Cited by 85Growth Hormone and Insulin-like Growth FactorsPancreatic function and diabetesDiabetes, Cardiovascular Risks, and Lipoproteins

Low plasma insulin-like growth factor-1 levels are associated with reduced insulin sensitivity and increased insulin secretion in nondiabetic subjects

Succurro, E., Andreozzi, F., Marini, M.A., Lauro, R., Hribal, M.L., Perticone, F., Sesti, G.·2009·Nutrition Metabolism and Cardiovascular Diseases

Abstract

Background and aim Weight gain is associated with a decline in insulin sensitivity and a compensatory increase in insulin secretion. IGF-1 is a plausible candidate to explain these divergent phenomena. In this cross-sectional study, we analyzed the relationship between IGF-1 levels, insulin sensitivity and secretion in 110 nondiabetic subjects with a wide range of BMI to verify this hypothesis.Methods and results Subjects underwent OGTT, IVGTT and euglycemic-hyperinsulinemic clamp. HOMA-beta, IVGTT-derived and OGTT-derived indexes for first-phase and second-phase insulin secretion were higher in obese as compared with overweight and normal-weight groups, while glucose disposal was lower. IGF-1 levels were negatively correlated with IVGTT-derived and OGTT-derived indexes first-phase and second-phase insulin secretion, and positively correlated with glucose disposal. These correlations were no longer significant after adjustment for BMI. In a multivariate analysis, the variables associated with glucose disposal were IGF-1, age, triglycerides, and 2-h post-load glucose accounting for 23.4% of its variation. When BMI was entered into the model, the variables associated with glucose disposal were triglycerides, 2-h post-load glucose and BMI accounting for 27.2% of variation. In a multivariate analysis, the only variable associated with IVGTT-derived first-phase and second-phase insulin secretion was IGF-1 accounting for 10.4% and 15.1% of variation, respectively. When BMI was entered into the model, it became the only variable associated with both first-phase and second-phase insulin secretion accounting for 25.7% and 37.6% of variation, respectively.Conclusion These data suggest that progressive reduction in IGF-1 levels may be involved in obesity-related changes in both insulin sensitivity and secretion.

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Crossref · 10.1016/j.numecd.2008.12.011

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  • Low plasma levels of IGF1 predict development of type 2 diabetes and correlate with insulin resistance and increased risk of metabolic syndrome and cardiovascular disease.

    “There is evidence that low plasma levels of IGF1 predict the development of type 2 diabetes and correlate with insulin resistance and increased risk of metabolic syndrome and cardiovascular disease [[231], [232], [233]] (Table 1).”

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Authors
Succurro, E., Andreozzi, F., Marini, M. A., Lauro, R., Hribal, M. L., Perticone, F., & Sesti, G.
Affiliations
  • Magna Graecia University (IT)
  • University of Rome Tor Vergata (IT)
Corresponding author
Sesti, G.
Venue
Nutrition Metabolism and Cardiovascular Diseases
Publisher
Elsevier BV
Published
2009-12
Volume
19
Issue
10
Pages
713-719
ISSN
0939-4753 (ISSN-L)
OpenAlex
W2013138570
Cited by
85
References
33
Citations by year
2026: 3 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 24 · 2021: 8 · 2020: 5 · 2019: 1 · 2018: 4 · 2017: 4 · 2016: 4 · 2015: 4 · 2014: 4 · 2013: 5 · 2012: 3
FWCI
2.67
Type
journal article
Language
en
Open access
closed
Locations
  • Nutrition Metabolism and Cardiovascular Diseases (publishedVersion)
  • PubMed (publishedVersion)
  • Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
insulin-like growth factor I, insulin sensitivity, insulin secretion, obesity, weight gain, glucose disposal, first-phase insulin secretion, second-phase insulin secretion, body mass index, non-diabetic patients, triglycerides
MeSH terms
Insulin Secretion, Adult, Aged, Aging, Blood Glucose, Cross-Sectional Studies, Female, Glucose Tolerance Test, Humans, Insulin, Insulin Resistance, Insulin-Like Growth Factor I, Male, Middle Aged, Obesity, Triglycerides, Glucose Clamp Technique, Body Mass Index, White People, Adiposity, Overweight, Young Adult

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