Low plasma insulin-like growth factor-1 levels are associated with reduced insulin sensitivity and increased insulin secretion in nondiabetic subjects
Abstract
Background and aim Weight gain is associated with a decline in insulin sensitivity and a compensatory increase in insulin secretion. IGF-1 is a plausible candidate to explain these divergent phenomena. In this cross-sectional study, we analyzed the relationship between IGF-1 levels, insulin sensitivity and secretion in 110 nondiabetic subjects with a wide range of BMI to verify this hypothesis.Methods and results Subjects underwent OGTT, IVGTT and euglycemic-hyperinsulinemic clamp. HOMA-beta, IVGTT-derived and OGTT-derived indexes for first-phase and second-phase insulin secretion were higher in obese as compared with overweight and normal-weight groups, while glucose disposal was lower. IGF-1 levels were negatively correlated with IVGTT-derived and OGTT-derived indexes first-phase and second-phase insulin secretion, and positively correlated with glucose disposal. These correlations were no longer significant after adjustment for BMI. In a multivariate analysis, the variables associated with glucose disposal were IGF-1, age, triglycerides, and 2-h post-load glucose accounting for 23.4% of its variation. When BMI was entered into the model, the variables associated with glucose disposal were triglycerides, 2-h post-load glucose and BMI accounting for 27.2% of variation. In a multivariate analysis, the only variable associated with IVGTT-derived first-phase and second-phase insulin secretion was IGF-1 accounting for 10.4% and 15.1% of variation, respectively. When BMI was entered into the model, it became the only variable associated with both first-phase and second-phase insulin secretion accounting for 25.7% and 37.6% of variation, respectively.Conclusion These data suggest that progressive reduction in IGF-1 levels may be involved in obesity-related changes in both insulin sensitivity and secretion.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Low plasma levels of IGF1 predict development of type 2 diabetes and correlate with insulin resistance and increased risk of metabolic syndrome and cardiovascular disease.
“There is evidence that low plasma levels of IGF1 predict the development of type 2 diabetes and correlate with insulin resistance and increased risk of metabolic syndrome and cardiovascular disease [[231], [232], [233]] (Table 1).”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [232]
Cites
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502 · see citing works
The Physiology of Glucagon-like Peptide 1
Holst, J. J. (2007) · Physiological Reviews · doi:10.1152/physrev.00034.2006 · Cited by 3,371 · see citing works
Bergman, R. N., Phillips, L. S., & Cobelli, C. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110398 · Cited by 1,640 · see citing works
Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity.
Stümvoll, M., Mitrakou, A., Pimenta, W. P., Jenssen, T. G., Yki-Järvinen, H., van Haeften, T. W., Renn, W., & Gerich, J. E. (2000) · Diabetes Care · doi:10.2337/diacare.23.3.295 · Cited by 1,040 · see citing works
Abdul-Ghani, M. A., Jenkinson, C. P., Richardson, D. K., Tripathy, D., & DeFronzo, R. A. (2006) · Diabetes · doi:10.2337/db05-1200 · Cited by 500 · see citing works
Sandhu, M. S., Heald, A. H., Gibson, J. M., Cruickshank, J. K., Dunger, D. B., & Wareham, N. J. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08655-5 · Cited by 470 · see citing works
Liver-Specific igf-1 Gene Deletion Leads to Muscle Insulin Insensitivity
Yakar, S., Liu, J., Fernandez, A. M., Wu, Y., Schally, A. V., Frystyk, J., Chernausek, S. D., Mejía, W., & Roith, D. L. (2001) · Diabetes · doi:10.2337/diabetes.50.5.1110 · Cited by 343 · see citing works
Johannsson, G., Mårin, P., Lönn, L., Ottosson, M., Stenlöf, K., Björntorp, P. A., Sjöström, L., & Bengtsson, B. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.3.3809 · Cited by 336 · see citing works
Jensen, C. C., Cnop, M., Hull, R. L., Fujimoto, W. Y., Kahn, S. E., & the American Diabetes Association GENNID Study Group (2002) · Diabetes · doi:10.2337/diabetes.51.7.2170 · Cited by 312 · see citing works
Moses, A. C., Young, S. C., Morrow, L. A., O'Brien, M., & Clemmons, D. R. (1996) · Diabetes · doi:10.2337/diab.45.1.91 · Cited by 291 · see citing works
Leung, K., Doyle, N. S., Ballesteros, M., Waters, M. J., & Ho, K. K. Y. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.12.7017 · Cited by 261 · see citing works
Metabolic Syndrome Among HIV-Infected Patients
Jericó, C. R., Knobel, H., Montero, M., Ordóñez‐Llanos, J., Guelar, A., Gimeno, J. L., Saballs, P., López-Colomés, J. L., & Pedro‐Botet, J. (2005) · Diabetes Care · doi:10.2337/diacare.28.1.132 · Cited by 257 · see citing works
Rasmussen, M. H., HVIDBERG, A. D., Juul, A., Main, K. M., Gotfredsen, A., Skakkebæk, N. E., Hilsted, J., & Skakkebae, N. E. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.4.7536210 · Cited by 248 · see citing works
Johannsson, G. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.3.727 · Cited by 230 · see citing works
Sesti, G., Sciacqua, A., Cardellini, M., Marini, M. A., Maio, R., Vatrano, M., Succurro, E., Lauro, R., Federici, M., & Perticone, F. (2005) · Diabetes Care · doi:10.2337/diacare.28.1.120 · Cited by 184 · see citing works
Self-citationLaakso, M., Zilinskaite, J., Hansen, T. F., Boesgaard, T. W., Vänttinen, M., Stančáková, A., Jansson, P., Pellmé, F., Holst, J. J., Kuulasmaa, T., et al. (2007) · Diabetologia · doi:10.1007/s00125-007-0899-2 · Cited by 145 · see citing works
Self-citationLiver-Derived IGF-I is of Importance for Normal Carbohydrate and Lipid Metabolism
Sjögren, K., Wallenius, K., Liu, J., Bohlooly‐Y, M., Pacini, G., Svensson, L., Törnell, J., Isaksson, O. G. P., Åhrén, B., Jansson, J., et al. (2001) · Diabetes · doi:10.2337/diabetes.50.7.1539 · Cited by 136 · see citing works
Effects of insulin-like growth factor-I on glucose tolerance, insulin levels, and insulin secretion.
Zenobi, P. D., Graf, S., Ursprung, H., & Froesch, E. R. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115796 · Cited by 135 · see citing works
Leahy, J. L., & VanDeKerkhove, K. M. (1990) · Endocrinology · doi:10.1210/endo-126-3-1593 · Cited by 127 · see citing works
Morrow, L., O'Brien, M. B., Moller, D. E., Flier, J. S., & Moses, A. C. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.1.8027228 · Cited by 88 · see citing works
Retnakaran, R. R., Hanley, A. J., Connelly, P. W., Sermer, M., & Zinman, B. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1253 · Cited by 78 · see citing works
Bonora, E., Capaldo, B., Perin, P. C., Prato, S. D., Mattia, G. D., Frittitta, L., Frontoni, S., Leonetti, F., Luzi, L., Marchesini, G., et al. (2008) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2007.05.002 · Cited by 76 · see citing works
Self-citationFederici, M., Porzio, O., Lauro, D., Borboni, P., Giovannone, B., Zucaro, L., Hribal, M. L., & Sesti, G. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.8.4935 · Cited by 66 · see citing works
Self-citationChiu, K. C., Chuang, L., & Yoon, C. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.4.7432 · Cited by 59 · see citing works
Future perspectives on glucagon-like peptide-1, diabetes and cardiovascular risk
Mannucci, E., & Rotella, C. M. (2008) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2008.08.002 · Cited by 56 · see citing works
Korytkowski, M., Berga, S. L., & Horwitz, M. (1995) · Metabolism: Clinical and Experimental · doi:10.1016/0026-0495(95)90003-9 · Cited by 52 · see citing works
Andreozzi, F., Laratta, E., Cardellini, M., Marini, M. A., Lauro, R., Hribal, M. L., Perticone, F., & Sesti, G. (2006) · Diabetes · doi:10.2337/db06-0063 · Cited by 48 · see citing works
Self-citationFederici, M. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.8.2911 · Cited by 40 · see citing works
Rennert, N. J., Caprio, S., & Sherwin, R. S. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.76.3.8445040 · Cited by 32 · see citing works
Grottoli, S., Massimo, P., Maccario, M., Zini, M., Oleandri, S. E., Tassone, F., Valcavi, R., & Ghigo, E. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.7.4093 · Cited by 15 · see citing works
Perticone, F., Maio, R., Paola, R. D., Sciacqua, A., Marucci, A., Cosmo, S. D., Perticone, M., Sesti, G., & Trischitta, V. (2006) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2005.11.013 · Cited by 14 · see citing works
Self-citationKatz, L. E. L., Ferry, R. J., Stanley, C. A., Collett‐Solberg, P. F., Baker, L., & Cohen, P. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.9.5949 · Cited by 10 · see citing works
Flagged first, then by citations
1 of the 33 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Genetics of Insulin Resistance and the Metabolic Syndrome
Brown, A. E., & Walker, M. (2016) · Current Cardiology Reports · doi:10.1007/s11886-016-0755-4 · Cited by 354 · see citing works
Insulin-like growth factor-1 deficiency and metabolic syndrome
Aguirre, G. A., Ita, J. R. D., de la Garza, R. G., & Castilla‐Cortázar, I. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-015-0762-z · Cited by 297 · see citing works
Hepatokines and metabolism: Deciphering communication from the liver
Jensen-Cody, S. O., & Potthoff, M. J. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101138 · Cited by 252 · see citing works
Insulin-Like Growth Factor 1 (IGF-1) Signaling in Glucose Metabolism in Colorectal Cancer
Kasprzak, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126434 · Cited by 248 · see citing works
Mancini, A., Bruno, C., Vergani, E., d’Abate, C., Giacchi, E., & Silvestrini, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041667 · Cited by 189 · see citing works
Haywood, N. J., Slater, T. A., Matthews, C., & Wheatcroft, S. B. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.10.008 · Cited by 175 · see citing works
Higashi, Y., Sukhanov, S., Shai, S., Danchuk, S. D., Tang, R., Snarski, P., Li, Z., Lobelle‐Rich, P., Wang, M., Wang, D. D., et al. (2016) · Circulation · doi:10.1161/circulationaha.116.021805 · Cited by 122 · see citing works
Arturi, F., Succurro, E., Procopio, C., Pedace, E., Mannino, G. C., Lugarà, M., Procopio, T., Andreozzi, F., Sciacqua, A., Hribal, M. L., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1227 · Cited by 103 · see citing works
Self-citationRen, J. T., & Anversa, P. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.12.006 · Cited by 100 · see citing works
Acupuncture in the Treatment of Obesity: A Narrative Review of the Literature
Belivani, M., Dimitroula, C., Katsiki, N., Apostolopoulou, M. I., Cummings, M., & Hatzitolios, A. I. (2012) · Acupuncture in Medicine · doi:10.1136/acupmed-2012-010247 · Cited by 95 · see citing works
Marini, M. A., Succurro, E., Frontoni, S., Mastroianni, S., Arturi, F., Sciacqua, A., Lauro, R., Hribal, M. L., Perticone, F., & Sesti, G. (2012) · Diabetes Care · doi:10.2337/dc11-2181 · Cited by 90 · see citing works
Self-citationMarini, M. A., Succurro, E., Castaldo, E., Cufone, S., Arturi, F., Sciacqua, A., Lauro, R., Hribal, M. L., Perticone, F., & Sesti, G. (2012) · Diabetes Care · doi:10.2337/dc11-2032 · Cited by 79 · see citing works
Self-citationOne-Hour Postload Hyperglycemia: Implications for Prediction and Prevention of Type 2 Diabetes
Fiorentino, T. V., Marini, M. A., Succurro, E., Andreozzi, F., Perticone, M., Hribal, M. L., Sciacqua, A., Perticone, F., & Sesti, G. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-00468 · Cited by 56 · see citing works
Self-citationInteraction between maternal obesity and post-natal over-nutrition on skeletal muscle metabolism
Simar, D., Chen, H., Lambert, K., Mercier, J. G., & Morris, M. J. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.11.007 · Cited by 54 · see citing works
Central IGF1 improves glucose tolerance and insulin sensitivity in mice
Hong, H., Cui, Z.-Z., Zhu, L., Fu, S.-P., Rossi, M., Cui, Y.-H., & Zhu, B.-M. (2017) · Nutrition & Diabetes · doi:10.1038/s41387-017-0002-0 · Cited by 54 · see citing works
Revisiting the Relationship Between Blood Pressure and Insulin-Like Growth Factor-1
Schutte, A. E., Volpe, M., Tocci, G., & Conti, E. (2014) · Hypertension · doi:10.1161/hypertensionaha.113.03057 · Cited by 52 · see citing works
Chishima, S., Kogiso, T., Matsushita, N., Hashimoto, E., & Tokushige, K. (2017) · Internal Medicine · doi:10.2169/internalmedicine.56.7626 · Cited by 51 · see citing works
Thankamony, A., Capalbo, D., Marcovecchio, M., Sleigh, A., Jørgensen, S. W., Hill, N., Mooslehner, K., Yeo, G., Bluck, L., Juul, A., et al. (2014) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2013-4542 · Cited by 45 · see citing works
Mannino, G. C., Greco, A., Lorenzo, C. D., Andreozzi, F., Marini, M. A., Perticone, F., & Sesti, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0085483 · Cited by 43 · see citing works
Self-citationOne-hour post-load plasma glucose levels are associated with elevated liver enzymes
Succurro, E., Arturi, F., Grembiale, A., Iorio, F., Fiorentino, T. V., Andreozzi, F., Sciacqua, A., Hribal, M. L., Perticone, F., & Sesti, G. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2011.02.002 · Cited by 41 · see citing works
Self-citationMiao, X., Alidadipour, A., Saed, V., Sayyadi, F., Jadidi, Y., Davoudi, M., Amraee, F., Jadidi, N., & Afrisham, R. (2024) · Acta Diabetologica · doi:10.1007/s00592-024-02335-9 · Cited by 34 · see citing works
Sesti, G., Succurro, E., Arturi, F., Andreozzi, F., Laino, I., Perticone, M., Sciacqua, A., Hribal, M. L., & Perticone, F. (2010) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.02.008 · Cited by 33 · see citing works
Self-citationSuccurro, E., Arturi, F., Grembiale, A., Iorio, F., Laino, I., Andreozzi, F., Sciacqua, A., Hribal, M. L., Perticone, F., & Sesti, G. (2010) · European Journal of Endocrinology · doi:10.1530/eje-10-0113 · Cited by 33 · see citing works
Self-citationLiang, S., Hu, Y., Liu, C., Qi, J., & Li, G. (2016) · Lipids in Health and Disease · doi:10.1186/s12944-016-0275-7 · Cited by 33 · see citing works
Succurro, E., Marini, M. A., Arturi, F., Grembiale, A., Fiorentino, T. V., Andreozzi, F., Sciacqua, A., Lauro, R., Hribal, M. L., Perticone, F., et al. (2011) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2011.01.055 · Cited by 31 · see citing works
Self-citationInsulin-like Growth Factors in a clinical setting: Review of IGF-I
Frysak, Z., Schovanek, J., Iacobone, M., & Karasek, D. (2015) · Biomedical Papers · doi:10.5507/bp.2015.041 · Cited by 30 · see citing works
An update of the consensus statement on insulin resistance in children 2010
Tagi, V., Samvelyan, S., & Chiarelli, F. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1061524 · Cited by 26 · see citing works
Sesti, G., Mannino, G. C., Andreozzi, F., Greco, A., Perticone, M., Sciacqua, A., Marini, M. A., & Perticone, F. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.10.024 · Cited by 25 · see citing works
Self-citationSesti, G., Hribal, M. L., Procopio, T., Fiorentino, T. V., Sciacqua, A., Andreozzi, F., Marini, M. A., & Perticone, F. (2014) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2014.06.012 · Cited by 24 · see citing works
Self-citationMarini, M. A., Succurro, E., Arturi, F., Ruffo, M., Andreozzi, F., Sciacqua, A., Lauro, R. D., Hribal, M. L., Perticone, F., & Sesti, G. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2011.04.009 · Cited by 24 · see citing works
Self-citationMahmassani, Z. S., Reidy, P. T., McKenzie, A. I., Petrocelli, J. J., Matthews, O., de Hart, N. M. M. P., Ferrara, P. J., O’Connell, R. M., Funai, K., & Drummond, M. J. (2020) · Obesity · doi:10.1002/oby.22759 · Cited by 23 · see citing works
Santi, M. D., Annibalini, G., Marano, G., Biganzoli, G., Venturelli, E., Pellegrini, M., Lucertini, F., Brandi, G., Biganzoli, E. M., Barbieri, E., et al. (2023) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-023-04755-6 · Cited by 21 · see citing works
Al–Massadi, O., Parini, P., Fernø, J., Luquet, S. H., & Quiñones, M. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-022-09732-x · Cited by 19 · see citing works
Bruno, C., Vergani, E., Giusti, M., Oliva, A., Cipolla, C., Pitocco, D., & Mancini, A. (2021) · Nutrients · doi:10.3390/nu13103434 · Cited by 19 · see citing works
Fiorentino, T. V., Hribal, M. L., Andreozzi, F., Perticone, M., Sciacqua, A., Perticone, F., & Sesti, G. (2015) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2015.02.007 · Cited by 17 · see citing works
Self-citationYue, X., Hao, W., Wang, M., & Fu, Y. (2023) · Immunity Inflammation and Disease · doi:10.1002/iid3.1071 · Cited by 17 · see citing works
Serum level of insulin-like growth factor-I in type 2 diabetic patients: impact of obesity
Aleidi, S. M., Shayeb, E., Bzour, J., Abu-rish, E. Y., Hudaib, M., Alalawi, S., & Bustanji, Y. K. (2019) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2019-0015 · Cited by 15 · see citing works
Sabzikarian, M., Mahmoudi, T., Tabaeian, S. P., Rezamand, G., Asadi, A., Farahani, H., Nobakht, H., Dabiri, R., Mansour‐Ghanaei, F., Derakhshan, F., et al. (2020) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2020.1791187 · Cited by 15 · see citing works
Cardiometabolic Changes in Response to a Calorie-Restricted DASH Diet in Obese Older Adults
Perry, C. A., Guilder, G. P. V., Hossain, M., & Kauffman, A. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.647847 · Cited by 16 · see citing works
The possible role of endocrine dysfunction of adipose tissue in gestational diabetes mellitus
Šimják, P., Anderlová, K., Cinkajzlová, A., Pařı́zek, A., Kršek, M., & Haluzı́k, M. (2020) · Minerva Endocrinology · doi:10.23736/s0391-1977.20.03192-2 · Cited by 16 · see citing works
Jiang, F., Tang, Y., Guo, L., & Jiao, X. (2013) · PubMed · Cited by 13 · see citing works
Wang, R., Xu, D., Liu, R., Zhao, L., Hu, L., & Wu, P. (2017) · Medical Science Monitor · doi:10.12659/msm.902956 · Cited by 13 · see citing works
Insulin-like growth factor-1 is a negative modulator of glucagon secretion
Mancuso, E., Mannino, G. C., Fatta, C. D., Fuoco, A., Spiga, R., Andreozzi, F., & Sesti, G. (2017) · Oncotarget · doi:10.18632/oncotarget.18514 · Cited by 13 · see citing works
Self-citationInsulin sensitivity, and β-cell function in relation to hemoglobin A1C
Marini, M. A., Frontoni, S., Succurro, E., Arturi, F., Sciacqua, A., Hribal, M. L., Perticone, F., & Sesti, G. (2013) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2013.01.011 · Cited by 11 · see citing works
Self-citationSarcopenia in the setting of nonalcoholic fatty liver
Arrese, M. A., Cabello‐Verrugio, C., Arab, J. P., Francisco Barrera, M., Baudrand, R. F., Guarda, F. J., Gul, I., & Cabrera, D. (2022) · Metabolism and Target Organ Damage · doi:10.20517/mtod.2021.16 · Cited by 10 · see citing works
Endocrine response to acute resistance exercise in obese versus lean physically active men
Rubin, D. A., Pham, H., Adams, E. S., Tutor, A. R., Hackney, A. C., Coburn, J. W., & Judelson, D. A. (2015) · European Journal of Applied Physiology · doi:10.1007/s00421-015-3105-0 · Cited by 10 · see citing works
Liu, Z., Wang, H., Gong, X., Jiang, X., Yang, K., Jiang, L., Wang, Z., & Tong, Q. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1705122 · Cited by 7 · see citing works
Song, X., Zhong, W., Zheng, H., Ou, X., Zheng, D., & Li, Z. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1814752 · Cited by 7 · see citing works
IUGR with catch-up growth programs impaired insulin sensitivity through LRP6/IRS-1 in male rats
Long, W., Zhou, T., Xuan, X., Cao, Q., Luo, Z., Qin, Y., Ning, Q., Luo, X., & Xie, X. (2021) · Endocrine Connections · doi:10.1530/ec-21-0203 · Cited by 7 · see citing works
Job Related Burnout among Emergency Physicians and Nurses in Dammam City, Saudi Arabia
Alshahrani, A., Alhotheyfa, A. M., Alkhiraisy, S. Z., Abugad, H., & Alshahrani, B. F. (2022) · World Family Medicine Journal/Middle East Journal of Family Medicine · doi:10.5742/mewfm.2022.95219 · Cited by 6 · see citing works
Bashir Fadl, A. F., Al-Towerqi, A. M., Alharbi, A., kabrah, D. K., Almalki, A. A., Algethami, B. N., & Albogami, A. F. (2022) · World Family Medicine Journal/Middle East Journal of Family Medicine · doi:10.5742/mewfm.2022.95216 · Cited by 6 · see citing works
Jung, S. Y., Hursting, S. D., Guindani, M., Vitolins, M. Z., Paskett, E. D., & Chang, S. (2013) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-13-1053 · Cited by 6 · see citing works
Qiu, X., Wei, X., Guan, H., Su, H., Gong, J., Fang, K., Zou, X., Dong, H., Xu, L., & Lu, F. (2018) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2018/3248521 · Cited by 6 · see citing works
Alsuhaymi, N., Darwish, A. M., & Khattab, A. E.-N. A. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06448-0 · Cited by 6 · see citing works
RetractedNobakht, H., Mahmoudi, T., Rezamand, G., Tabaeian, S. P., Jeddi, G., Asadi, A., Farahani, H., Dabiri, R., Mansour‐Ghanaei, F., Kaboli, S. A., et al. (2022) · Laboratory Medicine · doi:10.1093/labmed/lmac039 · Cited by 6 · see citing works
Baba, M. A. K., Khan, S. E., Hasnain, F., Sakina, R., Talat, A., & Irfan, A. B. (2022) · World Family Medicine Journal/Middle East Journal of Family Medicine · doi:10.5742/mewfm.2022.95202 · Cited by 5 · see citing works
Association of IGF-1 and IGFBP-3 with metabolic abnormalities among children and adolescents
Zhao, Z., Ma, Y., Zhang, X., Liu, X., Li, Y., Fang, Z., Zheng, R., & Li, H. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1579107 · Cited by 4 · see citing works
Aging and IGF-I: relationships with vitamin D and body composition. A mediation analysis
Vicinanza, R., Frizza, A., Pollard, J. A., Mazza, V., Martino, M. U. D., Imbimbo, G., Pignatelli, P., Ettorre, E., Ben, M. D., & Molfino, A. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1585696 · Cited by 4 · see citing works
Glucose-dependent insulin-like growth factor 1 secretion promotes breast cancer cell tumorigenesis
Gentilini, V., Annibalini, G., Baldelli, G., Conti, A. M. F., Emili, R., Brandi, G., Barbieri, E., & Santi, M. D. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.124020 · Cited by 4 · see citing works
Metabolic imbalance of the insulin-like growth factor–I axis in Zucker diabetic fatty rats
Ceuninck, F. D., Rolin, J., Caliez, A., Baschet, L., & Ktorza, A. (2011) · Metabolism · doi:10.1016/j.metabol.2011.03.012 · Cited by 4 · see citing works
Deveci, O., Karaca, Z., Tanrıverdi, F., Deveci, K., Hacıoğlu, A., Ünlühızarcı, K., & Keleştimur, F. (2022) · Annales d Endocrinologie · doi:10.1016/j.ando.2022.11.003 · Cited by 4 · see citing works
Genetic Diversity of Insulin Resistance and Metabolic Syndrome
Lee, S., Ahn, J., Park, J., Na, H., Lee, Y.-K., Kim, Y., Hong, G., & Lee, K.-R. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.93906 · Cited by 4 · see citing works
Alshahrani, M. M., Alwabel, H. H. A., Alabisi, H. D., Alshehr, M. A., Alqahtani, A. M., Asiri, A. A., & Alqahtani, M. (2022) · World Family Medicine Journal/Middle East Journal of Family Medicine · doi:10.5742/mewfm.2022.95211 · Cited by 5 · see citing works
The insulin resistance syndrome
Sattar, N. A., Welsh, P. I., & Preiss, D. (2015) · doi:10.1002/9781118387658.ch23 · Cited by 4 · see citing works
Wystrychowski, G., Simka-Lampa, K., Witkowska, A., Sobecko, E., Skubis-Sikora, A., Sikora, B., Wojtyna, E., Golda, A., Gwizdek, K., Wróbel, M. P., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126644 · Cited by 3 · see citing works
Why patients go to private health care facilities? Perspectives from Qassim, Saudi Arabia
Sulaiman, A. A., Rabbani, U., AlShaya, S. S., Alyahya, M., Al-Gabbany, S. A., Kalevaru, C. S., Jahan, S., Aljubeilan, R. A., Almeman, A., & AlAhajji, B. A. (2022) · World Family Medicine Journal/Middle East Journal of Family Medicine · doi:10.5742/mewfm.2022.95212 · Cited by 3 · see citing works
Masarit, A. M., Alhafithi, M., Alsanna, H., & Almaghaslah, S. (2022) · World Family Medicine Journal/Middle East Journal of Family Medicine · doi:10.5742/mewfm.2022.95201 · Cited by 2 · see citing works
Naddeh, D., & Alsharei, A. S. A. (2022) · World Family Medicine Journal/Middle East Journal of Family Medicine · doi:10.5742/mewfm.2022.95221 · Cited by 2 · see citing works
Alhafithi, M., Al‐Dubai, S. A. R., Alalwan, S. S., & Masarit, A. M. (2022) · World Family Medicine Journal/Middle East Journal of Family Medicine · doi:10.5742/mewfm.2022.95204 · Cited by 2 · see citing works
Physicians’ Perceptions and Attitudes toward Use of Electronic Medical Record Systems in Riyadh
AlOtaib, Y. H., & AlSaedi, M. (2022) · World Family Medicine Journal/Middle East Journal of Family Medicine · doi:10.5742/mewfm.2022.95218 · Cited by 3 · see citing works
Lazúrová, I., Figurová, J., Lazúrová, Z., Dravecká, I., Mašlanková, J., & Mareková, M. (2021) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.4149/bll_2021_077 · Cited by 1 · see citing works
khmour, H. Y., Al-Rabeei, Y., Deen, N. Z., Elnour, S., Al-Karbi, K., Rashed, M. H., Al-Muhannadi, M., Elmahdi, M., Shamari, H. A., abugesiesa, M. A., et al. (2022) · World Family Medicine Journal/Middle East Journal of Family Medicine · doi:10.5742/mewfm.2022.95233 · Cited by 1 · see citing works
Alzunidi, M. A., Alowayyid, J. A., Benhadi, R. A., Farouk, H. H., Alshammari, M. H., Sultan, A. S., Almojil, R. A., Alshathri, A. A., Alsalman, N. N., Alshaya, S. S., et al. (2022) · World Family Medicine Journal/Middle East Journal of Family Medicine · doi:10.5742/mewfm.2022.95223 · Cited by 3 · see citing works
Zahrani, L. M., Abdulhaq, M. I., Shams, T. M., & Farahat, F. M. (2022) · World Family Medicine Journal/Middle East Journal of Family Medicine · doi:10.5742/mewfm.2022.95206 · Cited by 1 · see citing works
Hnish, M. A. J., Deen, N. Z., Snoussi, S., Mohamad, H., Abdalla, M., & Abdelbagi, I. (2022) · World Family Medicine Journal/Middle East Journal of Family Medicine · doi:10.5742/mewfm.2022.95234 · Cited by 1 · see citing works
Mallu, A. C. T., Sivagurunathan, S., Paul, D., Aggarwal, H., Nathan, A. A., Ravi, M. M., Boppana, R., Jagavelu, K., Santra, M. K., & Dixit, M. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.10.13.464163
The Quality of Life among the Adult Population during COVID-19 in Saudi Arabia
Goweda, R. A., Hammad, T. N., Khan, Z. A., Alghamdi, A. A., Alyazidi, A. O., Alharbi, A. G., Almalki, K. A., Alzahrani, M. A., & Alzubaidi, A. A. (2022) · World Family Medicine Journal/Middle East Journal of Family Medicine · doi:10.5742/mewfm.2022.95238
Documentation of paediatric observations in an urgent care setting; a Quality Improvement Project
Ali, R. Y. (2022) · World Family Medicine Journal/Middle East Journal of Family Medicine · doi:10.5742/mewfm.2022.95210 · Cited by 1 · see citing works
Al-Saiari, A. S., Alsaedi, S., Alzahran, E., Kutbi, L., Alsahafi, B. A. A., alharbi, G. G., Abdelsalam, M., & Bakhsh, A. A. (2022) · World Family Medicine Journal/Middle East Journal of Family Medicine · doi:10.5742/mewfm.2022.95235
Rare presentation of lower limb weakness, a case report
khmour, H. Y., el Nour, S., & Elmahdi, M. (2022) · World Family Medicine Journal/Middle East Journal of Family Medicine · doi:10.5742/mewfm.2022.95231
Insulin Resistance Related to Metabolic Syndrome
Shamery, H. T. A., & Sait, N. S. (2022) · World Family Medicine Journal/Middle East Journal of Family Medicine · doi:10.5742/mewfm.2022.95237
Shamery, H. T. A., Abouamer, W., & Sait, N. S. (2022) · World Family Medicine Journal/Middle East Journal of Family Medicine · doi:10.5742/mewfm.2022.95229
Sarmento‐Cabral, A., Alors‐Pérez, E., Sánchez‐Frías, M., Fuentes-Fayos, A. C., Lopez-Canovas, J. L., Luque, R. M., & Gahete, M. D. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119018
Papaccio, F., Scano, S., & Bellei, B. (2026) · Health Science Reports · doi:10.1002/hsr2.72950
- Authors
- Succurro, E., Andreozzi, F., Marini, M. A., Lauro, R., Hribal, M. L., Perticone, F., & Sesti, G.
- Affiliations
- Magna Graecia University (IT)
- University of Rome Tor Vergata (IT)
- Corresponding author
- Sesti, G.
- Venue
- Nutrition Metabolism and Cardiovascular Diseases
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 19
- Issue
- 10
- Pages
- 713-719
- ISSN
- 0939-4753 (ISSN-L)
- OpenAlex
- W2013138570
- Cited by
- 85
- References
- 33
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 24 · 2021: 8 · 2020: 5 · 2019: 1 · 2018: 4 · 2017: 4 · 2016: 4 · 2015: 4 · 2014: 4 · 2013: 5 · 2012: 3
- FWCI
- 2.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutrition Metabolism and Cardiovascular Diseases (publishedVersion)
- PubMed (publishedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- insulin-like growth factor I, insulin sensitivity, insulin secretion, obesity, weight gain, glucose disposal, first-phase insulin secretion, second-phase insulin secretion, body mass index, non-diabetic patients, triglycerides
- MeSH terms
- Insulin Secretion, Adult, Aged, Aging, Blood Glucose, Cross-Sectional Studies, Female, Glucose Tolerance Test, Humans, Insulin, Insulin Resistance, Insulin-Like Growth Factor I, Male, Middle Aged, Obesity, Triglycerides, Glucose Clamp Technique, Body Mass Index, White People, Adiposity, Overweight, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review