The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.
Social approach behaviors in oxytocin knockout mice: Comparison of two independent lines tested in different laboratory environments
Abstract
Oxytocin mediates social affiliation behaviors and social memory in rodents. It has been suggested that disruptions in oxytocin contribute to the deficits in reciprocal social interactions that characterize autism. The present experiments employed a new social approach task for mice which is designed to detect low levels of sociability, representing the first diagnostic criterion for autism. Two lines of oxytocin knockout mice were tested, the National Institute of Mental Health line in Bethesda, and the Baylor/Emory line at the University of North Carolina in Chapel Hill. Similar methods were used for each line to evaluate tendencies to spend time with a stranger mouse versus with an inanimate novel object with no social valence. Adult C57BL/6J males were tested identically, as controls to confirm the robustness of the methods used in the social task. Comprehensive phenotyping of general health, neurological reflexes, olfactory and other sensory abilities, and motor functions was employed to assess both lines. No genotype differences were detected in any of the control measures for either line. Normal sociability, measured as time spent with a novel stranger mouse as compared to time spent with a novel object, was seen in both the NIMH and the Baylor/Emory lines of oxytocin null mutants, heterozygotes, and wild-type littermate controls. Normal preference for social novelty, measured as time spent with a second novel stranger as compared to time spent with a more familiar mouse, was seen in both the NIMH and the Baylor/Emory lines of oxytocin null mutants, heterozygotes, and wild-type littermate controls, with minor exceptions. Similar behavioral results from two independent targeted gene mutations, generated with different targeting vectors, bred on different genetic backgrounds, and tested in different laboratory environments, corroborates the negative findings on sociability in oxytocin mutant mice. Intact tendencies to spend time with another mouse versus with a novel object, in both lines of oxytocin knockouts, supports an interpretation that oxytocin plays a highly specific role in social memory, but is not essential for general spontaneous social approach in mice.
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“Although constitutive KO of OXT does not alter social approach in mice (79), specific OXT systems do influence social reward, approach, and investigation.”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [79]
In the citing paper
“In contrast, the OT and AVP knockout (OTKO or AVPKO) mice display high levels of social contact that does not diminish over time, but also fail to show indication of familiarity (Crawley et al., 2007).”
From Oxytocin and vasopressin systems in genetic syndromes and neurodevelopmental disorders (2014) · cites this paper as Crawley et al., 2007
Citations
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Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
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Research works printed but not linked: 1
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Behavioural phenotyping assays for mouse models of autism
Silverman, J. L., Yang, M., Lord, C., & Crawley, J. N. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2851 · Cited by 1,462
Self-citationOxytocin: The Great Facilitator of Life
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Self-citationThe oxytocin receptor: from intracellular signaling to behavior
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Oxytocin and the Neural Mechanisms Regulating Social Cognition and Affiliative Behavior
Ross, H. E., & Young, L. J. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.05.004 · Cited by 856
“Studies of OTKO and OTRKO mice have been instrumental in further investigating the mechanisms by which OT enhances social recognition [15,77-81].”
BackgroundSelf-citationAutism‐like behavioral phenotypes in BTBR T+tf/J mice
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Self-citation
Metadata
- Authors
- Crawley, J. N., Chen, T., Puri, A., Washburn, R., Sullivan, T. L., Hill, J. M., Young, N. B., Nadler, J. J., Moy, S. S., Young, L. J., Caldwell, H. K., & Young, W. S.
- Affiliations
- National Institute of Mental Health (US)
- University of North Carolina at Chapel Hill (US)
- Emory University (US)
- National Institutes of Health (US)
- Venue
- Neuropeptides
- Publisher
- Elsevier BV
- Published
- 2007-06
- Volume
- 41
- Issue
- 3
- Pages
- 145-163
- ISSN
- 0143-4179 (ISSN-L)
- OpenAlex
- W2093346797
- Cited by
- 232
- References
- 75
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 8 · 2023: 12 · 2022: 11 · 2021: 7 · 2020: 9 · 2019: 7 · 2018: 10 · 2017: 10 · 2016: 14 · 2015: 16 · 2014: 13 · 2013: 11 · 2012: 15
- FWCI
- 25.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropeptides (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute for Health and Care Research
- National Institutes of Health (5u54mh066418-05)
- School of Medicine, Emory University
- National Institute of Mental Health (U54 MH 66418)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30-HD03110, P30HD003110)
- School of Medicine, University of North Carolina at Chapel Hill
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- oxytocin, social approach behavior, sociability, social novelty preference, autism spectrum disorder, social memory, genetic background effects, C57BL/6J mice
- MeSH terms
- Animals, Behavior, Animal, Exploratory Behavior, Feeding Behavior, Handling, Psychological, Health Status, Heterozygote, Locomotion, Male, Mice, Inbred C57BL, Mutation, Oxytocin, Phenotype, Reflex, Smell, Social Behavior, Vocalization, Animal, Mice, Knockout, Reverse Transcriptase Polymerase Chain Reaction, Mice
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