Cited by 254Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disordersNeurogenesis and neuroplasticity mechanisms

The DOI matches its Crossref record; 163 of the 165 references it cites were found in a registry or an index.

Modulation of learning and memory by cytokines: Signaling mechanisms and long term consequences

Open access

Donzis, Elissa J., Tronson, Natalie C.·2014·Neurobiology of Learning and Memory

DOI 10.1016/j.nlm.2014.08.008PMC PMC4250287

Open this paper in CoChat — free account

Abstract

This review describes the role of cytokines and their downstream signaling cascades on the modulation of learning and memory. Immune proteins are required for many key neural processes and dysregulation of these functions by systemic inflammation can result in impairments of memory that persist long after the resolution of inflammation. Recent research has demonstrated that manipulations of individual cytokines can modulate learning, memory, and synaptic plasticity. The many conflicting findings, however, have prevented a clear understanding of the precise role of cytokines in memory. Given the complexity of inflammatory signaling, understanding its modulatory role requires a shift in focus from single cytokines to a network of cytokine interactions and elucidation of the cytokine-dependent intracellular signaling cascades. Finally, we propose that whereas signal transduction and transcription may mediate short-term modulation of memory, long-lasting cellular and molecular mechanisms such as epigenetic modifications and altered neurogenesis may be required for the long lasting impact of inflammation on memory and cognition.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.nlm.2014.08.008

Cites

163 of 163 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Inflammatory Blockade Restores Adult Hippocampal Neurogenesis
Monje, M. L., Toda, H., & Palmer, T. D. (2003) · Science · doi:10.1126/science.1088417 · Cited by 2,426
Neurogenesis in the adult is involved in the formation of trace memories
Shors, T. J., Miesegaes, G. R., Beylin, A. V., Zhao, M., Rydel, T. A., & Gould, E. (2001) · Nature · doi:10.1038/35066584 · Cited by 2,014
The interleukin-1 family: back to the future
Garlanda, C., Dinarello, C. A., & Mantovani, A. (2013) · Immunity · doi:10.1016/j.immuni.2013.11.010 · Cited by 1,945 · cited 2×
“Interactions between IL-1b and other IL-1 family members (Garlanda et al., 2013) likely contribute the effects on memory.”
Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus
Schmidt-Hieber, C., Jonas, P., & Bischofberger, J. (2004) · Nature · doi:10.1038/nature02553 · Cited by 1,292
MAPK signalling pathways as molecular targets for anti-inflammatory therapy—from molecular mechanisms to therapeutic benefits
Kaminska, B. (2005) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2005.08.017 · Cited by 1,285
Immune system to brain signaling: Neuropsychopharmacological implications
Capuron, L., & Miller, A. H. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.01.014 · Cited by 1,195
The JAK-STAT Signaling Pathway: Input and Output Integration
Murray, P. J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.5.2623 · Cited by 1,179
IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans
Steensberg, A., Fischer, C. P., Keller, C., Møller, K., & Pedersen, B. K. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00074.2003 · Cited by 1,135
The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease
Stephan, A. H., Barres, B. A., & Stevens, B. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113810 · Cited by 1,113
Increased Neurogenesis in the Dentate Gyrus After Transient Global Ischemia in Gerbils
Liu, J., Solway, K., Messing, R. O., & Sharp, F. R. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-19-07768.1998 · Cited by 1,028
Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF
Schindler, R., Mancilla, J., Endres, S., Ghorbani, R., Clark, S., & Dinarello, C. (1990) · Blood · doi:10.1182/blood.v75.1.40.40 · Cited by 1,012
Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice
Peleg, S., Sananbenesi, F., Zovoilis, A., Burkhardt, S., Bahari-Javan, S., Agis-Balboa, R. C., Cota, P., Wittnam, J. L., Gogol-Doering, A., Opitz, L., et al. (2010) · Science · doi:10.1126/science.1186088 · Cited by 951
A Critical Period for Enhanced Synaptic Plasticity in Newly Generated Neurons of the Adult Brain
Ge, S., Yang, C.-H., Hsu, K.-S., Ming, G.-L., & Song, H. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.002 · Cited by 927
IL-1β is an essential mediator of the antineurogenic and anhedonic effects of stress
Koo, J. W., & Duman, R. S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708092105 · Cited by 862
Neurogenesis may relate to some but not all types of hippocampal‐dependent learning
Shors, T. J., Townsend, D. A., Zhao, M., Kozorovitskiy, Y., & Gould, E. (2002) · Hippocampus · doi:10.1002/hipo.10103 · Cited by 853
Inhibition of Viral Replication by Interferon-γ-Induced Nitric Oxide Synthase
Karupiah, G., Xie, Q. W., Buller, R. M. L., Nathan, C., Duarte, C. J., & MacMicking, J. D. (1993) · Science · doi:10.1126/science.7690156 · Cited by 810
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages
Yasukawa, H., Ohishi, M., Mori, H., Murakami, M., Chinen, T., Aki, D., Hanada, T., Takeda, K., Akira, S., Hoshijima, M., et al. (2003) · Nature Immunology · doi:10.1038/ni938 · Cited by 771
Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression
Goshen, I., Kreisel, T., Ben-Menachem-Zidon, O., Licht, T., Weidenfeld, J., Ben-Hur, T., & Yirmiya, R. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002055 · Cited by 762
Role of interleukin‐1β in postoperative cognitive dysfunction
Cibelli, M., Fidalgo, A. R., Terrando, N., Ma, D., Monaco, C. G., Feldmann, M., Takata, M., Lever, I. J., Nanchahal, J., Fanselow, M. S., et al. (2010) · Annals of Neurology · doi:10.1002/ana.22082 · Cited by 745
Reduced Hippocampal Neurogenesis in Adult Transgenic Mice with Chronic Astrocytic Production of Interleukin-6
Vallières, L., Campbell, I. L., Gage, F. H., & Sawchenko, P. E. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-02-00486.2002 · Cited by 608
Nuclear factor-κB is a critical mediator of stress-impaired neurogenesis and depressive behavior
Koo, J. W., Russo, S. J., Ferguson, D., Nestler, E. J., & Duman, R. S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910658107 · Cited by 607
Resolving postoperative neuroinflammation and cognitive decline
Terrando, N., Eriksson, L. I., Ryu, J. K., Yang, T., Monaco, C. G., Feldmann, M., Fagerlund, M. J., Charo, I. F., Akassoglou, K., & Maze, M. (2011) · Annals of Neurology · doi:10.1002/ana.22664 · Cited by 582
A dual role for interleukin-1 in hippocampal-dependent memory processes
Goshen, I., Kreisel, T., Ounallah-Saad, H., Renbaum, P., Zalzstein, Y., Ben‐Hur, T., Levy‐Lahad, E., & Yirmiya, R. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.09.004 · Cited by 535
Evidence for the involvement of TNF and NF-?B in hippocampal synaptic plasticity
Albensi, B. C., & Mattson, M. P. (2000) · Synapse · doi:10.1002/(sici)1098-2396(200002)35:2 · Cited by 527
C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia
Alberini, C. M., Ghirardl, M., Metz, R., & Kandel, E. R. (1994) · Cell · doi:10.1016/0092-8674(94)90386-7 · Cited by 523
A neuromodulatory role of interleukin-1β in the hippocampus
Schneider, H., Pitossi, F., Balschun, D., Wagner, A., del Rey, A., & Besedovsky, H. O. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7778 · Cited by 498
Tumor Necrosis Factor Receptor 1 Is a Negative Regulator of Progenitor Proliferation in Adult Hippocampal Neurogenesis
Iosif, R. E., Ekdahl, C. T., Ahlenius, H., Pronk, C. J., Bonde, S., Kokaia, Z., Jacobsen, S. E. W., & Lindvall, O. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2723-06.2006 · Cited by 462
Interleukin-1β (IL-1β) and tumour necrosis factor (TNF) inhibit long-term potentiation in the rat dentate gyrus in vitro
Cunningham, A. J., Murray, C. A., O'Neill, L. A. J., Lynch, M. A., & O'Connor, J. J. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(95)12252-4 · Cited by 433
Sustained hippocampal IL-1β overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology
Shaftel, S. S., Kyrkanides, S., Olschowka, J. A., Miller, J.-N. H., Johnson, R. E., & O’Banion, M. K. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31450 · Cited by 433
The consolidation of new but not reactivated memory requires hippocampal C/EBPβ
Taubenfeld, S. M., Milekic, M. H., Monti, B., & Alberini, C. M. (2001) · Nature Neuroscience · doi:10.1038/90520 · Cited by 426
Impaired interleukin‐1 signaling is associated with deficits in hippocampal memory processes and neural plasticity
Avital, A., Goshen, I., Kamsler, A., Segal, M., Iverfeldt, K., Richter‐Levin, G., & Yirmiya, R. (2003) · Hippocampus · doi:10.1002/hipo.10135 · Cited by 396
Interleukin-1β: A New Regulator of the Kynurenine Pathway Affecting Human Hippocampal Neurogenesis
Zunszain, P. A., Anacker, C., Cattaneo, A., Choudhury, S., Musaelyan, K., Myint, A. M., Thuret, S., Price, J., & Pariante, C. M. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.277 · Cited by 388
MHC Class I: An Unexpected Role in Neuronal Plasticity
Shatz, C. J. (2009) · Neuron · doi:10.1016/j.neuron.2009.09.044 · Cited by 388
Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain
Heyser, C. J., Masliah, E., Samimi, A., Campbell, I. L., & Gold, L. H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.4.1500 · Cited by 386
Activation of Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase in Hippocampal Circuitry Is Required for Consolidation and Reconsolidation of Recognition Memory
Kelly, A. M., Laroche, S., & Davis, S. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-12-05354.2003 · Cited by 373
The many paths to p38 mitogen-activated protein kinase activation in the immune system
Ashwell, J. D. (2006) · Nature reviews. Immunology · doi:10.1038/nri1865 · Cited by 370
The role of JAK-STAT signaling within the CNS
Nicolas, C. S., Amici, M., Bortolotto, Z. A., Doherty, A. J., Csaba, Z., Fafouri, A., Dournaud, P., Gressèns, P., Collingridge, G. L., & Peineau, S. (2013) · JAK-STAT · doi:10.4161/jkst.22925 · Cited by 355
TGFβ produced by IL‐10 redirected astrocytes attenuates microglial activation
Norden, D. M., Fenn, A. M., Dugan, A., & Godbout, J. P. (2014) · Glia · doi:10.1002/glia.22647 · Cited by 332
Tumor necrosis factor alters synaptic transmission in rat hippocampal slices.
Tancredi, V., D'Arcangelo, G., Grassi, F., Tarroni, P., Palmieri, G., Santoni, A., & Eusebi, F. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90071-e · Cited by 326
Interleukin‐6: a cytokine to forget
Balschun, D., Wetzel, W., del Rey, A., Pitossi, F. J., Schneider, H., Zuschratter, W., & Besedovsky, H. O. (2004) · The FASEB Journal · doi:10.1096/fj.04-1625fje · Cited by 317
Up-regulation of monocytic IL-10 by tumor necrosis factor-α and cAMP elevating drugs
Platzer, C., Meisel, C., Vogt, K., Platzer, M., & Volk, H. (1995) · International Immunology · doi:10.1093/intimm/7.4.517 · Cited by 317
A Systematic Analysis of the Peripheral and CNS Effects of Systemic LPS, IL-1Β, TNF-α and IL-6 Challenges in C57BL/6 Mice
Skelly, D., Hennessy, E., Dansereau, M., & Cunningham, C. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069123 · Cited by 289
TNF-α protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation
Bélarbi, K., Jopson, T. D., Tweedie, D., Arellano, C., Luo, W., Greig, N. H., & Rosi, S. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-23 · Cited by 289
Selective Effects of Peripheral Lipopolysaccharide Administration on Contextual and Auditory-Cue Fear Conditioning
Pugh, C. R., Kumagawa, K., Fleshner, M., Watkins, L. R., Maier, S. F., & Rudy, J. W. (1998) · Brain, Behavior, and Immunity · doi:10.1006/brbi.1998.0524 · Cited by 286
The Jak-Stat Pathway: Cytokine Signalling from the Receptor to the Nucleus
Heim, M. H. (1999) · Journal of Receptors and Signal Transduction · doi:10.3109/10799899909036638 · Cited by 275
A Primer on the Use of Modern Missing-Data Methods in Psychosomatic Medicine Research
Enders, C. K. (2006) · Psychosomatic Medicine · doi:10.1097/01.psy.0000221275.75056.d8 · Cited by 274
Brain IL-6 elevation causes neuronal circuitry imbalances and mediates autism-like behaviors
Wei, H., Chadman, K. K., McCloskey, D. P., Sheikh, A. M., Malik, M. N., Brown, W. T., & Li, X. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.01.011 · Cited by 267
Brain-Derived Neurotrophic Factor-Dependent Synaptic Plasticity Is Suppressed by Interleukin-1β via p38 Mitogen-Activated Protein Kinase
Tong, L., Prieto, G. A., Kramár, E. A., Smith, E. D., Cribbs, D. H., Lynch, G., & Cotman, C. W. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.1253-12.2012 · Cited by 254
The Inhibitory Effects of Interleukin‐6 on Synaptic Plasticity in the Rat Hippocampus Are Associated with an Inhibition of Mitogen‐Activated Protein Kinase ERK
Tancredi, V., D’Antuono, M., Café, C., Giovedı̀, S., Buè, M. C., D’Arcangelo, G., Onofri, F., & Benfenati, F. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750634.x · Cited by 249
The Jak/STAT pathway is involved in synaptic plasticity
Nicolas, C. S., Peineau, S., Amici, M., Csaba, Z., Fafouri, A., Javalet, C., Collett, V. J., Hildebrandt, L., Seaton, G., Choi, S.-L., et al. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.024 · Cited by 246
The IκB Kinase Regulates Chromatin Structure during Reconsolidation of Conditioned Fear Memories
Lubin, F. D., & Sweatt, J. D. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.039 · Cited by 241
Sustained hippocampal IL-1β overexpression impairs contextual and spatial memory in transgenic mice
Hein, A. M., Stasko, M. R., Matousek, S. B., Scott-McKean, J. J., Maier, S. F., Olschowka, J. A., Costa, A. C. S., & O’Banion, M. K. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.10.002 · Cited by 235
Microglia
Benarroch, E. E. (2013) · Neurology · doi:10.1212/wnl.0b013e3182a4a577 · Cited by 232
Stress-induced neuroinflammation: mechanisms and new pharmacological targets
Munhoz, C. D., García‐Bueno, B., Madrigal, J. L. M., Lepsch, L. B., Scavone, C., & Leza, J. C. (2008) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2008001200001 · Cited by 231
NF-κB Regulates Spatial Memory Formation and Synaptic Plasticity through Protein Kinase A/CREB Signaling
Kaltschmidt, B., Ndiaye‐Lobry, D., Körte, M., Pothion, S., Arbibe, L., Prüllage, M., Pfeiffer, J., Lindecke, A., Staiger, V., Israël, A., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.8.2936-2946.2006 · Cited by 230
AAV serotype 2/1-mediated gene delivery of anti-inflammatory interleukin-10 enhances neurogenesis and cognitive function in APP+PS1 mice
Kiyota, T., Dixie, K. L. I., Swan, R. J., Jacobsen, M. T., Andrews, S. J., & Ikezu, T. (2011) · Gene Therapy · doi:10.1038/gt.2011.126 · Cited by 230
Brain Interleukin-1 Is Involved in Spatial Memory and Passive Avoidance Conditioning
Yirmiya, R. (2002) · Neurobiology of Learning and Memory · doi:10.1006/nlme.2002.4072 · Cited by 228
A dual role for interleukin-1 in LTP in mouse hippocampal slices
Ross, F. M., Allan, S. M., Rothwell, N. J., & Verkhratsky, A. (2003) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2003.08.030 · Cited by 227
Peripheral Nerve Injury Leads to Working Memory Deficits and Dysfunction of the Hippocampus by Upregulation of TNF-α in Rodents
Ren, W., Liu, Y., Zhou, L.-J., Li, W., Zhong, Y.-M., Pang, R., Xin, W.-J., Wei, X.-H., Wang, J., Zhu, H.-Q., et al. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.236 · Cited by 224
Ketamine attenuates post‐operative cognitive dysfunction after cardiac surgery
Hudetz, J. A., Iqbal, Z., Gandhi, S. D., PATTERSON, K. M., Byrne, A. J., Hudetz, A. G., Pagel, P. S., & Warltier, D. C. (2009) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.2009.01978.x · Cited by 220
Dissection of tumor-necrosis factor-α inhibition of long-term potentiation (LTP) reveals a p38 mitogen-activated protein kinase-dependent mechanism which maps to early—but not late—phase LTP
Butler, M. P., O'Connor, J. J., & Moynagh, P. N. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.11.040 · Cited by 218
Cognitive side effects of cancer therapy demonstrate a functional role for adult neurogenesis
Monje, M., & Dietrich, J. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.05.012 · Cited by 217
The dynamics of the LPS triggered inflammatory response of murine microglia under different culture and in vivo conditions
Lund, S., Christensen, K. V., Hedtjärn, M., Mortensen, A. L., Hagberg, H., Falsig, J., Hasseldam, H., Schrattenholz, A. S., Pörzgen, P., & Leist, M. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.07.007 · Cited by 217
The Inhibitory Effect of Interleukin-1β on Long-Term Potentiation Is Coupled with Increased Activity of Stress-Activated Protein Kinases
Vereker, E., O'Donnell, E., & Lynch, M. A. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-18-06811.2000 · Cited by 214
CNS expression of anti‐inflammatory cytokine interleukin‐4 attenuates Alzheimer's disease‐like pathogenesis in APP+PS1 bigenic mice
Kiyota, T., Okuyama, S., Swan, R. J., Jacobsen, M. T., Gendelman, H. E., & Ikezu, T. (2010) · The FASEB Journal · doi:10.1096/fj.10-155317 · Cited by 212
Role of Interleukin-4 in Regulation of Age-related Inflammatory Changes in the Hippocampus
Nolan, Y. M., Maher, F. O., Martin, D. S. D., Clarke, R. M., Brady, M. T., Bolton, A. E., Mills, K. H. G., & Lynch, M. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m412170200 · Cited by 210
CC Chemokine Receptor 2 deficiency aggravates cognitive impairments and amyloid pathology in a transgenic mouse model of Alzheimer's disease
Naert, G., & Rivest, S. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.0299-11.2011 · Cited by 207 · cited 2×
“Consistent with this protective effect of CCL2, CCR2 deficiency leads to exaggerated deficits in spatial memory and contextual fear conditioning deficits in an Alzheimer's model (Naert & Rivest, 2011).”
Molecular and cellular neuroinflammatory status of mouse brain after systemic lipopolysaccharide challenge: importance of CCR2/CCL2 signaling.
Cazareth, J., Guyon, A., Heurteaux, C., Chabry, J., & Petit-Paitel, A. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-132 · Cited by 206
Methylation-Dependent Gene Silencing Induced by Interleukin 1β via Nitric Oxide Production
Hmadcha, A., Bedoya, F. J., Sobrino, F., & Pintado, E. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.11.1595 · Cited by 204
Acetylation of Nuclear Factor-κB in Rat Amygdala Improves Long-Term but not Short-Term Retention of Fear Memory
Yeh, S.-H., Lin, C.-H., & Gean, P. (2004) · Molecular Pharmacology · doi:10.1124/mol.65.5.1286 · Cited by 203
A cytokine network involving brain-borne IL-1β, IL-1ra, IL-18, IL-6, and TNFα operates during long-term potentiation and learning
del Rey, A., Balschun, D., Wetzel, W., Randolf, A., & Besedovsky, H. O. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.05.011 · Cited by 190
AMPA receptors regulate transcription of the plasticity-related immediate-early gene Arc
Rao, V. R., Pintchovski, S. A., Chin, J., Peebles, C., Mitra, S. S., & Finkbeiner, S. M. (2006) · Nature Neuroscience · doi:10.1038/nn1708 · Cited by 190
Long-term effects of an acute and systemic administration of LPS on adult neurogenesis and spatial memory
Valero, J., Mastrella, G., Neiva, I., SÃ¡nchez, S., & Malva, J. O. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00083 · Cited by 186
Activation of p38 Plays a Pivotal Role in the Inhibitory Effect of Lipopolysaccharide and Interleukin-1β on Long Term Potentiation in Rat Dentate Gyrus
Kelly, A. M., Vereker, E., Nolan, Y. M., Brady, M., Barry, C. E., Loscher, C. E., Mills, K. H. G., & Lynch, M. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301938200 · Cited by 182
BDNF Selectively Regulates GABA A Receptor Transcription by Activation of the JAK/STAT Pathway
Lund, I. V., Hu, Y., Raol, Y. H., Benham, R. S., Faris, R., Russek, S. J., & Brooks‐Kayal, A. R. (2008) · Science Signaling · doi:10.1126/scisignal.1162396 · Cited by 181
Fornix-Dependent Induction of Hippocampal CCAAT Enhancer-Binding Protein β and δ Co-Localizes with Phosphorylated cAMP Response Element-Binding Protein and Accompanies Long-Term Memory Consolidation
Taubenfeld, S. M., Wiig, K. A., Monti, B., Dolan, B., Pollonini, G., & Alberini, C. M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-01-00084.2001 · Cited by 178
Cognitive dysfunction in mice deficient for TNF‐ and its receptors
Baune, B. T., Wiede, F., Braun, A., Golledge, J., Arolt, V., & Körner, H. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30712 · Cited by 173
Glucocorticoids exacerbate lipopolysaccharide-induced signaling in the frontal cortex and hippocampus in a dose-dependent manner
Munhoz, C. D., Sorrells, S. F., Caso, J. R., Scavone, C., & Sapolsky, R. M. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0303-09.2010 · Cited by 169
Cognitive changes with coronary artery disease: a prospective study of coronary artery bypass graft patients and nonsurgical controls
Selnes, O. A., Grega, M. A., Borowicz, L. M., Royall, R. M., McKhann, G. M., & Baumgartner, W. A. (2003) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(03)00021-3 · Cited by 165
Cognitive function in young and adult IL (interleukin)-6 deficient mice
Braida, D., Sacerdote, P., Panerai, A. E., Bianchi, M., Aloisi, A. M., Iosuè, S., & Sala, M. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.12.018 · Cited by 164
Sustained expression of interleukin-1β in mouse hippocampus impairs spatial memory
Moore, A. H., Wu, M., Shaftel, S. S., Graham, K. A., & O’Banion, M. K. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.08.073 · Cited by 159
Malaise in the water maze: Untangling the effects of LPS and IL-1β on learning and memory
Cunningham, C. M., & Sanderson, D. J. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.05.007 · Cited by 157
Interleukin-6 inhibits long-term potentiation in rat hippocampal slices
Li, A., Katafuchi, T., Oda, S., Hori, T., & Oomura, Y. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01283-8 · Cited by 155
Downregulation of IL-4-induced signalling in hippocampus contributes to deficits in LTP in the aged rat
Maher, F. O., Nolan, Y. M., & Lynch, M. A. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.07.002 · Cited by 153
Lipopolysaccharide‐induced increase in signalling in hippocampus is abrogated by IL‐10 – a role for IL‐1β?
Lynch, A. M., Walsh, C., Delaney, A., Nolan, Y. M., Campbell, V. A., & Lynch, M. A. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02157.x · Cited by 150
c-Rel, an NF-κB family transcription factor, is required for hippocampal long-term synaptic plasticity and memory formationPreprint
Ahn, H. J., Hernandez, C. M., Levenson, J. M., Lubin, F. D., Liou, H.-C., & Sweatt, J. D. (2008) · Learning & Memory · doi:10.1101/lm.866408 · Cited by 149
The interleukin‐1 signalling pathway in astrocytes: a key contributor to inflammation in the brain
Moynagh, P. N. (2005) · Journal of Anatomy · doi:10.1111/j.1469-7580.2005.00445.x · Cited by 144
Interleukin-1β mediates proliferation and differentiation of multipotent neural precursor cells through the activation of SAPK/JNK pathway
Wang, X., Fu, S., Wang, Y., Yu, P., Hu, J., Gu, W., Xu, X., & Lu, P. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2007.07.005 · Cited by 142
The Anti-inflammatory Cytokine, Interleukin (IL)-10, Blocks the Inhibitory Effect of IL-1β on Long Term Potentiation
Kelly, A. M., Lynch, A. M., Vereker, E., Nolan, Y. M., Queenan, P., Whittaker, E., O'Neill, L. A. J., & Lynch, M. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m108757200 · Cited by 140
The pro-inflammatory cytokine interleukin-18 impairs long-term potentiation and NMDA receptor-mediated transmission in the rat hippocampus in vitro
Curran, B. P., & O'Connor, J. J. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00405-5 · Cited by 138
Adult murine hippocampal neurogenesis is inhibited by sustained IL-1β and not rescued by voluntary running
Wu, M. D., Hein, A. M., Moravan, M. J., Shaftel, S. S., Olschowka, J. A., & O’Banion, M. K. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.09.012 · Cited by 134
Differential roles of TNFR1 and TNFR2 signaling in adult hippocampal neurogenesis
Chen, Z., & Palmer, T. D. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.01.083 · Cited by 131
The p38 mitogen-activated protein kinase inhibitor SB203580 antagonizes the inhibitory effects of interleukin-1β on long-term potentiation in the rat dentate gyrus in vitro
Coogan, A. N., O'Neill, L. A. J., & O'Connor, J. J. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00100-1 · Cited by 129
Inhibition of interleukin-6 trans-signaling in the brain facilitates recovery from lipopolysaccharide-induced sickness behavior
Burton, M. D., Sparkman, N. L., & Johnson, R. W. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-54 · Cited by 128
Prenatal lipopolysaccharide exposure increases depression-like behaviors and reduces hippocampal neurogenesis in adult rats
Lin, Y., & Wang, S. Z. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.10.034 · Cited by 127
Interleukin-1 receptor null mutant mice show decreased anxiety-like behavior and enhanced fear memory
Koo, J. W., & Duman, R. S. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.03.068 · Cited by 125
Acute and subacute IL-1β administrations differentially modulate neuroimmune and neurotrophic systems: possible implications for neuroprotection and neurodegeneration
Song, C., Zhang, Y., & Dong, Y. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-59 · Cited by 123
Pyrogens Specifically Disrupt the Acquisition of a Task Involving Cognitive Processing in the Rat
Aubert, A., Véga, C., Dantzer, R., & Goodall, G. (1995) · Brain Behavior and Immunity · doi:10.1006/brbi.1995.1013 · Cited by 122
Cognitive deficits in interleukin-10-deficient mice after peripheral injection of lipopolysaccharide
Richwine, A. F., Sparkman, N. L., Dilger, R. N., Buchanan, J. B., & Johnson, R. W. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.02.020 · Cited by 118
Participation of Rel/NF-κB transcription factors in long-term memory in the crab Chasmagnathus
Freudenthal, R., & Romano, A. G. (2000) · Brain Research · doi:10.1016/s0006-8993(99)02358-6 · Cited by 114
Intracerebral microinjection of interleukin-4/interleukin-13 reduces β-amyloid accumulation in the ipsilateral side and improves cognitive deficits in young amyloid precursor protein 23 mice
Kawahara, K., Suenobu, M., Yoshida, A., Koga, K., Hyodo, A., Ohtsuka, H., Kuniyasu, A., Tamamaki, N., Sugimoto, Y., & Nakayama, H. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.01.049 · Cited by 113
Epigenetic modifications in the nervous system and their impact upon cognitive impairments
Rudenko, A., & Tsai, L. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.01.043 · Cited by 111
Cytokine-mediated inflammation, tumorigenesis, and disease-associated JAK/STAT/SOCS signaling circuits in the CNS
Campbell, I. L. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.12.006 · Cited by 110
Learning modulation by endogenous hippocampal IL‐1: Blockade of endogenous IL‐1 facilitates memory formation
Depino, A. M., Alonso, M., Ferrari, C. C., del Rey, A., Anthony, D. C., Besedovsky, H. O., Medina, J. H., & Pitossi, F. J. (2003) · Hippocampus · doi:10.1002/hipo.10164 · Cited by 109
Cytokine Responses to LTP Induction in the Rat Hippocampus: A Comparison of In Vitro and In Vivo TechniquesPreprint
Jankowsky, J. L., Derrick, B. E., & Patterson, P. H. (2000) · Learning & Memory · doi:10.1101/lm.32600 · Cited by 109
A role for c-jun n-terminal kinase in the inhibition of long-term potentiation by interleukin-1β and long-term depression in the rat dentate gyrus in vitro
Curran, B. P., Murray, H. J., & O'Connor, J. J. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00941-7 · Cited by 107
Early-life infection leads to altered BDNF and IL-1β mRNA expression in rat hippocampus following learning in adulthood
Bilbo, S. D., Barrientos, R. M., Eads, A. S., Northcutt, A. L., Watkins, L. R., Rudy, J. W., & Maier, S. F. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2007.10.003 · Cited by 104
Astrocyte–neuron interplay in maladaptive plasticity.
Papa, M., De Luca, C., Petta, F., Alberghina, L., & Cirillo, G. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.01.010 · Cited by 104
Receptors for Interleukin (IL)-10 and IL-6-type Cytokines Use Similar Signaling Mechanisms for Inducing Transcription through IL-6 Response Elements
Lai, C., Ripperger, J. A., Morella, K. K., Jurlander, J., Hawley, T. S., Carson, W. E., Kordula, T., Caligiuri, M. A., Hawley, R. G., Fey, G. H., et al. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.24.13968 · Cited by 100
Il1-β Involvement in Cognitive Impairment after Sepsis
Mina, F., Comim, C. M., Dominguini, D., Cassol-Jr, O. J., Dall’Igna, D. M., Ferreira, G. K., Silva, M. C., Galant, L. S., STRECK, E. L., Quevedo, J., et al. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8581-9 · Cited by 99
NF‐κB transcription factor is required for inhibitory avoidance long‐term memory in mice
Freudenthal, R., Boccia, M. M., Acosta, G. B., Blake, M. G., Merlo, E., Baratti, C. M., & Romano, A. G. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04126.x · Cited by 98
Interleukin-6 and Memory Functions of Encoding and Recall in Healthy and Depressed Elderly Adults
Elderkin‐Thompson, V., Irwin, M. R., Hellemann, G., & Kumar, A. (2012) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e31825d08d6 · Cited by 92
Learning performances, brain NGF distribution and NPY levels in transgenic mice expressing TNF-alpha
Fiore, M., Angelucci, F., Alleva, E., Branchi, I., Probert, L., & Aloe, L. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00180-7 · Cited by 87
Influence of continuous infusion of interleukin-1β on depression-related processes in mice: corticosterone, circulating cytokines, brain monoamines, and cytokine mRNA expression
Anisman, H., Gibb, J., & Hayley, S. P. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1166-z · Cited by 87
TNF-α and its receptors modulate complex behaviours and neurotrophins in transgenic mice
Camara, M. L., Corrigan, F., Jaehne, E. J., Jawahar, M. C., Anscomb, H., Körner, H., & Baune, B. T. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.09.010 · Cited by 86
IL-1/IL-1ra balance in the brain revisited – Evidence from transgenic mouse models
Spulber, S. D., Bartfai, T., & Schultzberg, M. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.02.015 · Cited by 83
Environmental Enrichment Restores Memory Functioning in Mice with Impaired IL-1 Signaling via Reinstatement of Long-Term Potentiation and Spine Size Enlargement
Goshen, I., Avital, A., Kreisel, T., Licht, T., Segal, M., & Yirmiya, R. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5352-08.2009 · Cited by 82 · cited 1×
“In IL-1R knockout mice, several studies demonstrated impaired hippocampal LTP, spatial memory, or context fear conditioning, but intact auditory fear conditioning (Avital et al., 2003; Goshen et al., 2009).”
Proinflammatory cytokines differentially influence adult hippocampal cell proliferation depending upon the route and chronicity of administration
Hayley, S. P. (2008) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s4476 · Cited by 81
Memory impairment induced by IL-1β is reversed by α-MSH through central melanocortin-4 receptors
Gonzalez, P. V., Schiöth, H. B., Lasaga, M., & Scimonelli, T. N. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.03.001 · Cited by 81
Temporal requirement of C/EBPβ in the amygdala following reactivation but not acquisition of inhibitory avoidancePreprint
Milekic, M. H., Pollonini, G., & Alberini, C. M. (2007) · Learning & Memory · doi:10.1101/lm.598307 · Cited by 80
Hematopoietic CC-Chemokine Receptor 2 (CCR2) Competent Cells Are Protective for the Cognitive Impairments and Amyloid Pathology in a Transgenic Mouse Model of Alzheimer’s Disease
Naert, G., & Rivest, S. (2011) · Molecular Medicine · doi:10.2119/molmed.2011.00306 · Cited by 77
Neuroprotective actions of eicosapentaenoic acid on lipopolysaccharide‐induced dysfunction in rat hippocampus
Lonergan, P. E., Martin, D. S. D., Horrobin, D. F., & Lynch, M. A. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02689.x · Cited by 77
Increased IL-1β in cortex of aged rats is accompanied by downregulation of ERK and PI-3 kinase
Maher, F. O., Martin, D. S. D., & Lynch, M. A. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.08.007 · Cited by 73
Impaired long term memory consolidation in transgenic mice overexpressing the human soluble form of IL-1ra in the brain
Spulber, S. D., Mateos, L., Oprica, M., Cedazo-Mı́nguez, Á., Bartfai, T., Winblad, B. G., & Schultzberg, M. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.01.010 · Cited by 70
Interleukin 1 beta enhances conditioned fear memory in rats: possible involvement of glucocorticoids
Song, C., Phillips, A. G., & Leonard, B. E. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02886.x · Cited by 66
Histone H3 lysine methylation in cognition and intellectual disability disordersPreprint
Parkel, S., López‐Atalaya, J. P., & Barco, Á. (2013) · Learning & Memory · doi:10.1101/lm.029363.112 · Cited by 60
Lipopolysaccharide-induced increases in cytokines in discrete mouse brain regions are detectable using Luminex xMAP® technology
Datta, S. C., & Opp, M. R. (2008) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2008.08.007 · Cited by 60
Posttraumatic stress syndromes and health-related quality of life following myocardial infarction: 8-year follow-up
Ginzburg, K., & Ein‐Dor, T. (2011) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2011.08.015 · Cited by 60
Eighteen-Month-Old Fischer 344 Rats Fed a Spinach-Enriched Diet Show Improved Delay Classical Eyeblink Conditioning and Reduced Expression of Tumor Necrosis Factor α (TNFα) and TNFβ in the Cerebellum
Cartford, M. C., Gemma, C., & Bickford, P. C. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-14-05813.2002 · Cited by 58
Endogenous IL-1 in Cognitive Function and Anxiety: A Study in IL-1RI−/− Mice
Murray, C., Obiang, P., Bannerman, D. M., & Cunningham, C. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078385 · Cited by 57
Neuronal MEK is important for normal fear conditioning in mice
Shalin, S. C., Zirrgiebel, U., Honsa, K. J., Julien, J., Miller, F. D., Kaplan, D. R., & Sweatt, J. D. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20052 · Cited by 54
Interleukin-1 receptor antagonist exerts agonist activity in the hippocampus independent of the interleukin-1 type I receptor
Loscher, C. E., Mills, K. H. G., & Lynch, M. A. (2003) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(03)00072-9 · Cited by 54
Molecular mechanisms involved in interleukin 1-beta (IL-1β)-induced memory impairment. Modulation by alpha-melanocyte-stimulating hormone (α-MSH)
Gonzalez, P., Machado, I., Vilcaes, A. A., Caruso, C. M., Roth, G. A., Schiöth, H. B., Lasaga, M., & Scimonelli, T. N. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.08.007 · Cited by 54
Activation of the canonical nuclear factor-κB pathway is involved in isoflurane-induced hippocampal interleukin-1β elevation and the resultant cognitive deficits in aged rats
Li, Z., Rong, X.-Y., Liu, Y.-J., Ni, C., Tian, X., Mo, N., Chui, D., & Guo, X. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.08.003 · Cited by 53
Activation of c‐Jun‐N‐terminal kinase is critical in mediating lipopolysaccharide‐induced changes in the rat hippocampus
Barry, C. E., Nolan, Y. M., Clarke, R. M., Lynch, A. M., & Lynch, M. A. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.03011.x · Cited by 52
Myocardial Infarction - Stress PRevention INTervention (MI-SPRINT) to reduce the incidence of posttraumatic stress after acute myocardial infarction through trauma-focused psychological counseling: study protocol for a randomized controlled trial
Meister, R. E., Princip, M., Schmid, J., Schnyder, U., Barth, J., Znoj, H., Herbert, C., & von Känel, R. (2013) · Trials · doi:10.1186/1745-6215-14-329 · Cited by 52
A role for inflammatory mediators in the IL-18 mediated attenuation of LTP in the rat dentate gyrus
Cumiskey, D., Curran, B. P., Herron, C. E., & O'Connor, J. J. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.03.006 · Cited by 50
Cytokine signaling through the JAK/STAT pathway is required for long-term memory in Drosophila
Copf, T., Goguel, V., Lampin-Saint-Amaux, A., Scaplehorn, N., & Préat, T. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012919108 · Cited by 48
Cytokines and cholinergic signals co-modulate surgical stress-induced changes in mood and memory
Shapira‐Lichter, I., Beilin, B., Ofek, K., Bessler, H., Gruberger, M., Shavit, Y., Seror, D., Grinevich, G., Posner, E., Reichenberg, A., et al. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2007.09.006 · Cited by 47
Obovatol improves cognitive functions in animal models for Alzheimer’s disease
Choi, D., Lee, J. W., Peng, J., Lee, Y. J., Han, J., Lee, Y. H., Choi, I. S., Han, S., Jung, J., Lee, W. S., et al. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07642.x · Cited by 46
Hippocampal Interleukin‐1β Gene Expression during Long‐Term Potentiation Decays with Age
Balschun, D., Randolf, A., Pitossi, F. J., Schneider, H., del Rey, A., & Besedovsky, H. O. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb03132.x · Cited by 46
Occurrence of a transcription factor, signal transducer and activators of transcription 3 (Stat3), in the postsynaptic density of the rat brain
Murata, S., Usuda, N., Okano, A., Kobayashi, S., & Suzuki, T. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00077-2 · Cited by 46
Analysis of cognition, motor performance and anxiety in young and aged tumor necrosis factor alpha receptor 1 and 2 deficient mice
Naudé, P. J. W., Dobos, N., van der Meer, D., Mulder, C. K., Pawironadi, K. G. D., den Boer, J. A., van der Zee, E. A., Luiten, P. G. M., & Eisel, U. L. M. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.10.006 · Cited by 43
Epigenetic modification in neurons of the mollusc Pomacea canaliculata after immune challenge
Ottaviani, E., Accorsi, A., Rigillo, G., Malagoli, D., Blom, J. M. C., & Tascedda, F. (2013) · Brain Research · doi:10.1016/j.brainres.2013.09.009 · Cited by 42
Interleukin-18 regulates motor activity, anxiety and spatial learning without affecting synaptic plasticity
Yaguchi, T., Nagata, T., Yang, D., & Nishizaki, T. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.08.033 · Cited by 39
BDNF and TNF-α polymorphisms in memory
Yogeetha, B. S., Haupt, L. M., McKenzie, K. A., Sutherland, H. G. E., Okolicsyani, R. K., Lea, R. A., Maher, B. H., Chan, R. C. K., Shum, D., & Griffiths, L. R. (2013) · Molecular Biology Reports · doi:10.1007/s11033-013-2648-6 · Cited by 36
α-Melanocyte-stimulating hormone (α-MSH) reverses impairment of memory reconsolidation induced by interleukin-1 beta (IL-1 beta) hippocampal infusions
Machado, I., Gonzalez, P. V., Schiöth, H. B., Lasaga, M., & Scimonelli, T. N. (2010) · Peptides · doi:10.1016/j.peptides.2010.07.018 · Cited by 34
Memory formation requires p38MAPK activity in the rat hippocampus
Alonso, M., Bevilaqua, L. R., Izquierdo, I., Medina, J. H., & Cammarota, M. (2003) · Neuroreport · doi:10.1097/00001756-200310270-00022 · Cited by 34
Drug targets in the cytokine universe for autoimmune disease
Liu, X., Fang, L., Guo, T. B., Mei, H., & Zhang, J. Z. (2012) · Trends in Immunology · doi:10.1016/j.it.2012.10.003 · Cited by 34
Synaptic plasticity in the hippocampus shows resistance to acute ethanol exposure in transgenic mice with astrocyte-targeted enhanced CCL2 expression
Bray, J. G., Reyes, K. C., Roberts, A. J., Ransohoff, R. M., & Gruol, D. L. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.11.007 · Cited by 34
Induction of aberrant trimethylation of histone H3 lysine 27 by inflammation in mouse colonic epithelial cells
Takeshima, H., Ikegami, D., Wakabayashi, M., Niwa, T., Kim, Y.-J., & Ushijima, T. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs294 · Cited by 32
Interleukin-6: A Cytokine with a Pleiotropic Role in the Neuroimmunoendocrine Network
Guzmán, C., Hallal-Calleros, C., López-Griego, L., & Morales‐Montor, J. (2010) · The Open Neuroendocrinology Journal · Cited by 27
Modulation of TNF-α mRNA production in rat C6 glioma cells by TNF-α, IL-1β, IL-6, and IFN-α: In vitro analysis of cytokine-cytokine interactions
Gayle, D. A., Ilyin, S. E., Miele, M. E., & Plata‐Saláman, C. R. (1998) · Brain Research Bulletin · doi:10.1016/s0361-9230(98)00078-1 · Cited by 26
Peripheral nerve injury alters the expression of NF-κB in the rat's hippocampus
Chou, C.-W., Wong, G. T. C., Lim, G., McCabe, M. F., Wang, S., Irwin, M. G., & Mao, J. (2011) · Brain Research · doi:10.1016/j.brainres.2011.01.006 · Cited by 23
Cytokine Receptors in the Brain
Conti, B., Tabarean, I. V., Sánchez-Alavez, M., Davis, C., Brownell, S. E., Behrens, M. M., & Bartfai, T. (2008) · Neuroimmune biology · doi:10.1016/s1567-7443(07)10002-8 · Cited by 22
Neonatal immune challenge exacerbates seizure-induced hippocampus-dependent memory impairment in adult rats
Yin, P., Li, Z., Wang, Y., Qiao, N., Huang, S., Sun, R., & Wang, J. (2013) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2012.12.015 · Cited by 22
The STAT3-DNMT1 connection
Thomas, N. S. B. (2012) · JAK-STAT · doi:10.4161/jkst.22436 · Cited by 22
Epigenetics as a new therapeutic target for postoperative cognitive dysfunction
Wang, Y., Chen, Z., Zhao, Y., Shi, R., Wang, Y., Xu, J., Wu, A., Johns, R. A., & Yue, Y. (2012) · Medical Hypotheses · doi:10.1016/j.mehy.2012.11.041 · Cited by 14
Role of TNFα Induced Inflammation in Delay Eyeblink Conditioning in Young and Aged Rats.
Paredes, D., Acosta, S., Gemma, C., & Bickford, P. C. (2010) · PubMed Central · Cited by 13
Cytokines in Neural Signaling to the Brain
Goehler, L. (2008) · Neuroimmune biology · doi:10.1016/s1567-7443(07)10016-8 · Cited by 12
Effects of peripheral nerve ischemia-reperfusion model on serum cytokine levels.
Bağdatoğlu, Ö., Polat, G., Bağdatoğlu, C., & Atik, U. (2008) · PubMed · Cited by 11
JAK/STAT: The Enigma within the Mystery of NMDAR-LTD
Sacktor, T. C. (2012) · Neuron · doi:10.1016/j.neuron.2012.01.003 · Cited by 4
Memory loss following coronary artery bypass graft surgery: A discussion of the implications for nursing.
Fredericks, S. (2021) · doi:10.32920/ryerson.14669166.v1 · Cited by 3

Flagged first, then by citations

2 of the 165 references couldn’t be matched to a known paper.

Sorted by citations

The influence of neuroinflammation in Autism Spectrum Disorder
Matta, S. M., Hill‐Yardin, E. L., & Crack, P. J. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.04.037 · Cited by 431
Neuromodulation by the immune system: a focus on cytokines
Salvador, A. F., de Lima, K. A., & Kipnis, J. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-021-00508-z · Cited by 389
Neuroimmune Axes of the Blood–Brain Barriers and Blood–Brain Interfaces: Bases for Physiological Regulation, Disease States, and Pharmacological Interventions
Erickson, M. A., & Banks, W. A. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014647 · Cited by 398
Long-Term Neuroinflammation Induced by Influenza A Virus Infection and the Impact on Hippocampal Neuron Morphology and Function
Hosseini, S., Wilk, E., Michaelsen-Preusse, K., Gerhauser, I., Baumgärtner, W., Geffers, R., Schughart, K., & Korte, M. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.1740-17.2018 · Cited by 236
The role of cytokines in modulating learning and memory and brain plasticity
Bourgognon, J.-M., & Cavanagh, J. (2020) · Brain and Neuroscience Advances · doi:10.1177/2398212820979802 · Cited by 262

See all 254

Authors: Donzis, E. J., & Tronson, N. C.
Affiliations: University of Michigan (US)
Corresponding author: Tronson, Natalie C.
ORCID: Tronson, Natalie C.
Venue: Neurobiology of Learning and Memory
Publisher: Elsevier BV
Published: 2014-11
Volume: 115
Pages: 68-77
ISSN: 1074-7427 (ISSN-L)
DOI: 10.1016/j.nlm.2014.08.008
PMC: PMC4250287
OpenAlex: W1994707167
Cited by: 254
References: 165
Citations by year: 2026: 11 · 2025: 13 · 2024: 11 · 2023: 17 · 2022: 15 · 2021: 32 · 2020: 36 · 2019: 39 · 2018: 32 · 2017: 18 · 2016: 18 · 2015: 10 · 2014: 1
FWCI: 1.27
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Learning and Memory (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health R00 (MH093459)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: cytokines, learning and memory, neuroinflammation, synaptic plasticity, epigenetic modifications, neurogenesis, memory impairment, cognitive impairment, signal transduction
MeSH terms: Animals, Humans, Learning, Memory, Tumor Necrosis Factor-alpha, Signal Transduction, Interleukin-6, Cytokines, Interleukin-1beta

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Modulation of learning and memory by cytokines: Signaling mechanisms and long term consequences

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks