Inhibition of autoimmune encephalomyelitis by a tetracycline
Abstract
We have explored the use of minocycline, a tetracycline with antiinflammatory properties, to treat chronic relapsing-remitting experimental allergic encephalomyelitis, an animal model of multiple sclerosis. Therapeutic treatment with minocycline dramatically suppresses ongoing disease activity and limits disease progression. Disease suppression is associated with immune deviation in the periphery and with suppression of the inflammatory cascade in the central nervous system. This association is demonstrated by inhibition of microglial activation and metalloproteinase-2 expression, which results in a concomitant decrease in inflammation and demyelination. As an established antiinflammatory drug with neuroprotective properties, minocycline may provide a novel therapeutic agent for relapsing-remitting multiple sclerosis.
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Multiple sclerosis patients treated with minocycline have a reduced rate of relapses and amelioration of several immunological parameters such as IL-12p40, metalloproteinase-9, and soluble vascular cell adhesion molecule-1.
“Additionally, MS patients that were treated with the antibiotic minocycline, a broad-spectrum tetracycline, have reduced rate of relapses and amelioration of several immunological parameters (such as IL-12p40, metalloproteinase-9, and soluble vascular cell adhesion molecule-1) (145, 146).”
From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [146]
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- Authors
- Popovic, N., Schubart, A., Goetz, B. D., Zhang, S., Linington, C., & Duncan, I. D.
- Affiliations
- Max Planck Society (DE)
- University of Wisconsin–Madison (US)
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2001-12-21
- Volume
- 51
- Issue
- 2
- Pages
- 215-223
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2085429548
- Cited by
- 295
- References
- 39
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 8 · 2023: 6 · 2022: 7 · 2021: 7 · 2020: 10 · 2019: 7 · 2018: 8 · 2017: 14 · 2016: 14 · 2015: 7 · 2014: 7 · 2013: 11 · 2012: 9
- FWCI
- 8.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
- Keywords
- minocycline, tetracycline, experimental autoimmune encephalomyelitis, multiple sclerosis, relapsing-remitting multiple sclerosis, anti-inflammatory therapy, microglial activation, MMP-2, demyelination, neuroprotection, immune deviation
- MeSH terms
- Animals, Anti-Bacterial Agents, Brain, Chronic Disease, Encephalomyelitis, Autoimmune, Experimental, Female, Immunization, Minocycline, Myelin Proteins, Recurrence, Th1 Cells, Th2 Cells, Myelin-Associated Glycoprotein, Rats, Myelin-Oligodendrocyte Glycoprotein
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