MicroRNA miR-137 Regulates Neuronal Maturation by Targeting Ubiquitin Ligase Mind Bomb-1
Open accessAbstract
The maturation of young neurons is regulated by complex mechanisms and dysregulation of this process is frequently found in neurodevepmental disorders. MicroRNAs have been implicated in several steps of neuronal maturation including dendritic and axonal growth, spine development, and synaptogenesis. We demonstrate that one brain-enriched microRNA, miR-137, has a significant role in regulating neuronal maturation. Overexpression of miR-137 inhibits dendritic morphogenesis, phenotypic maturation, and spine development both in brain and cultured primary neurons. On the other hand, a reduction in miR-137 had opposite effects. We further show that miR-137 targets the Mind bomb one (Mib1) protein through the conserved target site located in the 3′ untranslated region of Mib1 messenger RNA. Mib1 is an ubiquitin ligase known to be important for neurodevelopment. We show that exogenously expressed Mib1 could partially rescue the phenotypes associated with miR-137 overexpression. These results demonstrate a novel miRNA-mediated mechanism involving miR-137 and Mib1 that function to regulate neuronal maturation and dendritic morphogenesis during development.
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miR-137 is a key regulator of neuronal development with roles in neurogenesis and maturation and is highly expressed at synapses in the cortex and hippocampus.
“miR-137 is a key regulator of neuronal development with roles in neurogenesis and maturation 64,65 and is highly expressed at synapses in the cortex and hippocampus. 66”
From Genetic architectures of psychiatric disorders: the emerging picture and its implications (2012) · cites this paper as [66]
miR-137 inhibits synaptic integration and dendritic spine growth when knocked down.
“These miRNAs include miR-132, which is most highly expressed in mature neurons, and miR-137, which inhibits synaptic integration and dendritic spine growth when knocked down [12, 13].”
From MiR-338-3p regulates neuronal maturation and suppresses glioblastoma proliferation. (2017) · cites this paper as [12]
miR-132 is most highly expressed in mature neurons.
“These miRNAs include miR-132, which is most highly expressed in mature neurons, and miR-137, which inhibits synaptic integration and dendritic spine growth when knocked down [12, 13].”
From MiR-338-3p regulates neuronal maturation and suppresses glioblastoma proliferation. (2017) · cites this paper as [12]
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Combinatorial microRNA target predictions
Krek, A., Grün, D., Poy, M. N., Wolf, R., Rosenberg, L., Epstein, E. J., MacMenamin, P., da Piedade, I., Gunsalus, K. C., Stoffel, M., et al. (2005) · Nature Genetics · doi:10.1038/ng1536 · Cited by 4,603 · see citing works
John, B., Enright, A. J., Aravin, A., Tuschl, T., Sander, C., & Marks, D. S. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020363 · Cited by 3,796 · see citing works
The Transcriptional Landscape of the Mammalian Genome
Carninci, P., Kasukawa, T., Katayama, S., Gough, J., Frith, M. C., Maeda, N., Oyama, R., Ravasi, T., Lenhard, B., Wells, C. A., et al. (2005) · Science · doi:10.1126/science.1112014 · Cited by 3,492 · see citing works
Mechanisms and Functional Implications of Adult Neurogenesis
Zhao, C., Deng, W., & Gage, F. H. (2008) · Cell · doi:10.1016/j.cell.2008.01.033 · Cited by 3,007 · see citing works
Functional neurogenesis in the adult hippocampus
van Praag, H., Schinder, A. F., Christie, B. R., Toni, N., Palmer, T. D., & Gage, F. H. (2002) · Nature · doi:10.1038/4151030a · Cited by 2,853 · see citing works
ADULT NEUROGENESIS IN THE MAMMALIAN CENTRAL NERVOUS SYSTEM
Ming, G., & Song, H. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.051804.101459 · Cited by 1,829 · see citing works
A brain-specific microRNA regulates dendritic spine development
Schratt, G. M., Tuebing, F., Nigh, E. A., Kane, C. G., Sabatini, M. E., Kiebler, M., & Greenberg, M. E. (2006) · Nature · doi:10.1038/nature04367 · Cited by 1,786 · see citing works
Transient expression of doublecortin during adult neurogenesis
Brown, J. P., Couillard‐Després, S., Cooper‐Kuhn, C. M., Winkler, J., Aigner, L., & Kuhn, H. G. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10874 · Cited by 1,494 · see citing works
GABA regulates synaptic integration of newly generated neurons in the adult brain
Ge, S., Goh, E. L. K., Sailor, K. A., Kitabatake, Y., Ming, G., & Song, H. (2005) · Nature · doi:10.1038/nature04404 · Cited by 1,261 · see citing works
Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus
Zhao, C., Teng, E. M., Summers, R. G., Ming, G.-L., & Gage, F. H. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3648-05.2006 · Cited by 1,257 · see citing works
The Adult Rat Hippocampus Contains Primordial Neural Stem Cells
Palmer, T. D., TAKAHASHI, J. C., & Gage, F. H. (1997) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1996.0595 · Cited by 1,090 · see citing works
The Postsynaptic Architecture of Excitatory Synapses: A More Quantitative View
Sheng, M., & Hoogenraad, C. C. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.060805.160029 · Cited by 1,010 · see citing works
Dendritic Spine Pathology: Cause or Consequence of Neurological Disorders?
Fiala, J. C., Spacek, J., & Harris, K. M. (2002) · Brain Research Reviews · doi:10.1016/s0165-0173(02)00158-3 · Cited by 811 · see citing works
A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis
Vo, N., Klein, M. E., Varlamova, O., Keller, D. M., Yamamoto, T. S., Goodman, R. H., & Impey, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508448102 · Cited by 799 · see citing works
Itoh, M., Kim, C., Palardy, G. R., Oda, T., Jiang, Y., Maust, D. T., Yeo, S., Lorick, K. L., Wright, G. J., Ariza‐McNaughton, L., et al. (2003) · Developmental Cell · doi:10.1016/s1534-5807(02)00409-4 · Cited by 779 · see citing works
MicroRNAs: key regulators of stem cells
Gangaraju, V. K., & Lin, H. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2621 · Cited by 731 · see citing works
An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP
Wayman, G. A., Davare, M., Ando, H., Fortin, D., Varlamova, O., Cheng, H.-Y. M., Marks, D., Obrietan, K., Soderling, T. R., Goodman, R. H., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803072105 · Cited by 559 · see citing works
Genetic ablation of the t-SNARE SNAP-25 distinguishes mechanisms of neuroexocytosis
Washbourne, P., Thompson, P. M., Carta, M., da Costa, E. T., Mathews, J. R., López‐Bendito, G., Molnár, Z., Bêcher, M. W., Valenzuela, C. F., Partridge, L. D., et al. (2001) · Nature Neuroscience · doi:10.1038/nn783 · Cited by 535 · see citing works
Cross talk between microRNA and epigenetic regulation in adult neurogenesis
Szulwach, K. E., Li, X., Smrt, R. D., Li, Y., Luo, Y., Lin, L., Santistevan, N. J., Li, W., Zhao, X., & Jin, P. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200908151 · Cited by 493 · see citing works
Self-citationMECHANISMS OF VERTEBRATE SYNAPTOGENESIS
Waites, C. L., Craig, A. M., & Garner, C. C. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144336 · Cited by 483 · see citing works
NONCODING RNAS IN THE MAMMALIAN CENTRAL NERVOUS SYSTEM
Cao, X., Yeo, G. W.-M., Muotri, A. R., Kuwabara, T., & Gage, F. H. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112839 · Cited by 432 · see citing works
microRNAs in Vertebrate Physiology and Human Disease
Chang, T.-C., & Mendell, J. T. (2007) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.8.080706.092351 · Cited by 429 · see citing works
Dindot, S. V., Antalffy, B. A., Bhattacharjee, M. B., & Beaudet, A. L. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm288 · Cited by 418 · see citing works
Experimental observations on the development of polarity by hippocampal neurons in culture.
Goslin, K., & Banker, G. A. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.108.4.1507 · Cited by 416 · see citing works
Rajasethupathy, P., Fiumara, F., Sheridan, R., Betel, D., Puthanveettil, S. V., Russo, J. J., Sander, C., Tuschl, T., & Kandel, E. (2009) · Neuron · doi:10.1016/j.neuron.2009.05.029 · Cited by 406 · see citing works
Zhao, X., Ueba, T., Christie, B. R., Barkho, B. Z., McConnell, M. J., Nakashima, K., Lein, E. S., Eadie, B. D., Willhoite, A. R., Muotri, A. R., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1131928100 · Cited by 376 · see citing works
Self-citationFiore, R., Khudayberdiev, S., Christensen, M., Siegel, G., Flavell, S. W., Kim, T., Greenberg, M. E., & Schratt, G. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.10 · Cited by 348 · see citing works
Locked nucleic acid-based in situ detection of microRNAs in mouse tissue sections
Obernosterer, G., Martı̂nez, J., & Alenius, M. (2007) · Nature Protocols · doi:10.1038/nprot.2007.153 · Cited by 327 · see citing works
Barkho, B. Z., Song, H., Aimone, J. B., Smrt, R. D., Kuwabara, T., Nakashima, K., Gage, F. H., & Zhao, X. (2006) · Stem Cells and Development · doi:10.1089/scd.2006.15.407 · Cited by 303 · see citing works
Self-citationBurbea, M., Dreier, L., Dittman, J. S., Grunwald, M. E., & Kaplan, J. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00749-3 · Cited by 294 · see citing works
Mechanisms of postnatal neurobiological development: Implications for human development
Webb, S. J., Monk, C. S., & Nelson, C. A. (2001) · Developmental Neuropsychology · doi:10.1207/s15326942dn1902_2 · Cited by 272 · see citing works
Mind bomb 1 is essential for generating functional Notch ligands to activate Notch
Koo, B., Lim, H., Song, R., Yoon, M.-J., Yoon, K., Moon, J.-S., Kim, Y.-W., Kwon, M.-C., Yoo, K.-W., Kong, M.-P., et al. (2005) · Development · doi:10.1242/dev.01922 · Cited by 247 · see citing works
Mecp2 deficiency leads to delayed maturation and altered gene expression in hippocampal neurons
Smrt, R. D., Eaves-Egenes, J., Barkho, B. Z., Santistevan, N. J., Zhao, C., Aimone, J. B., Gage, F. H., & Zhao, X. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.04.005 · Cited by 239 · see citing works
Self-citationExpression of microRNAs and their precursors in synaptic fractions of adult mouse forebrain
Lugli, G., Torvik, V. I., Larson, J., & Smalheiser, N. R. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05413.x · Cited by 228 · see citing works
Barkho, B. Z., Munoz, A. E., Li, X., Li, L., Cunningham, L. A., & Zhao, X. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0519 · Cited by 201 · see citing works
Self-citationYoon, K., Koo, B., Im, S.-K., Jeong, H., Ghim, J., Kwon, M.-C., Moon, J.-S., Miyata, T., & Kong, Y. (2008) · Neuron · doi:10.1016/j.neuron.2008.03.018 · Cited by 198 · see citing works
Multiplexing RT-PCR for the detection of multiple miRNA species in small samples
Lao, K., Xu, N. L., Yeung, V., Chen, C., Livak, K. J., & Straus, N. A. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.02.106 · Cited by 150 · see citing works
microRNA Regulation of Synaptic Plasticity
Smalheiser, N. R., & Lugli, G. (2009) · NeuroMolecular Medicine · doi:10.1007/s12017-009-8065-2 · Cited by 118 · see citing works
Expression and Function of SNAP-25 as a Universal SNARE Component in GABAergic Neurons
Tafoya, L. C. R., Mameli, M., Miyashita, T., Guzowski, J. F., Valenzuela, C. F., & Wilson, M. C. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1866-06.2006 · Cited by 115 · see citing works
Hippocampal Synaptic Plasticity in Mice Overexpressing an Embryonic Subunit of the NMDA Receptor
Okabe, S., Collin, C., Auerbach, J. M., Meiri, N., Bengzon, J., Kennedy, M. B., Segal, M., & McKay, R. D. G. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-11-04177.1998 · Cited by 109 · see citing works
Epigenetic Regulation of the Stem Cell Mitogen Fgf-2 by Mbd1 in Adult Neural Stem/Progenitor Cells
Li, X., Barkho, B. Z., Luo, Y., Smrt, R. D., Santistevan, N. J., Liu, C., Kuwabara, T., Gage, F. H., & Zhao, X. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804899200 · Cited by 107 · see citing works
Self-citationNew Neurons in the Adult Mammalian Brain: Synaptogenesis and Functional Integration
Song, H., Kempermann, G., Overstreet‐Wadiche, L., Zhao, C., Schinder, A. F., & Bischofberger, J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3452-05.2005 · Cited by 91 · see citing works
MicroRNAs in Adult and Embryonic Neurogenesis
Liu, C., & Zhao, X. (2009) · NeuroMolecular Medicine · doi:10.1007/s12017-009-8077-y · Cited by 85 · see citing works
Self-citationJugloff, D. G. M., Jung, B., Purushotham, D., Logan, R., & Eubanks, J. H. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.11.002 · Cited by 78 · see citing works
Lu, Y., Wang, F., Li, Y., Ferris, J., Lee, J., & Gao, F. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn373 · Cited by 75 · see citing works
Choe, E., Liao, L., Zhou, J.-Y., Cheng, D., Duong, D. M., Jin, P., Tsai, L., & Peng, J. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1408-07.2007 · Cited by 72 · see citing works
Self-citationPAR-1 Phosphorylates Mind Bomb to Promote Vertebrate Neurogenesis
Ossipova, O., Ezan, J., & Sokol, S. Y. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.06.010 · Cited by 67 · see citing works
Haloperidol blocks voltage-activated Ca2+ channels in hippocampal neurones
Fletcher, E. J., Church, J., & MacDonald, J. F. (1994) · European Journal of Pharmacology Molecular Pharmacology · doi:10.1016/0922-4106(94)90178-3 · Cited by 22 · see citing works
Silber, J., Lim, D. A., Petritsch, C., Persson, A. I., Maunakea, A. K., Yu, M., Vandenberg, S. R., Ginzinger, D. G., James, C. D., Costello, J. F., et al. (2008) · BMC Medicine · doi:10.1186/1741-7015-6-14
Siegel (2009) · doi:10.1038/ncb1876
Flagged first, then by citations
Research works printed but not linked: 2
- [29]Li X Barkho BZ Luo Y Epigenetic regulation of the stem cell mitogen Fgf-2 by Mbd1 in adult neural stem/progenitor cells J Biol Chem 2008 283 27644 27652 18689796 PMC2562066
- [47]Liu C Zhao X MicroRNAs in adult and embryonic neurogenesis Neuromolecular Med 2009 11 141 152 19598002 PMC2754598
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Study, T. D., De Rubeis, S., Autism, H. M. C. F., UK10K Consortium, The Autism Sequencing Consortium, He, X., Goldberg, A. P., Poultney, C. S., Samocha, K., Ercument Cicek, A., et al. (2014) · Nature · doi:10.1038/nature13772 · Cited by 2,746 · see citing works
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Im, H.-I., & Kenny, P. J. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.01.004 · Cited by 399 · see citing works
The epigenetics of aging and neurodegeneration
Lardenoije, R., Iatrou, A., Kenis, G., Kompotis, K., Steinbusch, H. W. M., Mastroeni, D., Coleman, P., Lemere, C. A., Hof, P. R., van den Hove, D. L. A., et al. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.05.002 · Cited by 381 · see citing works
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McNeill, E., & Van Vactor, D. (2012) · Neuron · doi:10.1016/j.neuron.2012.07.005 · Cited by 274 · see citing works
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Adlakha, Y. K., & Saini, N. (2014) · Molecular Cancer · doi:10.1186/1476-4598-13-33 · Cited by 213 · see citing works
Willemsen, M. H., Vallès, A., Kirkels, L. A. M. H., Mastebroek, M., Olde Loohuis, N., Kos, A., Wissink-Lindhout, W. M., de Brouwer, A. P. M., Nillesen, W. M., Pfundt, R., et al. (2011) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2011-100294 · Cited by 202 · see citing works
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“Particularly, several miRNAs have been shown to modulate neurological development, including neuronal migration [9], neurogenesis [10], axon and dendrite development [11, 12].”
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- Authors
- Smrt, R. D., Szulwach, K. E., Pfeiffer, R. L., Li, X., Guo, W., Pathania, M., Teng, Z.-Q., Luo, Y., Peng, J., Bordey, A., Jin, P., & Zhao, X.
- Affiliations
- University of New Mexico (US)
- Emory University (US)
- Department of Neurosurgery, Yale School of Medicine, New Haven, Connecticut, USA
- Corresponding author
- Jin, Peng
- Zhao, Xinyu
- ORCID
- Venue
- Stem Cells
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-04-21
- Volume
- 28
- Issue
- 6
- Pages
- 1060-1070
- ISSN
- 1066-5099 (ISSN-L)
- 1549-4918
- PMC
- PMC3140955
- OpenAlex
- W2025902983
- Cited by
- 404
- References
- 52
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 19 · 2023: 5 · 2022: 21 · 2021: 31 · 2020: 20 · 2019: 22 · 2018: 24 · 2017: 31 · 2016: 35 · 2015: 41 · 2014: 44 · 2013: 43 · 2012: 31
- FWCI
- 9.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Stem Cells (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- International Rett Syndrome Foundation (IRSF) and the NIH (NS051630, MH076090)
- IRSF
- NIH (MH080434, MH078972)
- Autism Speaks Postdoctoral Fellowship
- Institutional Minority Student Development program (NIH 2R25GM060201-09)
- Initiatives to Maximize Student Diversity (IMSD) program
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- miR-137, microRNA, neuronal maturation, MIB-1, ubiquitin ligase, dendrite morphogenesis, dendritic spine development, 3' untranslated region, brain development, neurodevelopmental disorders, primary neurons
- MeSH terms
- Animals, Base Sequence, Cell Differentiation, Cells, Cultured, Dendrites, Gene Expression Regulation, Mice, Inbred C57BL, Neurons, Phenotype, Protein Biosynthesis, MicroRNAs, Ubiquitin-Protein Ligases, Mice
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