The role of the gut microbiota in energy metabolism and metabolic disease

An obesity-associated gut microbiome with increased capacity for energy harvest

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Obesity is associated with macrophage accumulation in adipose tissue

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The metabolic syndrome—a new worldwide definition

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Inflammation and metabolic disorders

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Human gut microbes associated with obesity

Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785 · see citing works

Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics

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Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

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Metabolic Endotoxemia Initiates Obesity and Insulin Resistance

Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638 · see citing works

The gut microbiota as an environmental factor that regulates fat storage

Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245 · see citing works

Obesity alters gut microbial ecology

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Mechanisms linking obesity to insulin resistance and type 2 diabetes

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Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice

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Inflammation, stress, and diabetes

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CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

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TLR4 links innate immunity and fatty acid-induced insulin resistance

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IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

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Mechanisms underlying the resistance to diet-induced obesity in germ-free mice

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Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB

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Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia

Cani, P. D., Neyrinck, A. M., Fava, F., Knauf, C., Burcelin, R., Tuohy, K. M., Gibson, G. R., & Delzenne, N. M. (2007) · Diabetologia · doi:10.1007/s00125-007-0791-0 · Cited by 1,776 · see citing works

The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis

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Early differences in fecal microbiota composition in children may predict overweight

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Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes

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Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E

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Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis.

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A high-fat meal induces low-grade endotoxemia: evidence of a novel mechanism of postprandial inflammation.

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Resistance to Endotoxin Shock and Reduced Dissemination of Gram-Negative Bacteria in CD14-Deficient Mice

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The monocyte differentiation antigen, CD14, is anchored to the cell membrane by a phosphatidylinositol linkage.

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Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways

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Review article: prebiotics in the gastrointestinal tract

Macfarlane, S., Macfarlane, G. T., & Cummings, J. H. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.03042.x · Cited by 624 · see citing works

Energy intake is associated with endotoxemia in apparently healthy men

Amar, J., Burcelin, R., Ruidavets, J. B., Cani, P. D., Fauvel, J., Alessi, M., Chamontin, B., & Ferrières, J. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.5.1219 · Cited by 594 · see citing works

Evolution of Symbiotic Bacteria in the Distal Human Intestine

Xu, J., Mahowald, M. A., Ley, R. E., Lozupone, C., Hamady, M., Martens, E. C., Henrissat, B., Coutinho, P. M., Minx, P. J., Latreille, P., et al. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050156 · Cited by 585 · see citing works

Toll-Like Receptor-4 Mediates Vascular Inflammation and Insulin Resistance in Diet-Induced Obesity

Kim, F., Pham, M., Luttrell, I., Bannerman, D. D., Tupper, J., Thaler, J., Hawn, T. R., Raines, E. W., & Schwartz, M. W. (2007) · Circulation Research · doi:10.1161/circresaha.106.142851 · Cited by 584 · see citing works

Understanding and addressing the epidemic of obesity: an energy balance perspective.

Hill, J. (2006) · Endocrine reviews · doi:10.1210/er.2006-0032 · Cited by 559 · see citing works

Association of endotoxemia with carotid atherosclerosis and cardiovascular disease

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Adipose Tissue Macrophages, Low Grade Inflammation and Insulin Resistance in Human Obesity

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Gut microbiota modulation with norfloxacin and ampicillin enhances glucose tolerance in mice

Membrez, M., Blancher, F., Jaquet, M., Bibiloni, R., Cani, P. D., Burcelin, R. G., Corthesy, I., Macé, K., & Chou, C. J. (2008) · The FASEB Journal · doi:10.1096/fj.07-102723 · Cited by 493 · see citing works

Gut Bacterial Translocation via the Portal Vein: A Clinical Perspective with Major Torso Trauma

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Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes

Song, M. J., Kim, K. H., Yoon, J. M., & Kim, J. B. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.05.170 · Cited by 454 · see citing works

Inulin-type fructans modulate gastrointestinal peptides involved in appetite regulation (glucagon-like peptide-1 and ghrelin) in rats

Cani, P. D., Dewever, C., & Delzenne, N. M. (2004) · British Journal Of Nutrition · doi:10.1079/bjn20041225 · Cited by 447 · see citing works

Enterocyte TLR4 Mediates Phagocytosis and Translocation of Bacteria Across the Intestinal Barrier

Neal, M. D., Leaphart, C. L., Levy, R. M., Prince, J. M., Billiar, T. R., Watkins, S. C., Li, J., Çetin, S., Ford, H. R., Schreiber, A. D., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.5.3070 · Cited by 434 · see citing works

Using probiotics and prebiotics to improve gut health

Tuohy, K. M., Probert, H. M., Smejkal, C. W., & Gibson, G. R. (2003) · Drug Discovery Today · doi:10.1016/s1359-6446(03)02746-6 · Cited by 420 · see citing works

Improvement of Glucose Tolerance and Hepatic Insulin Sensitivity by Oligofructose Requires a Functional Glucagon-Like Peptide 1 Receptor

Cani, P. D., Knauf, C., Iglesias, M. A., Drucker, D. J., Delzenne, N. M., & Burcelin, R. (2006) · Diabetes · doi:10.2337/db05-1360 · Cited by 404 · see citing works

Obesity, Inflammation, and Periodontal Disease

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Inulin and Oligofructose as Dietary Fiber: A Review of the Evidence

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Bacterial Endotoxin Is an Active Component of Cigarette Smoke

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Oligofructose Promotes Satiety in Rats Fed a High‐Fat Diet: Involvement of Glucagon‐Like Peptide‐1

Cani, P. D., Neyrinck, A. M., Maton, N., & Delzenne, N. M. (2005) · Obesity Research · doi:10.1038/oby.2005.117 · Cited by 382 · see citing works

Oligofructose promotes satiety in healthy human: a pilot study

Cani, P. D., Joly, E., Horsmans, Y., & Delzenne, N. M. (2005) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602350 · Cited by 381 · see citing works

Effect of Lactobacillus plantarum 299v on cardiovascular disease risk factors in smokers

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C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet

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The CD14 Monocyte Differentiation Antigen Maps to a Region Encoding Growth Factors and Receptors

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Toll-Like Receptor 4 Mediates Maladaptive Left Ventricular Remodeling and Impairs Cardiac Function After Myocardial Infarction

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Gastrointestinal Satiety Signals

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Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat

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Impact of inulin and oligofructose on gastrointestinal peptides

Delzenne, N. M., Cani, P. D., Daubioul, C., & Neyrinck, A. M. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20041342 · Cited by 314 · see citing works

Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage

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Effects of Resistant Starch, A Non‐digestible Fermentable Fiber, on Reducing Body Fat

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Obesity and Periodontitis

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Antioxidative probiotic fermented goats' milk decreases oxidative stress-mediated atherogenicity in human subjects

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Modulation of the Human Gut Microflora Towards Improved Health Using Prebiotics - Assessment of Efficacy

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The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades

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Dietary non-digestible carbohydrates promote L-cell differentiation in the proximal colon of rats

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Modulatory effects of sCD14 and LBP on LPS-host cell interactions

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Endotoxemia, Immune Response to Periodontal Pathogens, and Systemic Inflammation Associate With Incident Cardiovascular Disease Events

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Colonic fermentation influences lower esophageal sphincter function in gastroesophageal reflux disease

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Attenuation of obesity-induced adipose tissue inflammation in C3H/HeJ mice carrying a Toll-like receptor 4 mutation

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The Severity of Periodontal Disease is Associated with the Development of Glucose Intolerance in Non-diabetics: The Hisayama Study

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Lipopolysaccharide (LPS)-Binding Protein Mediates LPS Detoxification by Chylomicrons

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Dietary fiber modulates intestinal proglucagon messenger ribonucleic acid and postprandial secretion of glucagon-like peptide-1 and insulin in rats.

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In Vivo Effects of Bifidobacteria and Lactoferrin on Gut Endotoxin Concentration and Mucosal Immunity in Balb/c Mice

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Involvement of endogenous glucagon-like peptide-1(7–36) amide on glycaemia-lowering effect of oligofructose in streptozotocin-treated rats

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Innate Immunity Modulates Adipokines in Humans

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Clinical laboratory differentiation of infectious versus non-infectious systemic inflammatory response syndrome

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The Role of Bifidobacteria in Gut Barrier Function After Thermal Injury in Rats

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Effect of fat replacement by inulin or lupin-kernel fibre on sausage patty acceptability, post-meal perceptions of satiety and food intake in men

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Peptide YY and Proglucagon mRNA Expression Patterns and Regulation in the Gut

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Minireview: Gut Peptides Regulating Satiety

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Role of ChREBP in hepatic steatosis and insulin resistance

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A place for dietary fibre in the management of the metabolic syndrome

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Dietary Fiber in Management of Diabetes

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Systemic exposure to Porphyromonas gingivalis predicts incident stroke

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Insulin, Glucagon-like Peptide 1, Glucose-Dependent Insulinotropic Polypeptide and Insulin-Like Growth Factor I as Putative Mediators of the Hypolipidemic Effect of Oligofructose in Rats

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Role of Central Nervous System Glucagon-Like Peptide-1 Receptors in Enteric Glucose Sensing

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Effect of Prebiotic Supplementation and Calcium Intake on Body Mass Index

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