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Cited by 17Memory and Neural MechanismsOlfactory and Sensory Function StudiesMemory Processes and Influences

Neural correlates of olfactory and visual memory performance in 3D-simulated mazes after intranasal insulin application

Brünner, Yvonne F., Rodriguez-Raecke, Rea, Mutic, Smiljana, Benedict, Christian, Freiherr, Jessica·2016·Neurobiology of Learning and Memory
DOI 10.1016/j.nlm.2016.07.027
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Abstract

This fMRI study intended to establish 3D-simulated mazes with olfactory and visual cues and examine the effect of intranasally applied insulin on memory performance in healthy subjects. The effect of insulin on hippocampus-dependent brain activation was explored using a double-blind and placebo-controlled design. Following intranasal administration of either insulin (40IU) or placebo, 16 male subjects participated in two experimental MRI sessions with olfactory and visual mazes. Each maze included two separate runs. The first was an encoding maze during which subjects learned eight olfactory or eight visual cues at different target locations. The second was a recall maze during which subjects were asked to remember the target cues at spatial locations. For eleven included subjects in the fMRI analysis we were able to validate brain activation for odor perception and visuospatial tasks. However, we did not observe an enhancement of declarative memory performance in our behavioral data or hippocampal activity in response to insulin application in the fMRI analysis. It is therefore possible that intranasal insulin application is sensitive to the methodological variations e.g. timing of task execution and dose of application. Findings from this study suggest that our method of 3D-simulated mazes is feasible for studying neural correlates of olfactory and visual memory performance.

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  • The same 40 IU IN insulin dose did not improve performance in 3D-simulated mazes and associated fMRI-assessed hippocampal activation.

    “the same dose did not improve performance in 3D-simulated mazes and associated fMRI-assessed hippocampal activation, which was attributed to the potential influence of subtle differences in timing.108”

    From Intranasal insulin (2021) · cites this paper as [108]

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Authors
Brünner, Y. F., Rodriguez-Raecke, R., Mutic, S., Benedict, C., & Freiherr, J.
Affiliations
  • Universitätsklinikum Aachen (DE)
  • Uppsala University (SE)
  • Fraunhofer Institute for Process Engineering and Packaging (DE)
Corresponding author
  • Brünner, Yvonne F.
  • Freiherr, Jessica
ORCID
Venue
Neurobiology of Learning and Memory
Publisher
Elsevier BV
Published
2016-10
Volume
134
Pages
256-263
ISSN
1074-7427 (ISSN-L)
DOI
10.1016/j.nlm.2016.07.027
OpenAlex
W2485863440
Cited by
17
References
35
Citations by year
2025: 5 · 2024: 2 · 2022: 1 · 2021: 3 · 2020: 2 · 2018: 2 · 2017: 2
FWCI
0.85
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neurobiology of Learning and Memory (publishedVersion)
  • PubMed (publishedVersion)
  • Fraunhofer-Publica (Fraunhofer-Gesellschaft) (submittedVersion)
  • RWTH Publications (RWTH Aachen) (submittedVersion)
Funders
  • Medical Faculty of Uniklinik RWTH Aachen (691140)
  • German Research Foundation
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords
intranasal insulin, olfactory memory, visual memory, spatial memory, hippocampus, olfaction, visuospatial memory, neural correlates of memory
MeSH terms
Administration, Intranasal, Adult, Brain, Double-Blind Method, Humans, Hypoglycemic Agents, Insulin, Magnetic Resonance Imaging, Male, Visual Perception, Maze Learning, Olfactory Perception, Young Adult, Functional Neuroimaging, Spatial Memory

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