Cited by 295Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration MechanismsPeripheral Neuropathies and Disorders

Inhibition of autoimmune encephalomyelitis by a tetracycline

Popovic, Natalija, Schubart, Anna, Goetz, Brian D., Zhang, Su‐Chun, Linington, Chris, Duncan, Ian D.·2002·Annals of Neurology

Abstract

We have explored the use of minocycline, a tetracycline with antiinflammatory properties, to treat chronic relapsing-remitting experimental allergic encephalomyelitis, an animal model of multiple sclerosis. Therapeutic treatment with minocycline dramatically suppresses ongoing disease activity and limits disease progression. Disease suppression is associated with immune deviation in the periphery and with suppression of the inflammatory cascade in the central nervous system. This association is demonstrated by inhibition of microglial activation and metalloproteinase-2 expression, which results in a concomitant decrease in inflammation and demyelination. As an established antiinflammatory drug with neuroprotective properties, minocycline may provide a novel therapeutic agent for relapsing-remitting multiple sclerosis.

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Crossref · 10.1002/ana.10092

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  • Multiple sclerosis patients treated with minocycline have a reduced rate of relapses and amelioration of several immunological parameters such as IL-12p40, metalloproteinase-9, and soluble vascular cell adhesion molecule-1.

    “Additionally, MS patients that were treated with the antibiotic minocycline, a broad-spectrum tetracycline, have reduced rate of relapses and amelioration of several immunological parameters (such as IL-12p40, metalloproteinase-9, and soluble vascular cell adhesion molecule-1) (145, 146).”

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Authors
Popovic, N., Schubart, A., Goetz, B. D., Zhang, S., Linington, C., & Duncan, I. D.
Affiliations
  • Max Planck Society (DE)
  • University of Wisconsin–Madison (US)
Venue
Annals of Neurology
Publisher
Wiley
Published
2001-12-21
Volume
51
Issue
2
Pages
215-223
ISSN
  • 0364-5134 (ISSN-L)
  • 1531-8249
OpenAlex
W2085429548
Cited by
295
References
39
Citations by year
2026: 1 · 2025: 2 · 2024: 8 · 2023: 6 · 2022: 7 · 2021: 7 · 2020: 10 · 2019: 7 · 2018: 8 · 2017: 14 · 2016: 14 · 2015: 7 · 2014: 7 · 2013: 11 · 2012: 9
FWCI
8.48
Type
journal article
Language
en
Open access
closed
Locations
  • Annals of Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
  • Max Planck Digital Library (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
Keywords
minocycline, tetracycline, experimental autoimmune encephalomyelitis, multiple sclerosis, relapsing-remitting multiple sclerosis, anti-inflammatory therapy, microglial activation, MMP-2, demyelination, neuroprotection, immune deviation
MeSH terms
Animals, Anti-Bacterial Agents, Brain, Chronic Disease, Encephalomyelitis, Autoimmune, Experimental, Female, Immunization, Minocycline, Myelin Proteins, Recurrence, Th1 Cells, Th2 Cells, Myelin-Associated Glycoprotein, Rats, Myelin-Oligodendrocyte Glycoprotein

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