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Cited by 207Microbial Metabolites in Food BiotechnologyAdipokines, Inflammation, and Metabolic DiseasesNatural Antidiabetic Agents Studies

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Oligofructose-enriched inulin improves some inflammatory markers and metabolic endotoxemia in women with type 2 diabetes mellitus: A randomized controlled clinical trial

Dehghan, Parvin, Pourghassem Gargari, Bahram, Asghari Jafar-abadi, Mohammad·2014·Nutrition
DOI 10.1016/j.nut.2013.09.005
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Abstract

Objectives Anti-inflammatory therapeutic approaches are considered for the management of type 2 diabetes and for the prevention of its complications. There is limited evidence regarding the effects of prebiotics on inflammation, especially in patients with type 2 diabetes. This trial aims to examine the effects of oligofructose-enriched inulin on glycemic status, inflammation markers, and metabolic endotoxemia in female patients.Methods Over a period of 8 wk, 52 women with body mass indices of >25 kg/m(2) but <35 kg/m(2) with type 2 diabetes were randomly assigned to either an intervention group, in which participants were given oligofructose-enriched inulin (n = 27, consuming 10 g/d of oligofructose-enriched inulin), or to a control group, in which participants were given maltodextrin (n = 25, consuming 10 g/d of maltodextrin). Fasting plasma glucose, glycosylated hemoglobin, high-sensitivity C-reactive protein, interleukin-6, tumor necrosis factor-α, interferon-γ, interleukin-10, and plasma lipopolysaccharide were measured before and after the intervention. Data were analyzed with the use of SPSS software version 13. Paired and unpaired Student t tests and analysis of covariance were used to compare quantitative variables.Results Oligofructose-enriched inulin caused a significant decrease in the levels of fasting plasma glucose (19.2 mg/dL; 9.50%), glycosylated hemoglobin (1.0%; 8.40%), interleukin-6 (1.3 pg/mL; 8.15%), tumor necrosis factor-α (3.0 pg/mL; 19.80%) and plasma lipopolysaccharide (6.0 EU/mL; 21.95%) as compared with maltodextrin (P < 0.05). Decreases in levels of interferon-γ (0.3 pg/mL; 16.50%) and high-sensitivity C-reactive protein (3.9 ng/mL; 31.70%) and an increase in the level of interleukin-10 (0.4 pg/mL, 11.50%) were not significant in the oligofructose-enriched inulin group as compared with the maltodextrin group.Conclusions In women with type 2 diabetes and suboptimal daily dietary fiber intake, oligofructose-enriched inulin may help to modulate some inflammatory markers.

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Metadata

Authors
Dehghan, P., Pourghassem Gargari, B., & Asghari Jafar-abadi, M.
Affiliations
Tabriz University of Medical Sciences (IR)
ORCID
Dehghan, Parvin
Venue
Nutrition
Publisher
Elsevier BV
Published
2014-04
Volume
30
Issue
4
Pages
418-423
ISSN
0899-9007 (ISSN-L)
DOI
10.1016/j.nut.2013.09.005
OpenAlex
W1977968392
Cited by
207
References
43
Citations by year
2026: 5 · 2025: 22 · 2024: 18 · 2023: 12 · 2022: 38 · 2021: 13 · 2020: 14 · 2019: 25 · 2018: 12 · 2017: 15 · 2016: 13 · 2015: 15 · 2014: 4
FWCI
9.87
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
University of Tabriz
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
Keywords
oligofructose-enriched inulin, prebiotics, type 2 diabetes, women, inflammatory markers, endotoxemia, lipopolysaccharide, glycemic control, HbA1c, fasting blood glucose, interleukin-6, TNF-α, C-reactive protein, IL-10, interferon-gamma
MeSH terms
Adult, Blood Glucose, C-Reactive Protein, Diabetes Mellitus, Type 2, Female, Glycated Hemoglobin, Humans, Inflammation, Interferon-gamma, Inulin, Lipopolysaccharides, Middle Aged, Oligosaccharides, Tumor Necrosis Factor-alpha, Biomarkers, Interleukin-6, Body Mass Index, Endotoxemia, Prebiotics

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