The DOI matches its Crossref record; 163 of the 165 references it cites were found in a registry or an index.
Modulation of learning and memory by cytokines: Signaling mechanisms and long term consequences
Open accessAbstract
This review describes the role of cytokines and their downstream signaling cascades on the modulation of learning and memory. Immune proteins are required for many key neural processes and dysregulation of these functions by systemic inflammation can result in impairments of memory that persist long after the resolution of inflammation. Recent research has demonstrated that manipulations of individual cytokines can modulate learning, memory, and synaptic plasticity. The many conflicting findings, however, have prevented a clear understanding of the precise role of cytokines in memory. Given the complexity of inflammatory signaling, understanding its modulatory role requires a shift in focus from single cytokines to a network of cytokine interactions and elucidation of the cytokine-dependent intracellular signaling cascades. Finally, we propose that whereas signal transduction and transcription may mediate short-term modulation of memory, long-lasting cellular and molecular mechanisms such as epigenetic modifications and altered neurogenesis may be required for the long lasting impact of inflammation on memory and cognition.
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“Increased inflammatory cytokines are known to impair LTP in the hippocampus, affecting synaptic plasticity (56).”
From Deletion of Abi3 gene locus exacerbates neuropathological features of Alzheimer’s disease in a mouse model of Aβ amyloidosis (2021) · cites this paper as [56]
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Inflammatory Blockade Restores Adult Hippocampal Neurogenesis
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The interleukin-1 family: back to the future
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“Interactions between IL-1b and other IL-1 family members (Garlanda et al., 2013) likely contribute the effects on memory.”
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Flagged first, then by citations
2 of the 165 references couldn’t be matched to a known paper.
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The influence of neuroinflammation in Autism Spectrum Disorder
Matta, S. M., Hill‐Yardin, E. L., & Crack, P. J. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.04.037 · Cited by 431
Neuromodulation by the immune system: a focus on cytokines
Salvador, A. F., de Lima, K. A., & Kipnis, J. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-021-00508-z · Cited by 389
Erickson, M. A., & Banks, W. A. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014647 · Cited by 398
Hosseini, S., Wilk, E., Michaelsen-Preusse, K., Gerhauser, I., Baumgärtner, W., Geffers, R., Schughart, K., & Korte, M. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.1740-17.2018 · Cited by 236
The role of cytokines in modulating learning and memory and brain plasticity
Bourgognon, J.-M., & Cavanagh, J. (2020) · Brain and Neuroscience Advances · doi:10.1177/2398212820979802 · Cited by 262
Metadata
- Authors
- Donzis, E. J., & Tronson, N. C.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Tronson, Natalie C.
- ORCID
- Tronson, Natalie C.
- Venue
- Neurobiology of Learning and Memory
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 115
- Pages
- 68-77
- ISSN
- 1074-7427 (ISSN-L)
- PMC
- PMC4250287
- OpenAlex
- W1994707167
- Cited by
- 254
- References
- 165
- Citations by year
- 2026: 11 · 2025: 13 · 2024: 11 · 2023: 17 · 2022: 15 · 2021: 32 · 2020: 36 · 2019: 39 · 2018: 32 · 2017: 18 · 2016: 18 · 2015: 10 · 2014: 1
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neurobiology of Learning and Memory (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health R00 (MH093459)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- cytokines, learning and memory, neuroinflammation, synaptic plasticity, epigenetic modifications, neurogenesis, memory impairment, cognitive impairment, signal transduction
- MeSH terms
- Animals, Humans, Learning, Memory, Tumor Necrosis Factor-alpha, Signal Transduction, Interleukin-6, Cytokines, Interleukin-1beta
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