Functional neuroimaging of the olfactory system in humans
Abstract
Positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) have begun to provide unique information regarding the neural underpinnings of olfactory functioning in humans. We review the relative strengths and weaknesses of PET and fMRI techniques for studying olfaction. We then review PET and fMRI studies relating to the olfactory functions of the pyriform cortex, orbitofrontal cortex, amygdala and the entorhinal/hippocampal region. A pixelwise correlational analysis of PET data is also presented in order to clarify the relationship between blood flow in the medial temporal lobes and psychoperceptual variables.
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Olfactory perception engages an extensive network downstream of the olfactory bulb.
“Olfactory perception engages an extensive network downstream of the OB [57–59].”
From Positive early-life olfactory memory is rooted in the olfactory bulb and triggers large-scale changes beyond the olfactory system (2026) · cites this paper as [59]
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“Olfactory perception engages an extensive network downstream of the OB [57–59].”
- Authors
- Zald, D. H., & Pardo, J. V.
- Affiliations
- University of Minnesota (US)
- Corresponding author
- Zald, David H
- Venue
- International Journal of Psychophysiology
- Publisher
- Elsevier BV
- Published
- 2000-05
- Volume
- 36
- Issue
- 2
- Pages
- 165-181
- ISSN
- 0167-8760 (ISSN-L)
- OpenAlex
- W2017665251
- Cited by
- 334
- References
- 81
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 4 · 2023: 6 · 2022: 5 · 2021: 6 · 2020: 15 · 2019: 5 · 2018: 5 · 2017: 17 · 2016: 12 · 2015: 8 · 2014: 6 · 2013: 13 · 2012: 23
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Psychophysiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Veterans Affairs
- National Institute of Mental Health (F32MH011641, 1F32MH11641-01A1)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Keywords
- olfaction, olfactory system, piriform cortex, orbitofrontal cortex, amygdala, entorhinal cortex, hippocampus, positron emission tomography, functional MRI
- MeSH terms
- Brain, Humans, Magnetic Resonance Imaging, Nervous System, Smell, Tomography, Emission-Computed
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