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The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation

van Horssen, Jack, Singh, Shailender, van der Pol, Susanne, Kipp, Markus, Lim, Jamie L, Peferoen, Laura, Gerritsen, Wouter, Kooi, Evert-Jan, Witte, Maarten E, Geurts, Jeroen JG, de Vries, Helga E, Peferoen-Baert, Regina, van den Elsen, Peter J, van der Valk, Paul, Amor, Sandra·2012·Journal of Neuroinflammation
DOI 10.1186/1742-2094-9-156PMC PMC3411485
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Crossref · 10.1186/1742-2094-9-156

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  • In preactive lesions, microglia produce NADPH oxidase and increase harmful oxidative stress that may contribute to neuronal injury.

    “In the “preactive” lesions, microglia produce NADPH oxidase and increase harmful oxidative stress that may contribute to neuronal injury (Horssen et al. 2012).”

    From MiR-124 and MiR-155 as Therapeutic Targets in Microglia-Mediated Inflammation in Multiple Sclerosis (2025) · cites this paper as Horssen et al. 2012

  • Microglial activation occurs as an initial pathological process in the early stages of inflammation and demyelination, even before T-cell infiltration in RRMS, PPMS, and SPMS.

    “Microglial activation occurs as an initial pathological process in the early stages of inflammation and demyelination, even before T-cell infiltration in RRMS, PPMS, and SPMS, because microglial nodules have been detected in normal-appearing white matter in the early stages (Horssen et al. 2012).”

    From MiR-124 and MiR-155 as Therapeutic Targets in Microglia-Mediated Inflammation in Multiple Sclerosis (2025) · cites this paper as Horssen et al. 2012

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Research works printed but not linked: 31

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  11. De Groot CJ, Bergers E, Kamphorst W, Ravid R, Polman CH, Barkhof F, van der Valk P: Post-mortem MRI-guided sampling of multiple sclerosis brain lesions: increased yield of active demyelinating and (p)reactive lesions. Brain 2001, 124:1635–1645. · DOI
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  14. van Noort JM, van den Elsen PJ, van Horssen J, Geurts JJ, van der Valk P, Amor S: Preactive multiple sclerosis lesions offer novel clues for neuroprotective therapeutic strategies. CNS Neurol Disord Drug Targets 2011, 10:68–81. · DOI
  15. Van Horssen J, Schreibelt G, Bo L, Montagne L, Drukarch B, van Muiswinkel F, de Vries HE: NAD(P)H:quinone oxidoreductase 1 expression in multiple sclerosis lesions. Free Radic Biol Med 2006, 41:311–317. · DOI
  16. Verhoeven AJ, Bolscher BG, Meerhof LJ, van Zwieten R, Keijer J, Weening RS, Roos D: Characterization of two monoclonal antibodies against cytochrome b558 of human neutrophils. Blood 1989, 6:1686–1694. · DOI
  17. Fischer MT, Sharma R, Lim JL, Haider L, Frischer JM, Mahad D, Bradl M, van Horssen J, Lassmann H: NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury. Brain 2012, 135:886–899. · DOI · Paper page
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  19. Aboul-Enein F, Krssak M, Hoftberger R, Prayer D, Kristoferitsch W: Reduced NAA-levels in the NAWM of patients with MS is a feature of progression. A study with quantitative magnetic resonance spectroscopy at 3 Tesla. PLoS One 2010, 5:e11625. · DOI
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Metadata

Authors
van Horssen, J., Singh, S., van der Pol, S., Kipp, M., Lim, J. L., Peferoen, L., Gerritsen, W., Kooi, E.-J., Witte, M. E., Geurts, J. J., de Vries, H. E., Peferoen-Baert, R., van den Elsen, P. J., van der Valk, P., & Amor, S.
Venue
Journal of Neuroinflammation
Publisher
Springer Science and Business Media LLC
Published
2012-07-02
Volume
9
Issue
1
ISSN
1742-2094
DOI
10.1186/1742-2094-9-156
PMC
PMC3411485
Cited by
172
References
2
Language
en
Licence
www.creativecommons.org/licenses/by/2.0 (unspecified)

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