Role of partially hydrolyzed guar gum in the treatment of irritable bowel syndrome
Abstract
Irritable bowel syndrome (IBS) is the world's most common gastrointestinal functional disorder and is associated with several social and economic costs. Health-related quality of life is often impaired in patients with IBS. The pathophysiologic mechanisms underlying IBS remain poorly defined. The therapeutic approach to patients with IBS is based on symptoms, and fibers may play an important role in treatment. Among the various types of fiber, water-soluble, non-gelling fibers seem to be a promising option for treatment of IBS. Partially hydrolyzed guar gum (PHGG) is a water-soluble, non-gelling fiber that has provided therapeutic benefits. In clinical trials, PHGG decreased symptoms in constipation-predominant and diarrhea-predominant forms of IBS and decreased abdominal pain. Further, an improvement in quality of life was observed in patients with IBS during and after treatment with PHGG. Moreover, PHGG seems to have prebiotic properties because it increases the colonic contents of short-chain fatty acids, Lactobacilli, and Bifidobacteria.
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PHGG is a water-soluble, non-viscous, non-gelling vegetable dietary fiber derived from guar gum, a water-soluble, viscous, gelling polysaccharide found in the seeds of Cyamopsis tetragonolobus.
“Partially hydrolyzed guar gum (PHGG) is a water-soluble, non-viscous, non-gelling vegetable dietary fiber derived from guar gum, a water-soluble, viscous, gelling polysaccharide found in the seeds of Cyamopsis tetragonolobus (9, 10).”
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- Authors
- Giannini, E. G., Mansi, C., Dulbecco, P., & Savarino, V.
- Affiliations
- University of Genoa (IT)
- Corresponding author
- Giannini, Edoardo G.
- Venue
- Nutrition
- Publisher
- Elsevier BV
- Published
- 2006-03
- Volume
- 22
- Issue
- 3
- Pages
- 334-342
- ISSN
- 0899-9007 (ISSN-L)
- OpenAlex
- W2055486182
- Cited by
- 117
- References
- 7
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 7 · 2023: 12 · 2022: 3 · 2021: 4 · 2020: 9 · 2019: 5 · 2018: 5 · 2017: 1 · 2016: 8 · 2015: 5 · 2014: 7 · 2013: 8 · 2012: 4
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutrition (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
- Keywords
- irritable bowel syndrome, partially hydrolyzed guar gum, dietary fiber, irritable bowel syndrome with constipation, diarrhea-predominant irritable bowel syndrome, abdominal pain, health-related quality of life, prebiotics, short-chain fatty acids, lactobacilli, Bifidobacterium
- MeSH terms
- Constipation, Diarrhea, Dietary Fiber, Fermentation, Galactans, Humans, Hydrolysis, Mannans, Quality of Life, Abdominal Pain, Treatment Outcome, Dietary Supplements, Irritable Bowel Syndrome, Plant Gums
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