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Cited by 18

The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.

MiR-137–3p rescue motoneuron death by targeting calpain-2

Tang, Ying, Fu, Rao, Ling, Ze-Min, Liu, Lin-lin, Yu, Guang-yin, Li, Wen, Fang, Xin-yu, Zhu, Zhe, Wu, Wu-tian, Zhou, Li-Hua·2018·Nitric Oxide
DOI 10.1016/j.niox.2018.01.008
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Abstract

Brachial plexus root avulsion (BPRA) is a type of injury that leads to motor function loss as a result of motoneurons (MNs) degeneration. Here we identified that the reduced expression of rat miR-137-3p in the ventral horn of spinal cord was associated with MNs death. However, the pathophysiological role of miR-137-3p in root avulsion remains poorly understood. We demonstrated that the calcium-activated neutral protease-2 (calpain-2) was a direct target gene of miR-137-3p with miR-137-3p binding to the 3'-untranslated region of calpain-2. Silencing of calpain-2 suppressed the expression of neuronal nitric oxide synthase (nNOS), a primary source of nitric oxide (NO). After avulsion 2 weeks, up-regulation of miR-137-3p in the spinal cord reduced calpain-2 levels and nNOS expression inside spinal MNs, resulting in an amelioration of the MNs death. These events provide new insight into the mechanism by which upregulation of miR-137-3p can impair MN survival in the BPRA.

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Crossref · 10.1016/j.niox.2018.01.008

Cites

56 of 56 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 3

  1. Wu, 1994, Neuronal nitric-oxide synthase is induced in spinal neurons by traumatic injury, Neuroscience, 61, 719, 10.1016/0306-4522(94)90394-8 · DOI
  2. Goll, 2003, The calpain system, Physiol. Rev., 83, 731, 10.1152/physrev.00029.2002 · DOI · Paper page
  3. Ruitenberg, 2002, Adeno-associated viral vectors as agents for gene delivery: application in disorders and trauma of the central nervous system, Methods, 28, 182, 10.1016/S1046-2023(02)00222-0 · DOI

Cited by

See all 18

Metadata

Authors
Tang, Y., Fu, R., Ling, Z.-M., Liu, L.-L., Yu, G.-Y., Li, W., Fang, X.-Y., Zhu, Z., Wu, W.-T., & Zhou, L.-H.
Venue
Nitric Oxide
Publisher
Elsevier BV
Published
2018-04
Volume
74
Pages
74-85
ISSN
1089-8603
DOI
10.1016/j.niox.2018.01.008
Cited by
18
References
56
Language
en
Licence
Funders
  • National Science Foundation Council of China (31471030)
  • Guangdong Science Foundations (2015A030311014)
  • Guangzhou science and technology (201510010208)

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.