Inflammatory and Biomechanical Drivers of Endothelial-Interstitial Interactions in Calcific Aortic Valve Disease
Open accessAbstract
Calcific aortic valve disease is dramatically increasing in global burden, yet no therapy exists outside of prosthetic replacement. The increasing proportion of younger and more active patients mandates alternative therapies. Studies suggest a window of opportunity for biologically based diagnostics and therapeutics to alleviate or delay calcific aortic valve disease progression. Advancement, however, has been hampered by limited understanding of the complex mechanisms driving calcific aortic valve disease initiation and progression towards clinically relevant interventions.
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PRRX1 orchestrates the transition of stromal fibroblasts to myofibroblasts via TGF-β signaling, a mechanism known to take place in valve interstitial cells in CAVS.
“PRRX1 has been shown to orchestrate the transition of stromal fibroblasts to myofibroblasts via TGF-β signaling19, which is a known mechanism taking place in valve interstitial cells in CAVS20.”
From Integrative genomic analyses identify candidate causal genes for calcific aortic valve stenosis involving tissue-specific regulation (2024) · cites this paper as [20]
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Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606425
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606500
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606416
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606485
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606467
Zheng, Y., Wen, S., Jiang, S., He, S., Qiao, W., Liu, Y., Yang, W., Zhou, J., Wang, B., Li, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26606446
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- Authors
- Driscoll, K., Cruz, A. D., & Butcher, J. T.
- Affiliations
- Cornell University (US)
- Venue
- Circulation Research
- Published
- 2021-04-30
- Volume
- 128
- Issue
- 9
- Pages
- 1344-1370
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- PMC
- PMC8519486
- OpenAlex
- W3159358349
- Cited by
- 102
- References
- 221
- Citations by year
- 2026: 23 · 2025: 32 · 2024: 24 · 2023: 12 · 2022: 7 · 2021: 4
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL128745, R01HL151190, R01HL143247)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Aortic Disease and Treatment Approaches
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- calcific aortic valve disease, inflammation, biomechanics
- MeSH terms
- Aortic Valve, Aortic Valve Stenosis, Calcinosis, Homeostasis, Humans, Immune System, Nitric Oxide, Prognosis, Risk Factors, Vasculitis, Cell Adhesion Molecules, Reactive Oxygen Species, Disease Progression, Inflammation Mediators, Endothelial Cells, Nitric Oxide Synthase Type III
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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What counts as a claim ›How we measure confidence ›How we check this ›
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