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Cited by 30Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeurotransmitter Receptor Influence on Behavior

Learning-induced intrinsic and synaptic plasticity in the rodent medial prefrontal cortex

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Porter, James T., Sepulveda-Orengo, Marian T.·2020·Neurobiology of Learning and Memory
DOI 10.1016/j.nlm.2019.107117PMC PMC7060823
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Abstract

In rodents, the anterior cingulate (ACC), prelimbic (PL), and infralimbic cortex (IL) comprise the medial prefrontal cortex (mPFC). Through extensive connections with cortical and subcortical structures, the mPFC plays a key modulatory role in the neuronal circuits underlying associative fear and reward learning. In this article, we have compiled the evidence that associative learning induces plasticity in both the intrinsic and synaptic excitability of mPFC neurons to modulate conditioned fear and cocaine seeking behavior. The literature highlights the accumulating evidence that plasticity in the intrinsic excitability of mPFC neurons represents a major cellular mechanism that interacts with synaptic changes to alter the impact of the mPFC on fear and reward circuits.

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Crossref · 10.1016/j.nlm.2019.107117

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  • The mPFC has reward-regulated mechanisms of spatial learning.

    “The mPFC has an integrative role in object, place and time information [114, 115] as well as reward-regulated mechanisms of spatial learning [116, 117].”

    From The extracellular matrix and perineuronal nets in memory (2022) · cites this paper as [116]

    The Abstract (page unavailable) describes mPFC plasticity in reward learning, and the Cocaine section discusses cocaine-conditioned place preference. Neither passage establishes that reward regulates mechanisms of spatial learning; the review addresses reward learning and drug seeking instead. (LLM, conf=0.78)

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Authors
Porter, J. T., & Sepulveda-Orengo, M. T.
Affiliations
Ponce Health Sciences University (PR)
Corresponding author
Porter, James T.
ORCID
Venue
Neurobiology of Learning and Memory
Publisher
Elsevier BV
Published
2020-03
Volume
169
Pages
107117
ISSN
1074-7427 (ISSN-L)
DOI
10.1016/j.nlm.2019.107117
PMC
PMC7060823
OpenAlex
W2990442664
Cited by
30
References
15
Citations by year
2026: 6 · 2025: 5 · 2024: 2 · 2023: 6 · 2022: 5 · 2021: 6
FWCI
0.37
Type
journal article
Language
en
Open access
Licence
Locations
  • Neurobiology of Learning and Memory (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Minority Health and Health Disparities
  • Puerto Rico Science, Technology and Research Trust
  • National Institute of Mental Health
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
medial prefrontal cortex, intrinsic plasticity, synaptic plasticity, associative learning, intrinsic excitability, fear conditioning, cocaine seeking, reward learning, anterior cingulate cortex, prelimbic cortex, infralimbic cortex, neural circuits
MeSH terms
Action Potentials, Animals, Association Learning, Conditioning, Classical, Extinction, Psychological, Fear, Humans, Neuronal Plasticity, Neurons, Reward, Prefrontal Cortex, Drug-Seeking Behavior

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