichihara, S., Ohsako, S., & Ichihara, G. (2019) · Archives of Toxicology · doi:10.1007/s00204-019-02471-0 · Cited by 64 · see citing works

Co‐Culture of Neurons and Microglia

Roqué, P. J., & Costa, L. G. (2017) · Current Protocols in Toxicology · doi:10.1002/cptx.32 · Cited by 60 · see citing works

Mu-opioid receptor and delta-opioid receptor differentially regulate microglial inflammatory response to control proopiomelanocortin neuronal apoptosis in the hypothalamus: effects of neonatal alcohol

Shrivastava, P., Cabrera, M. A., Chastain, L. G., Boyadjieva, N. I., Jabbar, S., Franklin, T., & Sarkar, D. K. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0844-3 · Cited by 60 · see citing works

Systemic administration of β-glucan induces immune training in microglia

Heng, Y., Zhang, X., Borggrewe, M., van Weering, H. R. J., Brummer, M. L., Nijboer, T. W., Joosten, L. A. B., Netea, M. G., Boddeke, E., Laman, J. D., et al. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02103-4 · Cited by 59 · see citing works

In vivo characterization of functional states of cortical microglia during peripheral inflammation

Riester, K., Brawek, B., Savitska, D., Fröhlich, N. T., Zirdum, E., Mojtahedi, N., Heneka, M. T., & Garaschuk, O. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.12.007 · Cited by 59 · see citing works

Exploring the Role of Apigenin in Neuroinflammation: Insights and Implications

Charrière, K., Schneider, V., Perrignon-Sommet, M., Lizard, G., Bénani, A., Jacquin, A., & Véjux, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25095041 · Cited by 63 · see citing works

Region-Specific Phenotypes of Microglia: The Role of Local Regulatory Cues

Biase, L. M. D., & Bonci, A. (2018) · The Neuroscientist · doi:10.1177/1073858418800996 · Cited by 55 · see citing works

Microglia, autonomic nervous system, immunity and hypertension: Is there a link?

Li, Y., Wei, B., Liu, X., Shen, X. Z., & Shi, P. D. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104451 · Cited by 52 · see citing works

Immunomodulatory Effect of Microglia-Released Cytokines in Gliomas

Lanza, M., Casili, G., Campolo, M., Paterniti, I., Colarossi, C., Mare, M., Giuffrida, R., Caffo, M., Esposito, E., & Cuzzocrea, S. (2021) · Brain Sciences · doi:10.3390/brainsci11040466 · Cited by 47 · see citing works

Hypertension Accelerates Alzheimer’s Disease-Related Pathologies in Pigs and 3xTg Mice

Shih, Y., Wu, S.-Y., Yu, M., Huang, S.-H., Lee, C.-W., Jiang, M.-J., Lin, P., Yang, T.-T., & Kuo, Y. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00073 · Cited by 43 · see citing works

The Multifarious Role of Microglia in Brain Metastasis

Soto, M. S., & Sibson, N. R. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00414 · Cited by 42 · see citing works

Neuronal brain‐derived neurotrophic factor manipulates microglial dynamics

Onodera, J., Nagata, H., Nakashima, A., Ikegaya, Y., & Koyama, R. (2021) · Glia · doi:10.1002/glia.23934 · Cited by 42 · see citing works

Endocannabinoid signaling in microglia

Marinelli, S., Marrone, M. C., Domenico, M. D., & Marinelli, S. (2022) · Glia · doi:10.1002/glia.24281 · Cited by 40 · see citing works

Widespread activation of microglial cells in the hippocampus of chronic epileptic rats correlates only partially with neurodegeneration

Papageorgiou, I. E., Fetani, A. F., Lewen, A., Heinemann, U., & Kann, O. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0802-0 · Cited by 37 · see citing works

Immunisation with UB-312 in the Thy1SNCA mouse prevents motor performance deficits and oligomeric α-synuclein accumulation in the brain and gut

Nimmo, J., Smith, H., Wang, C. Y., Teeling, J. L., Nicoll, J. A. R., Verma, A. K., Dodart, J., Liu, Z., Feng, L., & Carare, R. O. (2021) · Acta Neuropathologica · doi:10.1007/s00401-021-02381-5 · Cited by 32 · see citing works

Regulation of Microglia Identity from an Epigenetic and Transcriptomic Point of View

Eggen, B. J. L., Boddeke, E. W. G. M., & Kooistra, S. M. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2017.12.010 · Cited by 25 · see citing works

Differential regulation of microglial states by colony stimulating factors

Stanley, E. R., Biundo, F., Gökhan, Ş., & Chiţu, V. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1275935 · Cited by 30 · see citing works

The role of microglial autophagy in Parkinson’s disease

Zhu, R., Luo, Y., Li, S., & Wang, Z. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1039780 · Cited by 30 · see citing works

Substance P enhances microglial density in the substantia nigra through neurokinin-1 receptor/NADPH oxidase-mediated chemotaxis in mice

Wang, Q., Oyarzabal, E. A., Wilson, B. C., Li, Q., & Hong, J. (2015) · Clinical Science · doi:10.1042/cs20150008 · Cited by 30 · see citing works

IL-37 expression reduces acute and chronic neuroinflammation and rescues cognitive impairment in an Alzheimer’s disease mouse model

Lonnemann, N., Hosseini, S., Ohm, M., Geffers, R., Hiller, K., Dinarello, C. A., & Körte, M. (2022) · eLife · doi:10.7554/elife.75889 · Cited by 28 · see citing works

6-methoxyflavone suppresses neuroinflammation in lipopolysaccharide- stimulated microglia through the inhibition of TLR4/MyD88/p38 MAPK/NF-κB dependent pathways and the activation of HO-1/NQO-1 signaling

Chen, W.-F., Shih, Y., Liu, H.-C., Cheng, C., Chang, C., Chen, C., Lin, I.-P., Lin, M.-Y., & Lee, C. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154025 · Cited by 27 · see citing works

Intermittent peripheral exposure to lipopolysaccharide induces exploratory behavior in mice and regulates brain glial activity in obese mice

Huang, H.-T., Chen, P. S., Kuo, Y., & Tzeng, S. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01837-x · Cited by 22 · see citing works

Hotspots and trends of microglia in Alzheimer's disease: a bibliometric analysis during 2000–2022

Zhang, L., Yao, Q., Hu, J., Qiu, B., Xiao, Y., Zhang, Q., Zeng, Y., Zheng, S., Zhang, Y., Wan, Y., et al. (2024) · European journal of medical research · doi:10.1186/s40001-023-01602-9 · Cited by 21 · see citing works

Activin A Inhibits MPTP and LPS-Induced Increases in Inflammatory Cell Populations and Loss of Dopamine Neurons in the Mouse Midbrain In Vivo

Stayte, S., Rentsch, P., Tröscher, A. R., Maximilian, B., Li, K. M., & Vissel, B. (2017) · PLoS ONE · doi:10.1371/journal.pone.0167211 · Cited by 21 · see citing works

Long-term in vivo two-photon imaging of the neuroinflammatory response to intracortical implants and micro-vessel disruptions in awake mice

Yang, Q., Vazquez, A. L., & Cui, X. T. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121060 · Cited by 20 · see citing works

Fetal inflammation is associated with persistent systemic and hippocampal inflammation and dysregulation of hippocampal glutamatergic homeostasis

Gisslen, T., Singh, G., & Georgieff, M. (2019) · Pediatric Research · doi:10.1038/s41390-019-0330-y · Cited by 17 · see citing works

Inhibition of Nigral Microglial Activation Reduces Age-Related Loss of Dopaminergic Neurons and Motor Deficits

Wang, T.-F., Wu, S.-Y., Pan, B., Tsai, S., & Kuo, Y. (2022) · Cells · doi:10.3390/cells11030481 · Cited by 18 · see citing works

Neuroprotective and plasticity promoting effects of repetitive transcranial magnetic stimulation (rTMS): A role for microglia

d’Errico, P., Früholz, I., Meyer‐Luehmann, M., & Vlachos, A. (2025) · Brain stimulation · doi:10.1016/j.brs.2025.03.012 · Cited by 16 · see citing works

Inhibitory Effects of Trifluoperazine on Peripheral Proinflammatory Cytokine Expression and Hypothalamic Microglia Activation in Obese Mice Induced by Chronic Feeding With High-Fat-Diet

Huang, H.-T., Chen, P., Chen, P. S., Chiu, W., Kuo, Y., & Tzeng, S. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.752771 · Cited by 14 · see citing works

Isolation driven changes in Iba1-positive microglial morphology are associated with social recognition memory in adults and adolescents

Ferrara, N. C., Trask, S., Yan, L., Padival, M., Helmstetter, F. J., & Rosenkranz, J. A. (2022) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2022.107626 · Cited by 12 · see citing works

Cerebellar microglia: On the edge between neuroinflammation and neuroregulation

Сергеевна, Д. М., Guo, J., Shen, E.-W., Liu, W., Huang, W., Shen, Y., & Wang, L. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00550 · Cited by 13 · see citing works

Hunger, Satiety, and Their Vulnerabilities

Stevenson, R. J., & Boutelle, K. N. (2024) · Nutrients · doi:10.3390/nu16173013 · Cited by 14 · see citing works

Multimodal magnetic resonance imaging quantification of gray matter alterations in relapsing‐remitting multiple sclerosis and neuromyelitis optica spectrum disorder

Andica, C., Hagiwara, A., Yokoyama, K., Kato, S., Uchida, W., Nishimura, Y., Fujita, S., Kamagata, K., Hori, M., Tomizawa, Y., et al. (2022) · Journal of Neuroscience Research · doi:10.1002/jnr.25035 · Cited by 12 · see citing works

The effect of morphine on rat microglial phagocytic activity: An in vitro study of brain region-, plating density-, sex-, morphine concentration-, and receptor-dependency

King’uyu, D. N., Nti-Kyemereh, L., Bonin, J. L., Feustel, P. J., Tram, M., MacNamara, K. C., & Kopec, A. M. (2023) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2023.578204 · Cited by 9 · see citing works

Indoleamine 2,3-dioxygenase (IDO1) – Can dendritic cells and monocytes expressing this moonlight enzyme change the phase of Parkinson’s Disease?

Gonçalves, M., Rodrigues‐Santos, P., Januário, C., Cosentino, M., & Pereira, F. C. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112062 · Cited by 9 · see citing works

Analysis of Signaling Mechanisms Regulating Microglial Process Movement

Kyrargyri, V., Attwell, D., Jolivet, R., & Madry, C. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9658-2_14 · Cited by 8 · see citing works

Enhanced Microglia Activation and Glioma Tumor Progression by Inflammagen Priming in Mice with Tumor Necrosis Factor Receptor Type 2 Deficiency

Liao, C., Fang, K., Huang, H.-T., Chang, W.-R., Chuang, C.-C., & Tzeng, S. (2021) · Life · doi:10.3390/life11090961 · Cited by 7 · see citing works

Microglial heterogeneity: influence of human 2D, 3D, and co-culture models on gene expression and immune function

Etebar, F., White, A. R., & Quek, H. (2026) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2026.1770518 · Cited by 4 · see citing works

Microbiome-Glia Crosstalk: Bridging the Communication Divide in the Central Nervous System

Tabatabaee, M. S. (2024) · Neuroglia · doi:10.3390/neuroglia5020007 · Cited by 4 · see citing works

The glia-neutrophil axis: an understudied crosstalk in bacteria-induced neuroinflammation

Dunphy, A. M., & Marriott, I. (2026) · Frontiers in Neurology · doi:10.3389/fneur.2026.1765892 · Cited by 3 · see citing works

Resveratrol Alleviates the Early Challenges of Implant-Based Drug Delivery in a Human Glial Cell Model

Schlotterose, L., Cossais, F., Lucius, R., & Hattermann, K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042078 · Cited by 2 · see citing works

Physical activity-associated extracellular vesicles inhibit inflammagen-induced microglial activation

Su, C.-Y., Hsu, H.-J., Wang, T.-F., Chou, H.-L., Tsai, S., Lee, C.-W., Cheng, C.-L., Wang, Y.-K., & Kuo, Y. (2026) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2026.101200 · Cited by 2 · see citing works

Early-Age Cuprizone Exposure Induces Region-Specific Demyelination and Neuroinflammation in Mice

Rokach, M., Levy, G., Elad‐Sfadia, G., & Barak, B. (2026) · NeuroMolecular Medicine · doi:10.1007/s12017-026-08911-2 · Cited by 2 · see citing works

SORLA Orchestrates microglial dynamics for enhanced neuroprotection and recovery following ischemic stroke

Ma, S., Zhang, T., Lv, J., Liang, S., Zhao, S., Nan, X., Dou, Z., Yang, J., Lu, Y., Liu, R., et al. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.05.016 · Cited by 2 · see citing works

Microglia contribute to the autonomic function and participate in neurogenic hypertension: non-immune function of central immune cells

Chen, N., CHENG, G., Wei, B., Bi, Q., Lu, C. C., Wang, S., & Shi, P. D. (2022) · Scientia Sinica Vitae · doi:10.1360/ssv-2022-0082 · Cited by 2 · see citing works

Cerebral Inflammation in an Animal Ischemia–Reperfusion Model Comparing Histidine-Tryptophan-α-Ketoglutarate and Del Nido Cardioplegia

Klaeske, K., Dieterlen, M., Kang, J., Detzer, Z., Ginther, A., Oßmann, S., Borger, M. A., Kiefer, P., & Hoyer, A. (2025) · Life · doi:10.3390/life15030451 · Cited by 1 · see citing works

The Dopamine D2R Antagonist Trifluoperazine Suppresses High-Fat Diet-Induced Hyperglycemia and Hypothalamic Gliosis in Obese MicePreprint

Huang, H.-T., Chen, P., Chen, P. S., Chiu, W., Kuo, Y., & Tzeng, S. (2021) · Research Square · doi:10.21203/rs.3.rs-382784/v1

Faculty Opinions recommendation of Local Cues Establish and Maintain Region-Specific Phenotypes of Basal Ganglia Microglia.

Gould, E. (2017) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.727795770.793537494

Characterisation of novel immune cell subsets in the central nervous system and its supporting tissues

Etebar, F. (2023) · Queensland University of Technology · doi:10.5204/thesis.eprints.244774

Additional file 7 of Systemic administration of β-glucan induces immune training in microglia

Heng, Y., Zhang, X., Borggrewe, M., van Weering, H. R. J., Brummer, M. L., Nijboer, T. W., Joosten, L. A. B., Netea, M. G., Boddeke, E., Laman, J. D., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14091486

Additional file 4 of Systemic administration of β-glucan induces immune training in microglia

Heng, Y., Zhang, X., Borggrewe, M., van Weering, H. R. J., Brummer, M. L., Nijboer, T. W., Joosten, L. A. B., Netea, M. G., Boddeke, E., Laman, J. D., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14091477

Brain Microstructure and Obesity Risk in Early Childhood: Insights from Restriction Spectrum ImagingPreprint

Bayat, M., Braun, B., Curzon, M., Hernandez, M. L., Curtis, M., Coccia, C. C., Garic, D., Watts, R., Irfanoglu, M. O., Graziano, P. A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.19.677172

Additional file 1 of Systemic administration of β-glucan induces immune training in microglia

Heng, Y., Zhang, X., Borggrewe, M., van Weering, H. R. J., Brummer, M. L., Nijboer, T. W., Joosten, L. A. B., Netea, M. G., Boddeke, E., Laman, J. D., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14091468

Additional file 5 of Systemic administration of β-glucan induces immune training in microglia

Heng, Y., Zhang, X., Borggrewe, M., van Weering, H. R. J., Brummer, M. L., Nijboer, T. W., Joosten, L. A. B., Netea, M. G., Boddeke, E., Laman, J. D., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14091480

Additional file 6 of Systemic administration of β-glucan induces immune training in microglia

Heng, Y., Zhang, X., Borggrewe, M., van Weering, H. R. J., Brummer, M. L., Nijboer, T. W., Joosten, L. A. B., Netea, M. G., Boddeke, E., Laman, J. D., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14091483

Additional file 3 of Systemic administration of β-glucan induces immune training in microglia

Heng, Y., Zhang, X., Borggrewe, M., van Weering, H. R. J., Brummer, M. L., Nijboer, T. W., Joosten, L. A. B., Netea, M. G., Boddeke, E., Laman, J. D., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14091474

Additional file 8 of Systemic administration of β-glucan induces immune training in microglia

Heng, Y., Zhang, X., Borggrewe, M., van Weering, H. R. J., Brummer, M. L., Nijboer, T. W., Joosten, L. A. B., Netea, M. G., Boddeke, E., Laman, J. D., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14091489

Additional file 2 of Systemic administration of β-glucan induces immune training in microglia

Heng, Y., Zhang, X., Borggrewe, M., van Weering, H. R. J., Brummer, M. L., Nijboer, T. W., Joosten, L. A. B., Netea, M. G., Boddeke, E., Laman, J. D., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14091471

Additional file 1 of Hotspots and trends of microglia in Alzheimer's disease: a bibliometric analysis during 2000–2022

Zhang, L., Yao, Q., Hu, J., Qiu, B., Xiao, Y., Zhang, Q., Zeng, Y., Zheng, S., Zhang, Y., Wan, Y., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26672235

Regional and sub-regional microglial heterogeneity in the steady-state mouse brain and retinaPreprint

Etebar, F., Whatmore, P., Harkin, D. G., Quek, H., Eme‐Scolan, E., McMenamin, P. G., & Dando, S. J. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.16.699866

Contrôle de l'activation microgliale par les lymphocytes T dans un modèle murin de neurodégénérescence induite par la 6-OHDA

Uhlrich, J. (2014) · theses.fr (ABES) · doi:10.70675/a6a8c526zbc17z4d58za205z11fd3c99adf0

Impact d'une supplémentation en actifs d'origine marine sur la neuroinflammation associée au déclin cognitif lié à l'âge

Chataigner, M. (2021) · theses.fr (ABES) · doi:10.70675/a4317690zc4c8z4ba6za738zd457c6bb9b74

Regional difference in inflammatory response to LPS-injection in the brain: Role of microglia cell density

Pintado, C., Revilla, E., Vizuete, M., Jiménez, S., García-Cuervo, L., Vitórica, J., Ruano, D., & Castaño, A. (2011) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2011.06.017 · Cited by 32 · see citing works

Brain region-specific microglial and astrocytic activation in response to systemic lipopolysaccharides exposure

Brandi, E., Torres-Garcia, L., Svanbergsson, A., Haikal, C., Liu, D., Li, W., & Li, J. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.910988 · Cited by 44 · see citing works

Regional Difference in Susceptibility to Lipopolysaccharide-Induced Neurotoxicity in the Rat Brain: Role of Microglia

Kim, W., Mohney, R. P., Wilson, B. C., Jeohn, G., Liu, B., & Hong, J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-16-06309.2000 · Cited by 881 · see citing works

Differential Regional Vulnerability of the Brain to Mild Neuroinflammation Induced by Systemic LPS Treatment in Mice

Jung, H., Lee, H., Kim, D., Cheong, E., Hyun, Y., Yu, J., & Um, J. W. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s362006 · Cited by 31 · see citing works

Brain Region-dependent Heterogeneity and Dose-dependent Difference in Transient Microglia Population Increase during Lipopolysaccharide-induced Inflammation

Furube, E., Kawai, S., Inagaki, H., Takagi, S., & Miyata, S. (2018) · Scientific Reports · doi:10.1038/s41598-018-20643-3 · Cited by 118 · see citing works