Developmental treatment with bisphenol A causes few alterations on measures of postweaning activity and learning
Abstract
Widespread bisphenol A (BPA) exposure necessitates increased knowledge of its potential effects for better risk assessment and regulatory guidance. Here, female Sprague-Dawley rats, reared in low exogenous estrogen environments and bred at adulthood, were gavaged on gestational days 6-21 with vehicle (VEH), 2.5 or 25.0 μg/kg/day BPA, or 5.0 or 10.0 μg/kg/day ethinyl estradiol (EE₂). Offspring were orally treated on postnatal days (PNDs) 1-21 with the same dose their dam received. A naïve control group (NC) was not gavaged. Post-weaning, one offspring/sex/litter (n=11-12/sex/group) was assessed for the typical behaviors measured in developmental neurotoxicology studies. At PND 29, novelty preference was unaffected by treatment; however, relative to the VEH group, males and females of both EE₂ groups were more active. VEH males appeared somewhat hypoactive in open field assessments at PNDs 40-42 and, as a result, males of the BPA and EE₂ groups were significantly more active. Latency to locate the Barnes maze escape box at PNDs 47-50 was increased in males and females of the 5.0 μg/kg/day EE₂ group. Relative to other male groups, VEH males exhibited an increased startle response on the first trial block at PND 54 and thus, males of both BPA groups and the 10.0 μg/kg/day EE₂ group exhibited a significantly decreased startle response. PNDs 43-44 motor coordination and PNDs 75-79 water maze performance were unaffected by treatment. These results indicate few consistent or dose-rel…
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Previously, the authors described few BPA effects on pre- and postweaning behaviors that are not generally thought to be sexually dimorphic.
“Previously, we described few BPA effects on pre-and postweaning behaviors that are not generally thought to be sexually dimorphic (Ferguson et al., 2012(Ferguson et al., , 2011)).”
From Developmental Treatment with Ethinyl Estradiol, but Not Bisphenol A, Causes Alterations in Sexually Dimorphic Behaviors in Male and Female Sprague Dawley Rats (2014) · cites this paper as Ferguson et al., 2012
The lack of significance for BPA treatment here is consistent with previous descriptions from the same cohort.
“Additionally, the lack of significance for BPA treatment here is consistent with our previous descriptions from the same cohort (Ferguson et al., 2011(Ferguson et al., , 2012)).”
From Developmental Treatment with Ethinyl Estradiol, but Not Bisphenol A, Causes Alterations in Sexually Dimorphic Behaviors in Male and Female Sprague Dawley Rats (2014) · cites this paper as Ferguson et al., 2012
Our previous descriptions of significant EE2, but few BPA, effects on pre- and postweaning behaviors add to the growing body of literature indicating lack of effect at these orally administered BPA doses.
“Our previous descriptions of significant EE 2 , but few BPA, effects on pre-and postweaning behaviors (Ferguson et al., 2011(Ferguson et al., , 2012) ) add to the growing body of literature indicating lack of effect at these orally administered BPA doses.”
From Developmental Treatment with Ethinyl Estradiol, but Not Bisphenol A, Causes Alterations in Sexually Dimorphic Behaviors in Male and Female Sprague Dawley Rats (2014) · cites this paper as Ferguson et al., 2012
Cites
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Self-citationPrenatal exposure to ethinylestradiol elicits behavioral abnormalities in the rat
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Cao, J., Rebuli, M. E., Rogers, J., Todd, K. L., Leyrer, S. M., Ferguson, S. A., & Patisaul, H. B. (2013) · Toxicological Sciences · doi:10.1093/toxsci/kft035 · Cited by 141 · see citing works
Self-citationShould oral gavage be abandoned in toxicity testing of endocrine disruptors?
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“, 2011) and certain postweaning behaviors (Ferguson et al., 2012).”
Self-citation
- Authors
- Ferguson, S. A., Law, C. D., & Abshire, J. S.
- Affiliations
- National Center for Toxicological Research (US)
- Corresponding author
- Ferguson, Sherry A.
- ORCID
- Ferguson, Sherry A.
- Venue
- Neurotoxicology and Teratology
- Publisher
- Elsevier BV
- Published
- 2012-11
- Volume
- 34
- Issue
- 6
- Pages
- 598-606
- ISSN
- 0892-0362 (ISSN-L)
- OpenAlex
- W2066407978
- Cited by
- 37
- References
- 5
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 2 · 2021: 4 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 5 · 2015: 5 · 2014: 9 · 2013: 4
- FWCI
- 3.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurotoxicology and Teratology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- bisphenol A, developmental neurotoxicity, prenatal exposure, postnatal exposure, ethinyl estradiol, novelty preference, locomotor activity, startle response, learning, Barnes maze, water maze, sexual dimorphism, Sprague-Dawley rats
- MeSH terms
- Bisphenol A Compounds, Acoustic Stimulation, Animals, Behavior, Animal, Benzhydryl Compounds, Dose-Response Relationship, Drug, Estrogens, Non-Steroidal, Ethinyl Estradiol, Female, Male, Motor Activity, Phenols, Pregnancy, Prenatal Exposure Delayed Effects, Reflex, Startle, Weaning, Rats, Sprague-Dawley, Maze Learning, Rats
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