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Effect of CSF1R inhibitor on glial cells population and remyelination in the cuprizone model
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“Microglial depletion with PLX3399 as a CSF1R inhibitor (essential for microglial viability) in the cuprizone animal model of MS delays disease onset and progression and improves remyelination and repair.”
From MiR-124 and MiR-155 as Therapeutic Targets in Microglia-Mediated Inflammation in Multiple Sclerosis (2025) · cites this paper as Tahmasebi et al. 2021
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Cites
Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease
Prinz, M., & Priller, J. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3722 · Cited by 1,329
Glial response during cuprizone-induced de- and remyelination in the CNS: lessons learned
Gudi, V., Gingele, S., Skripuletz, T., & Stangel, M. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00073 · Cited by 375
Disease-specific molecular events in cortical multiple sclerosis lesions
Fischer, M. T., Wimmer, I., Höftberger, R., Gerlach, S., Haider, L., Zrzavy, T., Hametner, S., Mahad, D., Binder, C. J., Krumbholz, M., et al. (2013) · Brain · doi:10.1093/brain/awt110 · Cited by 311
Inhibition of autoimmune encephalomyelitis by a tetracycline
Popovic, N., Schubart, A., Goetz, B. D., Zhang, S., Linington, C., & Duncan, I. D. (2002) · Annals of Neurology · doi:10.1002/ana.10092 · Cited by 295
Research works printed but not linked: 35
- Airas, 2018, Evaluation of microglial activation in multiple sclerosis patients using positron emission tomography, Front. Neurol., 9, 181, 10.3389/fneur.2018.00181 · DOI
- Bizzozero, 2005, Elevated protein carbonylation in the brain white matter and gray matter of patients with multiple sclerosis, J. Neurosci. Res., 81, 687, 10.1002/jnr.20587 · DOI
- Bjartmar, 2000, Neurological disability correlates with spinal cord axonal loss and reduced N-acetyl aspartate in chronic multiple sclerosis patients, Ann. Neurol., 48, 893, 10.1002/1531-8249(200012)48:6<893::AID-ANA10>3.0.CO;2-B · DOI
- Correale, 2015, The role of astrocytes in multiple sclerosis progression, Front. Neurol., 6, 180, 10.3389/fneur.2015.00180 · DOI
- Cruz-Martinez, 2016, Intraventricular injections of mesenchymal stem cells activate endogenous functional remyelination in a chronic demyelinating murine model, Cell Death Dis., 7, 10.1038/cddis.2016.130 · DOI
- Davis, 2017, Characterizing microglia activation: a spatial statistics approach to maximize information extraction, Sci. Rep., 7, 1, 10.1038/s41598-017-01747-8 · DOI
- Domingues, 2016, Oligodendrocyte, astrocyte, and microglia crosstalk in myelin development, damage, and repair, Frontiers in cell and developmental biology, 4, 71
- Dutta, 2006, Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients, Ann. Neurol., 59, 478, 10.1002/ana.20736 · DOI
- Elmore, 2014, CSF1 receptor signaling is necessary for microglia viability, which unmasks a cell that rapidly repopulates the microglia-depleted adult brain, Neuron, 82, 380, 10.1016/j.neuron.2014.02.040 · DOI · Paper page
- Gibson, 2018, Bad wrap: myelin and myelin plasticity in health and disease, Developmental neurobiology, 78, 123, 10.1002/dneu.22541 · DOI
- Giustini, 2018, Tenosynovial giant cell tumor: case report of a patient effectively treated with pexidartinib (PLX3397) and review of the literature, Clinical sarcoma research, 8, 14, 10.1186/s13569-018-0101-2 · DOI
- Goldmann, 2013, Role of microglia in CNS autoimmunity, Clin. Dev. Immunol., 2013, 10.1155/2013/208093 · DOI
- Haider, 2011, Oxidative damage in multiple sclerosis lesions, Brain, 134, 1914, 10.1093/brain/awr128 · DOI
- Jäkel, 2017, Glial cells and their function in the adult brain: a journey through the history of their ablation, Front. Cell. Neurosci., 11, 24, 10.3389/fncel.2017.00024 · DOI
- Kant, 2020, Activated protein C attenuates experimental autoimmune encephalomyelitis progression by enhancing vascular integrity and suppressing microglial activation, Front. Neurosci., 14, 333, 10.3389/fnins.2020.00333 · DOI
- Kipp, 2009, The cuprizone animal model: new insights into an old story, Acta Neuropathol., 118, 723, 10.1007/s00401-009-0591-3 · DOI · Paper page
- Kramann, 2016, Laquinimod prevents cuprizone-induced demyelination independent of toll-like receptor signaling, Neurology-Neuroimmunology Neuroinflammation, 3, 10.1212/NXI.0000000000000233 · DOI
- Kuhlmann, 2008, Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis, Brain, 131, 1749, 10.1093/brain/awn096 · DOI · Paper page
- Liu, 2017, Myelin-specific multiple sclerosis antibodies cause complement-dependent oligodendrocyte loss and demyelination, Acta neuropathologica communications, 5, 1, 10.1186/s40478-017-0428-6 · DOI
- Monif, 2010, Microglia: proliferation and activation driven by the P2X7 receptor, Int. J. Biochem. Cell Biol., 42, 1753, 10.1016/j.biocel.2010.06.021 · DOI
- Nelson, 2002, Microglia in diseases of the central nervous system, Ann. Med., 34, 491, 10.1080/078538902321117698 · DOI
- Nimmerjahn, 2005, Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo, Science, 308, 1314, 10.1126/science.1110647 · DOI · Paper page
- Patel, 2009, Colony-stimulating factor-1 receptor inhibitors for the treatment of cancer and inflammatory disease, Curr. Top. Med. Chem., 9, 599, 10.2174/156802609789007327 · DOI
- Petiet, 2016, Gray and white matter demyelination and remyelination detected with multimodal quantitative MRI analysis at 11.7 T in a chronic mouse model of multiple sclerosis, Front. Neurosci., 10, 491, 10.3389/fnins.2016.00491 · DOI
- Petković, 2016, Astrocyte-targeted production of interleukin-6 reduces astroglial and microglial activation in the cuprizone demyelination model: implications for myelin clearance and oligodendrocyte maturation, Glia, 64, 2104, 10.1002/glia.23043 · DOI · Paper page
- Slowik, 2015, The sphingosine 1-phosphate receptor agonist FTY 720 is neuroprotective after cuprizone-induced CNS demyelination, Br. J. Pharmacol., 172, 80, 10.1111/bph.12938 · DOI · Paper page
- Steelman, 2012, Demyelination and remyelination in anatomically distinct regions of the corpus callosum following cuprizone intoxication, Neurosci. Res., 72, 32, 10.1016/j.neures.2011.10.002 · DOI · Paper page
- Suzuki, 2004, Production and release of neuroprotective tumor necrosis factor by P2X7 receptor-activated microglia, J. Neurosci., 24, 1, 10.1523/JNEUROSCI.3792-03.2004 · DOI · Paper page
- Szepesi, 2018, Bidirectional microglia–neuron communication in health and disease, Front. Cell. Neurosci., 12, 10.3389/fncel.2018.00323 · DOI · Paper page
- Tahmasebi, 2021, The effect of microglial ablation and mesenchymal stem cell transplantation on a cuprizone-induced demyelination model, J. Cell. Physiol., 236, 3552, 10.1002/jcp.30090 · DOI · Paper page
- Thameem Dheen, 2007, Microglial activation and its implications in the brain diseases, Curr. Med. Chem., 14, 1189, 10.2174/092986707780597961 · DOI
- van Horssen, 2012, Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation, J. Neuroinflammation, 9, 156, 10.1186/1742-2094-9-156 · DOI · Paper page
- Wang, 2019, Targeting microglia and macrophages: a potential treatment strategy for multiple sclerosis, Front. Pharmacol., 10, 286, 10.3389/fphar.2019.00286 · DOI
- Wies Mancini, 2019, Microglial modulation through colony-stimulating factor-1 receptor inhibition attenuates demyelination, Glia, 67, 291, 10.1002/glia.23540 · DOI
- Wolswijk, 2000, Oligodendrocyte survival, loss and birth in lesions of chronic-stage multiple sclerosis, Brain, 123, 105, 10.1093/brain/123.1.105 · DOI
Cited by
Sorted by citations
Microglia promote remyelination independent of their role in clearing myelin debris
Baaklini, C. S., Ho, M. F. S., Lange, T., Hammond, B. P., Panda, S. P., Zirngibl, M., Zia, S., Himmelsbach, K., Rana, H., Phillips, B., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113574 · Cited by 73
MiR-124 and MiR-155 as Therapeutic Targets in Microglia-Mediated Inflammation in Multiple Sclerosis
Asl, E. R., Hosseini, S. E., Tahmasebi, F., Bolandi, N., & Barati, S. (2025) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-025-01578-6 · Cited by 19
Self-citation
Metadata
- Authors
- Tahmasebi, F., Barati, S., & Kashani, I. R.
- Venue
- Neuropeptides
- Publisher
- Elsevier BV
- Published
- 2021-10
- Volume
- 89
- Pages
- 102179
- ISSN
- 0143-4179
- Cited by
- 17
- References
- 4
- Language
- en
- Licence
- Funders
- Tehran University of Medical Sciences and Health Services (95.04.3033645)
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