Cited by 254Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disordersNeurogenesis and neuroplasticity mechanisms

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Modulation of learning and memory by cytokines: Signaling mechanisms and long term consequences

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Donzis, Elissa J., Tronson, Natalie C.·2014·Neurobiology of Learning and Memory

DOI 10.1016/j.nlm.2014.08.008PMC PMC4250287

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Abstract

This review describes the role of cytokines and their downstream signaling cascades on the modulation of learning and memory. Immune proteins are required for many key neural processes and dysregulation of these functions by systemic inflammation can result in impairments of memory that persist long after the resolution of inflammation. Recent research has demonstrated that manipulations of individual cytokines can modulate learning, memory, and synaptic plasticity. The many conflicting findings, however, have prevented a clear understanding of the precise role of cytokines in memory. Given the complexity of inflammatory signaling, understanding its modulatory role requires a shift in focus from single cytokines to a network of cytokine interactions and elucidation of the cytokine-dependent intracellular signaling cascades. Finally, we propose that whereas signal transduction and transcription may mediate short-term modulation of memory, long-lasting cellular and molecular mechanisms such as epigenetic modifications and altered neurogenesis may be required for the long lasting impact of inflammation on memory and cognition.

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Authors: Donzis, E. J., & Tronson, N. C.
Affiliations: University of Michigan (US)
Corresponding author: Tronson, Natalie C.
ORCID: Tronson, Natalie C.
Venue: Neurobiology of Learning and Memory
Publisher: Elsevier BV
Published: 2014-11
Volume: 115
Pages: 68-77
ISSN: 1074-7427 (ISSN-L)
DOI: 10.1016/j.nlm.2014.08.008
PMC: PMC4250287
OpenAlex: W1994707167
Cited by: 254
References: 165
Citations by year: 2026: 11 · 2025: 13 · 2024: 11 · 2023: 17 · 2022: 15 · 2021: 32 · 2020: 36 · 2019: 39 · 2018: 32 · 2017: 18 · 2016: 18 · 2015: 10 · 2014: 1
FWCI: 1.27
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Learning and Memory (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health R00 (MH093459)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: cytokines, learning and memory, neuroinflammation, synaptic plasticity, epigenetic modifications, neurogenesis, memory impairment, cognitive impairment, signal transduction
MeSH terms: Animals, Humans, Learning, Memory, Tumor Necrosis Factor-alpha, Signal Transduction, Interleukin-6, Cytokines, Interleukin-1beta

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Modulation of learning and memory by cytokines: Signaling mechanisms and long term consequences

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