Cell signaling mediated by nitrated cyclic guanine nucleotide
Abstract
We recently clarified the physiological formation of 8-nitroguanosine 3',5'-cyclic monophosphate (8-nitro-cGMP) and its critical roles in nitric oxide (NO) signal transductions. This discovery of 8-nitro-cGMP is the first demonstration of a nitrated cyclic nucleotide functioning as a new second messenger in mammals since the identification of cGMP more than 40 years ago. By means of chemical analyses, e.g., liquid chromatography-tandem mass spectrometry, we unequivocally identified 8-nitro-cGMP formation, which depended on NO production, in several types of cultured cells, including macrophages and glial cells. Most important, we previously showed that 8-nitro-cGMP as an electrophile reacted with particular sulfhydryls of proteins to generate a unique post-translational modification that we called protein S-guanylation. In fact, certain specific intracellular proteins, such as the redox-sensor protein Keap1, readily underwent S-guanylation induced by 8-nitro-cGMP. 8-Nitro-cGMP activated the Nrf2 signaling pathway by triggering dissociation of Keap1, via S-guanylation of its highly nucleophilic cysteine sulfhydryls. We also determined that S-guanylation of Keap1 was involved in cytoprotective actions of NO and 8-nitro-cGMP by inducing oxidative stress response genes such as heme oxygenase-1. Such unique chemical properties of 8-nitro-cGMP shed light on new areas of NO and cGMP signal transduction. Protein S-guanylation induced by 8-nitro-cGMP may thus have important implications in NO-related physiology and pathology, pharmaceutical chemistry, and development of therapeutics for many diseases.
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Nitration of both fatty acids and guanine nucleotides has been shown to elicit responses that are protective against inflammatory tissue injury.
“nitration of both fatty acids and guanine nucleotides has been shown to elicit responses that are protective against inflammatory tissue injury[115, 116].”
From Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy (2011) · cites this paper as [115]
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Majors, A. K., Chakravarti, R., Ruple, L. M., Leahy, R., Stuehr, D. J., Lauer, M. E., ERZURUM, S. C., Janocha, A. J., & Aronica, M. A. (2018) · PLoS ONE · doi:10.1371/journal.pone.0200074
- Authors
- Akaike, T., Fujii, S., Sawa, T., & Ihara, H.
- Affiliations
- Kumamoto University (JP)
- Osaka Prefecture University (JP)
- Corresponding author
- Akaike, Takaaki
- Venue
- Nitric Oxide
- Publisher
- Elsevier BV
- Published
- 2010-11
- Volume
- 23
- Issue
- 3
- Pages
- 166-174
- ISSN
- 1089-8603 (ISSN-L)
- OpenAlex
- W1984465237
- Cited by
- 49
- References
- 49
- Citations by year
- 2025: 1 · 2022: 2 · 2021: 2 · 2020: 4 · 2018: 2 · 2017: 5 · 2016: 6 · 2015: 1 · 2014: 4 · 2013: 6 · 2012: 9
- FWCI
- 0.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nitric Oxide (publishedVersion)
- PubMed (publishedVersion)
- Kumamoto University Repository (Kumamoto University) (submittedVersion)
- Kumamoto University Repository System (submittedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Ministry of Health, Labour and Welfare
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phosphodiesterase function and regulation
- Keywords
- 8-nitro-cGMP, nitric oxide signaling, cGMP signaling, second messengers, Keap1, Nrf2 signaling, sulfhydryl modification, oxidative stress response, heme oxygenase-1, macrophages, glial cells, redox signaling
- MeSH terms
- Cyclic GMP, Humans, Nitric Oxide, Signal Transduction
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