Evaluation of chemoprevention of oral cancer with spirulina fusiformis
Abstract
The blue-green microalgae Spirulina, used in daily diets of natives in Africa and America, have been found to be a rich natural source of proteins, carotenoids, and other micronutrients. Experimental studies in animal models have demonstrated an inhibitory effect of Spirulina algae on oral carcinogenesis. Studies among preschool children in India have demonstrated Spirulina fusiformis (SF) to be an effective source of dietary vitamin A. We evaluated the chemopreventive activity of SF (1 g/day for 12 mos) in reversing oral leukoplakia in pan tobacco chewers in Kerala, India. Complete regression of lesions was observed in 20 of 44 (45%) evaluable subjects supplemented with SF, as opposed to 3 of 43 (7%) in the placebo arm (p < 0.0001). When stratified by type of leukoplakia, the response was more pronounced in homogeneous lesions: complete regression was seen in 16 of 28 (57%) subjects with homogeneous leukoplakia, 2 of 8 with erythroplakia, 2 of 4 with verrucous leukoplakia, and 0 of 4 with ulcerated and nodular lesions. Within one year of discontinuing supplements, 9 of 20 (45%) complete responders with SF developed recurrent lesions. Supplementation with SF did not result in increased serum concentration of retinol or beta-carotene, nor was it associated with toxicity. This is the first human study evaluating the chemopreventive potential of SF. More studies in different settings and different populations are needed for further evaluation.
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Arthrospira platensis fusiformis exhibits chemopreventive potential in humans with leukoplakia.
“Arthrospira platensis fusiformis also exhibits chemopreventive potential in humans with leukoplakia [132].”
From Application of Arthrospira platensis for Medicinal Purposes and the Food Industry: A Review of the Literature (2023) · cites this paper as [132]
The authors observed a partial regression of tumor lesions that developed on the inside of the cheek in 45% of patients and complete regression in 7% of patients.
“The authors observed a partial regression of tumor lesions that developed on the inside of the cheek in 45% of patients and complete regression in 7% of patients [132].”
From Application of Arthrospira platensis for Medicinal Purposes and the Food Industry: A Review of the Literature (2023) · cites this paper as [132]
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- Authors
- Mathew, B., Sankaranarayanan, R., Nair, P. P., Varghese, C., Somanathan, T., Amma, B. P., Amma, N. S., & Nair, M. K.
- Affiliations
- Regional Cancer Center, Thiruvananthapuram (IN)
- Centre international de recherche sur le cancer (FR)
- Beltsville Human Nutrition Research Center (US)
- Armed Forces Medical College (IN)
- Venue
- Nutrition and Cancer
- Publisher
- Informa UK Limited
- Published
- 1995-01
- Volume
- 24
- Issue
- 2
- Pages
- 197-202
- ISSN
- 0163-5581 (ISSN-L)
- 1532-7914
- OpenAlex
- W2221089757
- Cited by
- 183
- References
- 15
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 9 · 2022: 11 · 2021: 9 · 2020: 8 · 2019: 4 · 2018: 6 · 2017: 3 · 2016: 7 · 2015: 10 · 2014: 6 · 2013: 8 · 2012: 7
- FWCI
- 2.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutrition and Cancer (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral Health Pathology and Treatment
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Keywords
- oral cancer chemoprevention, oral leukoplakia, tobacco chewing, dietary supplementation, retinol, beta-carotene, micronutrients, lesion regression, recurrence
- MeSH terms
- Adult, Cyanobacteria, Carotenoids, Female, Food, Fortified, Humans, India, Leukoplakia, Oral, Male, Middle Aged, Mouth Neoplasms, Remission Induction, Vitamin A, beta Carotene
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