Fructo-oligosaccharides and fibre in enteral nutrition has a beneficial influence on microbiota and gastrointestinal quality of life
Abstract
OBJECTIVE: Intestinal microbiota is important in health and disease. The aim of this study was to evaluate the effect of fructo-oligosaccharides (FOS) and fibre-enriched tube feeding on quality of life and intestinal microbiota (faecal Bifidobacteria). MATERIAL AND METHODS: Nineteen out of 59 home-living, tube-feeding-dependent, adult patients and matched healthy controls were included in this randomized, double-blind study. After a washout period, patients received either no residue tube feeding (non-FOS group) or FOS and fibre-enriched tube feeding (FOS group). Quality of life as defined by the Gastrointestinal Quality of Life Index (GIQLI) and quantification of faecal Bifidobacteria were determined. RESULTS: At baseline, GIQLI scores in controls and patients were 88+/-12 and 67+/-14, respectively (p=0.001). Following 6 weeks' intervention, GIQLI scores remained stable (65+/-14 versus 67+/-17) in the FOS group, whereas the non-FOS group values decreased (68+/-17 versus 64+/-19). Baseline faecal samples contained 2. 1x 10(7)+/-3.5 x 10(7) and 2.1 x 10(6)+/-5.6 x10(6)Bifidobacteria (p=0.002) in controls and patients, respectively, with no differences between patient groups. During the intervention, this number remained stable in the FOS group (0.7 x 10(6)+/-1.3 x 10(6) versus 1.0 x 10(6)+/-1.3 x 10(6) baseline versus end-point), but decreased in the non-FOS group (3.6 x1 0(6)+/-8.0 x 10(6) versus 2.5 x 10(4)+/-4.0 x 10(4)). GIQLI scores were correlated with the number of faecal Bifidobacteria (r=0.41, p=0.007). CONCLUSIONS: The GIQL score for the tube-fed patients increased with the number of faecal Bifidobacteria, although in a non-linear way, and addition of FOS increased the number of Bifidobacteria. This suggests that prebiotic tube feeding may lead to a change in intestinal microbiota that could induce an increased quality of life in these patients.
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Prebiotic supplementation has positive effects on the gut microbial profile and quality of life in tube-fed patients.
“the positive effects of prebiotic supplementation on the gut microbial profile and quality of life in tube-fed patients [107]”
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- Authors
- Wierdsma, N. J., van Bodegraven, A. A., Uitdehaag, B. M. J., Arjaans, W., Savelkoul, P. H. M., Kruizenga, H. M., & van Bokhorst-de van der Schueren, M. A. E.
- Affiliations
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Corresponding author
- Wierdsma, Nicolette J.
- Venue
- Scandinavian Journal of Gastroenterology
- Publisher
- Informa UK Limited
- Published
- 2009-01
- Volume
- 44
- Issue
- 7
- Pages
- 804-812
- ISSN
- 0036-5521 (ISSN-L)
- 1502-7708
- OpenAlex
- W1975358609
- Cited by
- 33
- References
- 30
- Citations by year
- 2026: 1 · 2025: 4 · 2023: 2 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 1 · 2014: 1 · 2013: 4 · 2012: 1
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Scandinavian Journal of Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- fructooligosaccharides, dietary fiber, enteral nutrition, tube feeding, gut microbiota, Bifidobacterium, gastrointestinal quality of life, Gastrointestinal Quality of Life Index, home care, prebiotics, fecal microbiota, fecal calprotectin
- MeSH terms
- Aged, Aged, 80 and over, Bifidobacterium, Dietary Fiber, Enteral Nutrition, Feces, Humans, Intestines, Middle Aged, Oligosaccharides, Pilot Projects, Prospective Studies, Quality of Life, Surveys and Questionnaires, Case-Control Studies, Statistics, Nonparametric, Reverse Transcriptase Polymerase Chain Reaction
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