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Gut dysbiosis as a driver of neuroinflammation in attention-deficit/hyperactivity disorder: A review of current evidence
Open accessAbstract
There is mounting evidence for the involvement of the immune system, neuroinflammation and disturbed gut microbiota, or dysbiosis, in attention-deficit/hyperactivity disorder (ADHD). Gut dysbiosis is strongly implicated in many physical, autoimmune, neurological, and neuropsychiatric conditions, however knowledge of its particular pathogenic role in ADHD is sparse. As such, this narrative review examines and synthesizes the available evidence related to inflammation, dysbiosis, and neural processes in ADHD. Minimal differences in microbiota diversity measures between cases and controls were found, however many relative abundance differences were observed at all classification levels (phylum to strain). Compositional differences of taxa important to key gut-brain axis pathways, in particular Bacteroides species and Faecalibacterium, may contribute to inflammation, brain functioning differences, and symptoms, in ADHD. We have identified one possible model of ADHD etiopathogenesis involving systemic inflammation, an impaired blood-brain barrier, and neural disturbances as downstream consequences of gut dysbiosis. Nevertheless, studies conducted to date have varied degrees of methodological rigour and involve diverse participant characteristics and analytical techniques, highlighting a need for additional research.
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“the microbiome-gut-brain axis, which may influence both neuroinflammation and neurotransmitter synthesis [86]”
From ADHD in Adulthood: Clinical Presentation, Comorbidities, and Treatment Perspectives (2025) · cites this paper as [86]
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Cites
Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624
Diet rapidly and reproducibly alters the human gut microbiome
David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100
Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815
From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites
Koh, A., De Vadder, F., Kovatcheva-Datchary, P., & Bäckhed, F. (2016) · Cell · doi:10.1016/j.cell.2016.05.041 · Cited by 7,070
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · cited 8×
“The gut contains the greatest density of immune cells in the body and host-microbiota interactions in the gut induce the release of various chemicals such as pro-and anti-inflammatory cytokines, chemokines, neurotransmitters, and neuro-peptides (Cryan et al., 2019; Tillisch, 2014).”
InfluentialHost-gut microbiota metabolic interactions
Nicholson, J. K., Holmes, E., Kinross, J., Burcelin, R., Gibson, G., Jia, W., & Pettersson, S. (2012) · Science · doi:10.1126/science.1223813 · Cited by 4,760
Sokol, H., Pigneur, B., Watterlot, L., Lakhdari, O., Bermúdez-Humarán, L. G., Gratadoux, J.-J., Blugeon, S., Bridonneau, C., Furet, J.-P., Corthier, G., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804812105 · Cited by 4,413
Research works printed but not linked: 4
- Evrensel, 2020, Neuroinflammation, Gut-Brain Axis and Depression. Psychiatry Investigation., 17, 2
- Rooks, 2016, Garrett WSJNri gut microbiota, metabolites and host immunity, NatureReviews Immunology, 16, 341
- Sandgren, 2018, ADHD-originating in the gut?, The Emergence of a New Explanatory Model., 120, 135
- Schmitt, 2010, Is atopic disease a risk factor for attention-deficit/hyperactivity disorder?, A Systematic Review. Allergy., 65, 1506
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Lewis, N., Lagopoulos, J., & Villani, A. M. (2025) · Metabolites · doi:10.3390/metabo15050335 · Cited by 20
Self-citationImplications of Gut Microbiota-Derived Metabolites in Neurological Disorders
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ADHD in Adulthood: Clinical Presentation, Comorbidities, and Treatment Perspectives
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“This includes the role of neuroinflammation, with PET studies showing increased microglial activation in adults with ADHD [85], and the microbiome-gut-brain axis, which may influence both neuroinflammation and neurotransmitter synthesis [86].”
Ghosh, S., & Singh, S. (2025) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-025-02822-6 · Cited by 11
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Libres, F. J. G., Silva, H. I. B., Lu, A. M. A., Sobrepena, K. M. P., & Comia, L. V. (2026) · International Conference on Mobile Computing and Sustainable Informatics (ICMCSI) · doi:10.1109/icmcsi67283.2026.11412518 · Cited by 7
Xiao, Y., Wei, L., Yu, J., & Liu, Y. (2025) · International Journal of General Medicine · doi:10.2147/ijgm.s548322 · Cited by 2
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Lewis, N., Levenstein, J. M., & Villani, A. M. (2026) · Nutritional Psychiatry · doi:10.1016/j.nupsyc.2026.100017 · Cited by 1
Self-citationMulti‐modal machine learning and gut microbiome pathway analysis for Alzheimer's risk prediction
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Petropoulos, A., Pergantis, P., Drosos, K., & Tafiadis, D. (2026) · Nutrients · doi:10.3390/nu18162664 · Cited by 1
Fan, J., Wu, S., Huang, C., Xiao, D., & Tang, F. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120168
Wu, H., Yu, M., Huang, S., Peng, Y., Guo, W., & Huang, C. (2026) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2026.100717
Owumi, S. E., Olabisi, T. P., Chimezie, J., Eso, V. O., Owolabi, O. A., Sanusi, A. A., Babalola, J. O., Akomolafe, A. P., Arunsi, U. O., & Irozure, C. E. (2026) · Toxicon · doi:10.1016/j.toxicon.2026.109093
Warner, J. O. (2026) · Pediatric Research · doi:10.1038/s41390-026-05241-8
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Sadowska, K., & Hart, K. H. (2026) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.70327
易, 媛. (2026) · Advances in Clinical Medicine · doi:10.12677/acm.2026.1682912
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Sharma, A. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-44631-3.00010-x
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Gasanov, R. F., Emelina, D. A., Кравченко, И. В., Makarov, I. V., & Prokhorenko, E. S. (2026) · V M BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY · doi:10.31363/2313-7053-2026-4-1302
Lewis, N., Levenstein, J. M., & Villani, A. M. (2026) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2026.10.006
Self-citationProbiotics in ADHD: Treating the child, the gut, or the rating scale?
Baboe, E. C., & Kalalo, R. T. (2026) · Psychiatry Research Communications · doi:10.1016/j.psycom.2026.100293
Metadata
- Authors
- Lewis, N., Villani, A., & Lagopoulos, J.
- Affiliations
- University of the Sunshine Coast (AU)
- Corresponding author
- Lewis, Naomi
- Villani, Anthony
- Lagopoulos, Jim
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2025-03
- Volume
- 569
- Pages
- 298-321
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W4406661039
- Cited by
- 25
- References
- 279
- Citations by year
- 2026: 17 · 2025: 8
- FWCI
- 2.21
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neuroscience (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- attention deficit hyperactivity disorder, gut dysbiosis, neuroinflammation, gut-brain axis, gut microbiota, Bacteroides, Faecalibacterium, blood-brain barrier, systemic inflammation, microbiome diversity
- MeSH terms
- Gastrointestinal Microbiome, Brain-Gut Axis, Neuroinflammatory Diseases, Animals, Attention Deficit Disorder with Hyperactivity, Brain, Humans, Inflammation, Dysbiosis
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