Cited by 123Cardiac Valve Diseases and TreatmentsAortic Disease and Treatment ApproachesAtherosclerosis and Cardiovascular Diseases

Inflammatory and Biomechanical Drivers of Endothelial-Interstitial Interactions in Calcific Aortic Valve Disease

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Driscoll, Katherine, Cruz, Alexander D., Butcher, Jonathan T.·2021·Circulation Research

Abstract

Calcific aortic valve disease is dramatically increasing in global burden, yet no therapy exists outside of prosthetic replacement. The increasing proportion of younger and more active patients mandates alternative therapies. Studies suggest a window of opportunity for biologically based diagnostics and therapeutics to alleviate or delay calcific aortic valve disease progression. Advancement, however, has been hampered by limited understanding of the complex mechanisms driving calcific aortic valve disease initiation and progression towards clinically relevant interventions.

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Crossref · 10.1161/circresaha.121.318011

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  1. [102]Mónica FZ, Bian K, Murad F. The Endothelium-Dependent Nitric Oxide–cGMP Pathway. In: Khalil RA, editor. Endothelium, vol. 77, Academic Press; 2016, p. 1– 27. doi: 10.1016/bs.apha.2016.05.001. 27451093 · DOI
  2. [136]Gould ST, Matherly EE, Smith JN, Heistad DD, Anseth KS. The role of valvular endothelial cell paracrine signaling and matrix elasticity on valvular interstitial cell activation. Biomaterials 2014; 35: 3596– 3606. doi: 10.1016/j.biomaterials.2014.01.005. 24462357 PMC4040249 · DOI
  3. [212]Merryman WD, Lukoff HD, Long RA, Engelmayr GC, Hopkins RA, Sacks MS. Synergistic effects of cyclic tension and transforming growth factor-β1 on the aortic valve myofibroblast. Cardiovasc Pathol 2007; 16: 268– 276. doi: 10.1016/j.carpath.2007.03.006. 17868877 PMC2094120 · DOI

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Authors
Driscoll, K., Cruz, A. D., & Butcher, J. T.
Affiliations
Cornell University (US)
Venue
Circulation Research
Published
2021-04-30
Volume
128
Issue
9
Pages
1344-1370
ISSN
  • 0009-7330 (ISSN-L)
  • 1524-4571
OpenAlex
W3159358349
Cited by
102
References
221
Citations by year
2026: 23 · 2025: 32 · 2024: 24 · 2023: 12 · 2022: 7 · 2021: 4
FWCI
3.32
Type
journal article
Language
en
Open access
Locations
  • Circulation Research (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Heart, Lung, and Blood Institute (R01HL128745, R01HL151190, R01HL143247)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Aortic Disease and Treatment Approaches
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Keywords
calcific aortic valve disease, inflammation, biomechanics
MeSH terms
Aortic Valve, Aortic Valve Stenosis, Calcinosis, Homeostasis, Humans, Immune System, Nitric Oxide, Prognosis, Risk Factors, Vasculitis, Cell Adhesion Molecules, Reactive Oxygen Species, Disease Progression, Inflammation Mediators, Endothelial Cells, Nitric Oxide Synthase Type III

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