Impact of nutritional support on clinical outcome in patients at nutritional risk: A multicenter, prospective cohort study in Baltimore and Beijing teaching hospitals

In the Jie et al. study, the lower overall complication rate was primarily because of a lower rate of infectious complications (10.5% vs 18.9%, p<0.001).

“The overall complication rate was significantly lower in the group with nutritional therapy than in the no-support group (20.3% vs. 28.1%,p ¼ 0.009), primarily because of the lower rate of infectious complications (10.5% vs. 18.9%, p < 0.001).”

Several prospective cohort studies showed a prevalence of malnutrition risk of approximately 40-50% in a hospitalized population of tertiary centers.

“Several prospective cohort studies showed a prevalence of approximately 40e50% in a hospitalized population of tertiary centers [16,17].”

In the Jie et al. study, the overall complication rate was significantly lower in the group with nutritional therapy than in the no-support group (20.3% vs 28.1%, p=0.009).

“The overall complication rate was significantly lower in the group with nutritional therapy than in the no-support group (20.3% vs. 28.1%,p ¼ 0.009), primarily because of the lower rate of infectious complications (10.5% vs. 18.9%, p < 0.001).”

In the Jie et al. study, significantly lower complication rates were found only in patients who received enteral nutrition compared to the group without nutritional support (8.2% vs 28.1%, p<0.001).

“Also, in the same study, the effects of each medical nutrition therapy were analyzed separately, and significantly lower complication rates were found only in patients who received enteral nutrition (EN) compared to the group without nutritional support (8.2% vs. 28.1%,p < 0.001).”

In a prospective, non-randomized cohort study, Jie et al. found nutritional support was beneficial for polymorbid medical inpatients at nutritional risk as defined by NRS 2002.

“In a prospective, non-randomized cohort study, Jie et al. found nutritional support was beneficial for polymorbid medical inpatients at nutritional risk as defined by the NRS 2002 [17] (Level of evidence 2þ).”

In the Jie et al. study, these effects were robust after multivariate adjustment.

“These effects were robust after multivariate adjustment.”

Polymorbid medical inpatients are at high risk of malnutrition.

“Polymorbid medical inpatients are at high risk of malnutrition.”

In that study, when nutritional support was divided into PN and EN, overall complication rate and rates of infectious and non-infectious complications were significantly lower in patients receiving EN than in patients with no nutritional support (p=0.001).

“When the nutritional support group was further divided into those receiving PN and those receiving EN, the overall complication rate and the rates of infectious complications and non-infectious complications were significantly lower in those patients receiving EN than in those patients with no nutritional support (p ¼ 0.001).”

In polymorbid medical inpatients whose nutritional requirements cannot be met orally, EN may be superior to PN because of a lower risk of infectious and non-infectious complications and maintenance of gut integrity.

“In polymorbid medical inpatients whose nutritional requirements cannot be met orally, the use of EN may be superior to PN because of a lower risk of infectious, non-infectious complications and maintenance of gut integrity.”

In that study, in patients undergoing major abdominal surgery, no significant difference in complication rate was found between PN patients and control patients.

“Again, no significant difference in the complication rate was found between PN patients and control patients.”

In that study, no difference in complication rates was found between patients with PN and patients with no nutritional support (p=0.29).

“However, no difference in the complication rates was found between patients with PN and patients with no nutritional support (p ¼ 0.29).”